Carboxylic Acids

<p>D-Proline, (R)-pyrrolidine-2-carboxylic acid, is L-Proline's isomer, found in human plasma/saliva, possibly from bacteria or racemase activity.</p>

<p>N-(3-Phenylpropionyl)glycine, an acyl glycine, indicates medium-chain acyl-CoA dehydrogenase deficiency when detected in urine.</p>

<p>N-Acetyl-L-aspartic acid: second to glutamate in brain, from aspartate &amp; acetyl CoA, roles in osmoregulation, lipid synthesis, and energy.</p>

<p>L-Homoproline, an endogenous amino acid in animals, regulates testosterone and activates NMDA receptors.</p>

<p>DL-O-Phosphoserine (DL-SOP), a normal metabolite in human biofluid, is an ester of serine and phosphoric acid.</p>

<p>2-Hydroxyisobutyric acid, a MTBE metabolite, is excreted in air &amp; breaks down into TBA, formaldehyde, and others; used as a bactericide.</p>

<p>L-Lactic acid: organic, chiral, prevalent in organisms, vital in biochemistry, forms in muscles during exertion.</p>

<p>3,4-(Methylenedioxy)cinnamic acid (3-(Benzo[d][1,3]dioxol-5-yl)acrylic acid) is a plant-derived compound first extracted from roots of Asparagus officinalis and</p>

<p>Butanoic acid is an endogenous histone deacetylase (HDAC) inhibitor,IC50 for HDAC3, HDAC4, and HDAC1 is 2.4 mM, 4.5 mM, and 5.3 mM. High-Quality, Low-Cost!</p>

<p>Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of L. monocytogenes and E. coli.</p>

<p>Ammonium formate disrupts metabolism, causes acidosis, inhibits electron transport and ATP production, leading to cell death and increased ROS.</p>

<p>Methyl acetylacetate found in urine indicates propionyl-CoA carboxylase or 2-methylacetoacetyl-CoA thiolase deficiency.</p>

<p>D-Leucine stops seizures post-onset and lessens long-term potentiation without affecting basal synaptic transmission.</p>

<p>Applications Ethacrynic Acid Epoxide is an intermediate in the synthesis of Ethacrynic Acid (E676000), a diuretic used to treat high blood pressure and swelling caused by congestive heart failure, liver failure and kidney failure.<br>References Beyer, et al.: J. Pharmacol. Exp. Ther., 147, 1 (1965), Kim., et al.: Am. J. Cardiol., 27, 407 (1971), Williamson, H.E., et al.: J. Clin. Pharmacol., 17, 663 (1977),<br></p>

<p>Applications Magnesium Monoperoxyphthalic Acid Hexahydrate is used as an oxidant in various synthetic reactions. For example: it is a mild and efficient oxidant for the synthesis of selenones which are useful synthetic intermediates in the synthesis of different heterocyclic compounds.<br>References Temperini, A., et al.: Beilstein J. Org. Chem., 10, 1267 (2014); Salvador, J.A.R., et al.: Beilstein J. Org. Chem., 8, 164 (2012); Carvalho, J.F.S., et al.: Tetrahedron, 65, 2773 (2009)<br></p>

<p>Applications Triethyl Methanetricarboxylate is used in the synthesis of novel inhibitors of Hsp90. It is also used in the preparation of novel dihydroquinoline-3-carboxylic acids that function as HIV-1 integrase inhibitors.<br>References Day, J. et al.: Chem. A Eur. J., 16, 2758 (2010); Sechi, M. et al.: Bioorg. Med. Chem., 17, 2925 (2009);<br></p>

<p>Applications Phthalanilic acid is a compound that is useful in the production of fertilizers.<br>References Liang, S., et al.: Faming Zhuanli Shenqing.,4 (2019)<br></p>

<p>Applications Isophthalic Acid is a useful reagent for preparing semiconductor sealing materials, prepregs, build-up films, solder resists, dry films, and printed wiring boards.<br>References Matsumura, Y., &amp; Nakamura, A.: PCT Int. Appl. (2021), WO 2021006164 A1<br></p>

<p>Applications 2-(2-butoxyethoxy)acetic acid (cas# 82941-26-2) is a useful research chemical.<br></p>

<p>Applications N-[4-(-Carboxycyclohexylmethyl)]maleamidic Acid (cas# 72748-87-9) is a compound useful in organic synthesis.<br></p>

