Amines

<p>Applications 4-(Methylsulfinyl)-1-butylamine (cas# 187587-70-8) is a compound useful in organic synthesis.<br></p>

<p>Impurity Vildagliptin Impurity<br>Applications 1-Amino-3-nitroadamantane has potential application in co-catalyst for transition metal reactions and maybe a useful intermediate for the synthesis of Vildagliptin (V305000), an antidiabetic drug that inhibits dipeptidyl peptidase 4 (DPP-4). Vildagliptin exhibits antioxidant properties and may be an apoptotic compound against pancreatic cancer cells.<br>References Amritha, C., et al.: JCDR 9, FC14 (2015); Ahren, B., et al.: J. Clin. Endocrinol. Metab., 89, 2078 (2004), Ahren, B., et al.: Diabetes Care, 27, 2874 (2004), Barlocco, D., et al.: Curr. Opin. Invest. Drugs, 5, 1094 (2004)<br></p>

<p>Applications 12-(tert-Butoxycarbonylamino)dodecylamine can be used to synthesize inhibitors of topoisomerase I for use as anticancer agents.<br>References Cinelli, M., et al.:Bioorg. Med. Chem., 17, 7145 (2009); Morrell, A., et al.: J. Med. Chem., 50, 2040 (2007)<br></p>

<p>Applications 4,4'-Dimethoxydiphenylamine is a diphenylamine derivative used as a chemical additive for cured rubber. 4,4'-Dimethoxydiphenylamine is highly toxic and may potentially induce chromosome abberation.<br>References Kel'man, G.Y. et al.: Kauch. Rez., 26, 28 (1967); Sofuni, T. et al.: Mutat. res. Gen. Toxicol. Test., 24, 175 (1990);<br></p>

<p>Applications 2-[2-(2-azidoethoxy)ethoxy]ethanamine (cas# 166388-57-4) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 3-Aminocyclohexanol_x000D_(cis/trans mixture) (cas# 6850-39-1) is a compound useful in organic synthesis.<br></p>

<p>Applications N-Phenyl-4-biphenylamine (cas# 32228-99-2) is a useful reagent for the preparation of heterocyclic compounds for organic electrical devices.<br>References Oh, H. J., et al.: Repub. Korean Kongkae Taeho Kongbo (2020), KR 2020095104 A<br></p>

<p>Applications 2-(methylamino)benzene-1-sulfonamide (cas# 21639-28-1) is a useful research chemical.<br></p>

<p>Applications 3-[(2-Hydroxyethyl)Amino]Propanoic Acid (cas# 5458-99-1) is a useful research chemical.<br></p>

<p>Stability Air Sensitive<br>Applications A multifunctional compound which shows antioxidant activity in a skin cell model of UVA-induced stress.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sies, H., et al.: Eur. J. Biochem., 215, 213 (1993), Meotti, F., et al.: Environ. Res., 94, 276 (2004),<br></p>

<p>Applications N-(2-aminoethyl)benzamide (cas# 1009-17-2) is a useful research chemical.<br></p>

<p>Applications 5-Amino-1,2,3-thiadiazole, as a thiadiazole derivative, is a privileged structure in medicinal chemistry and has been investigated for anticonvulsant and antimicrobial activities.<br>References Matsumoto, T., et al.: Masakuni; PCT Int. Appl. (2006), WO 2006054652 A1 20060526; Gommaa, A., et al.: Alexandria J. Pharm. Sci., 5, 153 (1991)<br></p>

<p>Applications (2S)-2-acetamido-5-(diaminomethylideneamino)pentanoic Acid (cas# 155-84-0) is a useful research chemical.<br></p>

<p>Applications 2-(4-Aminophenyl)propanoic acid is a reagent in the preparation of 3-aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents (Erratum).<br>References Pevarello, P., et al.: J. Med. Chem., 48, 5058 (2005);<br></p>

<p>Applications 1,10-Diaminodecane (cas# 646-25-3) is a useful research chemical.<br></p>

<p>Applications 4-phenylcyclohexanamine (cas# 19992-45-1) is a useful research chemical.<br></p>

<p>Applications 4-Aminophenethyl Alcohol, is a building block that can be used in the synthesis of various compounds, such as in synthesis of 4-aminostyrene, and in functionalization of graphene nanoplatelets.<br>References Li L, et al.Polymer Journal 33(4), 364-370; Hagiwara T, et al. Macromolecules 24(26), 6856-6858, (1991);<br></p>

<p>Applications tert-Butyl 2-(3-Aminophenyl)acetate can be used as anti-heparanase to treat diseases and disorders associated with heparanase activity.<br>References Giannini, G., et.al.: PCT Int. Appl., 103, (2018);<br></p>

