Carboxylic Acids

<p>Applications TERT-BUTYL N-(DIAMINOMETHYLIDENE)CARBAMATE (cas# 219511-71-4) is a useful research chemical.<br></p>

<p>Applications 2-Mercapto-succinic acid diethyl ester (cas# 23060-14-2) is a useful research chemical.<br></p>

<p>Applications 9-Ethyl-9H-carbazole-3-carboxylic Acid is a useful reagent for the preparation of an oxime ester photoinitiator.<br>References Hu, C., &amp; Yu, P.: Faming Zhuanli Shenqing (2020), CN 111320714 A<br></p>

<p>Applications Benzyl Acetoacetic Amide (cas# 882-36-0) is a compound useful in organic synthesis.<br>References Sakaki, J., et al.: Chem. Pharm. Bull., 37, 2952 (1989),<br></p>

<p>Applications trans-1,2-Cyclohexanedicarboxylic Acid is used as a reagent in the synthesis of enantiopure (α-cyanoalkyl)(tetrahydropyrido[4,3-b]indolecarbonyl)cyclohexanecarboxamides and its analogs as selective cathepsin K inhibitors for the treatment of osteoarthritis. Also used as a reagent in the synthesis of novel cyclopentanedicarboxamide sodium channel blockers as a potential treatment for chronic pain.<br>References Dossetter, A.G., et al.: J. Med. Chem., 55, 6363 (2012); Shao, P.P., et al.: Bioorg. Med. Chem. Lett., 15, 1901 (2005)<br></p>

<p>Applications (1S,3R,4S)-Ethyl 4-Amino-3-((tert-butoxycarbonyl)amino)cyclohexanecarboxylate Oxalate has been used as a reactant for the preparation of oxadiazole compounds containing cyclohexanediamine moiety.<br></p>

<p>Applications Ethyl bromodifluoroacetate is a fluorinated compound commonly used in Reformatsky reactions to synthesize difluoro-beta-lactams. Ethyl bromodifluoroacetate is also used as a reagent to synthesize a gallic acid derivative that exhibits plant growth promoting activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Konas, D., et al.: Synthesis, 2002, 2616 (2002); Negi, A., et al.: Bioorg. Med. Chem. Lett., 15, 1243 (2005); Tarui, A., et al.: Heterocycles, 73, 203 (2007)<br></p>

<p>Applications 5-Aminononane-5-carboxylic Acid is a reagent used in the synthesis of Fmoc-α-​dialkylamino acids.<br>References Suresh B. et al.: Indian J. Chem. Section B: Chem. Inc. Med., 40B, 70 (2001);<br></p>

<p>Applications 5-[2-(Trifluoromethoxy)phenyl]-2-furancarboxylic Acid is a reactant used in the preparation of (phenyl)-N-[(mercapto)(pyrrolyl)triazolyl]furancarboxamide and (phenoxy)-N-[(mercapto)(pyrrolyl)triazolyl]acetamide derivatives as herbicides.<br>References Xue, S., Lu, C.: Youji Huaxue, 28, 1083 (2008)<br></p>

<p>Applications 1-Hydroxycyclopentanecarboxylic Acid is a reagent used in the preparation of pyridone-conjugated monobactam antibiotics showing gram-negative activity.<br>References Brown, M. et al.: J. Med. Chem., 56, 5541 (2013); Rozhko, E. et al.: ChemCatChem., 5, 1998 (2013);<br></p>

<p>Applications 2-Ethoxy-4-ethoxysulfonylbenzoic Acid is a derivative of Methyl 2-Ethoxybenzoate (M220113), a useful chemical reagent, used in the synthesis and antibacterial triazoles and oxadiazoles, as well as sulfonamide compounds.<br>References Shi, Z. et al.: Compt. Rend. Chim., 18, 1320 (2015);<br></p>

<p>Applications 3-Oxohexanoic Acid is an enzymatic metabolite and a building block for bacterial autoinducers.<br>References Naef, R., et al.: J. Agric. Food Chem., 56, 517-527 (2008);<br></p>

<p>Applications 3-(3-Furyl)acrylic Acid is a reactant in the preparation of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.<br>References Hornberger, K.R., et. al.: Bioorg. Med. Chem. Lett., 23, 4517 (2013)<br></p>

<p>Applications 5-Ethyl-2-fluorophenylboronic acid<br></p>

<p>Applications 3,4-Bis(isobutoxycarbonyl)benzoic Acid is a useful reagent in organic synthesis.<br></p>

<p>Applications Methyl Diethylphosphonoacetate (cas# 1067-74-9) is a useful research chemical.<br></p>

<p>Applications 4'-Hydroxybiphenyl-3-carboxylic Acid is a biaryl compound that can be prepared via palladium bis[(dipiperidinylphosphino)amino]phenyl-catalyzed Suzuki-Miyaura cross coupling reactions of organoboronic acids or trifluoroborates and aryl bromides and can also be synthesized by simultaneous hydroxylation and carboxylation of biphenyls. 4'-Hydroxybiphenyl-3-carboxylic Acid is a useful building block with applications in various syntheses.<br>References Shibahara, F., et al.: Org. Lett., 6, 2437 (2004); Bolliger, J., Frech, C.: Adv. Synth. Catal., 352, 1075 (2010);<br></p>

<p>Applications 1-Butenylboronic Acid is a reagent used in the synthesis of polyene natural products.<br>References Lee, S. J., et al.: J. Am. Chem. Soc., 130, 466-468 (2008)<br></p>

<p>Applications 4-Nitrobenzyl Acetoacetate acts as a reagent in the preparation of panipenem via esterification of nitrobenzyl alcohol followed by substitution, cyclizations and hydrogenation. Panipenem I is a new carbapenem antibiotic for the treatment of inflammation.<br>References Fang, H., et al.: hongguo Yaowu Huaxue Zazhi, 21, 216 (2011)<br></p>

<p>Applications An intermediate in the preparation of Digallic Acid<br></p>

<p>Applications 4-tert-Butoxyphenylboronic Acid is a compound used in the preparation of nitrophenylphenol via cross-coupling reaction of nitrohalobenzenes with phenylboronic acids and deprotection.<br>References Kumamoto, N., et al.: Preparation of nitrophenylphenol, JP 2001055360 (2001);<br></p>

<p>Applications A reactant used in the preparation of (-)-Amathaspiramide F.<br>References Sakaguchi, K. et al.: Tetrahedron, 65, 10355 (2009); Sakaguchi, K. et al.: Org. Lett., 10, 5449 (2008)<br></p>

<p>Applications tert-Butyl ((2S,3R,E)-3-hydroxy-1-((2-oxido-1,3,2-dioxaphospholan-2-yl)oxy)octadec-4-en-2-yl)carbamat is an intermediate for the synthesis of D-erythro-Sphingosylphosphorylcholine (S681700), which is involved in cell regulation, and transmembrane signaling. A putative lipid second messenger, connected via Protein Kinase C to the phosphatidylinositol-derived second messengers for signal transduction.<br>References Kratzer, B. and Schmidt, R.R.: Liebigs Ann., 955-963 (1995)<br></p>

<p>Applications 2-Isopropoxy-2-phenylacetic acid<br></p>

<p>Applications 2-amino-6-hydroxybenzoic acid (cas# 567-62-4) is a useful research chemical.<br></p>

<p>Applications 5-Ethyl-6-hydroxyhexanoic Acid is an intermediate in the synthesis of metabolites of Bis(2-ethylhexyl) Phthalate (DEHP) (B433850).<br>References Kaulen, J., et al.: Tetrahedron., 38, 3299 (1982);<br></p>

<p>Impurity Ketoprofen EP Impurity G<br>Applications 3-​(2-Hydroxyethyl)​benzoic Acid (Ketoprofen EP Impurity G) is an impurity in the synthesis of Ketoprofen (K200800), anti-inflammatory (1,2); analgesic.<br>References 1. Ueno, K. et al.: J Med Chem. 1976 Jul;19(7):941-6. 2. Jamali, F. et al.: Clin Pharmacokinet. 1990 Sep;19(3):197-217.<br></p>

<p>Applications 5-Hydroxy-3-phenylbenzoic Acid can be used in biological study of preparation and identification of hydroxybenzoic acids as lactate receptor agonists and antilipolytics. It can also be used in discovery of new series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design.<br>References Duffy, B. C., et al.: Bioorg Med Chem Lett, 25, 2818 (2015), Dvorak, C. A., et al.: ACS Med Chem Lett, 3, 637 (2012)<br></p>

<p>Applications Thiazol-4-ylboronic acid (cas# 1016642-07-1) is a useful research chemical.<br></p>

<p>Applications 2-(1,3-BENZOTHIAZOL-2-YLTHIO)SUCCINIC ACID (cas# 95154-01-1) is a useful research chemical.<br></p>

<p>Applications cis-10-Pentadecenoic Acid is a monounsaturated fatty acid, that can inhibits IFN-γ-induced production of kynurenine in Thp-1 cells by 16%.<br>References Costabile M. et al.: Prostaglandins Leukot. Essent. Fatty Acids 122, 7-15 (2017).;<br></p>

