Amines

<p>Applications (9H-Purin-6-ylamino)-acetic acid (cas# 10082-93-6) is a useful research chemical.<br></p>

<p>Applications 2,2-DIMETHOXY-1-PROPANAMINE (cas# 131713-50-3) is a useful research chemical.<br></p>

<p>Applications Intermediate in the preparation of Trimebutine metabolites.<br></p>

<p>Applications (2R)-1-(9H-Purin-6-ylamino)-2-propanol is a reagent for the synthesis of tenofovir disoproxil fumarate, a medication for the treatment of hepatitis B and to prevent and treat HIV/AIDS.<br>References Yan, N., et al.: Jingxi Huagong, 31, 983 (2014); Ripin, D. H. B., et al.: Org. Process Res. Dev., 14, 1194 (2010)<br></p>

<p>Applications N-(Trifluoroacetyl)hexanolamine (cas# 40248-34-8) is a compound useful in organic synthesis.<br></p>

<p>Applications Used in the preparation of homobifunctional rhodamine for labeling proteins.<br>References Corrie, J. et al.; Bioconjugate Chem. 9, 160 (1998)<br></p>

<p>Applications TRIMETHYLSTEARYLAMMONIUM CHLORIDE (cas# 112-03-8) is a useful research chemical.<br></p>

<p>Applications 4-Amino-2-ethynylphenol is a disubstituted phenol.<br></p>

<p>Applications Methyl (2S)​-​2-​Aminobutanoate is a general chemical reagent used in the synthesis of methylsulphonamide based small molecule legumain inhibitors.<br>References Ness, K. et al.: Bioorg. Med. Chem. Lett., 26, 413 (2016);<br></p>

<p>Applications 4-(4-Aminophenoxy)benzonitrile<br></p>

<p>Applications Cyclopentylmethanamine<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Phosphorylating reagent.<br>References Santner, T. et al.: Bioorg. Med. Chem, 20, 2416 (2012); Sun, D. et al.: ChemMedChem, 4, 1649 (2009)<br></p>

<p>Applications 2-Aminothiophen-3-ol, is a heterocyclic building block used for the synthesis of various pharmaceutical compounds.<br></p>

<p>Applications N-Ethyl-3-phenylpropylamine is an intermediate in the synthesis of 4-Hydroxy Alverine (H827950), a metabolite of Alverine (A575780) in plasma.<br>References Bouvier, M., et al.: Gastroenterol. Clin. Biol., 16, 334 (1992), Mitchell, S., et al.: Aliment. Pharmacol. Ther., 16, 1187 (2002), Hayase, M., et al.: Br. J. Pharmacol., 152, 1228 (2007),<br></p>

<p>Applications 5-chloro-2,1,3-benzoxadiazol-4-amine (cas# 80277-04-9) is a useful research chemical.<br></p>

<p>Applications An intermediate of Synergistin. Antibacterial.<br></p>

<p>Applications 2-((tert-bButoxycarbonyl)amino)-2-(hydroxymethyl)-4-(4-octylphenyl)butyl Acetate is the intermediate in the synthesis of Mono-O-acetyl Fingolimod TFA (F524600), which is an impurity of Fingolimod (F805000, HCl salt) which is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs.<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001). Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002). Mtaloubian, M., et al.: Nature, 427, 355 (2004)<br></p>

<p>Applications (1S,2S)-1,2-Diphenyl-1,2-ethanediamine (cas# 29841-69-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Amino-2-butenediamide (cas# 18486-76-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Z-3-(Tributylstannyl)-2-propen-1-amine (cas# 146829-37-0) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-Amino-N,N-dimethylbenzenesulfonamide is an intermediate used to prepare LDK378 as potent and selective anaplastic lymphoma kinase inhibitor.<br>References Marsilje, T., et al.: J. Med. Chem., 56, 5675 (2013)<br></p>

<p>Applications 7-Amino-alpha-tetralone<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 3-Aminohydantoic Acid is an intermediate in the synthesis of new derivative of 5-Nitro-2-furfural, proved to be bactericidal.<br>References Swirska, A., et al.: Rocz. Chem., 31, 1335 (1957);<br></p>

<p>Applications Ammonium Bromide is used as a bromide activated chloramine biocide for effective control of volatile fatty acids and catalase and biofilm elimination in paper making industry. Also applied in biopharmaceuticals and dosage form designs.<br>References Bharati, S., et al.: Appita J., 56, 426 92003); Torosian, G., et al.: Am. J. Hosp. Pharm., 30, 716 (1973)<br></p>

<p>Applications Bis(4-diethylaminophenyl)methanol (cas# 134-91-8) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications S-(3-((4-Aminophenyl)amino)-3-oxopropyl) Methanesulfonothioate is an intermediate used in the synthesis of (E)-S-(3-((4-((4-(4-hydroxybutyl)phenyl)diazenyl)phenyl)amino)-3-oxopropyl) methanesulfonothioate (H895230), which a useful research chemical.<br></p>

<p>Applications S-(+)-2-Amino-1-propanol is an aliphatic amino alcohol shown to induce an antiproliferative effect in B16 melanoma cells. S-(+)-2-Amino-1-propanol is used in the preparation of oxazolines which are often used as ligands in homogeneous catalysis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Landau, O. et al.: Cancer Lett., 69, 203 (1993); Gant, T.G. et al.: Tetrahedron, 50, 2297 (1994);<br></p>

<p>Applications 3-Amino-3-(3-(p-tolyloxy)phenyl)propanoic Acid is a useful chemical reagent.<br></p>

<p>Applications 1,3-Diamino-2-propanol is a reagent used in the quantitative fluorescent detection of pyrophosphate with quinolin-ligated dinuclear zinc complexes.<br>References Mikata, Y., et al.: Inorg. Chem., 52, 10223 (2013)<br></p>

<p>Stability Hygroscopic<br>Applications 2-(2,5-diaminophenyl)ethanol Sulfate (cas# 93841-25-9) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications n-Dipropylamine is a useful reagent for the preparation of perylene derivatives for photosensitive fluorescent resins.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jang, H., et al.: PCT Int. Appl. (2021), WO 2021010703 A1<br></p>

<p>Applications 5-(Aminomethyl)furan-2-carboxylic Acid Hydrochloride is a useful reagent in the preparation of novel heteroaromatic substrates of GABA aminotransferase.<br>References Hawker, D. D., et al.: Bioorg. Med. Chem., 20, 5763 (2012)<br></p>

<p>Methyl 2-(methylamino)benzoate is a compound that belongs to the group of antimicrobial agents. It is used in the preparation of pharmaceuticals and other chemical substances. Methyl 2-(methylamino)benzoate has been shown to be toxic to the liver and may cause liver lesions. In addition, this compound has photochemical properties, which make it a potential environmental pollutant. Methyl 2-(methylamino)benzoate can react with uv light and form compounds such as benzene, phenols, and fatty acids. These products can lead to toxicity in humans and animals.</p>

<p>Please enquire for more information about 2-(5-chloro-2-methyl-1H-indol-3-yl)ethanamine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 4-(N-Methylamino)phenylboronic acid pinacol ester including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about N,N-Bis[3-(methylamino)propyl]methylamine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Z-3-(Tributylstannyl)-2-propen-1-amine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>4-Amino-3-bromo-1-(tert-butyl)-1H-pyrazolo[3,4-d]pyrimidine is a drug that inhibits the growth of tumour cells by binding to and inhibiting kinases. It has been shown to have a significant inhibitory effect on lung cancer cells and pyridazine derivatives in vitro. 4-Amino-3-bromo-1-(tert-butyl)-1H-pyrazolo[3,4-d]pyrimidine has been shown to be effective against lung cancer cells in vivo. This drug may be useful for the treatment of cancer.</p>

<p>Please enquire for more information about [(1,4-Dimethyl-1H-benzimidazol-2-yl)methyl]amine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2-(2-Methoxyphenoxy)ethylamine base is an inorganic base with a hydroxyl group. It is soluble in organic solvents and has been used as a coumarin derivative. 2-(2-Methoxyphenoxy)ethylamine base has shown potential use as an antifungal agent, which may be due to its ability to cause lysis in fungi cells. This compound has also shown in vitro activity against bacteria and viruses, including herpes simplex virus type 1 and HIV-1. The 2-(2-methoxyphenoxy)ethylamine base can be sulfonated or acid catalyzed to produce other derivatives that have potential use as anti-inflammatory or analgesic agents.</p>

<p>O,O'-Bis(3-aminopropyl)polyethylene glycol is a PEG polymer categorised as homobifunctional PEG (X-PEG X). Used as a linker, O,O'-bis(3-aminopropyl)polyethylene glycol is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>Dihydroergotamine mesylate is a medication that is used in the treatment of migraines. It belongs to the group of drugs called ergot alkaloids and has been shown to have high values in cerebral metabolism. Dihydroergotamine mesylate has also been shown to have an effect on dopamine levels in human serum, which may be due to its ability to inhibit neuronal death. Dihydroergotamine mesylate is administered intravenously, orally or intramuscularly for the treatment of acute migraine attacks. The drug can also be given rectally for the prevention of chronic migraine episodes. This drug may cause side effects such as nausea, vomiting and dizziness.</p>

