Building Blocks

<p>Applications 2-Fluorobenzonitrile-d4 (CAS# 2256740-46-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Sodium Butyrate-4,4,4-d3 (CAS# 347840-05-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 5-Nitropyridin-2(1H)-one can be used for molecular crystal optical materials.<br>References Uemya, T., et.al., Jpn. Kokai Tokkyo Koho, 22, (1995);<br></p>

<p>Applications N,N-Dimethylethanolamine-d10 (OH) is a useful isotopically labeled compound of 2-Dimethylaminoethanol (D471170)<br></p>

<p>Applications Sodium Butyrate-3,3,4,4,4-d5 (CAS# 204244-79-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications An impurity of Isoniazid (I821450), potent antitubercular agent against M. tuberculosis.<br>References Brewer, G.A., et al.: Anal. Profiles. Drug. Subs., 6, 183 (1977), Andrade, C., et al.: Lett. Drug. Des. Discov., 5, 377 (2008)<br></p>

<p>Applications 4-Fluorobenzyl-2,3,5,6-d4-amine (CAS# 1219798-96-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Nitrobenzyl-d6 Alcohol (CAS# 1219795-18-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Methyl Dl-2-(1-Boc-Piperidin-4-Yl)-Beta-Glycinate (cas# 362703-57-9) is a useful research chemical.<br></p>

<p>Applications 1-Cbz-piperazine is used in the synthesis of serotonin 5-HT6 and dopamine D2 receptor ligands (1,2). It can also be used for the synthesis of a 11-C labelled ligands for imaging vesicular acetylcholine transporter.<br>References (1) Kindahl, T. et al.: Org. Biomol. Chem., 12, 4461 (2014) (2) Krogsgaard-Larsen, N., et al.: J. Med. Chem., 57, 5823 (2014)<br></p>

<p>Applications Sodium n-hexadecyl-d33 sulfate is labelled Sodium n-hexadecyl sulfate.It is an anionic surfactant.<br>References Nikas, Y., et al.: Langmuir, 10, 3512 (1994); Moradi, M., et al.: Talanta, 82, 1864 (2010)<br></p>

<p>Stability Temperature Sensitive<br>Applications 2,5-Dimethyl-4-hydroxy-3(2H)-furanone is a component of meat essence composition. 2,5-Dimethyl-4-hydroxy-3(2H)-furanone is used in the flavor and perfume industry due to its sweet strawberry aroma.<br>References Farmer, L., et al.: J. Sci. Food Agric., 1992, 60, 489 (1992); Koutsidis, G., et al.: Meat Sci., 79, 124 (2008); Myers, A., et al.: Meat Sci., 82, 59 (2009);<br></p>

<p>Stability Moisture Sensitive<br>Applications Seyferth-Gilbert Reagent<br></p>

<p>Applications 2,3-Dimethylbenzothiazolium Methyl Sulfate (cas# 2038-15-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(5-formyl-2-methoxyphenoxy)acetic Acid (cas# 19728-22-4) is a useful research chemical.<br></p>

<p>Applications Intermediate in the preparation of Ximelagatran.<br>References Smits, R., et al.: J. Med. Chem., 51, 7855 (2008), Sander, K., et al.: Bioorg. Med. Chem., 17, 7186 (2009), Selness, S., et al.: Bioorg. Med. Chem. Lett., 19, 5851 (2009),<br></p>

<p>Applications Cyclopentane-d9 (CAS# 80862-68-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications o-Tolunitrile-d7 (CAS# 1138681-69-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Dimethyl 3-Methoxyallylidenemalonate is used to prepare pyridinonyl PDK1 inhibitors and pyrrolo[3,2-c]pyridine derivatives as kinase inhibitors for treating cancer.<br>References Lind, K., et al.: PCT Int. Appl., WO 2008005457 A2 20080110 (2008); Borzilleri, R., et al.: U.S. Pat. Appl. Publ., US 20050239820 A1 20051027 (2005)<br></p>

<p>Applications 3-Hydroxy-3-methylpentane-1,5-dioic Acid (cas# 503-49-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 3,6-Dihydro-2H-pyridine-1-N-Boc-4-boronic acid, pinacol ester<br></p>