<p>Applications 4-Hydroxy-3-nitrobenzoic acid<br></p>

<p>Applications 2,4,5-TRIMETHOXYBENZOIC ACID (cas# 490-64-2) is a useful research chemical.<br></p>

<p>Applications Substituted cinnamic and dihydrocinnamic acids show anti-inflammatory and analgesic activity, with cinnamic acids being more biologically active.<br>References Runwal, L. et al.: Eastern Pharmacist 38, 141 (1995)<br></p>

<p>Applications Used in the synthesis of anti-tumor compounds comprising of hydroxyisovalerylshikonin analogs. Furthermore, the compound is a reagent in the synthesis of class II c-Met inhibitors, in the treatment of c-Met dependant tumors.<br>References Rao, Z. et al.: Eur. J. Med. Chem., 46, 3934 (2011); Liu, L. et al.: J. Med. Chem., 55, 1868 (2012);<br></p>

<p>Applications Dibenzo[b,d]furan-2-sulfonic acid (cas# 83863-63-2) is a useful research chemical.<br></p>

<p>Applications Phenethyl Carbamate is an impurity in the synthesis of Felbamate (F231000), an antiepileptic, structurally similar to meprobamate.<br>References Swinyard, E.A., et al.: Epilepsia, 27, 27 (1986), Remmel, R.P., et al.: Ther. Drug Monit., 12, 90 (1990), Sofia, R.D., et al.: Epilepsy Res. Suppl., 3, 103 (1991),<br></p>

<p>Applications Maleimidoacetic Acid (cas# 25021-08-3) is a compound useful in organic synthesis.<br>References Brownlee, J., et al.: Bioorg. Chem., 34, 424 (2006),<br></p>

<p>Applications Triethyl Orthoacetate is used in the preparation of potent and selective human A3 adenosine receptor antagonists. Also used in the preparation of 1,3,4-oxadiazoles for potential antimicrobial activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Squarcialupi, L. et al.: J. Med. Chem., 56, 2256 (2013); Vodela, S. et al.: Chin. Chem. Lett., 24, 625 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications Propylphosphonic Acid, is an alkylphosphonic acid, and a building block used in the synthesis of chemical compounds such as extremely toxic nerve agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Deepak P. et al.: J. of Cherom. A. 1141(2), 151-157 (2007);<br></p>

<p>Applications 3-​[[[3-​(Aminomethyl)​-​5-​methyl-​1-​oxohexyl]​amino]​methyl]​-​5-​methyl-hexanoic Acid is an intermediate in synthesizing 4,9-Diisobutyl-1,6-diazecane-2,7-dione (D456300), an impurity of rac-Pregabalin (P704800) which is a GABA analogue used as an anticonvulsant.<br>References Taylor, C.P., at al.: Epilepsy Res., 14, 11 (1993), Field, M.J., et al.: Pain, 80, 391 (1999)<br></p>

<p>Applications 3-{4-[(furan-2-ylmethyl)sulfamoyl]phenyl}prop-2-enoic acid (cas# 391229-93-9) is a useful research chemical.<br></p>

<p>Applications 3-Phosphonobenzoic Acid (cas# 14899-31-1) is a useful research chemical.<br></p>

<p>Applications Chromane-2-carboxylic Acid is used in the synthesis of 4-quinazolinones as Rho kinase inhibitors for application towards glaucoma, hypertension and spinal cord injuries. It is also used in the preparation of chromanyl-benzamidazoles as anti-bacterial compounds.<br>References Fang, X. et al.: Bioorg. Med. Chem. Lett., 21, 1844 (2011); Raut, C. et al.: J. Hetero. Chem., 47, 582 (2010);<br></p>

<p>Applications 1,2,4,5-BENZENETETRACARBOXYLIC ACID (cas# 89-05-4) is a useful research chemical.<br></p>

<p>Applications Intermediate in the preparation of nitro substituted quinazolones.<br>References Sirisoma, N., et al.: J. Med. Chem., 52, 2341 (2009), Zeng, X., et al.: Bioorg. Med. Chem. Lett., 20, 6282 (2010),<br></p>

<p>Applications 3-((1-Oxo-1-(3-(trimethylsilyl)propoxy)propan-2-yl)thio)propanoic acid is useful reagent for organic reactions and synthesis.<br></p>

<p>Applications (E)-2-Thiopheneacrylic Acid is used in the synthesis of anti-HIV HEPT analogs. Also used in the synthesis of benzimidazole and caffeine (C080100) analogs as inhibitors of monoamine oxidase B.<br>References Pontikis, R. et al.: J. Med. Chem., 40, 1845 (1997); van den Berg, D. et al.: Bioorg. Med. Chem., 15, 1692 (2007);<br></p>

