Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Bromo-5-methylthiophene-2-carboxylic acid (3BMT) is a drug that inhibits the enzyme succinate dehydrogenase. Succinate dehydrogenase is an enzyme that catalyzes the conversion of succinate to fumarate in the citric acid cycle, which is a series of biochemical reactions in cellular respiration. 3BMT prevents the formation of acetyl coenzyme A, which is needed for the production of energy in cells. This drug also has a pyrrole moiety that can be oxidized by difluoromethylating it and then reacting with pyrrole to form 2,4-dichloropyrimidine. 3BMT has been shown to inhibit carboxamides such as L-aspartate oxidase and glutamate decarboxylase.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Methyl-2-phenylthiazole-5-carboxylic acid hydrazide is a potent anticancer agent. It has been shown to inhibit the growth of cancer cells through inhibition of DNA synthesis and protein synthesis, as well as by inducing apoptosis. 4-Methyl-2-phenylthiazole-5-carboxylic acid hydrazide binds to the active site of DNA gyrase, an enzyme that maintains the integrity of bacterial DNA. This binding prevents the formation of an antibiotic-inhibitor complex with the enzyme cell wall synthesis that is required for cell wall biosynthesis, inhibiting protein synthesis and cell division. The antitumor activity was found to be mediated through interactions with pharmacological targets such as butanamide, phenacyl, dioxane, and chlorides. These drugs bind to pharmacophores on tumor cells and are able to penetrate into tumor cells more easily than other drugs. The potent anticancer</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(Pyridin-2-yl)pyrimidin-4-amine (PPPA) is an antimicrobial agent that is used in the treatment of bacterial infections. It binds to the chloride ion in the cell wall and prevents the formation of a functional pore, causing leakage of cellular contents. PPPA reacts with cyanamide to form 2-(pyridin-2-yl)pyrimidin-4(1H)-one (PPPOH), which is more reactive than PPPA. The reactivity of PPPOH causes damage to the cell's cytoplasmic membrane, leading to cell death. PPPA also reacts with nitro, alkynyl, and alkylaminoalkyl groups, as well as carboxy, cyano, and alkenyl groups on proteins and amino acids. PPPA hydrolyzes phenoxy and cyclohexane rings found in some antibiotics such as tetracycline.</p>

<p>Versatile small molecule scaffold</p>

<p>3-Hydroxy-4-propoxybenzaldehyde is a metabolically stable inhibitor of the enzyme, phenylalanine 4-hydroxylase. 3HPA inhibits the production of phenolic compounds and reduces the risk of cancer. It has been shown to be potently active against human leukemia cells in vitro, but less active against other cell lines. 3HPA is also selective for tumor cells, which may be due to its ability to inhibit DNA synthesis by preventing the formation of n-substituted benzylamino compounds. 3HPA stabilizes DNA and RNA synthesis, which may help prevent tumor growth.</p>

<p>5-Aminoquinolin-2(1H)-one is an antimicrobial agent that has been shown to have antibacterial activity against gram-positive and gram-negative organisms. The structure of 5-aminoquinolin-2(1H)-one is a carboxylic acid with a hydrogen atom on the alpha carbon, which gives it an alkylamino group and amino group. The tautomeric form of this compound is a quinolinate ester. 5-Aminoquinolin-2(1H)-one has been shown to be effective against drug resistant bacteria, such as Staphylococcus aureus, Streptococcus pneumoniae, and Pseudomonas aeruginosa. This drug also inhibits the growth of Mycobacterium tuberculosis at low concentrations.<br>5-Aminoquinolin-2(1H)-one may act by inhibiting the synthesis of proteins or DNA in cells by</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2,2-Dimethylchromane-6-carbaldehyde is a flavonoid compound that is structurally similar to abyssinone and resacetophenone. It has been shown to have anti-oxidant activity in the presence of hydrogen peroxide in vitro. 2,2-Dimethylchromane-6-carbaldehyde has also been shown to inhibit the growth of MCF7 cells by inducing apoptosis and cell cycle arrest at G0/G1 phase.</p>

