Building Blocks

<p>Applications Ethyl 3-benzoylacrylate is an impurity of Enalapril (E555250), an antihypertensive and an angiotensin-converting enzyme (ACE) inhibitor.<br>References Gross, M., et al.: J. Pharmacol. Exp. Ther., 216, 552 (1980), Gomez, H.J., et al.: J. Cardiovasc. Pharmacol., 15, Suppl. 3, S26-S29, (1990), MacFadyen, J., et al.: Clin. Pharmacokinet., 25, 274 (1993), Malini, P.L.: Adv. Ther., 10, 253 (1993),<br></p>

<p>Applications is a building block used in various chemial synthesis such in the preparation of 6-(carboxymethylureido)-(±)-nicotine (CMUNic), nicotine immunogen, and  imidazo[1,2-c]-quinazoline-2,5-(3H,6H)dione.<br>References Y Hieda et. al,: The Journal of pharmacology and experimental therapeutics, 283(3), undefined (1998-2-12); Papadopoulos EP.Journal of Heterocyclic Chemistry 18(3), 515-518,<br></p>

<p>Applications Ethyl 2-Aminothiophene-3-carboxylate (cas# 31891-06-2) is a compound useful in organic synthesis.<br></p>

<p>Applications Ethyl Carbazate is used in the synthesis of P1 aryl heterocycle-based thrombin inhibitors. It can be also used to prepare diazenedicarboxamides as inhibitors of alanylalanine ligase.<br>References Young, M., et al.: J. Med. Chem., 47, 2995 (2004); Kovac, A., et al.: Bioorg. Med. Chem. Lett., 17, 2047 (2007)<br></p>

<p>Applications Ethyl Cyano(ethoxymethylene)acetate is an intermediate in the synthesis of anti-inflammatory agents with gastroprotective effect in rats.<br>References Karoui, A., et al.: Med. Chem. Res., 23, 1591 (2014);<br></p>

<p>Applications 3-Ethylsalicylaldehyde is an intermediate in the synthesis of thiosemicarbazones, inhibitors of lysophosphatidic acid acyltransferase.<br>References PCT Int. Appl. (2015), WO 2015157242 A1 20151015. Johnston, E V., et al.: J. Org. Chem., 75, 4596 (2010);<br></p>

<p>Applications Reagent used to conduct (Methoxymethoxy)methyl additions<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-Butynoic Acid is used as a reagent in the synthesis of BMS 911543 (B596075); a potent JAK2 inhibitor used as a potential treatment for myeloproliferative disorders. 2-Butynoic Acid is also used in the preparation of chirally pure 1,2,3,4-tetrahydroisoquinoline analogs as anti-cancer agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fitzgerald, M.A., et al.: J. Org. Chem., 80, 6001 (2015); Ramanivas, T., et al.: Eur. J. Med. Chem., 92, 608 (2015)<br></p>

<p>Applications 1-(5-Bromo-2-hydroxyphenyl)ethanone<br></p>

<p>Applications 2-Thiophenecarbonyl Chloride is used in the synthesis of substituted pyridines as selective and highly effective GPR119 agonists. It is also seen in the preparation of diuretics.<br>References Wu, Y. et al.: Bioorg. Med. Chem. Lett., 20, 2577 (2010); Plattner, J. et al.: J. Med. Chem., 27, 1016 (1984)<br></p>

<p>Applications 4,4,4-Trifluoro-3-oxobutanoic Acid Ethyl Ester is used in the synthesis of fluorinated 2-thiouracil analogs as antithyroid agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References He, J.Y., et al.: Biotechnol. J., 2, 260 (2007); Mize, P.D., et al.: Anal. Biochem., 179, 229 (1989);<br></p>

<p>Applications 4-Chloro-2-oxo-2H-chromene-3-carbaldehyde (cas# 50329-91-4) is a useful research chemical.<br></p>

<p>Applications 2-sec-Butylphenol is a substance used in checking the effect of different enhancers on transdermal permation of insulin. It also acts as one of the substances used as models, which are helpful for aiding screening and development of androgenic compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yerramsetty, K. M., et al.: Int. J. Pharm., 398, 83 (2010); Jia, Y., et al.: isuanji Yu Yingyong Huaxue, 24, 1469 (2007)<br></p>

<p>Applications Phthalodinitrile monomers can be polymerized thermally in the presence of small amounts of curing agents into thermosetting polymers. Phthalodinitrile is a precursor to phthalocyanine which is used as a dye or pigment.<br>References Sastri, S. B. and Keller, T. M.: J. Polym. Sci. A Polym. Chem., 36, 1885-1890(1998), Löbbert, G. Phthalocyanines. In Ullmann's Encyclopedia of Industrial Chemistry, (Ed.)., (2000).<br></p>

<p>Stability Moisture sensitive<br>Applications Octanoyl Chloride is commonly used as an acylating agent for a variety of compounds such as sugars (e.g. Sucrose [S697000]), aromatic compounds (e.g. Anisole [A673900]), and monoglycerides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bass, D., et al.: J. Biol. Chem., 263, 19610 (1988); Ganong, B., et al.: P. Natl. Acad. Sci. USA, 83, 1184 (1986); Shih, P., et al.: Catal. Today, 93-95, 365 (2004); Thévenet, S., et al.: J. Carbohyd. Chem., 16, 691 (1997)<br></p>

<p>Stability Light Sensitive<br>Applications 3-Furaldehyde is a volatile compound of honey of various floral origin.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Alissandrakis, E., et al.: Food Chem., 100, 396 (2007), Baltrusaityte, V., et al.: Food Technol. Biotechnol., 45, 201 (2007),<br></p>

<p>Applications Phenyl chloroformate is a corrosive liquid that is used to synthesize Urazole, a five membered heterocyclic compound that reacts with aldoses to form α and β pyranosides and furanosides. Phenyl chloroformate is also used as a reagent to prepare Sorafenib (S676850), a multikinase inhibitor that targets the tumour and tumour vasculature in patients with melanoma.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Boettecher, B. &amp; Meister, A.: Anal. Biochem., 138, 449 (1984); Chai, W., et al.: Tetrahedron Lett., 53, 3514 (20112); Eisen, T., et al.: Brit. J. Cancer, 95, 581 (2006); Kolb, V., et al.: J. Mol. Evol., 38, 549 (1994); Llovet, J., et al.: Engl. J. Med., 359, 378 (2008)<br></p>