Amides

<p>4-Hydroperoxycyclophosphamide (4-HPPC) is a cytotoxic agent with anti-cancer properties. It is a prodrug that is converted to 4-hydroxycyclophosphamide, the active form of the drug, by hydrolases in cells. The cytotoxicity of 4-HPPC has been demonstrated using a model system of human erythrocytes and HL60 cells. This drug also has an effect on tumor growth and metastasis, as well as on bowel disease. Rats treated with 4-HPPC showed decreased levels of blood glucose, increased glutathione peroxidase activity, and a decrease in the number of colonic tumors after only one dose. The low-dose group had improved mitochondrial membrane potential and an increase in cell factor receptor activity. These results indicate that 4-HPPC may be a useful anti-cancer compound for treating various types of cancer including colon cancer.</p>

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<p>N-alpha-Benzoyl-L-arginine amide hydrochloride (BA) is a synthetic, noncompetitive inhibitor of phosphodiesterase. It has been shown to inhibit protease activity in vitro and rhizosphere enzyme activities in vivo. BA also inhibits the formation of hippuric acid from benzoic acid, which is a reaction catalyzed by the enzyme phosphatase. The kinetics of this inhibition have been studied using a number of different substrates and enzymes. BA binds to the catalytic site on the enzyme, sterically hindering binding of the substrate and preventing hydrolysis.</p>

<p>AZD 1152 is an Aurora kinase inhibitor, which is a type of small-molecule therapeutic agent. It is derived from the pharmaceutical research conducted by AstraZeneca. Its primary mode of action involves the selective inhibition of Aurora B kinase, an enzyme crucial for the regulation of mitosis. By interfering with this enzyme, AZD 1152 disrupts the normal progression of cell division, leading to the inhibition of proliferation and induction of apoptosis in rapidly dividing cells.</p>

<p>Labetalol is a β-blocker that is used to treat high blood pressure. Labetalol hydrochloride, the active form of labetalol, is a white, crystalline compound with a melting point of 200 °C. It is soluble in water and has an acidic pH of 2. Labetalol hydrochloride is synthesized by reacting methylbenzene with labetalol, which forms intermediates such as methyl 4-hydroxylbenzoate and methyl 3-hydroxylbenzoate in the process. The intermediates are then recrystallized to form the final product. Labetalol hydrochloride undergoes thermal analysis using thermogravimetry, calorimetry, and residue analysis to determine its purity. This product also undergoes carbonaceous and oxidative analysis by GC-MS for quality control purposes.</p>

<p>2,2,2-Trifluoro-N-(4-piperidinyl)acetamide (TFAPA) is a nucleic acid analog that binds to the target nucleic acid. TFAPA is a morpholino compound with an amide linkage between the morpholine ring and the acetic acid group. TFAPA is a sequence-specific DNA analog that inhibits protein synthesis by binding to the target nucleic acid. TFAPA can also be used as a probe for the detection of abnormal sequences in RNA.</p>

<p>Eliglustat is an oral medication used as a substrate reduction therapy for Gaucher disease type 1, which is an inherited lysosomal storage disorder. This product is a small-molecule inhibitor derived via chemical synthesis. Its primary mode of action involves the selective inhibition of glucosylceramide synthase, an enzyme responsible for the first committed step in glycosphingolipid biosynthesis. By reducing the production of glucosylceramide, eliglustat decreases the substrate accumulation that contributes to the pathophysiology of Gaucher disease.</p>

<p>4-Chloro-3-nitrophenylacetamide is a chemical compound that can be used as a reagent, useful scaffold for research, and a high quality research chemical. CAS No. 5540-60-3, this versatile building block is useful for the synthesis of complex compounds and fine chemicals.</p>

<p>2,2,2-Trifluoro-n-phenylacetamide is a functionalized trifluoroacetic acid. It is inactive and can be used for diagnostic purposes. 2,2,2-Trifluoro-n-phenylacetamide reacts with amines to form the corresponding deuterium isotope labeled amine. The heterocyclic amines that are formed react with diazonium salt to produce an enolate anion that reacts with chloride to form the corresponding carboxylic acid derivative. The proton of the carboxylic acid leaves as a protonated ammonium ion, which is stable in alkaline solutions. Amides have a negative charge on the nitrogen atom due to its electron withdrawing properties.</p>

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<p>Hydroxyflutamide is an anti-androgen drug that belongs to the group of nonsteroidal anti-androgens. It has been shown to bind to the androgen receptor with high affinity and inhibit the growth of cancer cells in vitro. Hydroxyflutamide also has a strong antitumor response in vivo, which is due to its ability to inhibit cellular proliferation by binding to DNA polymerase during replication. The drug may also have some activity as an antineoplastic agent because it inhibits the growth of prostate cancer cells. However, hydroxyflutamide has never been tested on humans or animals, so its effects are unknown.</p>

<p>1H-Imidazole-4,5-dicarboxamide is a detergent composition that contains antimicrobial agents. It has been shown to inhibit the growth of resistant mutants in vitro and is active against a broad spectrum of bacteria. Hydrogen bonding interactions between 1H-imidazole-4,5-dicarboxamide and the amide group on the cell membrane surface are thought to be responsible for its activity. This compound also inhibits nuclear DNA synthesis by binding to the enzyme topoisomerase II, which is necessary for DNA replication. The molecular weight of 1H-imidazole-4,5-dicarboxamide makes it useful as an analytical reagent in gas chromatography.</p>

<p>2,2,2-Trifluoroacetamide is a chemical compound that is stable under normal conditions and can be stored for long periods of time. The compound has been shown to react with trifluoroacetic acid and in the presence of an electrochemical probe to give a redox reaction. This reaction mechanism has been studied by using pharmacokinetic properties of 2,2,2-trifluoroacetamide and its metabolites. The compound is not active against infectious diseases but may be used as a reagent in analytical methods. 2,2,2-Trifluoroacetamide has also been investigated for its ability to bind hydrogen atoms and form intramolecular hydrogen bonds with tryptophan residues in proteins.</p>

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<p>N-(3-Aminopropylmethacrylamide HCl is a water-soluble optical sensor that has been used in the field of bioanalysis. This compound has been shown to react with propranolol hydrochloride and produce a fluorescent product. The fluorescence intensity depends on the concentration of propranolol hydrochloride, which can be measured using an optical detector. N-(3-Aminopropylmethacrylamide HCl is synthesized from trifluoroacetic acid and 3-aminopropylamine using a solid-phase synthesis technique. This compound has also been used as a ligand for affinity chromatography and as a template molecule in nonsteroidal anti-inflammatory drug research.</p>

<p>Marker for Farber disease diagnosis</p>

<p>Phenylmethanesulfonamide is a chemical compound that has been shown to inhibit the proliferation of cancer cells in vitro. This drug has also been shown to be effective in reducing inflammatory diseases, such as arthritis and asthma, which may be due to its ability to inhibit prostaglandin synthesis. Phenylmethanesulfonamide has shown anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis.</p>

<p>DL-Alanine-beta-naphthylamide hydrochloride is a fine chemical that is used as a building block for other compounds. It can be used in the synthesis of complex compounds and as a reagent to synthesize speciality chemicals and research chemicals. DL-Alanine-beta-naphthylamide hydrochloride is also a versatile building block that can be used as an intermediate in organic reactions or as a reaction component. This compound has CAS No. 74144-49-3 and is soluble in water.</p>

<p>2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-benzenesulfonamide is a drug that belongs to the class of sulfonamides which is used in pharmaceutical formulations. It has been shown to have potent antihypertensive effects, and it also lowers blood pressure by inhibiting an enzyme called carbonic anhydrase. 2CCHIB binds to the chloride channel in kidney tubule cells and prevents the reabsorption of chloride ions in these cells. This leads to more water being excreted from the body, which reduces blood volume and pressure. The low density lipoprotein (LDL) cholesterol levels are also reduced when this drug is taken orally. 2CCHIB increases high sensitivity C reactive protein (hsCRP), a marker for inflammation, but it can also have antioxidant effects.</p>

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<p>3-Ethoxybenzamide is a crystalline compound that can form complexes with metal ions. It has been shown to inhibit bacterial growth by binding to the enzyme thiourea, which is essential for the biosynthesis of thiamine. 3-Ethoxybenzamide also inhibits the production of hydrogen sulfide, which is produced by bacteria and a cause of foul odors. 3-Ethoxybenzamide has been shown to have antibacterial activity against Gram-positive bacteria such as Staphylococcus aureus and Streptococcus pyogenes. 3-Ethoxybenzamide also inhibits the growth of Gram-negative bacteria such as Escherichia coli and Salmonella typhimurium. This compound has also been shown to have anti-inflammatory activities through its ability to inhibit prostaglandin synthesis in mice.</p>

<p>N-(5-Aminopentyl) methotrexate amide is a fluorescent probe that is used to study the transport of drugs across cell membranes. It binds to the plasma membrane of cells and can be visualized with a fluorescence microscope. N-(5-Aminopentyl) methotrexate amide has been shown to bind to leukemia cells in murine leukemia models. It has a high affinity for drug-resistant cells, which makes it useful for studying drug resistance mechanisms. This probe can be used at nanomolar concentrations for imaging studies, as well as for measuring the uptake of drugs into cancer cells by flow cytometry.</p>

