Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

N-Phenylaminosulfonamide is a prodrug that is metabolized in the body to release oxadiazole. It has been shown to lower intracellular calcium levels by targeting response elements and hydrogen bonds in the cell. N-Phenylaminosulfonamide also inhibits fatty acid synthesis, which may be due to its ability to inhibit 3t3-l1 preadipocytes. The drug has been shown to have an anti-obesity effect by inhibiting energy metabolism through inhibition of hydroxyl group oxidation, leading to reduced glucose uptake and glycolysis.

4-(Methoxymethoxy)benzoic acid (MMBA) is a synthetic compound that is used in the synthesis of allyl compounds. MMBA is not chemically reactive and does not undergo any reactions at room temperature. This substance can be activated by adding a nucleophile, such as an alcohol or water molecule, which will then react with the electrophilic carbon atom. This reaction produces epoxide and an alkene product. The most common reaction occurs with methanol, producing methoxypropane, which can then be converted to other organic compounds. Research has shown that MMBA has anticancer properties due to its ability to inhibit cell growth and induce apoptosis in humans.

Versatile small molecule scaffold

2-(2-Aminoethanesulfonyl)propane hydrochloride (AMPS) is a compound that can be used in the treatment of cancer. It inhibits the activity of tyrosine kinases and has been shown to have synergistic effects when combined with other compounds, such as cisplatin and doxorubicin. AMPS has also been shown to inhibit the growth of human lung cancer cells. AMPS is an inhibitor of family 3 phosphotyrosine protein kinase enzymes, which are involved in cell signaling pathways.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-Phenylpent-4-yn-1-ol is a ketone that can be synthesized by the desulfonylation of 1,3-dibromopropane. It is a radical that has been shown to have potential in the synthesis of polymers and pharmaceuticals. This compound undergoes sequential desulfonylative coupling with alcohols such as phenylethyl alcohol to produce phenylethylphenol. The use of 1-phenylpent-4-yn-1-ol in this process makes it an environmentally friendly alternative to other more toxic reagents.

Versatile small molecule scaffold

Versatile small molecule scaffold

This molecule is a synthetic, physicochemical drug that is used to treat women with metastatic breast cancer. It binds to glutamate receptors and blocks the metabotropic glutamate receptor. Pyrazolo[1,5-a]pyridine has been shown to be effective in clinical trials in treating melanotic lesions. The drug has been shown to have a dose-dependent effect on the central nervous system and can lead to death due to cardiac arrest.

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Chloro-5-nitroquinoline is an oxidized aminoquinoline that is synthesized from nitric acid and benzene. It contains a nitro group, which makes it susceptible to oxidation. 2-Chloro-5-nitroquinoline is used as a solvent for rubber, plastics, and waxes. It can also be used as a solvent in the production of quinolines and other nitrogen compounds. Nitration of this compound produces 2-chloroquinoline, which can be transformed into 2-chloroquinolinium hydroxide by reaction with sodium hydroxide. The substituent on the ortho position can be determined by oleum or bromine water.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2,4-Diethoxybenzoic acid is a chemical compound which is found in the essential oil of the plant Dalbergia sissoo. It has been shown to have anti-inflammatory properties and to be a potential therapeutic agent. 2,4-Diethoxybenzoic acid is an acetylated phenolic compound that is used in the production of heartwood extractions. It can act as a mathematical component and can be used in the synthesis of natural products such as isoflavanones. 2,4-Diethoxybenzoic acid has been shown to have antioxidant properties and to inhibit lipid peroxidation at high concentrations.

Versatile small molecule scaffold

Thiophen-3-amine hydrochloride is a heterocyclic amine that is structurally related to quinaldine. It has shown nitro transfer and nitroso transfer, which are mechanisms for the formation of nitro and nitrosamines. Thiophen-3-amine hydrochloride has low energy, which makes it an excellent candidate for rechargeable batteries. The amines in this compound have affinity for functional groups on the backbones of polymers and monomers, making them useful in research and optimization.

Versatile small molecule scaffold

1-Chloro-4-methoxyphthalazine is a new member of the family of phthalonitriles. It has been shown that this compound is electron rich and can be oxidized to give a radical anion, which can then be used for C-C bond formation. The elimination of chlorine from 1-chloro-4-methoxyphthalazine can take place electrochemically, following the mechanism of the reversible transfer reaction. This chemical property allows 1-chloro-4-methoxyphthalazine to act as an electron source in electrochemical reactions.