<p>Applications Hexanedioic Acid Mono(4-hydroxybutyl) Ester is an intermediate in the synthesis of aliphatic polyesters.<br>References McCabe, R. W., et al.: Tetrahedron., 60, 765 (2004);<br></p>

<p>Applications 2-Azidobenzoic Acid (cas# 31162-13-7) is a useful research chemical.<br></p>

<p>Applications 4-ETHYL-3-NITROBENZOIC ACID (cas# 103440-95-5) is a useful research chemical.<br></p>

<p>Applications Diammonium salt of Phosphoric Acid, used in various chemical processes as a phosphorylating compound. Also used in the preparation of prosthetics and collagen nanocomposites due to the bone-like properties.<br>References Ezhova, Z. et al.: Russ. J. Inorg. Chem., 58, 1177 (2013); Wu, Y. et al.: Asian J. Chem., 25, 5881 (2013);<br></p>

<p>Applications Antioxidant.<br>References Arnous, A., et al.: J. Agr. Food Chem., 49, 5736 (2001), Guendez, R., et al.: Food Chem., 89, 1 (2005), Proestos, C., et al.: Food Control,16, 319 (2005)<br></p>

<p>Applications tert-butyl N-[3-(chlorosulfonyl)propyl]carbamate (cas# 1196153-59-9) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 3-Sulfanylhexyl Acetate is a precursor of 3-mercaptohexan-1-ol (M225270) found in grape juice.<br>References Harsch, M.J., et al.: J. Agri. Food. Chem., 61, 3703 (2013); Makhotkina, O., et al.: Food. Chem., 135, 486 (2012);<br></p>

<p>Applications 2-(formylamino)benzoic acid (cas# 3342-77-6) is a useful research chemical.<br></p>

<p>Applications Used in the biological study of differentiation induced by nicotinic acid, nicotinamide and isonicotinic acid in human leukemia cell lines.<br>References Zeilinger, S., et al.: J. Biol. Chem., 271, 25624 (1996), Panagiotou, G., et al.: J. Biotechnol., 118, 304 (2005),<br></p>

<p>Stability Hygroscopic<br>Applications N-​(4-​Amino-​5-​oxoheptyl)​guanidine is a biosynthetic intermediate in the study of saxitoxin gene cluster in cyanobacteria.<br>References Kellmann, R., et al.: Appl. Environ. Microbiol., 74, 4044 (2008)<br></p>

<p>Applications (Z)-11-Tetradecenyl Acetate is a sex pheremone component that can be found in various insect specie, such as O. nubilalis and Asian and European corn borers.<br>References Leary, G.P., et al.: Proc. Natl. Acad. Sci. U.S.A., 109, 14081 (2012);<br></p>

<p>Applications (1-acetyl-2,3-dihydro-1H-indol-5-yl)boronic acid (cas# 905971-97-3) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Methane disulfonic acid is used in esterification.<br></p>

<p>Applications An effective agent for increasing nicotinamide adenine dinucleotide (NAD) concentrations in mammalian cells.<br>References Yang, T. et al.: J. Med. Chem., 50, 6458 (2007);<br></p>

<p>Applications 3,5-Di-tert-butyl-4-hydroxybenzoic acid<br></p>

<p>Applications Difluoroacetic acid<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 3-Azidopropionic Acid is a mutagenic substance.<br>References LaVelle, J. M., et al.: Mutat. Res., 177, 27 (1987); Carlsson, L., et al.: J. Chem. Inf. Model., 49, 2551 (2009)<br></p>

<p>Applications 2-(4-Hydroxycyclohexyl)acetic acid (cas# 99799-09-4) is a useful research chemical.<br></p>

<p>Applications Tetradecanedioic acid (cas# 821-38-5) is a useful research chemical.<br></p>

<p>Applications DL-2-aminobutyric acid<br></p>

<p>Applications Trimellic Acid is a reagent used in the preparation of coordination polymers containing various luminescent properties.<br>References Zhang, Z. et al.: Crys. Grow. Des., 13, 4338 (2013); Qin, L. et al.: Trans. Met. Chem., 38, 627 (2013);<br></p>

<p>Applications 4-octylbenzoic acid (cas# 3575-31-3) is a useful research chemical.<br></p>

<p>Applications β-Formylpropionic Acid is used in the synthesis of potent and orally available nonpeptide antagonist of human gonadotropin-releasing hormone receptor. It is also a reagent in the synthesis of human melanocortin-4 receptor antagonists with a pyrrolidinone moiety.<br>References Chen, C. et al.: J. Med. Chem., 51, 7478 (2008); Jiang, W. et al.: Bioorg. Med. Med. Chem. Lett., 17, 5610 (2007);<br></p>

<p>Applications 3-Hydroxyphenylacetic Acid (cas# 621-37-4) is a compound useful in organic synthesis.<br></p>

<p>Applications rac 3-Hydroxydecanoic Acid (cas# 5561-87-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-[(phenylsulfanyl)methyl]benzenecarboxylic acid (cas# 1699-03-2) is a useful research chemical.<br></p>

<p>Applications 3-O-Ethyl-L-ascorbic Acid could be a useful stabilizing agent for a para-​hydroxyacetophenone solution.<br>References Zhang, H., et al.: Faming Zhuanli Shenqing (2020), CN 111937874 A<br></p>

<p>Stability Moisture Sensitive<br>Applications Ethyl Trifluoroacetate is an intermediate used in the synthesis of various pharmaceutically active molecules and agricultural products. Ethyl Trifluoroacetate is also useful for the preparation of trifluoroacylated compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References HugenBerg, V., J. Fluorine. Chem., 131, 942 (2010); Belyakova, Z.V., et al.: Russ. J. Gen. Chem., 79, 2634 (2009); Wu, J.L., et al.: Jingxi. Huagong. Zhongjianti., 40, 64 (2010);<br></p>

<p>Applications ethyl 2-cyclopropyl-2-hydroxyacetate (cas# 1185387-66-9) is a useful research chemical.<br></p>

<p>Applications Phosphoric Acid Tris(2-​methylpropyl) Ester is found in the groundwater downgradient of a landfill (Grindsted, Denmark). It is also a flame retardant and plasticizer.<br>References Holm, J., et al.: Environ. Sci. Technol., 29, 1415 (1995); Rodil, R., et al.: J. Chrmoat. A, 1216, 2958 (2009); Carcia-Lopez, M., et al.: J. Chromat., A, 1166, 9 (2007)<br></p>

<p>Applications 2,3-Dihydroxypropanoic acid(20% in water) (cas# 473-81-4) is a useful research chemical.<br></p>

<p>Stability Light Sensitive<br>Applications TRANS-2-OCTENOIC ACID (cas# 1871-67-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Glutaconic Acid is used in the synthesis of dialkyltin derivatives of dicarboxylic acids which display antitumor properties. Also used in the synthesis of novel tetracyclic compounds as peripheral benzodiazepine receptor ligands with potential use for CNS illness treatments.<br>References Gielen, M. et al.: Hetero. Chem., 3, 449 (1992); Okubo, T. et al.: Bioorg. Med. Chem. Lett., 12, 3569 (2004);<br></p>

<p>Applications Trimesinic Acid is used for multifunctional therapeutics. It shows inhibitory activity against Torpedo Californica acetylcholinesterase and prevented amyloid-β peptide aggregate formation.<br>References Peckels, C., et al.: Curr. Enz. Inhib., 9, 67 (2013)<br></p>

<p>Applications A solid phase organic linker for synthesis of tethering carboxylic acids to support.<br>References Backes, B.J. and Ellman, J. A.: J. Org. Chem., 64, 2322 (1999)<br></p>

<p>Applications 2,2,5-Trimethyl-1,3-dioxane-5-carboxylic Acid (cas# 16837-14-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-(ETHOXYCARBONYL)BENZOIC ACID (cas# 713-57-5) is a useful research chemical.<br></p>

<p>Applications 7H-Dodecafluoroheptanoic Acid is a derivative of Heptanoic Acid (H998455) which can be used as an organic building blocks for the synthesis of variety of chemical compounds. Heptanoic Acid is used in the synthesis of 17-epi-Testosterone Enanthate (T155095). It is used in the preparation of esters, such as ethyl heptanoate, which are used in fragrances and as artificial flavors. It is also one of many additives in cigarettes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anneken, D. et al.: Fatty Acids, Ullmann's Encyclopedia of Industrial Chemistry (2006); Wudy, S., et al.: Steroids, 66, 759 (2001); Kootstra, P., et al.: Anal. Chim. Acta., 586, 82 (2007); Sten, T., et al.: Drug Metab. Dispos., 37, 417 (2009)<br></p>

