Building Blocks

<p>N-Phenylpivalamide is an asymmetric synthesis that is a reaction yield of activated secondary amine and alkylsulfonyl chloride. The effective dose of n-phenylpivalamide is 0.01 mg/kg and the chloride ion, nitrogen atoms, and amines are all reactive functional groups. The nmr spectra show that this compound has stereoisomers.</p>

<p>2-(Benzyloxy)propanoic acid is a carboxylic acid that is used in biotechnology as a substrate for the production of optically pure carboxylic acids. It can be converted to pure hydroxyapatite, which is an important component of bone grafts and dentures. The microbial synthesis of 2-(benzyloxy)propanoic acid has been studied extensively. The n-terminal amino group can be removed by reduction with sodium sulfate or sodium borohydride, and the resulting alcohols can be converted to esters either enzymatically or with organic acids. 2-(Benzyloxy)propanoic acid also reacts with dodecyl mercaptan to give the corresponding dodecyl sulfate.</p>

<p>5-Chloro-N-(2-chlorophenyl)-2-hydroxybenzamide is a promyelocytic leukemia (PML) inhibitor that has been shown to have significant cytotoxicity against leukemia cells. 5-Chloro-N-(2-chlorophenyl)-2-hydroxybenzamide also inhibits the growth of prostate cancer cells and cervical cancer cells. It has been shown to inhibit the expression of oncogenes, such as sarcoma viral oncogene (SV40), and induce apoptosis in human cancer cells. This drug also shows significant cytotoxicity against human leukemia HL60 cells and erythroleukemia U937 cells.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Pyrrolidin-1-yl-acetic acid hydrochloride is a drug that inhibits the enzyme protease, which is involved in the replication of HIV. It also inhibits the enzyme piperazine, an essential cofactor for retroviral replication. Pyrrolidin-1-yl-acetic acid hydrochloride has been shown to inhibit insulin resistance and increase glucose uptake in animal models. This drug may be a potential treatment for diabetes mellitus type 2. The structural formula of this drug is shown below:</p>

<p>Versatile small molecule scaffold</p>

<p>9-Chlorofluorene is a synthetic chemical that has been used as an intermediate for the production of polymers and dyes. It is a colorless liquid with a chloroform-like odor. 9-Chlorofluorene reacts with hydrogen chloride to form the chlorinated derivative, fluorene dichloride. This chemical is also known to react with other compounds such as alcohols, amines, and phenols in the presence of moisture or heat to produce unwanted byproducts including aldehydes, chlorides, and hydrocarbons. 9-Chlorofluorene may be contaminated with impurities such as carbon tetrachloride, which can lead to toxic effects on humans and animals. There are bioassays that measure the toxicity of this substance in mice. The toxicity of 9-chlorofluorene has been shown to depend on the electron transfer reactions it undergoes during metabolism.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Anilinopyridine is a reactive compound that binds to the mitochondrial membrane potential and inhibits the electron transport chain. It has been shown to be cytotoxic against colorectal adenocarcinoma cells in vitro. 2-Anilinopyridine binds to the carbonyl group of proteins, disrupting the function of proteins and leading to cell death by apoptosis. The compound was tested in vivo in a mouse model for cancer and showed promising results. 2-Anilinopyridine has also been shown to induce DNA strand breaks, which are used as biomarkers for carcinogenicity.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3,5-Diamino-4-methylbenzoic acid is a chemical compound with the formula C6H3N3O2. It is an organic nitrite that reacts readily with nucleophiles such as alcohols, phenols, and amines to form the corresponding N-substituted benzoic acid. The reaction proceeds via a two step process in which 3,5-diamino-4-methylbenzoic acid first reacts with sodium nitrite to produce 3,5-diamino-4-nitrobenzoic acid followed by hydrolysis of this intermediate to form the desired product. Nitrite salts are used in the food industry as preservatives and antimicrobials. They can be applied as a gas or dissolved in water. Nitrite salts are also used for wastewater treatment and for environmental remediation.</p>