<p>Fmoc-trans-4-(aminomethyl)cyclohexane-1-carboxylic acid is a synthetic amino acid that has been shown in vitro to inhibit the growth of prostate cancer cells. It is an analog of butyric acid, a naturally occurring fatty acid. Fmoc-trans-4-(aminomethyl)cyclohexane-1-carboxylic acid has been synthesized by solid phase methods and labeled with radiotracers such as indium 111 or technetium 99m. The use of Fmoc-trans-4-(aminomethyl)cyclohexane-1-carboxylic acid in vivo is limited by its short circulating half life, rapid metabolism, and high toxicity.</p>

<p>Please enquire for more information about 2-(2-Methyl-1H-indol-3-yl)ethanamine oxalate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about (4-Ethoxyphenyl)ethylamine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2-Aminomethyl-18-crown-6 is a crown ether that can be used to transport molecules across membranes. It has been shown to form ionic or nonionic complexes with single-stranded DNA, as well as having bifunctional properties. It can also be used to immobilize organic molecules on surfaces and can be synthesized in the laboratory by reacting an imine with sodium salts. The crown ethers have the ability to solvate hydrophobic molecules and are able to form hydrogen bonds with water. 2-Aminomethyl-18-crown-6 has been shown to have synergistic effects with other drugs, including antibiotics, due to its ability to bind divalent cations such as magnesium and calcium. This molecule has functional groups that are reactive towards nucleophilic attack, which makes it a good candidate for molecular modeling studies of proteins and peptides.br&gt;br&gt; 2-Aminomethyl-18</p>

<p>Please enquire for more information about 5'-Amino-5'-deoxy-2',3'-O-(1-methylethylidene)-adenosine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 3-Methoxy methamphetamine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Hydroxylamine HCl is a chemical compound that has been shown to exhibit anti-inflammatory properties. It is a nitrosobenzene derivative with the molecular formula NH2OH, and it is also known as hydroxylamine salt or hydroxylamine sulfate. Hydroxylamine HCl has been used in pharmaceutical preparations for the treatment of inflammatory bowel diseases such as ulcerative colitis and Crohn's disease. This drug inhibits the production of inflammatory cytokines by binding to the receptor sites on cells in the body. Hydroxylamine HCl binds to the herpes simplex virus (HSV) and inhibits viral replication, which may be due to its ability to inhibit protein synthesis at an early stage of HSV infection. This drug also binds to CD-1 mouse liver cells and blocks cellular respiration, leading to cell death.</p>

<p>4,6-Diaminobenzene-1,3-dicarboxylic acid is an inorganic copper compound that is used as a copper salt. It has been shown to be effective as a chelating agent for the treatment of copper toxicity. 4,6-Diaminobenzene-1,3-dicarboxylic acid binds to metal ions and forms a complex with them. This complex can then be excreted from the body through urine or bile.</p>

<p>Fmoc-1-amino-4,7,10-trioxa-13-tridecanamine succinimic acid is a synthetic amide that is used as an intermediate in the synthesis of peptides. It has a conformational structure and can be labeled with dyes to study the structures of proteins or peptides. Fmoc-1-amino-4,7,10-trioxa-13-tridecanamine succinimic acid has been used as an immunogen in the preparation of monoclonal antibodies. It also can be conjugated to drugs or other compounds for use as bioconjugates. This compound has been shown to have enzymatic activity and can be used as a substrate for enzyme linked immunosorbent assays (ELISA). Trifluoroacetic acid is commonly used in the synthesis of this compound.</p>

<p>Please enquire for more information about [(6-Chloro-1-isopropyl-1H-benzimidazol-2-yl)methyl]amine dihydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2-(2-Aminothiazol-4-yl)acetic acid HCl is a white to off-white crystalline solid that is soluble in organic solvents. It is an intermediate used in the synthesis of thiourea derivatives, which are used as pharmaceuticals and agrochemicals. 2-(2-Aminothiazol-4-yl)acetic acid HCl is synthesized by the reaction of 2-aminothiazole with acetic anhydride. The purity can be determined using GC or NMR spectroscopy. Impurities may be removed by recrystallization with a solvent such as chloroform or dichloromethane. The melting point of 2-(2-aminothiazol-4-yl)acetic acid HCl is 147°C (298K). 2-(2-Aminothiazol-4-yl)acetic acid HCl can be purified by distillation at</p>

