Building Blocks

2-Hydroxy-3-methoxybenzenecarbonitrile (2HMB) is a reagent that is used in the synthesis of benzofurans. It is an analog of 2,2'-dichlorodiethyl carbonate. The reaction mechanism involves the conversion of 2HMB to 2-chloro-3-methoxybenzenecarbonitrile, followed by the elimination of chloride to yield 3-hydroxybenzofuran. This reagent also has the ability to catalyze reactions such as demethylation and alkylations.

2,3-Dihydro-1,4-benzoxathiine is a chemical compound that blocks the action of ethylene. It is an antimycotic and has been used to treat fungal infections. The structure of 2,3-dihydro-1,4-benzoxathiine is similar to that of the estrogen molecule and it binds to the estrogen receptor with high affinity. This drug also acts as a selective serotonin receptor ligand and binds selectively to serotonin receptors. In addition, this drug has been shown to act on the nucleus by inhibiting melatonin synthesis in rats.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Hydroxy-4-phenylbutanoic acid is a chemical compound that is used in the synthesis of medicines. It is a stereospecific, water soluble, and soluble form of butyric acid. 3-Hydroxy-4-phenylbutanoic acid can be synthesized by Streptomyces coelicolor through biosynthesis. This process involves two steps: the first step is the synthesis of butyryl coenzyme A from acetone and acetoacetate; and the second step is the conversion of butyryl coenzyme A to 3-(3-hydroxyphenyl)-4-(1,1,2,2,-tetrafluoroethyl)butyric acid. The use of this compound as a carbon source in high temperature cultures has been shown to increase production of other metabolites such as antibiotics.

Phenylacetamide is a white crystalline solid that belongs to the group of phenyl compounds. It can be synthesized from acetamide and phenylmagnesium bromide. Phenylacetamide has been shown to interact with proteolytic enzymes, such as trypsin, chymotrypsin, papain, and elastase. The interaction between phenylacetamide and these enzymes is thought to be based on the similarity in their chemical structures. The skeleton of phenylacetamide contains an active methylene group that can react with lipases or carbon tetrachloride to form profiles. Phenylacetamide also reacts with amines to form amides.

Versatile small molecule scaffold

Phenyloxolan-2-one is a metabolite of glutethimide. It has been shown to produce dose-dependent sedation and hypnosis in rats. It is also a potent inhibitor of the enzyme gamma-aminobutyric acid transaminase, which is responsible for the conversion of GABA to succinic semialdehyde, and may inhibit the formation of gamma-aminobutyric acid from glutamate. Phenyloxolan-2-one can be detected in urine as a metabolite of glutethimide and has been used as an analytical tool for monitoring glutethimide use.

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Propylcyclohexan-1-amine is a hydrogenation reaction intermediate that is produced by the thermodynamic equilibrium of cyclohexanone. It is a colorless liquid that has an amine odor. 2-Propylcyclohexan-1-amine can be used as a solvent and as a reactant in industrial processes. The phosphide ion, P, in this compound can be oxidized to form phosphoric acid with heat or light. This reaction has an activation energy (Ea) of 78 kJ/mol and produces hydrogen gas and the corresponding acid from 2-propyclohexanone. The bond cleavage reaction between phosphine and cyclohexane has an Ea of 54 kJ/mol and produces hydrogen gas, phosphate ions, and the corresponding alcohol.

4-Chloro-1,6-naphthyridine is a chlorinated derivative of 1,6-naphthyridine. It is synthesized by catalytic hydrogenation. Catalytic hydrogenation of 4-chloro-1,6-naphthyridine yields two isomeric products: 4-chloronicotinamide and 4-chlorobenzamide. The industrial process for the synthesis of 4-chloro-1,6-naphthyridine involves condensation with ethyl acetate to form the N-(4'-chlorophenyl)ethane sulfonate salt followed by reaction with potassium chloride in alcoholic solution.

3-Chloropyrazine 1-oxide is a colorless solid that is soluble in chloroform, acetonitrile, and ethyl acetate. It has a molecular weight of 171.44 and a melting point of -8°C. 3-Chloropyrazine 1-oxide is used as an intermediate in the preparation of quinoxalines using the cross-coupling reaction with palladium complexes. This product can be used to synthesize unsymmetrical compounds that contain nitrogen atoms by reacting with pyridine ring, which will result in a frequency shift. The chloride ion in this compound is minuscule and does not participate in any reactions. 3-Chloropyrazine 1-oxide reacts with phosphine to form chlorobenzene, which is then oxidized to form n-oxide.

Versatile small molecule scaffold

Versatile small molecule scaffold

(5,6,7,8-Tetrahydronaphthalen-2-yl)methanol is a hexacyclic molecule that is used as an intermediate in the production of drugs. It can also be used as a precursor for the synthesis of various nitrogen compounds. This compound has potent inducers of cytochrome P450 and hydroxylase enzymes. This product is also considered to be carcinogenic and has been shown to cause tumors in rats when given orally.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Phenyl-1H-indole-2-carboxylic acid is a chemical compound that has an acidic property. It is used in the analysis of hormones, such as testosterone and estradiol. 3-Phenyl-1H-indole-2-carboxylic acid is used to analyze the biotic and abiotic properties of a sample by liquid chromatography. It can be used for the profiling of steroids, such as cortisol and cortisone, and sex hormones. This chemical is also used to highlight the presence of acetonitrile in a sample.

N-Methoxy-N-methylbenzamide is an amide that has been synthesized and characterized. It is a hydrogen bonding compound with the ability to form stable complexes with boron trifluoride etherate. This complex can be used as a reagent for the synthesis of quinoxalines from carbocations, which are formed by the reaction of trifluoroacetic acid with amides. The synthesis of N-Methoxy-N-methylbenzamide has been shown to be an efficient method for the production of quinoxalines. N-Methoxy-N-methylbenzamide has also been found to have anticancer activity, which may be due to its absorption in the UV region.

Versatile small molecule scaffold

2-Azidoethylbenzene is a coumarin derivative that has been identified as an important bioactive molecule. It is synthesized by the reaction of azides and benzene using a reaction solution. The compound reacts with hydroxyl groups to form a C-N bond, which may be responsible for its biological activity. 2-Azidoethylbenzene has been shown to have anti-leukemia effects in radiation-sensitive leukemia cells. It also has vasodilatory properties that may be related to the increase in blood pressure induced by the compound. 2-Azidoethylbenzene has also been shown to be effective against hypoxia inducible factors such as HIF1α, which are proteins involved in cell growth and proliferation.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold