Building Blocks

<p>Versatile small molecule scaffold</p>

<p>5-Amino-1,2,3,4-tetrahydronaphthalen-1-one is an organic compound that belongs to the class of heterocyclic compounds. It has been shown to act as a superacid and has been used in the synthesis of multidrug resistant cancer cells. 5-Amino-1,2,3,4-tetrahydronaphthalen-1-one also binds to topoisomerase II and III and inhibits DNA replication. The drug can also inhibit the function of p-glycoprotein and other multidrug resistant transporters at the cellular level.</p>

<p>Versatile small molecule scaffold</p>

<p>3-{[2-(Morpholin-4-yl)ethyl]amino}propanenitrile is a prodrug that is metabolized to the active drug, 2-morpholinoethanol. It is used for the treatment of breast cancer and mastitis (inflammation of the breast). 3-{[2-(Morpholin-4-yl)ethyl]amino}propanenitrile has a high water solubility and high stability, which makes it an ideal candidate for injection as a sustained release drug. This drug can be injected into solid tumors that are difficult to treat with other drugs and may also be used in conjunction with chemotherapy. 3-{[2-(Morpholin-4-yl)ethyl]amino}propanenitrile inhibits the production of estrogen, which plays a role in the growth of some types of breast cancer cells.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>6-Hydroxy-2-methylnicotinonitrile is a reagent that is used for the condensation of aldehydes and amines. It can also be used to form enamines from primary amines with carbonyl compounds. Dimethyl acetal, dimethyl, methyl methacrylate, cyclized, methacrylate, acetal are some of the products that are made using 6-Hydroxy-2-methylnicotinonitrile.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-Methylbenzenecarboximidamide hydrochloride is a chemical substance that belongs to the class of benzamidine. It is used as an intermediate in the synthesis of other chemicals and drugs, such as 3-methylcholanthrene, which is used for the treatment of cancer. N-Methylbenzenecarboximidamide hydrochloride is synthesized by solid-phase synthesis on a silica gel support using benzamidine as a starting material. The final product can be purified by chromatography with a solvent system consisting of hexane and ethyl acetate. This reaction mechanism involves oxidation of the methyl group to form an epoxide, followed by nucleophilic attack by water on the epoxide to form an enol. The enol undergoes reductive elimination to produce the desired product. The optimal reaction conditions are achieved at 60 degrees Celsius and a pH between 5 and 7.</p>

<p>Ethyl 2-acetyl-4-oxopentanoate is a modification of the molecule pentanoic acid. It is a functional molecule that can be modified by substitutions and modifications. The pharmacokinetic properties of this compound have been studied in rats, which showed that it has a high absorption rate when administered orally. Pharmacokinetic studies also revealed that ethyl 2-acetyl-4-oxopentanoate is metabolized to carboxyethyl 2-acetyl-4-oxopentanoate and pyridazine ethyl 2-acetyl-4-oxopentanoate, which are both neuropathic pain drugs with similar pharmacodynamics. This drug has shown promise as a lead compound for the treatment of neuropathic pain due to its α2δ subunit binding activity.</p>

<p>Versatile small molecule scaffold</p>

<p>3-Chlorophenylacetaldehyde is a chemical compound with the molecular formula CHClO. It is a colorless solid that crystallizes in the form of its dimers, (3-chlorophenyl)acetaldehyde and (3-chloro-2-phenylethynyl) acetaldehyde. It is an intermediate in the synthesis of other compounds, such as phenylethenes and annulated polycyclic aromatic hydrocarbons. 3-Chlorophenylacetaldehyde can be synthesized by transforming naphthalene or phenylethenes with heat or light. In addition, it can be synthesized from photodimerization of 2-(3-chlorophenyl)ethanol and phenylethanone. The transformation of 3-chlorophenylacetaldehyde to 3-(2-phenylethynyl) acetaldehyde can take place through a series of reactions including alkene formation, dimerization, carbon atom rearrangement and annulation</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-(1,3-Dioxaindan-5-yl)pentanoic acid is a natural product that was isolated from the leaves of peperomia. It has been shown to have antimicrobial effects against various bacteria and fungi, including methicillin-resistant Staphylococcus aureus (MRSA). This compound binds to bacterial DNA at the gyrase site, inhibiting transcription and replication. 5-(1,3-Dioxaindan-5-yl)pentanoic acid also inhibits protein synthesis by binding to the bacterial ribosomes.</p>

<p>Versatile small molecule scaffold</p>

<p>2-methyl-5-phenyl-2,4-dihydro-3H-pyrazol-3-one is a synthesized compound that has been studied by coupling with diamines and pyrazolones. The compound is also structurally related to arylamines.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 5-iodopyridine-2-carboxylate is an amino acid analog that specifically binds to lysine residues. This compound inhibits the incorporation of lysine into proteins, which may be important for the study of protein synthesis. Methyl 5-iodopyridine-2-carboxylate has been shown to react with aromatic amino acids and form amidines that are stable in aqueous solution. It can also react with tryptic peptides to yield model compounds.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Chloro-4-(2,2-diethoxyethoxy)benzene (1C4DEB) is a human chorionic gonadotropin (hCG) functional theory and polychlorinated biphenyls (PCBs) organocatalytic inhibitor. 1C4DEB binds to the active site of hCG and prevents the binding of follitropin, an allosteric modulator, to this site. This results in a decrease in the maximal response of hCG to follitropin. 1C4DEB has been shown to be an experimental model for pesticides that are known as dihedral bond cleavage agents.</p>

<p>Tolimidone is an enzyme inhibitor that binds to the active site of the enzyme HMG-CoA reductase. It inhibits the synthesis of cholesterol, leading to reduced levels of LDL and VLDL cholesterol. Tolimidone has also been shown to reduce plasma glucose and pro-inflammatory cytokines. This drug is currently being investigated as a potential treatment for high cholesterol and diabetes. The effective dose of tolimidone is not yet known, but it has been shown in vivo that it can lower cholesterol levels by up to 60%.</p>

<p>Versatile small molecule scaffold</p>

<p>The synthesis of diethyl 3,4-pyrroledicarboxylate was achieved by copolymerizing the monomers 1,2-diethoxyethane and 2,5-dimethoxytetrahydrofuran. This compound can be synthesized in a stereoselective way and is a stereospecific intramolecular hydrogen donor. The compound has been shown to inhibit the growth of leukemia cells and other cancer cells in vitro. It also induces cell death in HL-60 cells by producing reactive oxygen species (ROS). This compound has also been shown to have antitumor activity against L1210 cells and is an inhibitor of DNA synthesis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>