<p>Applications Reagent used for Horner-Emmons modification.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hediger, M., et al.: Bioorg. Med. Chem., 12, 4995 (2004), Kim, J., et al.: Nat., 452, 239 (2008),<br></p>

<p>Applications Phosphoric acid, ammonium salt (1:1) is a useful reagent for organic synthesis.<br></p>

<p>Applications 1,2,3,4-Cyclobutanetetracarboxylic Acid 1,2,3,4-Tetramethyl Ester is product from the formation of a mixture of maleic anhydride and hexamethylbenzene when exposed to ultraviolet irradiation.<br>References Raciszewski, Z.: J. Chem. Soc., 12, 1147-1155 (1966);<br></p>

<p>Applications 2-(4-Hydroxybenzoyl)benzoic acid<br></p>

<p>Applications 2-(Hydroxyimino)-3-phenylpropanoic acid (cas# 3682-17-5) is a useful research chemical.<br></p>

<p>Applications A benzoic acid derivative used in photolysis reactions and biomaterial studies.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wetzels, G.M. et al.: Biomaterials., 20, 1879 (1999); Mao, C. et al.: Adv. Coll. Int. Sci., 110, 5 (2004);<br></p>

<p>Applications 2-Tetrahydrofuroic acid is used as a reagent to synthesize Alfuzosin (HCl: A532000), an unselective alpha-1 blocker that is used to treat lower urinary tract symptoms and benign prostatic hyperplasia.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Grasso, M., et al.: Arch. Esp. Urol., 48, 97 (1994); Roehrborn, C., et al.: BJU Int., 92, 257 (2003)<br></p>

<p>Applications N,N'-Bis(2,6-diisopropylphenyl)-1,6,7,12-tetraphenoxy-3,4,9,10-perylenetetracarboxylic Diimide has applications in the photosensors and optical detectors.<br>References Wang, Shaojun, et al.: ACS Photonics, 5(6), 2478-2485 (2018);Wang, Hanlin, et al.: Adv. Mat., 29(32), n/a. (2017)<br></p>

<p>Applications 4-GUANIDINOBENZOIC ACID METHANESULFONATE (cas# 148720-07-4) is a useful research chemical.<br></p>

<p>Applications 2-Ethoxybenzoic Acid is a component of dental cement. Low concentrations of 2-Ethoxybenzoic Acid in combination with Eugenol (E938640), gives a stabilizing effect to liposomes to lower damages to cells.<br>References Fujisawa, S., et al.: J. Dent. Res., 82, 43(2003); Brauer, G.M., et al.: J. Dent. Res., 62, 366 (1983); Brauer, G.M., et al.: J. Dent. Res., 63, 137 (1984); Fujisawa, S., et al.: J. Biomed. Mater. Res., 21, 89 (1987)<br></p>

<p>Applications Levulinic Acid is derived from the degredation of cellulose and is a potential precursor to biofuels. Levulinic acid is also a photosensitizer for photodynamic therapy.<br>References Serrano-Ruiz, J.C., et al.: Catalysis., 195, 162 (2012); Liedtke, A.J. et al.: Tetrahedron., 68, 10049 (2012);<br></p>

<p>Applications 1,1-Cyclohexanediacetic acid monoamide is an impurity of Gabapentin (G117250), an amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Gabapentin is used as an anticonvulsant.<br>References Vollmer, K.-O. et al.: Arzneimittel-Forshc., 36, 830 (1986), Saletu, B., et al.: Int. J. Clin. Pharmacol. Ther. Toxicol., 24, 362 (1986)<br></p>

<p>Applications Pentafluorobenzoic acid (cas# 602-94-8) is a useful research chemical.<br></p>

<p>Applications DL-3-phenyllactic acid had been identified as a urinary food intake biomarker for milk, cheese and soy-based drinks.<br>References Munger, L.H.; et al.: J. Proteome Res., 16, 3321 (2017)<br></p>

<p>Applications 2-Mercaptoisobutyric Acid, 90% (cas# 4695-31-2) is a compound useful in organic synthesis.<br>References McIntosh, J.M. and Siddiqui, M.A.: Can. J. Chem., 61, 1872-1875 (1983), Bienlarz, C. and Cornwall, M.J.: Tetrahedron Lett., 34 (6), 939-942 (1993)<br></p>

