Building Blocks

Applications 4-Chlorocinnamic Acid is a derivative of Cinnamic Acid (C442030) and plays an important role in the development of plants. 4-Chlorocinnamic Acid may also show potential antimicrobial, antioxidant, anti-inflammatory, and antitumoral activity.
References Jitareanu, A., et al.: Not. Bot. Horti. Agrobo., 39, 130 (2011)

Stability Unstable in Aqueous Solution
Applications 1-(4-Chlorophenyl)-3-(dimethylamino)propan-1-one Hydrochloride

Stability Air Sensitive, Light Sensitive
Applications Propargyl Sulfide (cas# 13702-09-5) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Methyl 3-amino-2-methylbenzoate (cas# 18583-89-6) is a useful research chemical.

Applications 1-Chloroadamantane-d15 is the isotope labelled analog of 1-Chloroadamantane, an adamantane derivative shown to exhibit virucidal activity against the Newcastle disease virus in chick embryo fibroblasts.
References Aigami, K., et al.: J. Med. Chem., 18, 713 (1975)

Applications 1,4-Cyclohexane-d10-diamine (cis/trans mixture) (CAS# 1219802-80-8) is a useful isotopically labeled research compound.

Applications 2-Nitro-m-toluic Acid, is a building block used for the synthesis of various compounds. It can be used for the synthesis of novel Indolin-2-one derivatives as protein tyrosine phosphatase 1B inhibitors.
References Dai, H., et al.: Lett. Org. Chem., 8, 526 (2011);

Applications N-Methylacetoacetamide is a starting material in the synthesis of 1-Carbamoyl-2-oxopropyl acetate with the aid (diacetoxyiodo)benzene (DIB) as the oxidant. Also, it is a reagent used in the synthesis of 10H-Phenothiazines, which possesses for their biological activity against the regulatory enzymes involved in inflammatory diseases.
References Liu, W., et al.: Beilstein J. Org. Chem., 7, 1436-1440 (2011); Sadanandam, Y. S., et al.: Eur. J. Med. Chem., 44, 197-202 (2009)

Applications Bis(2-Chloroethyl)Ether (D8, 98%) (cas# 93952-02-4) is a useful research chemical.

Applications 2,3,4-Trihydroxybenzoic Acid is used in preparation of Polyester Polyol for solar backboard coating adhesive.
References Hu, Y., et al.: Faming Zhuanli Shenqing, (2020);

Applications 2-Cyanopyridine-d4 (CAS# 1219795-17-1) is a useful isotopically labeled research compound.

Applications 1,3-Dimethoxybenzene-d10 (CAS# 340257-57-0) is a useful isotopically labeled research compound.

Applications 3-Cyano-4-oxo-piperidine-1-carboxylic Acid tert-Butyl Ester is a useful research reagent for organic synthesis and other chemical processes.
References Guo, X., et al.: Molecules, 16, 2626 (2011); Chai, Y., et al.: Bioorg. Med. Chem. Lett., 20, 5195 (2010); Chai, Y., et al.: Bioorg. Med. Chem. Lett., 21, 3377 (2011)

Applications tert-Butyl-1,1,1,3,3,3-d6 Alcohol (CAS# 53853-65-9) is a useful isotopically labeled research compound.

Applications Cyclopentane-d9 (CAS# 80862-68-6) is a useful isotopically labeled research compound.

Applications Coumarin-3-carboxylic acid (cas# 531-81-7) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications (±)-Tetrahydro-2-furoic-d7 Acid (CAS# 1219798-42-1) is a useful isotopically labeled research compound.

Applications 5-Oxohexanoic Acid Ethyl Ester is a useful synthetic intermediate. It is used to prepare tyrosine-derived RGD peptidomimetics containing oligoethylene glycol (OEG) spacers. It is also used to synthesize constrained glycyl amides derived from RGD tripeptide as nonpeptide αvβ3 antagonists.
References Rerat, V., et al.: J. Med. Chem., 52, 7029 (2009); Meissner, R., et al.: Bioorg. Med. Chem. Lett., 12, 25 (2001)

Applications Nefiracetam improves post-ischemia evoke-nonconvulsive seizure by altering pro-inflammatory cytokines.
References Fu, C. et al: Cell. Phys. Biochem., 37, 2023 (2015);

Applications Methyl phenyl sulfone (cas# 3112-85-4) is a useful research chemical.

Applications Chromone-3-carboxylic Acid (cas# 39079-62-4) is a useful research chemical.

Applications 5alpha-Cholestane-3,3-d2 (CAS# 122241-86-5) is a useful isotopically labeled research compound.

Applications 4-Chlorothiobenzamide-2,3,5,6-d4 (CAS# 1219802-58-0) is a useful isotopically labeled research compound.

Applications 3-Chlorothiophene-2-carboxylic acid

Applications 4-Chlorotoluene-d7 (CAS# 84344-06-9) is a useful isotopically labeled research compound.