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Chloro-2-methyl-5-nitrophenol is a white solid with an alkaline reaction. It is used in the production of sulfonated dyes, as well as in the manufacture of certain drugs and pesticides. 4-Chloro-2-methyl-5-nitrophenol can be made industrially by the elimination of toluene under acidic conditions. This product also reacts with nitric acid to form a radical intermediate that adds to a phenyl group, forming a nitro group at position 2 on the ring structure, yielding 4-(2'-methylpropyl)-phenylamine. This compound can also be made by reacting 2,4,5-trichlorophenol with phosphorus pentachloride or thionyl chloride. The resulting chlorinated compound is then oxidized to produce 4-(2'-methylpropyl)-phenylamine and HCl gas.

Versatile small molecule scaffold

8-Oxononanoic acid is a fatty acid that is found in the human body. It has been shown to have health effects such as decreasing the risk of cancer and lowering the rate of cardiovascular disease. 8-Oxononanoic acid is a coeluting compound, which means that it shares properties with other molecules. It has been shown to inhibit the growth of cancer cells by inhibiting tyrosinase, β-glucosidase, and lipid biosynthesis. 8-Oxononanoic acid also inhibits the production of lipids by blocking the enzyme acetyl-CoA carboxylase (ACCase). This enzyme catalyzes the conversion of acetyl-CoA into malonyl-CoA, which is then used in fatty acid synthesis.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-Methyl-4-phenyl-1H-1,2,3-triazole is a ligand that interacts with copper. It is used in the synthesis of pyridine complexes and as a reagent for the preparation of other organometallic compounds. 1-Methyl-4-phenyl-1H-1,2,3-triazole has been shown to be able to replace azide or chloride ligands in some metal coordination complexes. It has been observed in spectra of copper and rhenium complexes with axially coordinated ligands. The X ray crystal structures of 1 methyl 4 phenyl 1H 1 2 3 triazole have revealed that it can be either a luminescent or nonluminescent compound depending on the type of solvent used during its preparation.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Benzyl Methyl Malnonate (BMM) is a polycarboxylic acid that has an inhibitory effect on the receptor binding of inorganic acids. It is used as a solid catalyst for the oxidative carbonylation of olefins and dienes. BMM can also be used to prepare heterocycles by the reaction of an active methylene with malonic acid and fluorine. The hydroxyl group on the benzyl methyl malonate molecule can undergo thermally induced oxidative carbonylation, which produces benzoic acid and formaldehyde.

tert-Butyl 4-aminobutanoate is an amine that has been shown to stabilize the natural formyl group of the molecule. It is a nucleophilic reactant, which means it will react with electrophiles. The nucleophilic attack occurs when a nucleophile reacts with an electrophile, leading to the formation of a new bond between the two molecules. Tert-butyl 4-aminobutanoate also has a hydroxymethyl group on its side chain. This hydroxymethyl group can be reduced by pyridoxal phosphate in order to form gamma-aminobutyric acid.

Versatile small molecule scaffold

Cyclopentane-1,2-dicarboxylic acid is a bioactive chemical that contains nitrogen atoms. It has a structural formula of C5H8O4 and an x-ray structure with antibacterial properties. Cyclopentane-1,2-dicarboxylic acid can be found in cocatalyst preparations for organic solvents such as benzene, toluene, and xylene. This compound has been shown to inhibit the growth of bacteria by binding to amines and forming coordination complexes with carboxylate groups on the surface of bacterial cells. The crystal structures of cyclopentane-1,2-dicarboxylic acid have not yet been determined due to its alicyclic nature.

3-(1H-Pyrazol-1-yl)benzaldehyde is an oxime that is used as a ligand in coordination chemistry. It has been shown to catalyze the coupling of piperidine and aryl halides, yielding carboxylic acid derivatives. 3-(1H-Pyrazol-1-yl)benzaldehyde also efficiently catalyzes the synthesis of pharmaceuticals containing pyrrolidines, such as amino acids or nucleophiles. 3-(1H-Pyrazol-1-yl)benzaldehyde is a good ligand for metal ions due to its ability to form strong bonds with them. In addition, it can be used as an additive in the synthesis of amines and imines due to its ability to chelate metals.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold