Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(Quinolin-2-yl)acetonitrile is an acceptor molecule in the nitrobenzene oxidation scheme. It has a nitro group, which is converted to a chiral chromophore by diethyl etherate. This compound also has oxygen atoms that can act as nucleophiles and activated malonate anions. 2-(Quinolin-2-yl)acetonitrile is an alkylating agent that is used for the synthesis of chiral compounds.</p>

<p>Versatile small molecule scaffold</p>

<p>(-)-Menthone is a plant metabolite that is found in peppermint and other mint oils. It can be synthesized by the action of caffeic acid esterase on menthol, which is also present in peppermint oil. (-)-Menthone has been shown to inhibit the enzyme activities of human pathogens such as Salmonella typhimurium, Escherichia coli, and Shigella sonnei. (-)-Menthone also has genotoxic activity and has been shown to cause chromosome breaks in human lymphocytes. The reaction mechanism of (-)-menthone involves an intramolecular hydrogen transfer from one carbon atom to another. X-ray diffraction data from (-)-menthone crystals show a phase transition temperature of approximately -5°C for the molecule.</p>

<p>Versatile small molecule scaffold</p>

<p>5-Nitropyrimidine is a chemical with antiviral properties. It inhibits the synthesis of new viruses by reacting with malonic acid, which is an intermediate in the virus's life cycle. 5-Nitropyrimidine has also been shown to have anti-malarial and anti-parasitic properties. This compound binds to amines and inhibits their production, which may be due to its ability to react with dialkylamino groups in proteins. 5-Nitropyrimidine has been found in humans and animals, but not plants or fungi.</p>

<p>Versatile small molecule scaffold</p>

<p>4-Aminothieno[2,3-d]pyrimidine is a potent inhibitor of the P-glycoprotein multidrug transporter. It has been shown to inhibit chloride transport in the kidney and gastrointestinal tract. 4-Aminothieno[2,3-d]pyrimidine also inhibits the function of amine oxidase, which is involved in the metabolism of endogenous compounds such as catecholamines and serotonin. This drug may also be effective against cancer cells. The mechanism of action for this drug is not well understood but it has been shown to have an effect on DNA replication and repair by inhibiting phosphorous acid and formamidines. 4-Aminothieno[2,3-d]pyrimidine can produce crosslinking between DNA strands that leads to chain termination or intramolecular hydrogen transfer with formamidines. This process produces formaldehyde, which can react with other molecules to produce crosslinks between</p>

<p>4-Hydrazinothieno[2,3-d]pyrimidine is an anti-cancer drug that is activated by xylene. It is used in the treatment of bowel disease and cancer. 4-Hydrazinothieno[2,3-d]pyrimidine has been shown to have antibacterial properties against Gram-positive bacteria and may be effective as a topical agent for skin infections. This drug also has platelet activating properties, which are mediated through the p2y12 receptor. This receptor is involved in inflammatory bowel disease, as well as other tissues such as the brain and heart. 4-Hydrazinothieno[2,3-d]pyrimidine may be useful in treating cancer because it inhibits the production of TNF-α (tumour necrosis factor alpha) which leads to tumor growth inhibition.</p>

<p>2-(5-Amino-3-phenylpyrazol-1-yl)ethanol is a chemical compound that is used in the preparation of mezlocillin, an antibiotic medicine. It is also used as a raw material for the production of ampicillin sodium by crystallization with sodium hydroxide. 2-(5-Amino-3-phenylpyrazol-1-yl)ethanol has been shown to inhibit bacterial growth by binding to penicillin binding proteins, which prevents the formation of an antibiotic inhibitor complex with enzymes involved in cell wall synthesis, inhibiting protein synthesis and cell division.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Methylbenzyl mercaptan is a heterocyclic compound that is found in the sulfoxides and azides classes. It can be synthesized by treating 2-methylbenzaldehyde with trifluoromethanesulfonic acid or trifluoroacetic acid. The chloride yields are high and the reaction is catalysed by aluminum chloride, triethylamine, or zinc chloride. This compound can be converted to a bioconjugate through ring-opening reactions with carboxyamide groups, which are present on proteins in mammalian cells. The bioconjugate can then be used as a fluorescent probe to detect the presence of specific proteins in living cells.</p>