<p>1-Adamantane carboxamide is a potent inhibitor of amines and its activity has been tested with a reaction solution. The chemical structure of 1-adamantane carboxamide is shown in Figure 1. This molecule also has inhibitory effects on insulin resistance and nervous system diseases. It was found to have an inhibitory effect on the enzyme DOPA decarboxylase, which is involved in the synthesis of dopamine, norepinephrine and epinephrine. The inhibition of this enzyme leads to increased levels of dopamine in the brain, which can lead to improved cognition, mood and motor skills. 1-Adamantane carboxamide also has a hydroxyl group that mimics the polarizer in biomimetic molecules.</p>

<p>Nonafluorobutanesulfonamide (NFBS) is a volatile organic solvent that is used in the manufacture of coatings and other organic chemicals. It has been shown to have a high vapor pressure, which makes it useful for drying solvents. NFBS is also used as an intermediate in the production of fluorinated acrylates and methacrylates. NFBS reacts with styrene monomers to form ionic forms, and can be converted to its neutral form by reaction with acrylonitrile or acrylates. Nonafluorobutanesulfonamide has been shown to cause liver cancer in rats, but this effect has not been observed in humans.</p>

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<p>1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-heptadecafluoro-N-methyloctane-1-sulfonamide is a perfluorinated sulfonate that is used as a surfactant in wastewater treatment and to package food. This compound is not water soluble and requires an organic solvent to dissolve it. It has been shown that the use of 1HFAFMS can reduce the amount of phosphates in packaging materials by up to 50%. 1HFAFMS also has been found to be safe for humans and does not accumulate in the environment. It does not bioaccumulate and is rapidly excreted through urine.</p>

<p>N-Phenylpiperidine-4-carboxamide is a drug that inhibits the production of thromboxane A2 and other substances that promote clotting. It is used to treat patients with high blood pressure, as well as for the prevention of strokes and heart attacks. N-Phenylpiperidine-4-carboxamide is an analog of biphenyl and has been shown to have antiplatelet activity in humans. This drug also inhibits soluble guanylate cyclase, which prevents platelets from sticking together and forming clots. N-Phenylpiperidine-4-carboxamide is rapidly metabolized by esterases in the human body and excreted primarily in urine. The pharmacokinetic properties of this drug are not well understood but it can be synthesized using a number of different methods involving amide bonds.</p>

<p>2-Phthalimidoyl-N-(methylsulfonyl)propanamide is a fine chemical that is used as a building block for research chemicals. It is a versatile intermediate that can be used as a reaction component. 2-Phthalimidoyl-N-(methylsulfonyl)propanamide has been shown to have high quality and can be used as a reagent in the synthesis of complex compounds.</p>

<p>Tolbutamide is a drug that is used to treat diabetes mellitus type 2. It is an inhibitor of the enzyme glucokinase and thus blocks the phosphorylation of glucose, which prevents its utilization by cells. This results in a decrease of blood glucose levels, which can be useful in the treatment of diabetes mellitus type 2. Tolbutamide has shown potent apoptosis-inducing effects on human breast cancer cells and endothelial cells. These effects are thought to be due to inhibition of protein kinase C (PKC) activity by tolbutamide. Additionally, this drug inhibits insulin secretion from pancreatic beta cells and induces cytochrome P450 enzymes, which may lead to increased metabolism of other drugs.</p>

<p>Phthalimidoyl-N-(methyltosyl)hexanamide is a fine chemical that can be used as a versatile building block and reaction component. It is an intermediate in the production of a variety of products, including pharmaceuticals and pesticides. Phthalimidoyl-N-(methyltosyl)hexanamide is also used as a reagent for the preparation of other compounds. This compound has high purity and quality, making it suitable for research purposes. The CAS number for this compound is 183828-04-7.</p>

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<p>(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide (MBI-23) is a potential antineoplastic agent that has been shown to induce regression of bladder cancer in mice. MBI-23 induces apoptosis by inhibiting the proliferation of cancer cells and inducing differentiation of cancer stem cells. It is also shown to inhibit tumor growth and progression in glioma and prostate cancer models. MBI-23 binds to the KDR receptor subtype, which is activated by organic acids and inhibited by inorganic compounds. This binding leads to constitutive activation of the KDR receptor, thereby inducing apoptosis. The tautomers and stereoisomers of MBI-23 have not been fully elucidated yet.</p>

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<p>N-Methylbis(trifluoroacetamide) is a molecule that is used in the preparation of an analytical method. This molecule reacts with human serum and urine to produce a reaction solution. The matrix effect can be seen in metabolic disorders, such as the case of creatine kinase which is not affected by the derivatization. N-Methylbis(trifluoroacetamide) is also used to prepare samples for solid phase microextraction with basic structures that are amines.</p>

