Building Blocks

<p>Applications cis-1-Butene-1,4-diol is used in the synthesis of bezoxazinyl-oxazolidinones as promising antbacterial agents. Also used in the preparation of AMF-26, an antitumor agent for inhibition of the golgi system, targeting a specific ribosylation factor.<br>References Guo, B. et al.: J. Med. CHem., 56, 2642 (2013); Shiina, I. et al.: J. Med. CHem., 56, 150 (2013);<br></p>

<p>Applications Mesitaldehyde (cas# 487-68-3) is a compound useful in organic synthesis.<br></p>

<p>Applications Methyl 4-(Bromomethyl)-3-methoxybenzoate is an intermediate used to prepare heteroarylphenyloxoacetyl and heteroarylphenylsulfonyl benzoylpiperazine analogs of BMS 378806 as HIV entry inhibitors. It is also used to synthesize steroid 5α-reductase inhibiting acylpiperidines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lu, R., et al.: J. Med. Chem., 52, 4481 (2009); Picard, F., et al.: J. Med. Chem., 45, 3406 (2002)<br></p>

<p>Applications N-Boc-piperazine (cas# 57260-71-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Chloroethylamine Hydrochloride is used as a reagent in the synthesis of 6-desfluoroquinolones as potential anti-HIV drugs. Also used as a reagent in the synthesis of ellipticine derivatives as anticancer agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sancineto, L., et al.: Bioorg. Med. Chem., 22, 4658 (2014); Mori, R., et al.: Eur. J. Med. Chem., 82, 16 (2014)<br></p>

<p>Applications (+)-(S)-Tylophorine is a a major alkaloid of Tylophora indica. (+)-(S)-Tylophorine is an immunosuppressant and inflammation inhibitor. (+)-(S)-Tylophorine showed antiproliferative activity and induction of apoptosis in tumor cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gopalakrishnan, C. et a.: Ind. J. Med. Chem., 71, 940 (1980); Ganguly, T.et al.: Phytomedicine, 9, 288 (2002); Gao, W. et al.: Cancer, Res., 64, 678 (2004);<br></p>

<p>Applications 3-Methyl-2-hexanamine HCl Salt is more stable and easier to purify compared to the free base.<br></p>

<p>Applications 7-Methoxy-4-methylcoumarin (cas# 2555-28-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Bromobenzyl bromide<br></p>

<p>Applications 2-(6-methoxynaphthalen-2-yl)propanenitrile (cas# 86603-94-3) is a useful research chemical.<br></p>

<p>Impurity Cefoperazone EP Impurity C<br>Applications N-Methyl-5-tetrazolethiol (Cefoperazone EP Impurity C) is an impurity of Cefoperazone.<br>References Kitson, T., et al.: Biochem. J., 175, 83 (1978), Elenbaas, R., et al.: Clin. Pharmacol. Ther., 32, 347(1982),<br></p>

<p>Applications 2-Chloroethyl Methyl Ether is used as a reagent in the synthesis of Piperonyl Methoxyethyl Ether (P490475); a selective inhibitor of the cytochrome P450-dependent monooxygenase from the housefly.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Motoyama, N., et al.: Rev. Pestic. Toxicol., 1, 173 (1991)<br></p>

<p>Stability Volatile<br>Applications 5-Ethylidene-2-norbornene is a diene monomer that is used as a self healing agent for polymeric composites and also used to reinforce multiwalled carbon nanotubes. 5-Ethylidene-2-norbornene is potentially toxic to humans.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ballantyne, B., et al.: J. Appl. Toxicol., 17, 197 (1997); Jeong, W. &amp; Kessler, M.: Carbon, 47, 2406 (2009); Lee, J., et al.: Macromol. Res., 12, 478 (2004)<br></p>

<p>Applications 9-cis-Retinyl Stearate-d5, is the labeled analogue of 9-cis-Retinyl Stearate (R275600), a fatty acid ester of Retinol isomer, found mainly in the retina.<br>References Bridges, C.D.B., et al.: Methods Enzymol., 81, 463 (1982),<br></p>

<p>Applications 4-Methylenepiperidine Hydrochloride is a building block that can be coupled with aryl halides via Suzuki cross-coupling to give benzyl piperidines and related compounds.<br>References Vice, S., et al.: J. Org. Chem., 66, 2487 (2001);<br></p>

<p>Impurity Imatinib EP Impurity I<br>Stability Hygroscopic<br>Applications Dimethylamine hydrochloride (Imatinib EP Impurity I) is a precursor to several industrially significant compounds. It is a COVID19-related research product.<br>References Burton, P., et al.: Biochem. J., 432, 575 (2010); Shim, K.S., et al.: DNA Repair., 5, 718 (2006); Robacker, D.C., et al.: J. Chem. Ecol., 23, 1263 (1997);<br></p>