<p>Versatile small molecule scaffold</p>

<p>1,3-Diphenylpropan-1-ol is a benzyl alcohol derivative. It is a white solid that can be used as a dehydrogenation agent for the synthesis of chalcone derivatives. It has been used as an intermediate in the synthesis of other organic compounds and has been detected in the reaction solution by thin layer chromatography. 1,3-Diphenylpropan-1-ol is also involved in the catalytic transfer of acetylacetonate to benzaldehyde or benzoic acid. The resulting anion can be neutralized with hydrochloric acid to produce benzyl alcohol or reacted with sodium hydroxide to produce dihydrochalcone.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-benzylsulfamide is a synthetic cannabinoid derivative that is activated by hydrochloric acid in the stomach. It is an agonist of the cannabinoid receptor, which is found in the brain and nervous system. N-benzylsulfamide has been shown to produce muscle relaxation by increasing potassium efflux from muscle cells and decreasing calcium influx, leading to decreased contractions. N-benzylsulfamide has also been shown to have anti-inflammatory effects. It inhibits prostaglandin synthesis by inhibiting cyclooxygenase activity, thus reducing inflammation. The molecule also binds to benzodiazepine receptors and can be used as a treatment for seizures or convulsions.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Cyclopropyl-2-phenylethan-1-one is a synthetic compound that can be obtained by the ring opening of an epoxide. It has two carbonyl groups, two aldehyde groups, and one fluorine atom. This molecule can be synthesized in high yields and has been shown to react with nucleophiles due to its electrophilic nature. 1-Cyclopropyl-2-phenylethan-1-one reacts with chlorine atoms or chlorine ions to form 1-(chloromethyl)cyclopropane or 1-(chloromethyl)cyclobutane respectively. The regiospecificity of this reaction is determined by the stereochemistry of the cyclopropane ring.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Hydroxy-N-phenylbenzamide is an organic solvent that is used as a potentiator in hexane. This compound has been shown to have potentiating effects on the solubility and volatility of hexane, which are important for industrial applications. 4-Hydroxy-N-phenylbenzamide also has carcinogenic properties, which may be due to its ability to induce DNA transfer reactions with nitro groups or due to its ability to react with chloride ions in the presence of human colon carcinoma cells. The carcinogenic effects of this compound are not limited to humans; it also induces cancerous transformation in mice. Impurities found in this compound include 5-hydroxytryptamine (serotonin) and carboxyamide (NH2CONH2).</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Phenyl-2,3-dihydropyridazin-3-one is a natural product that has been found in the human liver. It is also an organic solvent that is used in pest control to kill insects and spiders. 2-Phenyl-2,3-dihydropyridazin-3-one is a model system for studying cancer, as it has been shown to induce tumor formation in animals. It is also active against cervical cancer cells at low concentrations and induces apoptosis at high concentrations. This compound can be used as a potential therapeutic agent for the treatment of cancer in humans.</p>

<p>Versatile small molecule scaffold</p>

<p>4-(2-Bromoethyl)phenol is a synthetic substance that has been shown to have antinociceptive properties. It is an organic compound that is used in the synthesis of other substances. 4-(2-Bromoethyl)phenol has been shown to inhibit the growth of cancer cells, and it inhibits the production of microalgal lipids and proteins. This substance also has inhibitory properties against copper chromite (CuCrO4) oxidation and can be used as a biodegradable additive for oil paints or lacquers. 4-(2-Bromoethyl)phenol can also be used as an active substance in therapeutic drugs for the treatment of pain or cancer.</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 4-amino-3,5,6-trichloropicolinate (MTAP) is a synthetic compound that inhibits fatty acid transport. It was found to have potent antiviral activity against HIV and it has been used as a topical treatment for herpes. MTAP inhibits the biosynthesis of fatty acids by inhibiting the enzyme phospholipase A2. This inhibition prevents the hydrolysis of phospholipids into free fatty acids and glycerides. MTAP also has been shown to be a potent inhibitor of human leukemia cells in culture and is under investigation for its potential use in cancer treatment.</p>

<p>N-Methylquinolin-8-amine (NMQ) is a cytosolic calcium ionophore, which is a drug target for the treatment of HIV infections. NMQ binds to the cytosolic calcium channels and potently inhibits the release of this ion from the cells. It also has stereoselective binding to phenyl groups and terminal alkynes. This drug has been shown to have anti-cancer properties in vitro and in vivo, as well as chemokine inhibition. The synthesis of NMQ was achieved by reacting aniline with chloroacetaldehyde followed by quinolinoyl chloride and then methylation with methyl iodide.</p>

<p>Versatile small molecule scaffold</p>

<p>4-Phenylpiperidine-2,6-dione is a pharmacological agent that binds to the lipoprotein receptor, which is found on the surface of cells. It has been shown to reduce serum lipid levels in animals by decreasing the synthesis of cholesterol and triglycerides. 4-Phenylpiperidine-2,6-dione has also been shown to inhibit the activity of chylomicrons and very low density lipoproteins (VLDL) by reducing their production or increasing their catabolism. The affinity of 4-phenylpiperidine-2,6-dione for chylomicrons and VLDLs can be measured using assay methods such as ELISA or Western blot analysis.</p>

