Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4H,5H,6H-Thieno[3,4-c]pyrrole-4,6-dione is a potent antitumor agent that inhibits the activity of protein kinases. It has been shown to have the ability to inhibit tumor growth in animal models and has been shown to be effective against resistant microorganisms such as Staphylococcus aureus and Mycobacterium tuberculosis. 4H,5H,6H-Thieno[3,4-c]pyrrole-4,6-dione has also been shown to improve hematopoiesis by stimulating colony stimulating factor production. This compound is metabolized through a number of metabolic transformations including oxidative deamination by monoamine oxidase or pyridoxal phosphate dependent aminotransferases. The biological properties of 4H,5H,6H-Thieno[3,4-c]pyrrole-4</p>

<p>Versatile small molecule scaffold</p>

<p>3-(Thiophen-2-yl)propan-1-amine is an organic solvent that is used as a reactant in the production of polyphosphoric acid. It is also used in the synthesis of pharmaceuticals. This compound can be produced by reacting chloroformate with propylamine and aluminium chloride in a solution of hydrochloric acid, producing 3-(thiophen-2-yl)propan-1-amine and hydrogen chloride gas. The reaction can also be carried out using phosphoryl chloride and propylamine to produce 3-(thiophen-2-yl)propan-1-amine and phosphorus pentoxide.</p>

<p>Mesityl oxide is a colorless liquid with a sweet odor that is used as a flavor and fragrance agent. It can be found in the volatile fraction of many essential oils such as lavender, rosemary, and sage. Mesityl oxide has been identified by gas chromatography-mass spectrometry (GC-MS) to be present in the volatile fraction of these oils. It is also found in many foods such as red wine, coffee, and beer. Mesityl oxide has been shown to have differentiating properties in initially similar samples. This compound can be detected by GC-MS using an oxidized pentane extraction procedure.<br>Mesityl oxide is not considered to be toxic at low doses but may cause irritation at high doses.</p>

<p>Versatile small molecule scaffold</p>

<p>2,2-Dimethyl-1-(4-methylphenyl)propan-1-ol is a product of the dehydration of 2,2-dimethylcyclohexanol. The hydrogenolysis reaction with metals such as palladium or platinum has been shown to produce retropinacol in high yields. The catalytic dehydroxylation reaction can be carried out using a variety of metal catalysts, such as palladium or platinum. 2,2-Dimethyl-1-(4-methylphenyl)propan-1-ol is also produced by the isomerization of other alcohols and can be synthesized by reacting an alkyl halide with carbonium ions.</p>

<p>Versatile small molecule scaffold</p>

<p>N-(1H-Indol-5-yl)benzamide is a tetraaryl compound that acts as a catalyst. It has been shown to be active against Gram-positive bacteria, such as Streptococcus pneumoniae and Staphylococcus aureus, at 10 μM. This compound has high activity against these bacteria and is more stable at higher temperatures. N-(1H-Indol-5-yl)benzamide has also been shown to have good stability in the presence of clarithromycin, which is an antibiotic used to treat bacterial infections. This drug can form a complex with clavulanic acid (a β-lactamase inhibitor) and thus can inhibit bacterial growth by binding to the ribosomal RNA of the bacteria. The molecular weight of N-(1H-indol-5-yl)benzamide is 169 g/mol and its functional groups are hydroxyl, carbonyl, and car</p>

<p>4-Hydroxy-2,3-dimethylbenzoic acid is a hydroxybenzoic acid that is soluble in oil solutions. It has been shown to be a ligand with additives such as hydrocarbon groups and can be used as an additive for hydrocarbons. 4-Hydroxy-2,3-dimethylbenzoic acid also has cyclic properties and can be used as a lubricant. This compound has been shown to have anticorrosive properties and can be used to treat metals. 4-Hydroxy-2,3-dimethylbenzoic acid is also a reactive compound with the chemical formula CH(COOH)CH(OH)COOH. It reacts with trifluoromethanesulfonic acid (TFMS) to produce the corresponding carboxylic acid and sulfonic acid products, which are strong absorbers of UV light. 4-Hydroxyl benzoic acid is found in the molecule</p>

<p>4-Chloropyrrolo[1,2-a]quinoxaline is an organic compound that is used in the synthesis of other drugs. It is a chiral molecule that can be derived from the natural product quinoxaline. 4-Chloropyrrolo[1,2-a]quinoxaline has been shown to inhibit efflux proteins in mammalian cells and to inhibit the kinase activity of hepg2 cell lines. These effects may be due to its ability to bind to the ATP binding site of these enzymes and prevent ATP hydrolysis. 4-Chloropyrrolo[1,2-a]quinoxaline has been shown to bind selectively with protein kinases and has antimalarial activity against Plasmodium falciparum, a parasite that causes malaria.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Quinoline-4-sulfonic acid is a chemical compound that belongs to the class of quinoline derivatives. It has a linear range of activity and inhibits enzymes such as glutamicum, organisms, additives, metal ion, alkali metal, heterocycle, methyl groups and oxygenated. The optimum pH for this compound is 7. Quinoline-4-sulfonic acid is not very soluble in water but is soluble in an organic solvent such as acetone or ethanol. This molecule has been shown to be active against strains of Escherichia coli.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2H,3H-Naphtho[1,2-b]furan-2-one is a potent antagonist of the plasminogen activator inhibitor type 1 (PAI-1) and the urokinase-type plasminogen activator (uPA). It has been shown to be a potential therapeutic agent for the treatment of cancer and rheumatoid arthritis. The inhibition of PAI-1 and uPA by 2H,3H-Naphtho[1,2-b]furan-2-one leads to an increase in fibrinolysis or dissolution of blood clots, as well as angiogenesis. This may account for its antitumor activity. 2H,3H-Naphtho[1,2-b]furan-2-one has also been synthesized using intramolecular cyclization reactions with high yields and purity.</p>

<p>2-Oxaspiro[4.5]decane-1,3-dione is a heterocyclic compound that is used in pharmaceutical research and the development of new drugs. It can be synthesized by reacting phenylhydrazine with 2-oxaspiro[4.5]decane-1,3-dione. The nitrogen atom in this molecule is essential for its activity and pharmacological properties, which are similar to those of phenacetin. The profile of 2-oxaspiro[4.5]decane-1,3-dione has been studied using physicochemical parameters such as molecular weight and melting point. This molecule was first discovered to have antilead activities by Friedel and Crafts reaction with lead iodide.</p>

<p>2-Phenylbut-3-en-2-ol is a synthetic molecule that has been shown to be an efficient ligand for the treatment of halides. It also has been used in allylation reactions with proton catalysis and as an epoxide functional group. This compound can be synthesized from the reaction of acetone, propylene oxide, and butadiene. 2-Phenylbut-3-en-2-ol is a byproduct of the synthesis of obtustyrene. This compound has been used in cross coupling reactions as well as carbonic acid transfer reactions.</p>

<p>1-(Ethylsulfanyl)-2-[(2-ethylsulfanyl) ethyl]sulfanylethane is a polymerizable and ultraviolet absorber that can be used in acrylic paints. It interacts with the double bonds of acrylic resin to form cross-linked polymers, thereby increasing the hardness and durability of the paint. 1-(Ethylsulfanyl)-2-[(2-ethylsulfanyl) ethyl]sulfanylethane absorbs UV light in the range of 320 - 350 nm and exhibits high optical purity.</p>

<p>Versatile small molecule scaffold</p>

<p>2,3,4,9-Tetrahydro-1H-pyrido[3,4-β]indole-3-carboxylic acid is an organic compound that is found in plant sources. It is an isomer of tryptophan and can be found as a racemic mixture. 2,3,4,9-Tetrahydro-1H-pyrido[3,4-β]indole-3-carboxylic acid has been shown to have antiplatelet activity in animals and humans because it inhibits the release of acetylcholine from platelets.</p>

