Building Blocks

<p>Trans-2-Amino-cyclopentanol is a chemical compound with the molecular formula CHCH(NH)COH. It is a colorless liquid that can be used as a solvent and as an intermediate in organic synthesis. Trans-2-Amino-cyclopentanol is found in human livers, where it may undergo biotransformations and acetylation. The isolated yield of this amine is dependent on the conditions of the reaction, such as temperature and pH. This amine has been shown to react chemically with anthracene to form trans-2-(aminomethyl)cyclohexanone, which can then be hydrolyzed by lipase to form trans-2-(aminomethyl)cyclohexanol. Trans-2-Amino-cyclopentanol is also used in chemoenzymatic reactions and can serve as an intermediate for the production of enantiopure pyrrolid</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(3-Thienyl)ethanamine is a fluorescent compound that has been shown to be an acceptor for fluorescence resonance energy transfer. It also has the ability to form a conformational equilibrium between two different tautomers, which can be distinguished by their nmr spectra. 2-(3-Thienyl)ethanamine is an enzyme inhibitor that blocks the conversion of polyphosphoric acid into polyphosphate by inhibiting the enzyme polyphosphate kinase. The synthesis of this compound involves reacting 3-phenylacetonitrile with ethylamine and triethyloxonium chloride. This synthetic process produces substituted amines and alkylating agents as side products.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Chlorothiophene-2-carboxylic acid is a chloride that is used as an inorganic base. It has potent inhibitory activity against acetylsalicylic and p2y12, and can be used to treat coagulation disorders. 3-Chlorothiophene-2-carboxylic acid is a polymorphic compound with a sequence specificity. This compound may have supramolecular properties, which would make it useful for the treatment of infectious diseases. The hydrogen bond between the three chlorines on the molecule help stabilize the structure.</p>

<p>Versatile small molecule scaffold</p>

<p>4-Amino-2-methoxy-5-nitrobenzoic acid is a benzotriazole derivative that was synthesized by reacting 4-amino-2,5-dimethoxybenzoic acid with nitric acid. It has been used as an intermediate in the preparation process of benzotriazole and other organic compounds.</p>

<p>6-Methoxy-1H-1,2,3-benzotriazole-5-carboxylic acid is a liquid chromatography (LC) standard. It is used as an analytical reference substance for the calibration of LC methods. 6-Methoxy-1H-1,2,3-benzotriazole-5-carboxylic acid has been shown to be recoverable in high purity with average recoveries of 99.8%. This product is hydrophobic and elutes between 3 and 4 minutes on a column with a flow rate of 1 mL/min. It is also linear over the concentration range from 0.05 to 10 μg/mL and can be used for validation of analytical methods in LC.</p>

<p>Versatile small molecule scaffold</p>

<p>2,3-Diamino-5-bromo-6-methylpyridine is an organic compound that belongs to the class of heterocyclic compounds. It is a heterocyclic compound that has been shown to undergo cyclization reactions at low temperatures. This substance forms azeotropic mixtures with water and alcohols and is used in the synthesis of other substances.</p>

<p>1-(Bromomethoxy)propane is a solvent that is used in laboratories to dissolve other substances. It is a cyclopentadienyl, which has the chemical formula CH3-CH2-CCl3. This solvent is used as a reaction vessel that contains anions and aromatic hydrocarbons. It reacts with halides to form reaction intermediates, including chloride and methoxymethyl. 1-(Bromomethoxy)propane can be used as an organic solvent for reactive molecules such as carbostyril and anilines.</p>

<p>Versatile small molecule scaffold</p>

<p>4-Phenoxyphenyl Isocyanate is an amino acid that is used as a reuptake inhibitor for the treatment of depression. It binds to the l-phenylalanine transporter, which is responsible for transporting l-phenylalanine into the brain and blocking its uptake. This leads to increased levels of l-phenylalanine in the brain, which may be responsible for 4-Phenoxyphenyl Isocyanate's antidepressant effects.<br>4-Phenoxyphenyl Isocyanate has been shown to inhibit the transport of L-amino acids across cell membranes, which decreases their uptake and increases their concentration in cells. This inhibition also has cross-coupling effects on β-amino acids and inhibits their transport across cell membranes. As a result, this compound may have therapeutic applications in treating diabetes and obesity.</p>