<p>Versatile small molecule scaffold</p>

<p>3-Ethyl-2,5-dihydrofuran-2,5-dione is a phenylsiloxane that has been synthesized by the reaction of 2,5-diiodohexene with ethyl 2,3-epoxypropanoate. It is soluble in organic solvents and has been used as an antibacterial agent. 3-Ethyl-2,5-dihydrofuran-2,5-dione is also used as a coating material with excellent barrier properties and good resistance to water. This compound can be modified to produce reactive silanes or silicon polymers.</p>

<p>2-Chloropteridine is a surfactant that has been shown to have antibacterial, antifungal, and antiviral activities. This compound is a triethyl orthoformate derivative of 2-chloro-1,3-dimethylhydrazine. It has been shown to have antimicrobial activity against gram positive bacteria such as methicillin resistant Staphylococcus aureus (MRSA) and Acinetobacter baumannii. 2-Chloropteridine also inhibits the production of TNF-α in macrophages by suppressing the transcription of NF-κB. This molecule can be used as a fluorescent probe for nucleic acid hybridization studies. It can also be used in an electroluminescent device or an ethyl orthoformate based light emitting diode (LED).</p>

<p>2-(Cyclohex-1-en-1-yl)pyridine (CXEP) is a synthetic precursor in the synthesis of aminopyridines. CXEP has been used as a reagent for the synthesis of pyrimidine compounds, and it has been proposed as a possible antibacterial agent. This compound reacts with alcohols to form cyclohexene derivatives that have antibacterial properties. It can also be used as an acceptor in mechanistic studies or to connect two molecules together.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(3-Chlorophenyl)propanoic acid is a surfactant that is soluble in water. It has been shown to be an effective reactant in the liquid phase of a reaction system. The molecular structure of 2-(3-Chlorophenyl)propanoic acid has been determined by optical and nuclear magnetic resonance spectroscopy. Its chemical formula is C8H10ClO2, with a molecular weight of 228.19 g/mol. It can be hydrolyzed by lipases, which are enzymes that catalyze the hydrolysis of ester bonds in lipids and other organic compounds. The reaction was monitored by high-performance liquid chromatography (HPLC). 2-(3-Chlorophenyl)propanoic acid is used as an intermediate in the production of polymers, plastics, and pharmaceuticals.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Hydroxy-6-methylpicolinic acid is a pyridine derivative, a carboxylic acid and an isomer of picolinic acid. It was first synthesized in 1884 by the French chemist Pierre Paul Emile Leloir. 3-Hydroxy-6-methylpicolinic acid is produced by the ammonolysis of picoline with ammonia or ammonium salts at high pressure and temperature. The product is used as a precursor to other compounds, such as methylpyridines and ethylpyridines. It can also be used to make the cyanogen chloride gas, which has been used as a chemical weapon in World War II.</p>

<p>Versatile small molecule scaffold</p>

<p>6-Phenylhexan-2-one is a ketone that can be synthesized by the reaction of benzene with perborate. The compound is used as a starting material in organic synthesis, for example in the phenylation of an alcohol. 6-Phenylhexan-2-one has been shown to react with anhydrous hydrogen peroxide and form benzoyl peroxide.</p>

<p>Octahydroindolizin-1-one is a biologically active organic compound that has been shown to be effective against bowel disease and inflammatory bowel disease. The major pathway of metabolism for this drug is hydroxylation followed by conjugation with glucuronic acid. It also undergoes oxidative deamination, which produces the corresponding amide. Octahydroindolizin-1-one has been shown to have an effect on growth factor receptors, and can inhibit serine proteases in striatal dopamine. The drug has not been found to be enantioselective, with both the (S)- and (R)-isomers being synthesized during its synthesis.</p>