<p>2-(4-Aminophenyl)acetamide is a white crystalline solid with a melting point of 146°C. It has the optical rotation of +232° and 13c-nmr spectroscopy in DMSO-d6, with chemical shifts at δ = 9.3 (1H), 8.8 (1H), 7.5 (2H), 5.9 (1H), 5.8 (1H). 2-(4-Aminophenyl)acetamide has been synthesized from 4-aminobenzenesulfonyl chloride and 2-methylacetic acid in the presence of triethylamine and potassium carbonate as catalysts. This compound has two conformations, one being lamellar and the other being switchable between lamellar and non-lamellar structures due to its amide linkage. In addition, this compound can be used to study bacterial cell wall biosynthesis by using microscopy</p>

<p>Benzothiazol-2-yl-(4-ethoxy-phenyl)-amine is a compound that has been shown to be active against solid tumours and metastases. It has been shown to inhibit phosphatase activity in the presence of monoclonal antibodies, which is an indicator for cancerous cells. Benzothiazol-2-yl-(4-ethoxy-phenyl)-amine may be used as a diagnostic marker for determining the presence of cancer cells in patients with infectious diseases, such as HIV/AIDS. This compound has also been shown to inhibit phosphatase activity in the presence of monoclonal antibodies, which is an indicator for cancerous cells. Benzothiazol-2-yl-(4-ethoxy-phenyl)-amine may be used as a diagnostic marker for determining the presence of cancer cells in patients with infectious diseases, such as HIV/AIDS.</p>

<p>Versatile small molecule scaffold</p>

<p>Cyclopentylpropan-1-one is an organic compound with the chemical formula CH3C(O)CH2CH2CH2. It is a cyclic ketone that can be synthesized by reacting boron trifluoride etherate with aldehydes. Cyclopentylpropan-1-one has stereochemical and diastereomeric properties, which can be determined by looking at the spectral data. The molecular geometry of cyclopentylpropan-1-one is also chiral and there are two possible configurations of this molecule.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Methyl-1,2,3,4-tetrahydroquinoxaline is an enantioselective antioxidant that has been shown to have a chiral conformation. It has also been found to be a catalyst in the reductive elimination of hydrochloric acid. This compound can be hydrogenated by catalytic hydrogenation and this reaction produces tetralin as a by-product. 2-Methyl-1,2,3,4-tetrahydroquinoxaline is used in research because it contains a methyl group and amines that are important for biological functions.</p>

<p>Versatile small molecule scaffold</p>

<p>Dichloropyridazine-3,6-diol is a furan derivative that has been shown to act as an inhibitor of the oxidative deamination of pyridine. It is also a nucleophilic reagent with a chlorine atom and two hydroxylamine groups in its structure. The carbonyl oxygen atom and the cyclic carbonyl group are both susceptible to oxidation and can be used to form chlorides. Dichloropyridazine-3,6-diol is resistant to acid chlorides such as thionyl chloride or phosphoric acid. This compound undergoes dehydration reactions with carboxylic acids and chlorides, yielding the corresponding carboxylate or chloride.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>6-(4-Bromophenyl)-2H,3H,5H,6H-imidazo[2,1-b][1,3]thiazole is a phosphatase inhibitor. It is used to treat hyperphosphatemia in patients with end-stage renal disease who are on dialysis. 6-(4-Bromophenyl)-2H,3H,5H,6H-imidazo[2,1-b][1,3]thiazole inhibits the activity of tyrosine phosphatases and prevents the uptake of calcium and phosphate from the gastrointestinal tract. This drug has been shown to improve bone mineralization in postmenopausal women with osteoporosis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-(Chloromethyl)-4-ethoxybenzene is an alkylation agent that is used as a phase transfer catalyst in the conversion of toluene to ethylbenzene. The reaction can be catalyzed by sodium hydroxide, which causes the chloride ion from 1-(chloromethyl)-4-ethoxybenzene to react with sodium hydroxide and form sodium chloride (table salt). This reaction produces an ether group (-O-CH2-) on the benzene ring of 1-(chloromethyl)-4-ethoxybenzene. Elemental analysis has shown that 1-(chloromethyl)-4-ethoxybenzene has a 98% yield for the product, ethylbenzene. Spectrometry has confirmed that 1-(chloromethyl)-4-ethoxybenzene contains three carbon atoms, nine hydrogen atoms, two chlorine atoms, and one oxygen atom.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Bromooxane is a molecule that binds to the alkylthio group on the surface of cells. It has been shown to be effective in the treatment of hepatitis and inflammatory diseases such as rheumatoid arthritis. 2-Bromooxane has also been shown to induce apoptotic cell death in macrophages, which may be due to its ability to inhibit the synthesis of inflammatory cytokines and chemokines. This drug also has nitrogen atoms that can form hydrogen bonds with hydroxyl groups in proteins, which may account for its biological properties.</p>