<p>Versatile small molecule scaffold</p>

<p>1,2,3,4-Tetrahydro-2,2,4,7-tetramethylquinoline is a synthetic derivative of the natural quinoline alkaloid 1,2,3,4-tetrahydro-2,2,4-trimethylquinoline. It acts as an acceptor of hydrogen peroxide and has been shown to have antioxidant effects in human lymphocytes. 1,2,3,4-Tetrahydro-2,2,4-trimethylquinoline has also been found to be genotoxic and able to induce micronuclei and genotoxicity. This compound can be used for the treatment of oxidative stress and damage.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>6-chloroquinoline-2-carboxylic acid is a metabolite that is formed by the coupling of two molecules of ethanolamide. The coupling reaction was first developed by Miyaura and Suzuki in 1980. 6-Chloroquinaline-2-carboxylic acid is used in marine chemistry to synthesize tetracyclic molecules with a side chain.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2,5-Dichloroquinoline is an efficient and versatile organic compound that can be used in the synthesis of a variety of different compounds. It is also used as an intermediate in the synthesis of eupolauramine. 2,5-Dichloroquinoline has been synthesized from 2,5-dichloroaniline and ammonia. This chemical has been manufactured in Australia since 1891.</p>

<p>Methyl 2-(dimethylamino)pent-4-enoate is a chemical compound that is used in organic chemistry as a reagent to convert esters into alcohols. It can also be used to synthesize ammonium salts from amines. Methyl 2-(dimethylamino)pent-4-enoate is typically synthesized by the reaction of benzene and methoxide or phenoxide. The yields are low, with transesterification being the most effective method for converting esters into alcohols. In addition, methyl 2-(dimethylamino)pent-4-enoate reacts with sodium methoxide or phenoxide to produce ammonium salts from amines.<br>Methyl 2-(dimethylamino)pent-4-enoate has no known analogues.</p>

<p>Methyl thiazole-4-carboxylate is an organic compound that is a derivative of thiabendazole. It is used as a fungicide and insecticide. Methyl thiazole-4-carboxylate binds to the benzene ring of the aromatic hydrocarbon, acetaldehyde, and inhibits its ability to interact with the acetyl group of acetylation. This results in the accumulation of acetaldehyde within cells, which can lead to cancerous growth. Methyl thiazole-4-carboxylate also has anti-inflammatory properties that may be due to its ability to inhibit prostaglandin synthesis.</p>

<p>2-(4-Aminophenyl)propanoic acid (APPA) is an organic compound that is used in the synthesis of other chemicals. It can be synthesized by nitrating 4-aminophenol, which has a phenyl ring and a nucleophilic acetonitrile group. This reaction produces 2-nitrophenol, which can then be reduced to APPA. The nitro groups on APPA are cleaved by dithiothreitol and the reagents are deactivated by endogenous thiolates. Monitoring of these reactions is carried out using kinetic analysis.</p>

<p>2-(3-Bromophenyl)propionaldehyde (BPPA) is a nonsteroidal anti-inflammatory drug that has been shown to be effective in animal studies. It is an oxime, which is a class of drugs that are used to reduce inflammation by inhibiting the release of prostaglandins. BPPA also inhibits the formation of amines, such as ethylene and benzonitrile, which are involved in inflammatory reactions. The mechanism of BPPA's anti-inflammatory activity may involve its ability to inhibit the production of hydrochloric acid and other pro-inflammatory agents by reducing oxidative stress.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>2-Iodobenzyl chloride is a reactive compound that is used in the synthesis of organic molecules. It reacts with amines to form 2-iodobenzamide, which is an antihistaminic drug. 2-Iodobenzyl chloride can be used to synthesize a variety of compounds, including benzamides, phenols, and other aromatic compounds. The addition of 2-iodobenzyl chloride to dibutyltin oxide creates an organotin halide, which then reacts with chlorides and produces cross-coupling products. This reaction is stereoselective because the two iodines are not exchanged in the same reaction.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Chloro-2,3-dimethylpyrazine is a trisubstituted methyl pyrazine that is used in the synthesis of insecticides. It has been shown to be a potent inhibitor of mandibular gland and formicidae activity. 5-Chloro-2,3-dimethylpyrazine has also been shown to have chromatographic properties and to produce spectra that are different from other methyl pyrazines. 5-Chloro-2,3-dimethylpyrazine may be a positional isomer of 2,5-dimethylpyrazine, but this has not yet been confirmed.</p>

<p>1H-Indole-3-carbonyl chloride is a chemical compound that has been shown to have anticancer activity. It binds selectively to the 5-HT4 receptor, inhibiting the growth of colorectal adenocarcinoma cells in cell culture. The binding of 1H-indole-3-carbonyl chloride to the 5HT4 receptor leads to an increase in intracellular calcium, which inhibits proliferation and induces apoptosis. 1H-Indole-3-carbonyl chloride also inhibits fatty acid synthesis in bacteria such as Escherichia coli and Saccharomyces cerevisiae. This compound can be synthesized from 1H-indole and chloroformate using a method called Grignard reaction.</p>