<p>Hexahydropyrrolizin-1-one is an aryl halide that has been shown to reduce the severity of colitis and other inflammatory bowel diseases. It has been proposed that this drug uses hydrogen bonding with dimethyl fumarate to form a stable, non-polar, hydrophobic complex. This complex is then taken up by intestinal cells and causes the release of inflammatory mediators. Hexahydropyrrolizin-1-one may also be useful in treating infectious diseases caused by gram-positive bacteria due to its ability to inhibit protein synthesis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>(R)-2-Phenylpropylamide is an organic compound that has been synthesized to be a potential fungicide. It has been shown to inhibit the growth of Fusarium verticillioides, a fungus that causes wilt disease in plants. The compound is stereoselective and inhibits the growth of the fungus by inhibiting carbon metabolism at the level of pantolactone synthesis. The bacterial strain used in this study was Pantoea agglomerans, which was found on leaves and roots of six different plant species. (R)-2-Phenylpropylamide also showed antibacterial activity against Pantoea agglomerans and other bacteria. This compound had no significant effect on plant height, leaf area, or total root length. The metabolites were not detected in soil samples after two months, suggesting that (R)-2-phenylpropylamide may not have long-term effects on soil quality.</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 1,2,5-trimethyl-1H-pyrrole-3-carboxylate is a benzenoid compound that can be synthesized from methyl acetoacetate and potassium hydroxide. The yield of the reaction is about 65%. Methyl 1,2,5-trimethyl-1H-pyrrole-3-carboxylate can be used in organic synthesis as an intermediate for other chemicals. This compound undergoes photolysis and has been observed to produce dimethylbenzene and rearrangements such as cyanohydrin formation. The tautomeric form of this compound is hydroxymethylfurfuraldehyde. This compound can also undergo hydrogenolysis with methanolic potassium hydroxide to produce two products: methyl furan carboxylate and methylamine hydrochloride.</p>

<p>1,4-Dimethyl 2-amino-3-methylbenzene-1,4-dicarboxylate (DMAD) is a benzenoid that can be synthesized from 1,4-dimethylbenzene and formaldehyde in the presence of potassium t-butoxide and potassium hydroxide. DMAD is a precursor to other compounds that are used in the production of nylon and polyurethane. The reaction involves two steps: first, the formaldehyde molecule reacts with the dimethyl group on the benzene ring to produce a methylene bridge between two carbon atoms. This intermediate product then reacts with another molecule of formaldehyde or methylene chloride to create an amide bond between the two carbon atoms. DMAD is also an excellent reducing agent and yields hydrogen gas when heated with sodium or potassium cyanide.</p>

<p>2,5-Diiodobenzoic acid is a molecule that has been shown to have anti-cancer properties. It was found to inhibit the growth of malignant glioma cells in vitro and in vivo. The mechanism by which 2,5-diiodobenzoic acid inhibits the growth of these cells is not clear, but it may be due to its ability to change the permeability of the cell membrane or alter the function of proteins such as G proteins. This molecule has also been shown to bind with high affinity to cell nuclei, suggesting that it may be an effective imaging agent for use in diagnosis.</p>

<p>6-Chloro-2,3,4,9-tetrahydro-1H-carbazol-1-one is a pyrrole with a planar conformation. It has hydrogen bonds to the carbonyl group and two benzenes. The molecule is centrosymmetric and has a dihedral angle of 180°. 6-Chloro-2,3,4,9-tetrahydro-1H-carbazol-1-one crystallizes in the orthorhombic system. The unit cell dimensions are a=8.05 Å b=8.05 Å c=7.04 Å α=β=γ=90°</p>

<p>3,5-Dinitrobenzaldehyde is an experimental herbicide that has been shown to be effective in the control of weeds. 3,5-Dinitrobenzaldehyde is a protonated electrophilic species that reacts with a variety of electron-rich aromatic compounds by nucleophilic attack at the ortho position. The reaction with benzene, for example, yields phenyl trifluoride and benzenesulfonic acid. This molecule also reacts with chloride to form chlorobenzene and dinitrobenzene. 3,5-Dinitrobenzaldehyde has kinetic properties that are dependent on frequency and layeredness as well as kinetic and dihedral angles. It is also a catalytic reagent that undergoes rapid reaction at room temperature.</p>

<p>2-(4-Methylbenzenesulfonyl)cyclohexan-1-one is a peptide that is used as a research tool. It has been shown to act as an activator of ion channels and to bind to antibodies. 2-(4-Methylbenzenesulfonyl)cyclohexan-1-one can be used in the study of protein interactions and receptor ligand interactions. This product is available in both powder form and as an acetate salt.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(1H-Tetrazol-1-yl)aniline is a nitroaniline that has been shown to form complexes with copper. It is an efficient method for the synthesis of 2-(1H-tetrazol-1-yl)anilines from nitrobenzenes, which are orthoformic and can be used as the starting material. 2-(1H-Tetrazol-1-yl)anilines can be used as a reagent in complex formation reactions, such as the nitration of orthoformates, or as a precursor to synthesize other compounds. The biological activity of 2-(1H-tetrazol-1-yl)aniline has been demonstrated by its ability to inhibit cyclocondensation and catalyze the hydrolysis of basic compounds. This compound also shows high efficiency in catalytic reactions with copper salts, which makes it reusable.</p>