<p>Please enquire for more information about Demethyl benzydamine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>4-Amino-3,5-difluorobenzoic Acid is a chemical compound that is used to manufacture dyes and pharmaceuticals. It is prepared by the reaction of dimethyl formamide with bromobenzoate and hydrobromic acid. The reaction product is decompressed to remove the toxic hydrogen cyanide gas and then reacted with sodium borohydride in liquid ammonia. This process yields 4-amino-3,5-difluorobenzoic acid which can be purified by recrystallization from water or chloroform.</p>

<p>Please enquire for more information about N-Trifluoroacetyl (S)-amphetamine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2-(Dimethylamino)ethanol is a colorless liquid that has a molecular weight of 78.1 g/mol and a boiling point of 176.1 °C. It can be found in many household products as well as cosmetics, pharmaceuticals, and chemical manufacturing. 2-(Dimethylamino)ethanol is a precursor to acetaldehyde and acetic acid, which are important intermediates in the production of polymers such as nylon. It can also be used to synthesize other chemicals such as dimethylformamide, ethylene glycol, and methyl methacrylate. This chemical reacts with calcium to form insoluble calcium 2-(dimethylamino)ethanolate (Ca(DMAE)). This reaction is reversible and the equilibrium can be shifted by changing the pH or adding another reactant such as hydrogen peroxide or hydroxide ions.</p>

<p>Ammonium carbonate is an inorganic salt that consists of ammonium ion and carbonate ion. It is a white crystalline solid with a molecular weight of about 166.4 g/mol. Ammonium carbonate is soluble in water, alcohol, acetone, and other organic solvents. It has been used as a buffer solution for pH adjustment and as a source of ammonium ions in analytical chemistry. Ammonium carbonate can be formed by the reaction of sodium carbonate with ammonia gas or liquid ammonia, or the reaction of sodium bicarbonate with ammonia gas or liquid ammonia. The thermal expansion coefficient of ammonium carbonate is higher than those of sodium salts such as sodium chloride and potassium chloride. Electrochemical impedance spectroscopy (EIS) measurements have shown that the reactivity between ammonium carbonate and plasma mass spectrometry is high due to its high values on the electric spectrum graph at low frequencies (1 kHz).</p>

<p>4-Aminoisoxazole is a triazole that has been found to be active against tumor cell lines. It is synthesized by reacting zinc powder with an acid solution containing 4-nitrobenzaldehyde, which results in the formation of 4-aminobenzonitrile, which subsequently undergoes nitration and reduction to form 4-aminoisoxazole. The synthesis of this compound can also be achieved by reacting ammonium nitrate with nitric acid in the presence of hydrochloric acid.</p>

<p>(R)-(-)-2-Amino-1-butanol is an organic compound that is used as a reagent in the synthesis of pharmaceuticals. It has antimycobacterial properties and can be used to treat tuberculosis. The mechanism for its antimycobacterial activity is not fully understood, but it may involve copper complex formation with the mycobacteria. The chloride ion may also play a role in this process by binding to the copper complex and increasing its solubility in water. This compound may react with aminothiols from the host cell, leading to degradation of DNA, RNA, and proteins. (R)-(-)-2-Amino-1-butanol has been shown to have cytotoxic effects on colorectal adenocarcinoma cells and human lung cancer cells in culture. It also inhibits human colon carcinoma cells in culture through the production of organic acids such as formic acid and acetic acid.</p>

3,4-(Dibenzyloxy)phenethylamine Hydrochloride is an antidiabetic drug that belongs to the class of medicines used to treat diabetes mellitus. This drug inhibits the synthesis of fatty acids and the production of glucose by pancreatic β-cells. 3,4-(Dibenzyloxy)phenethylamine Hydrochloride also has a hypoglycemic effect on rats with diabetes mellitus. The medicine has been shown to be effective in inhibiting apoptotic cell death in k562 cells and also has an inhibitory effect on dopamine-stimulated cAMP production.

