Carboxylic Acids

<p>Applications Bromosuccinic acid is prepared from Succinic acid (S688765), an important precursor in many chemicals used in the food, chemical and pharmaceutical fields. Bromosuccinic acid is also used as a reagent to prepare L-Hydrazinosuccinic acid.<br>References Gutowsky, H., et al.: J. Chem. Phys., 31, 1278 (2004); Song, H. &amp; Lee, S.: Enzyme Microb. Tech., 39, 352 (2006); Yamada, R., et al.: BBA-Prot. Struc. Mol. Enzym., 831, 82 (1985)<br></p>

<p>Applications 2-(Diphenylphosphino)benzoic Acid is used in small molecule control of protein function through staudinger reduction.<br>References Luo, J., et al.: Nat. Chem., 8, 1027 (2016)<br></p>

<p>Applications 5-Ethyl-2-fluorophenylboronic acid<br></p>

<p>Applications 3-(3-Furyl)acrylic Acid is a reactant in the preparation of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.<br>References Hornberger, K.R., et. al.: Bioorg. Med. Chem. Lett., 23, 4517 (2013)<br></p>

<p>Applications Methyl 2-Cyclopentanonecarboxylate is used in the synthesis of functionalized ketones.<br>References Mashima, K. et al.: J. Org. Chem., 59, 3064 (1994); Hamashima, Y. et al.: J. Am. Chem. Soc., 124, 11240 (2002);<br></p>

<p>Applications 4-(4-hydroxyphenyl)butanoic acid (cas# 7021-11-6) is a useful research chemical.<br></p>

<p>Impurity Lubiprostone Impurity VI<br>Applications 7-((1R,2R,3R)-3-(cyclohexylmethoxy)-2-(4,4-difluoro-3-oxooctyl)-5-oxocyclopentyl)heptanoic Acid is a useful chemical reagent.<br></p>

<p>Applications 3-Cyclohexylbutanoic Acid (cas# 4361-38-0) is a useful reagent for the preparation of oxoheterocyclylalkyl hydroxypiperidinylketones as USP19 inhibitors for treating diseases.<br>References Hewitt, P., et al.: PCT Int. Appl. (2018), WO 2018020242 A1<br></p>

<p>Applications 3,4-Epoxycyclohexanecarboxylate Methyl Ester is a useful reagent for organic synthesis.<br></p>

<p>Applications 6-Chloro-1-benzofuran-2-carboxylic Acid is used to prepare cis-diaminocyclohexane derivatives as factor Xa inhibitors. It is also used to synthesize tachykinin NK2 receptor antagonists.<br>References Bioorg. Med. Chem., 17, 8206 (2009); Gensini, M., et al.: ChemMedChem, 5, 65 (2010)<br></p>

<p>Applications exo-2,3-Norbornanedicarboxylic Acid Monoamide is an impurity in the synthesis of Lurasidone (L474920) an antipsychotic used for treatment of schizophrenia.<br>References Ishiyama, T., et al.: Eur. J. Pharmacol., 572, 160 (2007), Cole, P., et al.: Drugs of the Fut., 33, 316 (2008),<br></p>

<p>Applications 2,4-Dihydroxy-5-((4-sulfophenyl)diazenyl)benzoic Acid is an intermediate in the synthesis of Acid Orange 24 (A189835), which is used in trickling biofilters for wastewater treatment. Acid Orange 24 is used in suncare compositions. It also serves as a raw material for cosmetics. Mutagenicity test for dye compositions in cosmetics.<br>References Garzon-Zuniga, M. A., et al.: Water Environ. Res., 83, 107 (2011); Anon.: IP.com Journal, 11, 5 (2011); Muzzall, J. M., et al.: Mutat. Res., Genet. Toxicol. Testing, 67, 1 (1979)<br></p>

<p>Applications tert-Butyl Bromoacetate is a halogenated t-butyl acetate commonly used as an alkylating agent. tert-Butyl Bromoacetate is used in the synthesis of collagenase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Steinman, D.H. et al.: Bioorg. Med. Chem. Lett., 8, 2087 (1998); Fray, M.J. et al.: J. Med. Chem., 46, 3514 (2003): Neri, P. et al.: J. Org. Chem., 59, 3880 (1994);<br></p>

<p>Applications 6-Chloronicotinic Acid, is an organic building block used for the synthesis of various biologically active compounds, including inhibitors. It is an intermediate for the synthesis of N-(thiophen-2-yl) benzamide derivatives as BRAFV600E inhibitors, and novel DNA-gyrase B inhibitors.<br>References Xie, Y., et al.: Bioorg. Med. Chem. Lett., 23, 2306 (2013); Shiroya, U., et al.: Med. Chem. Res., 22, 5227 (2013);<br></p>