<p>Applications Methyl-4-Chloro-7-methoxyquinoline-6-carboxylate is used pharmaceutically for treating infection after burns. It is also used as reagents in the preparation of naphthamides as inhibitors of vascular endothelial growth factor (VEGF) receptor tyrosine kinase.<br>References Zhang, M. et al.: Faming Zhuanli Shenqing (2016), CN 105601566 A 20160525; Harmange, J., et al.: J. Med. Chem., 51, 1649 (2008)<br></p>

<p>Applications m-Toluidine-d9 (CAS# 352431-22-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Maleimide (cas# 541-59-3) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications p-Toluidine-d3 (methyl-d3) (CAS# 23346-25-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Hydroxy-6-methylpyran-2-one was used in the synthesis of pyrano[3,2-c]pyridones with antiproliferative and apoptosis inducing activities. It was also used in the design of benzisothiazolone human leukocyte elastase inhibitors.<br>References Magedov, I., et al.: Bioorg. Med. Chem. Lett., 17, 3872 (2007); Hilasta, D., et al.: J. Med. Chem., 38, 4687 (1995)<br></p>

<p>Stability Hygroscopic<br>Applications Tetrahydrofuran-2,5-dicarboxylic Acid (cas# 2240-81-5) is a compound useful in organic synthesis.<br></p>

<p>Stability Extremely Moisture Sensitive<br>Applications Hexylphosphonic Dichloride acts as a reagent for the preparation of enantiomeric phosphonates which are inhibitors of cholesterol esterase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gillespie, S. G., et al.: Phosphorus, Sulfur Silicon Relat. Elem., 122, 205 (1997)<br></p>

<p>Applications 3-Hydroxypiperidine is used as a reagent to synthesize trisubstituted ureas, compounds that act as thrombin receptor (PAR-1) antagonists. 3-Hydroxypiperidine is also a metabolite of Piperidine (P479985), Piperidine is an organic heterocyclic amine widely used as building block and reagent in the synthesis of organic compounds including pharmaceuticals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Barrow, J., et al.: Bioorg. Med. Chem. Lett., 11, 2691 (2001); Reshmi, S.K., et al.: J. Med. Plant. Res., 4, 1535 (2010); Wiles, J.A., et al.: J. Med. Chem., 54, 3418 (2011);<br></p>

<p>Applications 1-Hydroxyisoquinoline (cas# 491-30-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Glyceryl Tri(hexadecanoate-16,16,16-d3) (CAS# 285979-78-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications p-​Tolunitrile-d7 is an isotopic analog of p-​Tolunitrile (T536235), a reagent used in the preparation of 1H-Indazoles from imidates and nitrosobenzenes.<br>References Wang, Q. et al.: Org. Lett., 18, 2102 (2016);<br></p>

<p>Applications 10-Undecen-1-ol (cas# 112-43-6) is a useful research chemical.<br></p>

<p>Stability Readily Oxidized<br>Applications A volatile aroma compound. We will provide a detailed procedure for the preparation of the thiol from the thiolacetate with spectral data upon request.<br>References Majcher, M., et al.: J. Agric. Food Chem., 55, 5754 (2007), Akiyama, M., et al.: Food Sci. Technol. Res., 15, 233 (2009), Breme, K., et al.: J. Agric. Food Chem., 57, 8572 (2009),<br></p>

<p>Applications p-Toluidine-d9 (CAS# 352431-23-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Methyl-3-phenylpyrazine (cas# 29444-53-9) is a useful research chemical.<br></p>

<p>Applications L-Proline-d3-N-Fmoc was used to prepare potent bombesin-like peptides for GRP-receptor targeting of tumors. It was also used to synthesize tetrapeptide aldehyde inhibitors of dengue virus NS3 protease.<br>References Nock, B., et al.: J. Med. Chem., 48, 100 (2005); Yin, Z., et al.: Bioorg. Med. Chem. Lett., 16, 40 (2006)<br></p>

<p>Applications p-Xylene-alpha,alpha,alpha-d3 (CAS# 26204-18-2) is a useful isotopically labeled research compound.<br></p>