<p>4-Aminomethylphenylacetic acid is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It belongs to the class of peptidomimetics, which are compounds that mimic the structure of a natural biological molecule. 4-Aminomethylphenylacetic acid has an analog with a lactam ring at position 3, which is not present in other NSAIDs. This structural difference may contribute to its high stability and low reactivity. 4-Aminomethylphenylacetic acid has been shown to exhibit antiviral activity against viruses such as HIV or Hepatitis C virus by inhibiting viral replication.</p>

<p>Methyl-1-naphthalenemethylamine is a synthetic drug that is used as an anti-fungal agent. It is used to treat dermatophytosis and onychomycosis caused by Trichophyton mentagrophytes. Methyl-1-naphthalenemethylamine has been shown to have a clinical response in patients with the skin condition tinea pedis. This drug inhibits the growth of fungi by inhibiting cell membrane synthesis, which leads to cell death. Methyl-1-naphthalenemethylamine has been shown to be effective against Trichophyton mentagrophytes in plasma samples from patients with tinea pedis who were treated with this drug. The effectiveness of this drug may be due to its ability to inhibit the synthesis of polysaccharides, proteins, and lipids in the fungal cell membrane, or its ability to inhibit protein synthesis by binding with ribos</p>

<p>Please enquire for more information about N-Methyl-1-(3,4,5-trimethoxyphenyl)methanamine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2-Diethylaminoethyl 1-cyclohexylcyclohexane-1-carboxylate hydrochloride is a methyltransferase inhibitor that blocks the synthesis of monoethyl ether, which is used to synthesize dicyclomine. It has been shown to be effective in vitro against biological samples such as rat liver and blood cells. 2-Diethylaminoethyl 1-cyclohexylcyclohexane-1-carboxylate hydrochloride also has been shown to have a pharmacological effect on rats with bowel disease, congestive heart failure, and crystalline cellulose. The chemical structure of 2-Diethylaminoethyl 1-cyclohexylcyclohexane-1-carboxylate hydrochloride is similar to that of phosphorus pentoxide, which makes it difficult for this drug to cross the blood brain barrier.</p>

<p>Diclofenac epolamine is a nonsteroidal anti-inflammatory drug that belongs to the class of diclofenac. It has been shown in clinical studies, with statistically significant results, to be effective against allergic reactions. Diclofenac epolamine is a film-forming polymer that can be used as a matrix for microcapsules containing diclofenac or other NSAIDs. This drug was designed to target tissue and provide effective analgesia at low doses. Diclofenac epolamine has an experimental model that uses monoclonal antibody-mediated delivery of diclofenac into the target tissue through microcapsules, which are then degraded by proteases present in the target tissue.</p>

<p>2-(2-Aminoethyl)-1,3-dioxolane is a model membrane used to study the transport of hydrazides across membranes. It is also a vector for the study of supramolecular polymers and has been shown to be activated by aldehydes. 2-(2-Aminoethyl)-1,3-dioxolane has biological activity against human cells and has been used as a screening agent for hydrazide drugs. This compound can be used to study transport efficiency and functionality in vitro.</p>

<p>Please enquire for more information about Quaternary ammonium compounds, bis(hydroxyethyl) methyltallow alkyl, chlorides, salts with bentonite including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2-Amino-5,6-dichlorobenzothiazole is an aminobenzothiazole derivative that has been shown to have antibacterial activity. It is a hydrophobic molecule with a skeleton consisting of alternating amines and carboxylic acids. 2-Amino-5,6-dichlorobenzothiazole binds to the fatty acid ester component of bacterial cell walls by hydrogen bonding or ionic interactions, disrupting the integrity of the cell wall and inhibiting the growth of bacteria. 2-Amino-5,6-dichlorobenzothiazole can be used to decolorize dyes and textiles that have been stained by oily materials. It is also used as a surfactant in personal care products such as shampoos and conditioners.</p>

<p>Diisopropylammonium dichloroacetate (DADCA) is a chemical that inhibits the metabolism of glucose. It has been shown to have a hypoglycemic effect in rats and is being investigated as a treatment for metabolic disorders such as diabetes and obesity. DADCA has also been shown to reduce liver lesions in animals with chronic viral hepatitis, and has been found to be effective in reducing tumor growth in mice. This drug can also be used to treat bowel disease by reducing the amount of ammonia released by bacteria. DADCA may also have physiological effects on humans, including an increase in blood pressure and fever, although these effects have not yet been studied.</p>

<p>Please enquire for more information about Z-(R,S)-3-amino-7-chloro-5-(2-chlorophenyl)-2-oxo-1,4-benzodiazepine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>4-Ethyl-2,5-dimethoxy-benzeneethanamineHydrochloride is a metabolic substrate of CYP2D6. It is also an inhibitor of CYP1A2 and CYP3A4. The class of 4-Ethyl-2,5-dimethoxy-benzeneethanamineHydrochloride is not yet known. 4-Ethyl-2,5-dimethoxy-benzeneethanamineHydrochloride has been shown to cause toxicity in animal studies. Toxicity may be due to its inhibition of cytochrome P450 enzymes, which are involved in metabolism and detoxification.</p>