<p>2-[6-(Methylsulfanyl)hexyl]-2,3-dihydro-1H-isoindole-1,3-dione is a racemic mixture of the two enantiomers diptocarpiline and diptocarpidine. Diptocarpiline is a potent analgesic that has been shown to be an effective treatment for chronic pain in animals. The drug binds to opioid receptors in the body and blocks pain signals from being transmitted to the brain. Diptocarpiline also has antiinflammatory properties. DPTD can be used as an alternative therapy for those who have become resistant to other opioids or who cannot take them because of side effects.</p>

<p>Versatile small molecule scaffold</p>

<p>6-bromo-2,3,4,9-tetrahydro-1h-carbazol-1-one is a palladium catalyzed amidation process that produces high yields of the desired product. The use of palladium as a catalyst in this process has been shown to be effective in generating high yields of the desired product. This process also utilizes bromoindole as an amine donor and can be used with other heterocycles. The reaction is catalytic and can be done in high yield by using an efficient catalytic system.</p>

<p>1,8-Naphthyridine-2,4-diol (1,8ND) is a naphthyridine alkynyl that has been shown to have herbicidal activity. It is a plant growth regulator and can be used in the production of alkenyl and alkoxy derivatives. 1,8ND has been shown to have herbicidal activity against dicotyledonous plants and haloalkyl derivatives.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Cyclohexylpiperidin-4-amine is an organic compound that is structurally related to the amino acid piperidine. It has been shown to have a number of biological activities, including antagonistic activity against extracellular matrix proteins and chemokine production. 1-Cyclohexylpiperidin-4-amine can be used as a potential therapeutic agent for autoimmune diseases such as rheumatoid arthritis or inflammatory bowel disease. It can also be used to modify the immune system in order to prevent diseases, such as cancer. The compound can be modified by adding functional groups at specific positions on the molecule, which may alter its activity. Optimization of the molecule can be achieved by screening it against different chemokines or modifying it with different side chains at specific positions in order to improve its potency or specificity.</p>

<p>Diketene is a hydrogen-bonded chain that has been stabilized by ethyl 5-amino-3-(methylsulfanyl)-1H-pyrazole-4-carboxylate. It can be used to prevent the formation of diketones, which are harmful to both humans and the environment. Diketene is also used to make other substances, such as pharmaceuticals and plastics.</p>

<p>5-(Thiophen-2-yl)-2H-1,2,3,4-tetrazole is an antibiotic that belongs to the group of tetrazoles. It has been shown to have bactericidal and bacteriostatic properties against Streptococcus and Staphylococcus strains. 5-(Thiophen-2-yl)-2H-1,2,3,4-tetrazole inhibits bacterial growth by inhibiting the enzyme dehydrogenase that catalyzes the conversion of branched chain amino acids into energy. 5-(Thiophen-2-yl)-2H-1,2,3,4-tetrazole also has a strong disinfectant effect on bacteria because it reacts with acid in the environment to form a highly reactive species that damages DNA.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>2-Bromo-4-phenylpyrimidine is a nucleophilic reagent that has been used in the synthesis of heterocyclic compounds. It can act as a scavenger of unsaturated groups, and can be introduced into a molecule by an electrophilic substitution reaction. 2-Bromo-4-phenylpyrimidine is also able to deplete electron density from the heterocyclic ring, which leads to increased yields in reactions with electron deficient molecules such as water. The molecule undergoes oxidation when exposed to air, so it must be stored under nitrogen or argon gas.<br>2-Bromo-4-phenylpyrimidine is not soluble in water, but is soluble in organic solvents such as dichloromethane and chloroform. The compound has been used for optimizing electron deficiency in molecules such as 3,5-dimethoxybenzoic acid and 4-(trifluorometh</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Methyl-4-phenyl-1H-pyrazole is a regiospecific cross-coupling agent that reacts with alkenes to form pyrazoles. It is typically used in palladium-catalyzed cross-coupling reactions for the synthesis of 1,2,3-triazoles. Pyrazoles are also found as natural products in plants and animals and have been shown to be effective as anti-cancer drugs and against chronic viral infections. They are also involved in iron binding and have been shown to inhibit the activity of isomerases such as glucose 6 phosphate isomerase. 1Methyl-4-phenyl-1H-pyrazole is commercially available, but can be synthesized by reacting benzonitrile with styrene followed by allylation with ethylene or propylene oxide. The compound has been optimized for photocleavage, which makes it useful for generating azadiene derivatives.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Diethyl Isobutylmalonate is a solid catalyst that is used in the organic synthesis of ester compounds. This compound is an organometallic compound with a diethyl group bound to an iso-butyl group and malonic acid. The active methylene group of this molecule reacts with carboxylic acids, such as picolinic acid, to form esters. Diethyl Isobutylmalonate can be used with an acid catalyst to cross-link peptides. The hydroxyl group on the molecule can react with amine groups on proteins and also bind to aromatic hydrocarbons.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>4-Phenylbut-3-yn-1-ol is a chiral molecule with two stereogenic centers. It is an intermediate in the synthesis of indenes, which are used as pharmaceuticals and pesticides. 4-Phenylbut-3-yn-1-ol can be prepared by reacting diethyl etherate with acetaldehyde and malonate, or by reacting methylethylketone with ethylene oxide and carbon monoxide. The molecule has intramolecular hydrogen bonding due to the electron withdrawing effect of the carbonyl group on the adjacent phenyl ring. This allows for conformation changes that lead to catalytic activity.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Methylnaphthalen-1-ol is a binder that, when mixed with other organic materials, can be used to form a film. It can be used to bind many different types of sensitive material, including those that are heat-sensitive and cannot withstand high temperatures or those that are supercooled at low temperatures. 4-Methylnaphthalen-1-ol has been shown to react with alkylating agents such as diazo and naphthalenesulfonamide in the presence of iron catalyst and produce a high yield of products. These products have potential use in pharmaceuticals, plastics, rubber processing, and other industries.</p>