<p>2-Methyl-1-phenylbutane-1,3-dione is a chemical intermediate that belongs to the group of alkyl bromides. It is used as an herbicide and a pesticide, and can be reduced to 2-methyl-2-(4'-bromophenyl)pentanal by reductive cleavage with chlorine. The reduction of 2-methyl-1-phenylbutane-1,3-dione by hydrogen gas leads to the diastereoisomers 2-(4'-bromophenyl)-2-(2'-methylpropionyl)pentanal and 3-(4'-bromophenyl)-2-(2'-methylpropionyl)pentanal. The former is a chiral molecule that can be used as a medicine for high blood pressure, while the latter has been shown to be effective against microbial strains such as Escherichia coli and Candida albicans.</p>

<p>a-(1-Methylethyl)benzenemethanamine is a phenylalkylamine that has been modified to contain a chloride group. It can be used as an analytical tool to study the effects of molecular modifications on the inhibitory potency and selectivity of phenylalkylamines. The chloride group was introduced in order to increase the solubility of this molecule in water and make it more compatible with other molecules that are often used for analysis, such as isopropyl alcohol. Electrospray ionization (ESI) was employed to generate a positive ion spectrum, which was then analyzed by a mass spectrometer (MS). Molecular modeling studies were also conducted using quantum chemical tools to predict the structure of this compound. Structural modifications were made based on these predictions in order to optimize properties such as inhibitory potency and selectivity. These changes were validated using ESI-MS analysis and then confirmed by molecular modeling studies. This compound can be used</p>

<p>Tert-Butoxybenzene is a chemical compound that is used to manufacture other chemicals. It is used as a reagent in organic synthesis, in particular for the preparation of derivatives of salicylic acid. Tert-Butoxybenzene can be detected by electron spin resonance spectroscopy and nuclear magnetic resonance spectroscopy. The health effects of tert-butoxybenzene are not well known, but it has been linked with cancer in animals and humans. Tert-butoxybenzene also reacts with hydrochloric acid to produce hydrogen chloride and benzyl alcohol. Further reactions lead to the formation of isobutene, which can be converted into propylene carbonate or alkylated to form methyl tert-butyl ether (MTBE).</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5,7-Dimethyl-2,3-dihydro-1H-inden-1-one is a cytotoxic agent that is used in vivo to study tumor models. It has been shown to be potent and cytotoxic against tumor cells. The drug inhibits the growth of colon cancer cells by binding to the DNA chain at the level of purine nucleoside phosphorylase. 5,7-Dimethyl-2,3-dihydro-1H-inden-1-one also inhibits carboxamides and lipophilic substituents in the cell membrane. This drug is also an inhibitor that blocks purine nucleoside phosphorylase and prevents synthesis of purines from ATP and hypoxanthine.</p>

<p>1-Phenyl-2-pentanone is an organic solvent that is used to dissolve other substances. It can be found in coatings and resins, as well as in hexane and naphthol. 1-Phenyl-2-pentanone has been used in the synthesis of benzene derivatives, such as mandelonitrile. This compound is reactive with hydroxy groups and cyclic ethers, which may lead to the formation of benzoate esters. The phenyl groups allow for the detection of this compound by mass spectrometry.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Cycloheptylethan-1-one is a nitro compound that is used as an intermediate in the production of pharmaceuticals. It is also used to produce dyes and coolants. It has been shown to have bronchodilatory effects, which may be due to its ability to relax smooth muscle cells in the bronchi. 1-Cycloheptylethan-1-one has also been shown to have antiosteoporotic properties, which may be due to its ability to inhibit bone resorption and stimulate bone formation. 1-Cycloheptylethan-1-one has been reported as a racemate, but it has also been reported as a transfer agent.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3,5-Dinitrobenzenesulfonyl chloride is a sulfonyl chloride that is used as a precursor in the synthesis of dendrimers. 3,5-Dinitrobenzene-1-sulfonyl chloride has been used to synthesize dendrimers with sulfonate groups on their surface. The sulfonate groups can be used to attach other molecules to the dendrimer and provide functionality. This compound can also be used to form tetranitrochloride by reacting it with sodium chlorite in aqueous solution.</p>

