Building Blocks

<p>Versatile small molecule scaffold</p>

6-Chloro-3,4-dihydro-1,2,3-benzotriazin-4-one is a potent anti-inflammatory agent that belongs to the group of organic compounds. It has been shown to be more effective in inhibiting inflammation than other classes of drugs such as nonsteroidal anti-inflammatory agents. 6-Chloro-3,4-dihydro-1,2,3-benzotriazin-4-one also blocks the production of prostaglandins by inhibiting cyclooxygenase and lipoxygenases. This drug is not a nitrite but is converted into one by sodium nitrite in a reaction that releases nitric oxide. Nitric oxide causes vasodilation and inhibits platelet aggregation, which reduces blood clot formation.

<p>Versatile small molecule scaffold</p>

<p>1,3-Dimethyl 2-phenylpropanedioate is a molecule that is used in the production of malonic acid. The reaction mechanism involves an enzymatic homogenization of the reactants, which leads to the formation of carbonyl oxygens and reaction intermediates. The carbonyl oxygens are then protonated by ethyl diazoacetate to form allyl carbonates. This process occurs in the presence of immobilized enzymes and chemical reactions.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>1,2-Thiazinane-1,1-dione is a short-chain alkylating agent that has been shown to have neuropathic and inflammatory pain relief. It binds to a number of halides and inhibits their action, including the inhibition of angiotensin I-converting enzyme (ACE), which is an antihypertensive agent. 1,2-Thiazinane-1,1-dione also inhibits the production of epoxides in c1-4 alkyl groups. This drug also has antibacterial properties and can be used as a chemical probe for ligand binding studies.</p>

<p>Versatile small molecule scaffold</p>

<p>1-Phenylbut-3-en-2-one is an n-oxide that is the product of the reaction between 2,4,6-trinitrobenzenesulfonic acid and phenylacetic acid. It has been used as a horticultural agent for controlling mildew on plants. It has also been shown to have a potent inhibitory effect against cell growth in vitro at doses of 50 μmol/L. 1-Phenylbut-3-en-2-one will react with chlorine atoms in the environment to form chlorinated derivatives that may be more toxic than the parent compound. 1Phenylbut-3-en-2-one has neuroprotective properties and has been shown to reduce the incidence of cancer in rats by inhibiting carcinogenesis studies. This drug also exhibits antiangiogenic properties, which may be due to its inhibition of DNA synthesis and protein synthesis.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>1H-Pyrrole-2-carbothioamide is an analog of porphyrin. It has a macrocyclic structure with a central metal atom that is bonded to four sulfur atoms and two nitrogen atoms. It absorbs light in the visible region, which makes it appealing for use as a pigment or dye. 1H-Pyrrole-2-carbothioamide has been shown to be biocompatible with living cells and tissues, making it suitable for use in biomedical applications. This molecule can be synthesized by reacting potassium with methanesulfonic acid followed by addition of thiocyanate ion.</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 1-methyl-1H-indole-2-carboxylate is an organic compound that belongs to the family of indole carboxylic acid esters. It is an x-ray crystallographic study for the preparation process, and it has been shown to have antileishmanial activity. The methyl ester is a reagent for the synthesis of octahydroaziridine and can be used as a reagent in Grignard reactions.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Chloroisoquinoline-4-carboxylic acid methyl ester is a potent compound that acts as an antagonist of the prostanoid receptor. It blocks the binding of prostanoids to the receptor and inhibits the production of inflammatory molecules, such as leukotrienes. 1CIQME has been shown to have affinity for both Cox-1 and Cox-2, but is selective for Cox-2. This drug also competitively inhibits the enzyme cyclooxygenase (COX), which produces prostaglandins from arachidonic acid. 1CIQME has been shown to inhibit chemotaxis in mice and to block chemoattractant effects in human neutrophils.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>[(1-Hydroxy-2-oxo-2-phenylethyl)thio]acetic acid (HPTAA) is a selective inhibitor of the enzyme tyrosine kinase. It has been shown to have antiproliferative effects in vitro against glioblastoma cells lines and other cancer cell lines, as well as in vivo against established tumors. HPTAA inhibits the proliferation of cancer cells by interfering with the activation of multiple signaling pathways. This compound has been shown to be selective for cancer cells, while having no effect on normal cells at micromolar concentrations. HPTAA is currently being tested in preselected patients with malignant gliomas and recurrent testicular seminoma.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Pyrido[3,2-d]pyrimidin-4(3H)-one is a molecule that belongs to the class of antimalarial drugs. It inhibits plasmodium falciparum by inhibiting the biosynthesis of purine nucleotides. Pyrido[3,2-d]pyrimidin-4(3H)-one is chemically reactive and apolar. It was isolated from a chemically synthesized compound as an isomer mixture and has been shown to have high activity against erythrocytic stages of plasmodium falciparum in vitro. Pyrido[3,2-d]pyrimidin-4(3H)-one also has a clinical drug application in incrementing the response to other antimalarial drugs.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Methylpyrazine-2-carbohydrazide is a nitro compound that has been shown to have anti-diabetic properties. It can be used as an alternative to insulin in the treatment of diabetes mellitus type 2. 5-Methylpyrazine-2-carbohydrazide has also been shown to inhibit the growth of Staphylococcus aureus, which is a bacterium responsible for causing many types of infections including pneumonia and food poisoning. 5-Methylpyrazine-2-carbohydrazide is a fluorinated chemical that contains aluminium, chlorine, and fluorine atoms. This compound is capable of forming supramolecular complexes with electron deficient species such as sulphur, selenium, or tellurium. The synthesis of 5-methylpyrazine-2-carbohydrazide requires refluxing with chloride in hydrochloric acid and protonation with sodium hydroxide.</p>

<p>Chloro(chloromethanesulfonyl)methane is a herbicide that inhibits the growth of plants by blocking the enzyme responsible for synthesizing the amino acid methionine. It is an analog of sulfometuron-methyl and metolachlor, which are also used as herbicides. Chloro(chloromethanesulfonyl)methane has been shown to be toxic to ruminants, due to its ability to block the synthesis of methionine in their gut bacteria. This drug can also produce a metabolic acidosis in some animals, which may be caused by its ability to produce sulfide from sulfur-containing amino acids.</p>

<p>Versatile small molecule scaffold</p>