Building Blocks

<p>Applications 3,6-Bis(hydroxymethyl)-2,5-piperazinedione is an intermediate in the synthesis of impurities of Cycloserine (C988800), an antibacterial agent.<br>References Shields, J. E., et al.: Biochem., 5, 1041 (1966); Hidy, P.H., et al.: J. Am. Chem. Soc., 77, 2345 (1955);<br></p>

<p>Applications 6-Bromo-1-hexanol is a useful synthetic intermediate. 6-Bromo-1-hexanol is used as a reagent in the preparation of nitric oxide-donating analogues of Sulindac (S699215), a non-steroidal anti-inflammatory drug that has the ability to prevent colon cancer.<br>References Nortcliffe, A., et al.: Bioorg. Med. Chem., 22, 756 (2014); Pasricha, P., et al.: Gastroenterology, 109, 994 (1995); Yamamoto, Y., et al.: J. Biol. Chem., 274, 27307 (1999)<br></p>

<p>Applications Lapachol is a reagent used in the synthesis of B-Lapachones for use in anti-proliferative tumor studies. Lapachol itself is a powerful antidepressant compound, having the napthoquinone moiety in the substructure.<br>References Schaffner-Sabba, K. et al.: J. Med. Chem., 27, 990 (1984); Eyong, K.O. et al.: Eur. J. Med. Chem., 54, 804 (2012);<br></p>

<p>Applications Adipic Acid Monoethyl Ester is used in the selection of streptavidin binder from DNA-encoded chemical library. Reagent in the synthetic preparation of colchicine-SAHA hybrids as antitumor agents.<br>References Dumelin, C. E., et al.: Bioconjugate Chemistry, 17,366 (2006); Zhang, X., et al.: Bioorg. Med. Chem., 21, 3240 (2013)<br></p>

<p>Applications Dimethyl Yellow can induce cytochrome P-448, monooxygenase activities and UDPGT activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fujita, S., et. al.: Chem-Biol. Interact., 52, 15 (1984);<br></p>

<p>Applications 1-Bromonapthalene is used in the preparation of N-aryl imidazoles and diaryl ethers. Also used in the preparations of glutathione peroxidase-like antioxidant activity of diaryl diselenides.<br>References Ghorbani-Vaghei, R. et al.: Tetrahedron Lett., 54, 7095 (2013); Mugesh, G. et al.: J. Am. Chem. Soc., 123, 839 (2001);<br></p>

<p>Applications A substrate for the determination of lactate dehydrogenase isoenzymes.This compound is suitable for lactate dehydrogenase (LDH) related research.<br>References Hegeman, G., et al.: J. Bacteriol., 91, 1155 (1966), Dobritzsch, D., et al.: J. Biol. Chem., 273, 20196 (1998), Chang, A., et al.: Biochem. J., 339, 255 (1999),<br></p>

<p>Applications p-Toluoyl chloride is an aromatic compound used as a reagent to synthesize (+)-Yashabushitriol, a plant metabolite that is naturally found in the male flowers of Alnus sieboldiana matsum. p-Toluoyl chloride is also used as a reagent to prepare derivatives of Desloratadine (D290250). Desloratadine is a selective H1-receptor antagonist that has anti-inflammatory effects and is used to treat patients with allergic rhinitis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Berger, W.. et al.: Ann. All. Asth. Immun., 89, 485 (2002); Fang, Z., et al.: Tetrahedron Lett., 54, 6834 (2013); Feldman, K. &amp; Simpson, R.: Tetrahedron Lett., 30, 6985 (1989); Mu, S., et al.: Chin. Chem. Lett., 24, 531 (2013)<br></p>

<p>Applications 4-Iodo-N,N-dimethylaniline is a useful reactant for organic reactions and the synthesis of various compounds.<br>References Luo, X., et al.: Org. Lett., 20, 2997-3000 (2018); Hamasaka, G., et al.: Adv. Synth. Catal., 360, 1833-40 (2018);<br></p>

<p>Applications 3,5-Dicarboethoxy-2,6-dimethyl-1,4-dihydropyridine is a dihydropyridine derivative that have been tested for antimicrobial activities.<br>References Murthy, Y.L.. et al.: Bioorg. Med. Chem. Lett., 22, 6016 (2012); Vaitkuviene, A., et al.: Pharmacol. Rep., 58, 551 (2006);<br></p>

<p>Applications 1-CHLORO-3-ETHYLBENZENE (cas# 620-16-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 5-Chlorovaleronitrile is used as a reagent in the synthesis of cyanoguanidine derivatives which exhibit dual histamine H1 and H2 receptor antagonist activity. Also used in the synthesis of purine derivatives which exhibit antimicrobial activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kinali-Demirci, S., et al.: Med. Chem. Res., no vol., no pp. (2014); Sadek, B., et al.: Molecules, 18, 14186 (2013)<br></p>

<p>Stability Hygroscopic<br>Applications 2,6-Difluoroaniline is an important chemical in the sythesis technology for high-efficiency insecticide.<br>References Xiong, G.-I. et al.: ANh. Nong. Kex., 36, 9848 (2008);<br></p>

<p>Applications Butyronitrile Diethyl Malonate (cas# 63972-18-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 4,4'-Di-tert-butyl-2,2'-bipyridine acts as a reagent in the preparation, antiproliferative and cytotoxic activity of apoptotic ruthenium nitrogen heterocyclic complexes via combinatorial library synthesis.<br>References Mulcahy, S. P., et al.: Dalton Trans., 39, 177 (2010)<br></p>