Building Blocks

<p>Applications 2,7-Dibromo-9H-fluorene is a useful building block for organic synthesis.<br></p>

<p>Applications 1-(Methylthio)diphenylmethane is used in preparation of Thiols and Thioethers via reduction or methylation of Thiones with Lithium Diisopropylamide.<br>References Gebert, A., et al.: Helvetica Chimica Acta, 97, 931-938 (2014);<br></p>

<p>Applications Sodium 4-chlorophenoxyacetate (cas# 13730-98-8) is a useful research chemical.<br></p>

<p>Impurity Atenolol Impurity 3; Atenolol Impurity 1<br>Applications Atenolol Impurity 3. Atenolol Impurity 1.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications p-Toluoyl chloride is an aromatic compound used as a reagent to synthesize (+)-Yashabushitriol, a plant metabolite that is naturally found in the male flowers of Alnus sieboldiana matsum. p-Toluoyl chloride is also used as a reagent to prepare derivatives of Desloratadine (D290250). Desloratadine is a selective H1-receptor antagonist that has anti-inflammatory effects and is used to treat patients with allergic rhinitis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Berger, W.. et al.: Ann. All. Asth. Immun., 89, 485 (2002); Fang, Z., et al.: Tetrahedron Lett., 54, 6834 (2013); Feldman, K. &amp; Simpson, R.: Tetrahedron Lett., 30, 6985 (1989); Mu, S., et al.: Chin. Chem. Lett., 24, 531 (2013)<br></p>

<p>Applications 1,3-Diphenylacetone (cas# 102-04-5) is a useful research chemical.<br></p>

<p>Applications 4-Methylcatechol is a potent inducer of nerve growth factor (NGF) synthesis in vitro and in vivo.<br>References Kaechi, K., et al.: J. Pharmacol. Exp. Ther., 272, 1300 (1995); Hanaoka, Y., et al.: J. Neurol. Sci., 122, 28 (1994)<br></p>

<p>Applications 10H-Phenothiazine 5-Oxide is a by-product in the synthesis of Phenothiazine S,S-Dioxide (P297600). Phenothiazine S,S-Dioxide is a derivative of Phenothiazine (P318040), a key component of antipsychotic and antihistaminic drugs.<br>References Bansode, T., et al.: Eur. J. Med. Chem., 44, 5094 (2009); Baell, J., et al.: J. Med. Chem., 53, 2719 (2010); Howard, P., et al.: Environ. Sci. Technol., 44, 2277 (2010); Koren, J., et al.: J. Biol. Chem., 285, 2498 (2010); Amobi, N., et al.: Eur. J. Pharmacol., 627, 285 (2010)<br></p>

<p>Applications (-)-Form is a pyrolysis product of cellulose and cellulose-containing materials including pulp and paper waste products.Known as a pyrolytic product of cellulose, its very useful as a chiral source for synthesizing natural products because of its highly functionalized structure, which contains one chiral center. Used as chiral building block in organic synthesis.<br>References Essig, M.G., et al.: Carbohydr. Res., 156, 225 (1986), Taniguchi, T., et al.: Synlett, 971 (1996),<br></p>

<p>Stability Hygroscopic<br>Applications 2-Chloromandelic acid<br></p>

<p>Applications Monobenzyl Malonate is a useful synthetic intermediate. It was used to synthesize constrained cyclic agonists of the cholecystokinin CCK-B receptor. It was also used to prepare aspartate transcarbamoylase inhibitors.<br>References Blommaert, A., et al.: J. Med. Chem., 40, 647 (1997); Coudray, L., et al.: Bioorg. Med. Chem., 17, 7680 (2009)<br></p>

<p>Applications Citraconic Acid (cas# 498-23-7) is a useful research chemical.<br></p>

<p>Applications 2-Methyldibenzothiophene, is an alkyldibenzothiophene present in crude oil. Research concerning the biodegradation of Dibenzothiophene by different types of bacteria is a currently being carried out, as these bacteria have the ability to breakdown other harmful PAH’s as well. This may be used in removing spilled oil from marine and terrestrial environments.<br>References Boberg, F., et al.: Erdoel &amp; Kohle, Erdgas, Petrochemie, 47, 187 (1994); Tanaka, Y., et al.: Applied Microbiology and Biotech., 59 (2), 325 (2002); Prince, R., Spill Sci. Tech. Bulletin, 8 (2), 145 (2003);<br></p>

<p>Applications 4-Methyldibenzothiophene, is an alkyldibenzothiophene present in crude oil. Research concerning the biodegradation of Dibenzothiophene by different types of bacteria is a currently being carried out, as these bacteria have the ability to breakdown other harmful PAH’s as well. This may be used in removing spilled oil from marine and terrestrial environments.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Boberg, F., et al.: Erdoel &amp; Kohle, Erdgas, Petrochemie, 47, 187 (1994); Tanaka, Y., et al.: Applied Microbiology and Biotech., 59 (2), 325 (2002); Prince, R., Spill Sci. Tech. Bulletin, 8 (2), 145 (2003);<br></p>

<p>Applications Diphenylacetylene is a reagent used in the preparation of polysubstituded pyrroles via oxidative nitrene transfer. Also used in the aerobic coupling of salicyaldehydes with alkynes.<br>References Dewan, A. et al.: ACS Omega, 3, 5327 (2018); Yamane, S. et al.: Chem. A Eur. J., 24, 7852 (2018);<br></p>

<p>Applications Phenylboronic Acid is a compound used in organic synthesis of various pharmaceutical goods.<br>References Ainley, A.D., et al.: J. Chem. Soc., 2171 (1930);<br></p>

<p>Stability Hygroscopic<br>Applications rac-Citronellal is a monoterpenoid and the major isolate in citronella oil. Citronella oil is an essential oil bearing insecticidal properties. rac-Citronellal is also often used as a fragrance ingredient.<br>References Waliwitiya, R., et al.: J. Med. Entomol., 49, 614 (2012);<br></p>

<p>Applications (+)-Citronellal is a monoterpene compound that is formed by the metabolism of plants. (+)-Citronellal is a natural insect repellant, and is the main component of citronellal oil. (+)-Citronellal is also used as a starting material in the one pot synthesis of (-)-Menthol (M218875).<br>References Kwon, Y., et al.: Curr. Biol., 20, 1672 (2010); Lenardão, E., et al.: Tetrahedron, 63, 6671 (2007); Milone, C., et al.: Appl. Catal. A-Gen., 199, 239 (2000)<br></p>

<p>Impurity Ketotifen EP Impurity G<br>Applications Ketotifen (K315100) impurity. The 9- and 10-oxo derivatives of Ketotifen as antihistaminics.<br>References Waldvogel, E., et al.: Helv. Chim. Acta, 59, 866 (1976),<br></p>