<p>Stability Hygroscopic<br>Applications 2-(2,5-diaminophenyl)ethanol Sulfate (cas# 93841-25-9) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 5-Amino-2-bromobenzoic acid (cas# 2840-02-0) is a useful research chemical.<br></p>

<p>Applications Used for the preparation of dihydrouracils as anti-ictogenic or anti-epileptogenic agents.<br>References Akoulitchev, S., et al.: Nature, 377, 557 (1995), Marshall, N., et al.: J. Biol. Chem., 270, 12335 (1995), Marshall, N., et al.: J. Biol. Chem., 271, 27176 (1996), Shapiro, G., et al.: J. Clin. Oncol., 24, 1770 (2006),<br></p>

<p>Applications Lactosamine forms the backbone of several cell surface glycans such as sialylated glycans or keratin sulfates. Also, it is a basic structural element of Lewis type, and human milk oligosaccharides.<br>References Karoly, A., et al.: Tetrahedron Lett., 57, 2595-2597 (2016)<br></p>

<p>Applications ethyl 2-(methylamino)-2-oxoacetate (cas# 18522-95-7) is a useful research chemical.<br></p>

<p>Applications Tetramethylammonium Bromide (cas# 64-20-0) is a useful research chemical.<br></p>

<p>Applications Oleylamine is a surfactant in the synthesis of nanoparticles.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4,4'-Dimethyldiphenylamine is a reagent used in the comparative studies of the analgesic and anti-inflammatory properties of N-phenylanthranilic acids and mefenamic acid, and the anti parasitic activities of some substituted diphenylamines.<br>References Izard-Verchere, C., et al.: Chimica Therapeutica, 6, 346 (1971)<br></p>

<p>Applications (1R)-2,3-Dihydro-N-2-propen-1-yl-1H-inden-1-amine Ethanedioate is an intermediate used in the synthesis of propargylated aminoindan derivatives via allylation, bromination, dehalogenation sequence.<br>References Phull, M., et al.: PCT Int. Appl., WO 2009081148 A1 20090702 (2009)<br></p>

<p>Applications TRIMETHYLSTEARYLAMMONIUM CHLORIDE (cas# 112-03-8) is a useful research chemical.<br></p>

<p>Applications 5-Aminoboronphthalide is used as a reactant in the preparation of 2,1-benzoxaborole peptide isoquinoline derivatives as HCV NS3 protease inhibitors. It is also used as reactant in the synthesis of nanocarrier for chemomechanically driven guest delivery fueled by intracellular ATP.<br>References Li, X., et al.: Bioorg. Med. Chem. Lett., 21, 2048 (2011); Biswas, S., et al.: Nat. Chem., 5, 613 (2013);<br></p>

<p>Applications Di-[2-(2,3-dichlorophenyl)aminoethyl]amine is prepared from 1-Bromo-2,3-dichlorobenzene(B687435) and Diethylenetriamine (D444255). 1-Bromo-2,3-dichlorobenzene is a reagent used in the preparation of selective nonpeptidic inhibitors of striatal-enriched protein tryosine phosphatase.<br>References Baguley, T.D., et al.: J. Med. Chem., 56, 7636 (2013)<br></p>

<p>Applications trans-4-(Dimethylamino)-3-buten-2-one is an reagent used in the synthetic preparation of various substances.<br>References Maggiulli, C.A., et al.: Org. Prep. Pro. Int., 16, 31 (1984); Afarinkia, K., et al.: Sci. Syn., 14, 275 (2003);<br></p>

<p>Applications Lonidamine<br></p>

<p>Applications 2-amino-6-hydroxybenzoic acid (cas# 567-62-4) is a useful research chemical.<br></p>

<p>Applications In mammals, metabolism of 3-aminopropionitrile leads to release of cyanide ions. Metabolic activity is localized in the microsomal fraction of the liver, and is believed to proceed through a free-radical pathway.<br>References Fernandez, G., et al.: Vet. Human Toxicol., 33, 321 (1991)<br></p>

<p>Applications 2-Aminobenzenesulphonic acid (cas# 88-21-1) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Tetrabutylammonium Dibromochloride (cas# 64531-21-1) is a useful research chemical.<br></p>

<p>Applications B-[3-[[2-Hydroxy-3-[3-(triethoxysilyl)propoxy]propyl]amino]phenyl]boronic acid was prepared for the use as porous polymeric monolith for the specific capture of cis-​diol-​containing flavone under neutral condition.<br>References Pan, J., et al.: Chem. Eng. J., 317, 317-330 (2017);<br></p>