<p>4-Hydroxy-1,6-dimethyl-1H-pyridin-2-one is a heterocyclic compound that is used as an intermediate in the synthesis of other compounds. It has been shown to have antiproliferative activity against human tumor cells and induces apoptosis. This compound also has anti-inflammatory properties and can be used as a substitute for malononitrile in the synthesis of cytotoxic drugs. 4-Hydroxy-1,6-dimethyl-1H-pyridin-2-one is synthesized by cyclocondensation reaction between cyanate and sulfinyl chlorides. The yield of this compound can be increased with the use of a Lewis acid such as aluminum chloride or zinc chloride.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>cis-1,3-Cyclopentanedicarboxylic anhydride (cis-DCC) is a solvent that is used in analytical chemistry. It has a relatively high boiling point and is soluble in both organic solvents and water. cis-DCC's solvating properties are enhanced by its ability to form hydrogen bonds with the substrate. cis-DCC also has a limited ability to adsorb on surfaces due to its low surface tension. cis-DCC is thermally stable, which makes it useful as a solvent for reactions that require elevated temperatures.</p>

<p>Versatile small molecule scaffold</p>

<p>4-(4-Biphenylyl)butyric acid (4-BPBA) is a phenylbutazone analog that has been shown to have anti-inflammatory properties. It interacts with the nonsteroidal nitro group of 4-BPBA and inhibits the production of prostaglandins by inhibition of cyclooxygenase. 4-BPBA also interacts with serotonin, which may be due to its ability to inhibit phosphodiesterase activity. 4-(4-Biphenylyl)butyric acid is an orally active drug that can suppress inflammation in animals and humans. It has been shown to cause thrombocytopenia and hemolytic anemia in humans due to its effect on red blood cells.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Hydroxyhexanoic acid is a fatty acid that is used in the treatment of diabetic patients. It is an intermediate product of the metabolism of glucose, which can be obtained by hydrolysis of glycerol with hydrochloric acid and supercritical carbon dioxide. The molecule has two hydroxyl groups, which are important for its function as a substrate in chemical reactions. 2-Hydroxyhexanoic acid also reacts with lysine residues at neutral pH, forming an ester linkage. This reaction can be demonstrated by adding phosphotungstic acid to a solution containing 2-hydroxyhexanoic acid or lysine residues.</p>

<p>5-Aminopentanenitrile hydrochloride is a chemical compound that has been used as a food additive. It is also found in medicines and dietary supplements, where it is used to prevent the formation of gas in the stomach. The chlorine atom in 5-aminopentanenitrile hydrochloride can be substituted with other atoms, such as hydrogen or bromine, which changes its properties. Substituting the chlorine atom with an organic solvent such as ethylene (or replacing it with a nucleophilic group) will lead to different chemical transformations. When catalyzed by enzymes, 5-aminopentanenitrile hydrochloride becomes l-glutamic acid and l-phenylalanine through a process called amination. This transformation requires the presence of hydrogen peroxide and an organic solvent, such as ethylene or alcohols.</p>

<p>3,4-Dihydroxyflavonol is a potent antioxidant that prevents oxidative damage to DNA and proteins. It has been shown to be effective in experimental models of ischemia–reperfusion injury and cardiac ischemia reperfusion. 3,4-Dihydroxyflavonol also inhibits the production of reactive oxygen species during reperfusion and reduces the size of infarcted myocardial tissue. 3,4-Dihydroxyflavonol has been shown to have anti-cancer effects in animal models of bone cancer and mesenteric lymphadenopathy. In addition, it may have neuroprotective effects that are due to its ability to inhibit monoamine oxidase activity.</p>

<p>(Isothiocyanatomethyl)cyclopropane is a cyclopropane derivative that has been used to study the conformational properties of molecules in solution. It has been shown that the vibrational frequencies of (isothiocyanatomethyl)cyclopropane are strongly dependent on the solvent, temperature, and concentration. FT-IR spectra show that the molecule has a strong dipole moment and symmetrical vibrations. The theory behind this work is based on the functional theory of quantum mechanics, which predicts that the frequency of vibration should depend on the functions, intensities, and parameters of a molecule. This work also shows how conformational studies can be used to investigate different types of molecules.</p>

<p>Versatile small molecule scaffold</p>

<p>2-(Thien-2-yl)benzoic acid (TBA) is an organic compound. It is a structural analog of thiophene, with the sulfur replaced by a carbon atom. TBA has been shown to have functional groups that are activated by spontaneous reactions and is classified as an organic acid. TBA has been seen to have biological properties, such as being able to protect against radiation damage in the heart, and it also has been shown to be effective at lowering blood pressure in rats. TBA's chemical formula can be written as C6H5COOH.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-[3-(2-Carboxyethyl)phenyl]propanoic acid is a reagent used in oxidation reactions. It has been shown to be a good catalyst for the amination of alkanes, as well as oxidation of benzylic substrates. 3-[3-(2-Carboxyethyl)phenyl]propanoic acid is a dinuclear molecule with two sulfamoyl groups. The sulfamoyl group can be oxidized by adding an oxidizing agent such as hydrogen peroxide or potassium permanganate. This then leads to the formation of the sulfonamide and carboxylic acid products.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Chloro-1-N,1-N-dimethylbenzene-1,4-diamine is a chemical compound that belongs to the class of organic compounds. It is used as an analytical reagent for flow cells and has been shown to be adsorbed onto activated carbon under acidic conditions. The flow rate of 2CBDD can be determined by measuring the optical density at 250 nm. The elution time can be determined by measuring the absorption at 280 nm.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2,4,6-Trimethylphenyl Isothiocyanate is a reactive compound that can inactivate enzymes. It is used as a catalyst and an intermediate in the production of dyes and pharmaceuticals. 2,4,6-Trimethylphenyl Isothiocyanate reacts with dimethyldioxirane to form diphenylphosphine acid. This acid reacts with choline to produce sulfines. The sulfines react with hydrogen to yield the desired product or prodrug. 2,4,6-Trimethylphenyl Isothiocyanate also catalyzes the reaction between sulfur and hydrogen gas at high temperatures to form hydrogen sulfide gas.br&gt;br&gt;<br>br&gt;br&gt;<br>Yield: 100%</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Ethynyl(diphenyl)phosphine oxide is an amide that has been shown to be useful in coordination, catalysis, and organic chemistry. It is a conformational analog of the amide group. Ethynyl(diphenyl)phosphine oxide has been used as a hydrogen-bond donor in esterification reactions. This compound can be synthesized by reacting the corresponding boronic acid with ethynyl alcohol. The yields of this reaction are dependent on the temperature and have been found to range from 60% to 70%. The nmr spectra of this compound show two signals at δ 2.95 and δ 4.85 ppm, corresponding to two different conformers of ethynyl(diphenyl)phosphine oxide.</p>

Versatile small molecule scaffold

<p>4-(4-Nitrophenyl)-1H-1,2,3-triazole (NPT) is a bioactive molecule that inhibits the growth of promyelocytic leukemia cells by interfering with the activity of certain enzymes. NPT has been shown to inhibit the influenza virus and human cervical carcinoma cells in vitro. In addition, it has been shown to inhibit the proliferation of leukemia HL60 cells. NPT is an unsymmetrical molecule that forms an imine during the enzymatic process. The molecular modeling studies show that this compound binds to the active site of enzyme histidine kinase in a manner similar to ATP. This binding prevents ATP from forming a stable complex with histidine kinase and phosphorylating its target protein, which disrupts cellular homeostasis and leads to cell death.</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 2-nitropropanoate is a reactive compound that is used as an epigenetic marker. It reacts with lysine residues in proteins and histones, resulting in the methylation of these proteins. Methyl 2-nitropropanoate has been shown to inhibit the replication of DNA and induce cellular apoptosis in mammalian cells. The effector proteins H3K9me2 and H4K5me1 are involved in epigenetic changes that include gene silencing and histone demethylation. Methyl 2-nitropropanoate can also cause clastogenic effects by forming adducts on dna replication enzymes, such as amide and demethylation. Histone lysines are methylated by methyl 2-nitropropanoate, which causes histones to condense into tight bundles of DNA that contribute to the formation of actin filaments.</p>

<p>5,6-Dichlorobenzo(1,3)dioxole (DDD) is an inhibitor of both the cytochrome P450 and the dioxolane monooxygenase. It is stable in vivo and has been shown to have a high selectivity for these enzymes. DDD has been shown to inhibit monoxide production by phenobarbital in rat liver microsomes. This drug also inhibits hepatic microsomes of animals treated with β-naphthoflavone, but not those of animals treated with dioxolane. The inhibition may be due to the inhibition of cytochromes P450 and/or dioxolane monooxygenase by DDD.</p>