<p>Applications Used in the preparation of herbicides.<br></p>

<p>Applications 8,13(15)-Abietadienoic Acid is a derivative of Methyl Abietate (M271910) and has cytotoxic, antimycotic, and antiviral activites.<br>References Gonzalez, Miguel A., et al.: Eur. J. Med. Chem., 44(6), 2468-2472 (2009); Agudelo-Gomez, Lee Solbay., et al.: Pharmacologyonline, 1, 36-42 (2012)<br></p>

<p>Applications Intermediate in the synthesis of angiotensin and fosinopril. Impurity in the preparation of Fosinopril Sodium.<br>References Anderson, N. et al.; Org. Proc Res. and Develop 1, 315 (1997)<br></p>

<p>Applications tert-Butyl 2-(3-Aminophenyl)acetate can be used as anti-heparanase to treat diseases and disorders associated with heparanase activity.<br>References Giannini, G., et.al.: PCT Int. Appl., 103, (2018);<br></p>

<p>Applications Allylboronic acid pinacol ester<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4,4'-(1,3-Phenylene)dibutanoic Acid is a useful research chemical for organic synthesis and other chemical processes.<br>References Di R., et al.: Science, 356, 426 (2017), Schimelpfenig, C. W., et al.: J. Org. Chem., 40, 1493 (1975)<br></p>

<p>Applications A more base-stable alternative to Ellman’s reagent for the quantification of thiol contents and enzymatic assays under basic pH conditions. . It reacts with free thiols similar to Ellman’s reagent but has dramatically improved stability under alkaline conditions, making it an excellent alternative to Ellman’s reagent.<br>References Zhang, H., et al.: Bioorg. Chem., 26, 356 (1998), Chen, Y., et al.: Biochem., 43, 11491 (2004),<br></p>

<p>Applications 2-Acetylthioisobutyric Acid (cas# 135937-96-1) is a compound useful in organic synthesis.<br>References Souers, A., et al.: Bioorg. Med. Chem. Lett., 8, 2297 (1998), Deaton, D., et al.: Bioorg. Med. Chem. Lett., 18, 732 (2008),<br></p>

<p>Applications 8-chloro-2,3-dihydro-1,4-benzodioxine-5-carboxylic Acid (cas# 66411-24-3) is a useful research chemical.<br></p>

<p>Applications 4-Carboxyphenylboronic acid is a reagent used in suzuki coupling reactions.<br>References Hu, Z., et al.: Wuji Huaxue Xuebao, 34, 387 (2018); Ibrahim, M., et al.: J. Organomet. Chem., 859, 44 (2018); Erami, R. S., et al.: Catalysts, 7, 76 (2017)<br></p>

<p>Applications 2-((tert-bButoxycarbonyl)amino)-2-(hydroxymethyl)-4-(4-octylphenyl)butyl Acetate is the intermediate in the synthesis of Mono-O-acetyl Fingolimod TFA (F524600), which is an impurity of Fingolimod (F805000, HCl salt) which is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs.<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001). Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002). Mtaloubian, M., et al.: Nature, 427, 355 (2004)<br></p>

<p>Applications 4-Phthalimidobutyric Acid can be used to evaluate nootropicactivity of newly synthesized gaba derivative in mice.<br>References Saleem, S., et.al.: Indo Am. J. Pharm., 5, 5527-5547, (2018);<br></p>

<p>Applications S-Acetylthioacetic Acid (cas# 1190-93-8) is a compound useful in organic synthesis.<br>References Fox, M., et al.: J. Microbiol. Methods, 56, 221 (2004),<br></p>

<p>Stability Hygroscopic<br>Applications 2,​2-​Bis(hydroxymethyl)​propionic Acid is a reagent used in the synthesis of disulfide monomers for cross-linked poly(urethane-urea) coatings.<br>References Nevejans, S. et al.: Polym., 166, 229 (2019);<br></p>

<p>Applications tert-Butyl (2-((4-Aminophenyl)amino)-2-oxoethyl)carbamate is an intermediate in the synthesis of (E)-2-Formamido-N-(4-((4-(4-hydroxybutyl)phenyl)diazenyl)phenyl)acetamide (F792100), a compound useful in organic synthesis.<br></p>

<p>Applications (S)-(+)-Z-4-Amino-2-hydroxybutyric Acid is used in the synthesis of aminoglycoside antibiotics.<br>References Rai, R. et al.: Org. Lett., 8, 887 (2006); Li, Jie. et al.: J. org. Chem., 72, 4055 (2007);<br></p>