<p>Applications 1-Phenyl-2-(p-tolyl)ethylamine is an intermediate used to prepare γ-nitroaldehydes with quaternary stereogenic centers.<br>References Angewandte Chemie, International Edition, 52, 7228 (2013)<br></p>

<p>Applications Used in the preparation of pyrimidine derivatives.<br></p>

<p>Applications Methyl 4-(Methylamino)picolinate is a pyridinyl building block and a useful synthetic intermediate.<br></p>

<p>Applications 4-(Aminomethyl)-Cyclohexanecarboxylic Acid (cas# 701-54-2) is a useful research chemical.<br></p>

<p>Applications Used in the antileishmanial activity of lipidic amino alcohols.<br>References Coimbra, E.: Chem. Biol. Drug Des. 75, 233 (2010).<br></p>

<p>Applications 4-(3-aminopropyl)-N,N-dimethylaniline (cas# 112103-97-6) is a useful research chemical.<br></p>

<p>Applications (S)-2-Amino-3-(4-aminophenyl)propan-1-ol is derived from (2S)-2-Amino-3-(4-nitrophenyl)-1-propanol (A618365), which can be used as an intermediate in the synthesis of various pharmaceutical compounds. It is used in the preparation of a new series of 2-substituted thiazole carboxamides as potent inhibitors of Akt kinases.<br>References Shaohua, Ch., et al.: Bioorg. Med. Chem. Lett., 22, 1208 (2012);<br></p>

<p>Applications N-(Trifluoroacetyl)hexanolamine (cas# 40248-34-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 1,11-Diaminoundecane<br></p>

<p>Stability Light Sensitive<br>Applications A PEG derivative, which contains a free amine that can be conjugated to biological molecules directly by an amide linkage (or via the corresponding isothiocyanate) and an azide that can be reduced to an amine for conjugation to other molecules. PEG derivatives are water soluble. Bifunctional water soluble compounds with flexible dimensions allow for conjugation of small molecules to proteins or molecular probes. 1-amino-11-azido-3,6,9-trioxaundecane can be reacted with small organic molecules for the synthesis of heterobifunctional compounds. It has been used to synthesize a mannose-fluorescein conjugate for the study of cell-surface mannose-specific lectins.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Aslan, K., et al.: J. Fluoresc., 14, 391 (2004), Gole, A., et al.: Langmuir, 20, 7117 (2004), Cavalcante, A., et al.: Biochem. Eng. J., 29, 258 (2006),<br></p>

<p>Applications An intermediate of Synergistin. Antibacterial.<br></p>

<p>Applications Methyl 4-amino-2-fluorobenzoate<br></p>

<p>Applications Methyl (1R,4S)-4-Amino-2-cyclopentene-1-carboxylate (2S,3S)-2,3-Dihydroxybutanedioic Acid is an intermediate used in the synthesis of ent-Abacavir (A105015), which is an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.<br></p>

<p>Applications N-(4-Bromophenyl)-[1,1-biphenyl]-4-amine is a useful reagent for preparing carbazole and dibenzofuran-linked tertiary arylamine compounds, which may improve electroluminescent properties.<br>References Ito, H., et al.: Jpn. Kokai Tokkyo Koho (2020), JP 2020093979 A<br></p>

<p>Applications N-Hydroxybenzylamine Hydrochloride, is a versatile intermediate for the synthesis of various pharmaceutical compounds. It is used for the preparation of Ticagrelor (T437700) derivatives as novel antiplatelet agents.<br>References Zhang, H., et al.: Bioorg. Med. Chem. Lett., 22, 3598 (2012); Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007);<br></p>

<p>Applications 2-(3-Aminophenyl)ethanol is a useful compound for the synthesis of indolines and dihydrobenzofurans via iron and copper-catalyzed iodination and cyclization.<br>References Henry, M. C., et al.: J. Org. Chem., 84, 346 (2019)<br></p>

<p>Applications 4-Amino-2-isopropylphenol is a building block used in the preparation of benzoate and benzamide derivatives as FXR antagonists.<br>References Song, K., et al.: Bioorg. Med. Chem., 23, 6427 (2015);<br></p>

<p>Applications Ethyl 2-Amino(hydroxyimino)acetate is an intermediate used in the synthesis of N-(2-Hydroxyethyl)-5-methyl-1,2,4-oxadiazole-3-carboxamide (H942278), which is a photolysis product of Metronidazole (M338880), an antibiotic.<br>References Moore, Douglas E., et al.: Radiation Phy. and Chem., 36(4), 547-50 (1990)<br></p>

<p>Applications 6-AZIDOHEXAN-1-AMINE (cas# 349553-73-7) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>