<p>Versatile small molecule scaffold</p>

<p>1-(4-Nitrophenyl)-1H-1,2,3,4-tetrazole is a nitroarene that can be used in the synthesis of disubstituted tetrazoles. It reacts with alcohols to form tetrazole compounds and with water to form anhydrides. The high reactivity of 1-(4-Nitrophenyl)-1H-1,2,3,4-tetrazole makes it suitable for use as a reactant in organic synthesis. The regioselectivity of this compound means that it can be used to synthesize only one product from two different starting materials. 1-(4-Nitrophenyl)-1H-1,2,3,4-tetrazole has been shown to react with arylacetonitriles to produce isoxazoles.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Chloroisothiazole is a chlorinating agent that reacts with active methylene groups of organic molecules to form vicinal dioxides. 3-Chloroisothiazole has been used in the synthesis of isoxazoles and alkynes, as well as for the chlorination of organic compounds. The reaction proceeds by nucleophilic attack of chlorine on the active methylene group to form a chloride ion, which then reacts with an alkyne or alkene to form an isoxazole or alkene respectively. 3-Chloroisothiazole has been found to be toxic, although it can be used in small amounts without significant side effects.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 2-cycloheptylacetate is a prophylactic drug that belongs to the group of pharmaceutical salts. It is used for the treatment of bipolar disorder and depression, but not for prophylactic purposes. Methyl 2-cycloheptylacetate encompasses gabapentin, which is used to treat epilepsy and neuropathic pain. The mechanism of action of methyl 2-cycloheptylacetate has not been elucidated yet, but it may act as an agonist at GABA receptors.</p>

<p>2-Cycloheptylacetamide is a trisubstituted compound that is structurally related to the cannabinoid receptor agonist WIN 55212-2. This drug has been shown to inhibit proteasome activity and to have anti-cancer effects in vitro. 2-Cycloheptylacetamide has also been shown to inhibit the activity of the enzyme monoamine oxidase, which may be associated with its antidepressant and anxiolytic activities. 2-Cycloheptylacetamide has been shown to prevent oxidative damage in neuronal cells, suggesting that it may be useful for the treatment of Alzheimer's disease and depression.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-(Propan-2-yl)benzene-1,3-diamine is a mutagenic compound that belongs to the class of hydrolytic cleavage compounds. It has been shown to have mutagenic activity in Salmonella typhimurium and Escherichia coli. 4-(Propan-2-yl)benzene-1,3-diamine also has a high viscosity. This chemical is used as an intercept in tests for mutagens and carcinogens.br&gt;br&gt; <br>4-(Propan-2-yl)benzene-1,3-diamine hydrolyzes to form solvents such as isopropyl alcohol and water. The molecular weight of this compound is 162.17 g/mol.br&gt;br&gt; <br>4-(Propan-2-yl)benzene-1,3-diamine has not been shown to be carcin</p>

<p>3-(Hydroxymethyl)benzene-1,2-diol is an organic compound. The product is a colorless solid that has a molecular weight of 144.17 g/mol. 3-(Hydroxymethyl)benzene-1,2-diol reacts with metal surfaces and can be used in the synthesis of amides and amido groups. This product is reactive and acidic at high temperatures, but will not react with alcohols or amines. 3-(Hydroxymethyl)benzene-1,2-diol is also a reaction product from the synthesis of dopamine.</p>

<p>Ethanesulfonic acid, 1-methylethyl ester is a sealant that is used to coat the inside of an artery or vein. It has a low energy and is made up of formyl group, attenuating hydroxyl group, and chloride. This product also contains serine protease which can hydrolyze proteins in the plaque. The sealant contains functional groups such as cationic polymerization initiator and particle.</p>

<p>Versatile small molecule scaffold</p>

<p>1-(6-Chloropyridazin-3-yl)-3-methyl-4,5-dihydro-1H-pyrazol-5-one (1) was found to be a potent inhibitor of β amyloid fibril formation and a lead compound for the treatment of Alzheimer's disease. The compound inhibits amyloid fibril formation by binding to the hydrophobic region in the core of the fibrils and preventing crosslinking. 1 also inhibits pancreatic β cell secretion, resulting in reduced production of insulin, which causes glucose intolerance. This drug has been shown to reduce glycemic levels in diabetic mice without causing hypoglycemia.</p>

<p>Versatile small molecule scaffold</p>