<p>Versatile small molecule scaffold</p>

<p>5-Methylbenzofuran-2-carboxylic acid is a ligand that binds to the hydroxamic acid site on histone deacetylases, which are enzymes that remove acetyl groups from lysine residues on histones. This causes histones to become tightly packed, which inhibits transcription of DNA into RNA (gene expression). 5-Methylbenzofuran-2-carboxylic acid has been shown to be an inhibitor of the tumor growth and metastasis in animal models. The efficiencies of this drug in inhibiting the histone deacetylase enzyme have been found to be minimal. However, it is thought that this drug may be effective in combination with other drugs as a therapeutic agent for cancer treatment.</p>

<p>5-Nitrobenzofuran-2-carboxylic acid is a chromophore with an orange-yellow color. This compound has been identified in soil and water samples, but it is not known to be produced by any living organism. It is possible that 5-nitrobenzofuran-2-carboxylic acid is produced by thermally or opportunistic bacteria, such as Chromobacterium violaceum, as a result of the oxidation of 5-nitrobenzofuran. The molecule's fluorescence can be quenched by chloroformate, which suggests that this compound may play a role in the synthesis of other aromatic compounds. The enzyme ethyl bromoacetate alkylates 5-nitrobenzofuran-2-carboxylic acid and produces ethyl 2-(5'-nitrobenzo[d][1,3]dioxol-5'-yl)acetate.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Cyano-2-methoxyethyl acetic acid is a reactive organic solvent that has a boiling point of 152°C. It is soluble in water and has an acidic pH. This compound is used as a monomer, and is also used as an alkylating agent for the synthesis of polymers. 2-Cyano-2-methoxyethyl acetic acid can be copolymerized with other compounds to create a variety of products with different properties. The reaction time depends on the type of product being synthesized, but it typically takes up to 48 hours to complete the reaction. 2-Cyano-2-methoxyethyl acetic acid can react with c1–6 alkyl groups, which may affect its solubility. This compound has a high degree of configurability, which may allow it to be used in more chemical reactions than other organic solvents.</p>

<p>2-Azido-N-phenylacetamide is an anticancer drug that inhibits cancer cell growth. It is a noncompetitive inhibitor of tyrosine kinases, which are enzymes that control the cellular division cycle. The inhibition of tyrosine kinases prevents the activation of phosphatidylinositol 3-kinase (PI3K). This leads to a decrease in the production of proteins such as Bcl-2 and Bcl-xL, which are responsible for the survival and proliferation of cancer cells. 2-Azido-N-phenylacetamide has been shown to be active against human lung cancer cells in vitro and has also been used to treat bacterial infections. The molecular electrostatic potentials of this compound indicate that it may be an effective antibacterial agent due to its carbonyl group.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>