Applications A metabolite of 1-methyl-2-thioimidazole (methimazole). It inhibits bone resorption.
References Paterson, J.R., et al.: Biochem. Biophys. Res. Comm., 116, 449 (1983), Taurog, A., et al.: Endocrinology, 124, 30 (1989).

Applications 4-Chlorotoluene-2,3,5,6-d4 (CAS# 85577-24-8) is a useful isotopically labeled research compound.

Applications 2-Chloro-1,1,1-trimethoxyethanen is a reactant in the synthesis of α-chloro-β-aminosulfinyl imidates as chiral building blocks
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Col0paert, F., et. al.: J. Org. Chem., 76, 2204 (2011)

Applications 3-Chlorotoluene-d7 (CAS# 1219804-88-2) is a useful isotopically labeled research compound.

Applications N-Methyl-d3-acetamide-2,2,2-d3 (CAS# 3669-73-6) is a useful isotopically labeled research compound.

Applications 3-Chlorotoluene-2,4,6-d3 (CAS# 1219803-79-8) is a useful isotopically labeled research compound.

Applications N,N-Dimethylaniline-d3 (N-methyl-d3) (CAS# 88889-00-3) is a useful isotopically labeled research compound.

Applications N,​N-​Diethylethanol-1,1,2,2-d4-amine is deuterium labelled of 2-diethylaminoethanol, which is an inactive metabolite of 2-Chloroprocaine (HCl: C380265) and commonly used for epidural analgesia in obstetrics. It is also hypothesized to cause onset-asthma to humans following brief exposure. 2-Diethylaminoethanol also has the ability to inhibit growth of tomato roots.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Boll, W.: Science, 129, 330 (1959); Cornish, H.: Am. Ind. Hyg. Assoc. J., 26, 479 (1965); Foldes, F. & McNall, P.: Anasthesiology, 13, 287 (1952); Reisner, L., et al.: Anast. Analg., 59, 452 (1980)

Applications An intermediate for the synthesis of many biologically active molecules including receptor ligands and enzyme inhibitors
References Chesworth, R., et al.: Bioorg. Med. Chem. Lett., 15, 5562 (2005), Gupta, A., et al.: Med. Chem., 3, 241 (2007), Ramajayam, R., et al.: Eur. J. Med. Chem., 43, 2004 (2008),

Applications 3-Chloropyridine-d4 (CAS# 1001003-95-7) is a useful isotopically labeled research compound.

Applications (±)-2-Chloropropionyl-2,3,3,3-d4 Chloride (CAS# 1219794-98-5) is a useful isotopically labeled research compound.

Applications 1,1,1-Trifluoro-2-iodoethane (cas# 353-83-3) is a compound useful in organic synthesis.

Applications 4-Chloropyridine is used to synthesize Thrombin inhibitors, compounds that have potent anticoagulant activity. 4-Chloropyridine is also used as a reagent to synthesize Botryllazine A, a pyrazine alkaloid that exhibits cytotoxicity against human tumour cells.
References de Candia, M., et al.: J. Med. Chem., 56, 8696 (2013); Kodimuthali, A., et al.: Tetrahedron Lett., 50, 1618 (2009); Singh, P., et al.: J. Org. Chem., 78, 2639 (2013)

Applications 4-Methylimidazole-d6 (CAS# 1219804-79-1) is a useful isotopically labeled research compound.

Applications 4-Hydroxypiperidine-3,3,4,5,5-d5 (CAS# 1219799-35-5) is a useful isotopically labeled research compound.

Applications Used in the preparation of azaindazole compounds as CCR1 antagonists.

Applications 1-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-4-(2-phenoxyethyl)-1,2,4-triazolidine-3,5-dione, is a metabolite of Nefazodone (N389100), that has been shown to act as antidepressants that inhibit the serotonin (SERT) and norepinephrine transporters (NET).
References Eison, A.S., et al.: Psychopharmacol. Bull., 26, 311 (1990), Keller, M.B., et al.: N. Engl. J. Med., 342, 1462 (2000); Owens, M., et al.: J. Pharmacol. Exp. Therap., 283, 1305 (1997);

Applications 1-(2-Chloro-3-fluorophenyl)ethanone was used to prepare novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases.
References Steinig, A., et al.: Bioorg. Med. Chem. Lett., 23, 4381 (2013)

Applications 1,4-Dibromobenzene (D4, 98%) (cas# 4165-56-4) is a useful research chemical.

Applications Methyl Methoxyacetate is a reagent used in the synthesis of diphenylamine-terepthalaldehyde resins which maybe be used as a catalyst for tetrahydropyranylation.
References Tanemura, K. et al.: Org. Prep. Proc. Int., 48, 72 (2016); By: Robiette, R. et al.: J. Am. Chem. Soc., 138, 737 (2016);

Applications 2-Chloropropane-2-d1 (CAS# 53778-42-0) is a useful isotopically labeled research compound.

Applications 5-(3-Chlorophenyl)-2-furoic acid is a reactant in the preparation of dantrolene (D185000) which has a potential to treat vascular dysfunction.
References Ellis, K.O., et al.: J. Pharm. Sci., 69, 327 (1980); Harrison, G.G., et al.: Brit. J. Anaesth., 60, 279 (1988); Murasawa, S., et al.: Bioorg. Med. Chem., 20, 6384 (2012);

Applications 1,1,2-Trimethyl-1H-benzo[e]indole (cas# 41532-84-7) is a useful research chemical.

Applications 2-Iodopropane-2-d1 (CAS# 95927-03-0) is a useful isotopically labeled research compound.

Applications 1,4-Diethylbenzene-2,3,5,6-d4 (CAS# 923561-79-9) is a useful isotopically labeled research compound.

Applications The sodium salt of lactic acid (L113490). It acts as a preservative, acidity regulator, and bulking agent.
References Kim, Y., et al.: ?Food. Nutr. Res., 10, 588-605 (2019)

Stability Light Sensitive
Applications 4-Chlorophenylacetylene (cas# 873-73-4) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 6-Chloronicotinic Acid Ethyl Ester is a nicotinic acid derivative used in the preparation of potent H3 receptor antagonists.
References Pippel, D.J. et al.: Org. Proc. Res. Dev., 15, 638 (2011);

Applications 1,4-Diethylbenzene-d14 (CAS# 1219803-64-1) is a useful isotopically labeled research compound.

Applications 2,6-Dichloro-4-nitroanisole (cas# 17742-69-7) is a useful research chemical.

Applications Methyl 3'-Amino-1,1'-biphenyl-3-carboxylate is a useful reagent for organic synthesis and other chemical processes.
References Uehling, D. E., et al.: J. Med. Chem., 49, 2758 (2006); Kuppusamy, R., et al.: Eur. J. Med. Chem., 143, 1702 (2018)

Applications o-Chloromethyltoluene is a building block that has been used in the preparation of fenarimol analogs showing curative activity in an experimental model of Chagas disease.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Keenan, M., et. al.: J. med. Chem., 56, 10158 (2013)

Applications 1,3-Diethylbenzene-2,4,5,6-d4 (CAS# 1219803-29-8) is a useful isotopically labeled research compound.

Applications 5,6,7,8-tetrahydroquinazoline-6-carboxylic acid (cas# 1369096-46-7) is a useful research chemical.

Applications 1-Iodopropane-1,1,3,3,3-d5 (CAS# 1219794-94-1) is a useful isotopically labeled research compound.

Applications 1-Octen-3-one is a volatile unsaturated ketone that has a strong mushroom-like odour. 1-Octen-3-one is also a flavour component of the Agaricus bisporus mushroom and is used in a variety of food products.
References Culleré, L., et al.: Anal. Chim. Acta, 563, 51 (2006); Fickert, B. & Schieberle, P.: Food/Nahrung, 42, 371 (1998); Husson, F., et al.: Proc. Biochem., 37, 177 (2001)

Applications 2-Chloro-2-methylpropane-2-13C (CAS# 32488-42-9) is a useful isotopically labeled research compound.

Stability Hygroscopic
Applications 2-(1,3-Dioxo-3,4-dihydroisoquinolin-2(1H)-yl)acetic Acid (cas# 52208-61-4) is a useful research chemical.

Applications 2-Chloro-2-methylpropane is a starting molecule to carry out nucleophilic substitution reactions.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Eyet, N., et al.: J. Phy. Chem. A., 117, 1136 (2013); Eyet, N., et al.: J. Am. Mass. Spec., 18, 1046 (2007);

Applications Chloromethyl Pivalate is used in the synthesis of oxazolines used in the preparation of imidazolium triflates. Also used in the synthesis of Src Kinase inhibitors used as anti-tumor agents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Glorius, F. et al.: Chem. Comm., 22, 2704 (2002); Hennequin, L. et al.: J. Med. Chem., 49, 6465 (2006);

Applications 8-Chloro-3-methoxy-11-(1-methyl-4-piperidinyl)-6,11-dihydro-5H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-ol (cas# 165739-71-9) is a compound useful in organic synthesis.

Stability Moisture Sensitive
Applications Chlorocarbonylsulfenyl chloride is a useful research chemical for organic synthesis and other chemical processes.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sorra, K., et al.: Int. J. Mol. Sci., 15, 16500 (2014); Gurjar, A. S., et al.: Bioorg. Chem., 57, 90 (2014); Enache, L., et al.: e-EROS Encyclopedia of Reagents for Organic Synthesis, 1 (2005)

Applications 4-Chloroiodobenzene is used as a reagent in the synthesis of Clothiapine (C588550); an atypical antipsychotic of the dibenzothiazepine chemical class that has shown efficacy in treatment-resistant schizophrenic patients.
References Schmutz, J., et al.: Helvetica Chimica Acta 50, 245 (1967); Geller, V., et al.: Schizophrenia Research 80 (2-3), 343 (2005)

Applications 4-Bromochlorobenzene-d4 (CAS# 134415-42-2) is a useful isotopically labeled research compound.