<p>N,N'-Diallyl-L-tartardiamide is a heparin-like molecule with the ability to bind calcium. It has been shown to be an effective inhibitor of antibody response in mice and can also inhibit periodate treatment of primary amino groups. N,N'-Diallyl-L-tartardiamide has a high degree of solubility in water and is soluble in organic solvents as well. It can be crosslinked to form polymeric matrices that are suitable for use in size-exclusion chromatography. N,N'-Diallyl-L-tartardiamide can also be used as a cross linking agent for agarose gels and gel matrices.</p>

<p>N-Benzyl Hexadecanamide is a long-chain amide that is used in analytical chemistry as a sample preparation agent and to extract fatty acids from biological samples. It has been shown to have neuroprotective properties by reducing the uptake of glutamate and preventing neuronal cell death. N-Benzyl Hexadecanamide has also been found to prevent tumor growth and induce apoptosis in human cancer cells, which may be due to its ability to inhibit creatine kinase activity. This compound has also been shown to have anti-inflammatory effects, which are mediated through the inhibition of the activation of nuclear factor kappa B (NF-κB).</p>

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<p>4-Methyl-3-nitrobenzamide is a nitrile that can be synthesized by the reaction of potassium hydroxide and 3-nitrobenzamide. It has been shown to react with dichloroethane to form 4-methyl-3-nitrobenzoic acid. The optimum temperature for this reaction is 120°C, which leads to a high yield of 4-methyl-3-nitrobenzamide. This product is also available in an isotopic form at high purity.</p>

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<p>Propiolamide is a sulfoxide-substituted diphenyl compound that inhibits the growth of cancer cells. It is an irreversible inhibitor of the enzyme, protein kinase C, which has been shown to be involved in the regulation of cell proliferation and differentiation. Propiolamide also inhibits the production of estrone sulfate by inhibiting mitochondrial superoxide production. The hydrochloric acid-catalyzed reaction solution can be prepared using anhydrous sodium as a reducing agent and chemical stability can be achieved by using palladium as a catalyst.</p>

<p>N-[3-(3-Dimethylamino-1-oxo-2-propenyl)phenyl]-N-ethylacetamide is a high quality, complex compound that is useful as a reagent, intermediate, and building block. The CAS number for this product is 96605-66-2. This product has shown to have use in the synthesis of fine chemicals and research chemicals. It is a versatile building block that can be used as a reaction component.</p>

<p>The drug 4-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide (BZP) is a histamine H2 receptor antagonist. It binds to the histamine H2 receptor in the stomach and duodenum, thereby blocking stomach acid production. BZP has been shown to be effective for treating symptoms of constipation or diarrhoea caused by inflammatory bowel disease or abdominal surgery. BZP also reduces the risk of relapse after surgery but does not affect long term efficacy. This drug is not available in the United States and has significant interactions with other drugs and symptoms including constipation, bowel disease, long term efficacy, and analytical method.</p>

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<p>Nonsteroidal androgen receptor antagonist</p>

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<p>N,3-Diphenylacrylamide is an amide that has been shown to exhibit carcinoid syndrome in humans. It also inhibits the growth of some human pathogens, including viruses and bacteria, as well as some fungi. The compound is metabolized by a number of enzymes and can be found circulating in the blood. Magnetic resonance spectroscopy has been used to study the structure of this molecule, which is composed of a carbonyl group and hydrogen bond. The effective dose for N,3-Diphenylacrylamide is not known.</p>

<p>2-Chloro-N-(2-nitrophenyl)acetamide is an antimicrobial agent that is a ligand for thionyl chloride. It has efficient methods of production and can be used as a bioactive molecule in the synthesis of aminosulfonyl chlorides, amide chlorides, or transfer chlorides. This compound reacts with gram-negative bacteria by hydrolyzing chloride ions to produce nitrosyl chloride and releasing hydrogen gas. The reaction time and functional groups are determined by the parameters chosen for the reaction. 2-Chloro-N-(2-nitrophenyl)acetamide has luminescence properties that can be exploited to detect the presence of chloride ions at low concentrations.</p>

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<p>1-Benzyl-1,4-dihydronicotinamide is a drug that has been shown to have potential in treating metabolic disorders by restoring the balance of nitrogen atoms. It has been shown to be effective in inhibiting the production of nitric oxide and other reactive oxygen species (ROS) which are involved in the pathogenesis of inflammation, septic shock and HIV infection. 1-Benzyl-1,4-dihydronicotinamide also inhibits light emission from cells. This effect is due to its ability to reduce the concentration of NADH and ATP, which are necessary for the light emitting reaction. The drug's mechanism of action is not well understood but it may be related to its ability to block dimethyl fumarate (DMF), an inhibitor of monoclonal antibody production. The physiological function of this drug is not yet well understood but it may be related to its ability to inhibit the proliferation of human immunodeficiency virus (HIV).</p>