Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Pyrazolo[1,5-a]pyridin-4-ol is a heteroaromatic compound that acts as an inhibitor of phosphodiesterase (PDE). It prevents the breakdown of cyclic nucleotides and thus leads to increased levels of cAMP and cGMP. Pyrazolo[1,5-a]pyridin-4-ol has been shown to have bronchodilatory activity in animal models. The drug also inhibits the production of inflammatory mediators such as prostaglandins by inhibiting cyclooxygenases. In addition, pyrazolo[1,5-a]pyridin-4-ol has been shown to be a potential PDE inhibitor replacement for the more commonly used PDE inhibitors such as sildenafil and tadalafil. However, due to its lack of stereochemistry and its bicyclic chemical structure, pyrazolo[1,5-a]</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Chloro-2-methyl-5-nitroaniline is an organic compound with the chemical formula C6H4ClNO2. It is a nitro derivative of aniline. 4-Chloro-2-methyl-5-nitroaniline is a white solid that is soluble in water, alcohols, and ethers. It has a melting point around 206 °C and decomposes at temperatures over 350 °C. This compound can be obtained by reacting hydroxylamine with nitrous acid and chlorinating 2,5-dimethylaniline. The sequence of reactions can be summarized as follows: hydroxy group to nitro group, nitro group to methyl group, methyl group to acetyl or acetylamino, acetyl or acetylamino to acetylation or methylation, transformation from hydroxyl group to amino group and esterification from acid hydrazide to acid group.</p>

<p>Versatile small molecule scaffold</p>

<p>4-Bromo-1-hydroxynaphthalene-2-carboxylic acid (4BHN) is a spectroscopic compound that has been used as a radioligand to study the binding of dopamine and dopamine D3 receptors. This compound binds to the d3 receptor with high affinity and specificity, but it does not interact with the d1 or d2 receptors. 4BHN has been shown to act as an agonist at the dopamine D3 receptor. It also acts as an antagonist at the piperidine site of the dopamine D2 receptor. The effects of 4BHN are reversible, which means that it can be displaced by unlabeled 4BHN or other compounds that bind to the same site on the receptor. This technique is useful for studying drug interactions and for determining whether drugs have a subtype selectivity profile.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Tert-butyl (2S)-2-aminohexanoate is an intermediate that is used in the synthesis of glycine by the reaction of benzyl bromide and tert-butyl amine. The stereospecifically incorporated tert-butyl group has a high degree of enantioselectivity, which makes this intermediate useful in the synthesis of glycine. Tert-butyl (2S)-2-aminohexanoate can be synthesized using lithium diisopropylamide and a tertiary amine as an alkylating agent.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>