<p>Versatile small molecule scaffold</p>

<p>2-(3,4-Diethoxyphenyl)ethanamine is a quinazolone derivative that is electron deficient. It has been shown to inhibit the contractility of isolated rat ileum and guinea pig vas deferens preparations. 2-(3,4-Diethoxyphenyl)ethanamine also potently inhibits phosphorylation of myosin light chain and can be used as a tool for studying the involvement of phosphorylation in muscle contraction. It has been shown to inhibit lipid droplet formation in L6 cells by activating AMP-activated protein kinase (AMPK).</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Propan-2-yl (2S)-2-amino-3-methylbutanoate is an amino acid derivative that is used as a chiral auxiliary. The compound has been used in the synthesis of amides, esters, and other amine products. It has also been used in the preparation of enantiomerically pure protonated amines. Propan-2-yl (2S)-2-amino-3-methylbutanoate can be used as a chiral auxiliary in chromatographic techniques to separate racemic mixtures into their enantiomers. This compound is mesomorphic at low temperatures and becomes isotropic at higher temperatures. Propan-2-yl (2S)-2-amino-3-methylbutanoate is also soluble in solvents with different polarities, such as water and chloroform, and has a molecular weight of 158.25 g/mol.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Bromo-2-cyclohexen-1-ol is an organic compound that belongs to the group of chlorides, iodides, and yields. Mechanistic studies have shown that this compound reacts by nucleophilic attack at a reactive site that contains halides. The chloride ion is a terminal alkyne and has been shown to be reactive with 2-bromo-2-cyclohexen-1-ol. The indole nitrogen in 2-bromo-2-cyclohexenol has been shown to undergo nucleophilic substitution with an aryl chloride substrate. This reaction has been shown to be reversible by adding base.</p>

<p>Versatile small molecule scaffold</p>

<p>Prop-2-en-1-yl benzoic acid is an alkenoic, organometallic compound that is a metabolite of 2-bromopropane. It can be obtained from the bromolactonization of tetrahydrofuran with lithium aluminum hydride followed by allylic oxidation with chromium oxide and sodium hydroxide. Prop-2-en-1-yl benzoic acid has been shown to inhibit the enzyme acetylcholinesterase, which leads to increased levels of acetylcholine in the brain. This leads to increased activity on nicotinic receptors and improved cognition. This compound has also been shown to be a ligand for donepezil, which is an inhibitor of cholinesterases. Donepezil is used as a treatment for Alzheimer's disease and other forms of dementia, but it does not cross the blood brain barrier. In this case, prop-2-en-1</p>

<p>Versatile small molecule scaffold</p>

<p>2-(4-Amino-2-chloro-5-methylphenyl)-2-(4-chlorophenyl)acetonitrile is an analogue of diazocine. It has a dihedral angle of 12.3° and a benzene ring.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Amino-2-(naphthalen-1-yl)ethanol is a diastereomer that is expressed as an optically active propionic acid. It is industrially used for the production of naphthalene derivatives.</p>

<p>4-(1-Aminoethyl)benzonitrile (AEB) is a compound that is used to treat cardiac hypertrophy. It is an innovative drug that inhibits the growth of cardiomyocytes by inhibiting collagen synthesis and inducing their apoptosis. AEB inhibits the production of collagen, which is needed for the development of cardiac hypertrophy. AEB also modulates the expression of proteins involved in muscle function, including protein genes and lipase.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2,4,6-Trimethyl-1,3,5-dithiazinane (TMTD) is a heterocyclic compound that has been shown to be an effective inhibitor of glutamate dehydrogenase. TMTD has also been shown to have antioxidant properties and can be used in the treatment of cancer. The effect of TMTD on epidermal growth factor (EGF) and fatty acid metabolism has been investigated. It is also a methyl transferase inhibitor and can inhibit the synthesis of fatty acids in cells. TMTD can be used as a diagnostic agent for detection of the presence of glutamine synthetase in cells. The effective dose for TMTD varies depending on the type of application; for example, it may be administered orally at a dosage range between 5-50mg/kg body weight or topically at a dosage range between 0.001-0.1%.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Chloro-N-ethylpyrimidin-4-amine is a class I inhibitor of the cytochrome P450 that has been shown to inhibit the kinase activity of a number of protein tyrosine phosphatases. The inhibition of these enzymes results in an increase in cellular activities such as transcription and translation. 2-Chloro-N-ethylpyrimidin-4-amine has also been shown to have cytotoxic effects on cultured cells and is able to bind to hydrophobic regions on proteins, which may account for its ability to induce apoptosis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Ethyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-3-carboxylate is an isomeric mixture that can be obtained by an efficient method. It is stable in alkaline conditions and can be hydrolyzed in alkaline conditions.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Bromocyclopent-2-en-1-ol is an organic compound that is used in the synthesis of a variety of other compounds. This chemical can be synthesized by reacting cyclopentanone with bromine and then hydrolyzing the product. The resulting product has a configurational, asymmetric synthesis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>