<p>5-Chloro-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione is a dipole that has a geometry of an equilateral triangle with a dihedral angle of 120°. It has two hydrogen bonds and one intermolecular hydrogen bond. The molecule is photodimerized in low concentration and can form dimers by stacking interactions at low concentrations. This compound also interacts with uracils and has been shown to be stable when exposed to light. 5-Chloro-1,3-dimethylpyrimidine-2,4-dione has been shown to have interactions with the ftir spectra of other compounds.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-(Chloromethyl)pyrrolidin-2-one is a synthetic molecule that is used as an ion exchanger. It has been shown to be effective for the removal of chlorides, phosphates, and sulfates from solutions. This compound can also be used as a reagent in organic synthesis and can be used to prepare other compounds with higher molecular weights. 1-(Chloromethyl)pyrrolidin-2-one has been shown to interact with silicon and form a number of stable complexes. This molecule is labile and undergoes ring opening under acidic conditions to release chloride ions. X-ray diffraction studies have shown that 1-(chloromethyl)pyrrolidin-2-one adopts a planar conformation in the solid state.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Methyl-1,10-phenanthroline (4MP) is a functional molecule that has been extensively studied for its use as an anticancer agent. 4MP is a racemic mixture of 4-methyl and 1,10-phenanthroline enantiomers. It has shown anticancer activity in the L1210 murine leukemia model and cisplatin-resistant human ovarian cancer cells. The binding constants of 4MP to DNA depend on the orientation of the molecule with respect to the DNA helix. The cis configuration binds more tightly than the trans configuration, which may be due to steric hindrance. 4MP inhibits luminescence by interacting with micelles and forming aggregates in water.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Ethyl 5-amino-3-methyl-1-benzothiophene-2-carboxylate is a drug that inhibits the activity of 2,4-dichlorobenzoic acid, an enzyme involved in energy metabolism. It has been shown to bind to and inhibit a number of other enzymes, including carboxylase, decarboxylase, and transferase. This drug is used as an antimicrobial agent against pandemic influenza and other respiratory infections. The drug binds to the carboxylate group of the enzyme's active site and coordinates with the metal ion via its benzoate moiety. The coumarin derivative may be responsible for the observed inhibition by binding to a different site on the enzyme or by interacting with a second molecule of ethyl 5-amino-3-methyl-1-benzothiophene-2-carboxylate.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Aminoquinoline-3-carboxylic acid is a heterocyclic compound that contains a carboxylic group and a cyano group. It is used in research as a trackable cation. 2-Aminoquinoline-3-carboxylic acid has been shown to inhibit the binding of chloride ions to the cytoplasmic membrane, which decreases the permeability of the membrane to chloride ions, thus inhibiting its transport into cells. This compound also inhibits nitric oxide synthase and exhibits anti-inflammatory effects by suppressing cytokine release from macrophages. 2-Aminoquinoline-3-carboxylic acid may be synthesized from 2 amino quinolines and chlorides.</p>

<p>5-Phenylpyrimidin-2-amine is a synthetic chemical that is an intermediate in the production of other chemicals. It can be used to produce sulfate, nucleophilic amines, or active methylene compounds. 5-Phenylpyrimidin-2-amine can also be used as a starting material for the production of triethyloxonium chloride and 13C NMR spectroscopy reagents. 5-Phenylpyrimidin-2-amine has a nucleophilic nature and is capable of reacting with a variety of functional groups. This chemical can undergo demethylation reactions with sulfate, chlorides, and cyanamide, which are all reactive with the methyl group on this chemical. 5-Phenylpyrimidin-2-amine is an isomeric compound that exists in two forms: one with substituents at positions 2 and 6 (syn) and one with substituents at positions 3</p>

<p>Versatile small molecule scaffold</p>