<p>Applications 4-​Hydrazinobenzoic acid hydrochloride (cas# 24589-77-3) is a useful research chemical.<br></p>

<p>Applications DL-2,4-Diaminobutyric Acid Dihydrochloride (cas# 65427-54-5) is a useful research chemical.<br></p>

<p>Applications Sebacic Acid is a urinary metabolite that has been identified as an anti-fatigue biomarker.<br>References Ma, C. et. al.: J. Pharmaceut. Biomed. Anal. 105, 84 (2015)<br></p>

<p>Applications Phthalic Acid Bis(3,7-dimethyloctyl) Ester is a diester derivative of Phthalic Acid (P384480) and can be used as a plasticizer for PVC-type compositions.<br>References Takeuchi, H., et al. Jpn. Kokai Tokkyo Koho. JP 2001002829 A 20010109. Jan 9, 2001<br></p>

<p>Applications Polymaleic acid (cas# 26099-09-2) is a useful research chemical.<br></p>

<p>Applications Ethyl Cyano(hydroxyimino)acetate is used in peptide synthesis and has shown to suppress racemiztion, has high coupling efficiency in both solution and solid phase synthesis and is a non-explosive alternative to 1-hydroxybenzotriazole (HOBt) and 1-hydroxy-7-azabenzotriazole (HOAt).<br>References Khattab, S.N.: Bull. Chem. Soc. Jpn., 83, 1374 (2010)<br></p>

<p>Applications Ethyl 2-Mercaptoacetate is an off-odor compound in white wine and an eye irritant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nikolantonaki, M., Darriet, P.: J. Agr. Food Chem., 59, 10191 (2011); Bagley, D.M., et. al.: Toxicol. in vitro, 13, 505 (1999)<br></p>

<p>Applications 5,6-dibromonicotinic acid (cas# 29241-64-3) is a useful research chemical.<br></p>

<p>Applications Phenyl N-​(2-​Chloro-​4-​hydroxyphenyl)​carbamate is a reagent used in the prepartion of quinoline-carboxamide compounds including Lenvatinib (L329400), an orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors.<br>References Wang, N. et al.: Faming Zhuanli Shenqing (2017), CN 106632033 A 20170510.<br></p>

<p>Applications 2,2-Diphenylpentanoic Acid (cas# 841-32-7) is a compound useful in organic synthesis.<br></p>

<p>Applications Dithiocarbamate complexes serve as hosts for the specific binding of various metal cations.<br>References Bourson, J., et al.: J. Phys. Chem., 97, 4552 (1993), Lai, S., et al.: Inorg. Chem., 38, 4262 (1999),<br></p>

<p>2-Naphthoxyacetic acid is an endogenous metabolite that is an inhibitor of firefly luciferase (Potency=40 μm).</p>

<p>Applications 4-(2-Amino-ethyl)-benzoic Acid is a useful reagent for the preparation of amino acid derivatives with anticancer activity.<br>References Kim, S., et al.: PCT Int. Appl. (2020), WO 2020204548 A1<br></p>

<p>Impurity Orlistat USP Related Compound B<br>Applications Orlistat USP Related Compound B<br></p>

<p>Applications Decanoic acid is used in manufacturing of esters for artificial fruit flavors and perfumes.<br>References Oro, L., et al.: Acta Pharmacol. Toxicol., 18, 141 (1961),<br></p>

<p>Applications 4,4'-Dithiobisbenzoic Acid, Technical Grade (cas# 1155-51-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Hydroxyhexanedioic Acid gets excreted in increased amounts in the human urine under conditions of medium-chain triglyceride (MCT) feeding, abnormal fatty acid oxidation (FAO) and fasting.<br>References Duran, M., et al.: Eur. J. Pediatr., 150, 190 (1991); Svendsen, J. S., et al.: J. Chromatogr. B., 337, 9 (1985); Tserng, K. Y., et al.: Metabolism, 40, 676 (1991); Tserng, K. Y., et al.: Metabolism, 445, 162 (1996)<br></p>

<p>Applications 5-(3,4-dihydroxyphenyl)pentanoic Acid (cas# 31129-94-9) is a useful research chemical.<br></p>