<p>Applications 2-Hydroxy-5-(phenylethynyl)benzoic Acid has antiinflammatory activity.<br>References Shen, T.-Y., et al.: U.S. (1972), US 3657430 A<br></p>

<p>Applications Methyl Dimethoxyacetate is used as a reagent in the synthesis of benzimidazole derivatives for use as respiratory syncytial virus inhibitors.<br>References Cooymans, Ludwig Paul; D., et al. PCT Int. Appl. WO 2012080446 A1 20120621. Jun 21, 2012<br></p>

<p>Applications methyl amino(2-bromophenyl)acetate hydrochloride (cas# 1219408-44-2) is a useful research chemical.<br></p>

<p>Applications A useful wittig reagent.<br></p>

<p>Applications 3-Amino-4-hydroxybenzoic acid (cas# 1571-72-8) is a useful research chemical.<br></p>

<p>Applications tert-Butyl ((2S,3R,E)-3-hydroxy-1-((2-oxido-1,3,2-dioxaphospholan-2-yl)oxy)octadec-4-en-2-yl)carbamat is an intermediate for the synthesis of D-erythro-Sphingosylphosphorylcholine (S681700), which is involved in cell regulation, and transmembrane signaling. A putative lipid second messenger, connected via Protein Kinase C to the phosphatidylinositol-derived second messengers for signal transduction.<br>References Kratzer, B. and Schmidt, R.R.: Liebigs Ann., 955-963 (1995)<br></p>

<p>Applications 3-Amino-3-(3-(p-tolyloxy)phenyl)propanoic Acid is a useful chemical reagent.<br></p>

<p>Applications Benzothiophene-5-boronic acid<br></p>

<p>Applications 4-(Methylamino)benzoic Acid (cas# 10541-83-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-tert-Butoxyphenylboronic Acid is a compound used in the preparation of nitrophenylphenol via cross-coupling reaction of nitrohalobenzenes with phenylboronic acids and deprotection.<br>References Kumamoto, N., et al.: Preparation of nitrophenylphenol, JP 2001055360 (2001);<br></p>

<p>Applications 2,4-Diaminobenzenesulfonic acid (cas# 88-63-1) is a useful reagent for improving the chlorine resistance and water permeability of polyamide (PA) membrane in water treatment.<br>References Meng, Q. W., et al.: ACS Applied Mat., 12, 35393 (2020)<br></p>

<p>Applications (2-Oxopropyl)Carbamic Acid Tert-Butyl Ester (cas# 170384-29-9) is a useful research chemical.<br></p>

<p>Applications Clavulanic Acid 2-Amino-2,4,4-trimethylpentane Salt is an intermediate in the synthesis of Clavulanic Acid Potassium Salt (C563750), a β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Reading, C. and Cole, M.: Antimicrob. Ag. Chemother., 11, 852 (1977); Ball, A.P., et al.: Lancet, 1, 620 (1980); Brogden, R.N., et al. Drugs, 22, 337 (1981)<br></p>

<p>Applications Dibromoisocyanuric acid is a bromine compound with a superior bactericidal activity.<br>References Gottardi, W., et al.: J. Appl. Microbiol., 116, 1427 (2014)<br></p>

<p>Applications 4-(2-(Methoxycarbonyl)phenoxy)benzoic Acid is an intermediate in the synthesis of Balsalazide (B116300) related compounds.<br></p>

<p>Applications Benzenecarbothioic Acid is used in the preparation of anti-leishmanial activity. Also used in the preparation of agents for the treatment against Alzheimer’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Andrews, P. et al.: Aus. J. Chem., 66, 1297 (2013); Linning, P. et al.: Org. Biomol. Chem., 10, 8216 (2012);<br></p>

<p>Stability Volatile<br>Applications METHYL AZIRIDINE-2-CARBOXYLATE (cas# 5950-34-5) is a useful research chemical.<br></p>

<p>Applications 2-Amino-4-hydroxybenzoic acid (cas# 38160-63-3) is a useful research chemical.<br></p>

<p>Applications 2-CYCLOPENTYL-2-PHENYLACETIC ACID (cas# 3900-93-4) is a useful research chemical.<br></p>

<p>Applications B-[3-[[2-Hydroxy-3-[3-(triethoxysilyl)propoxy]propyl]amino]phenyl]boronic acid was prepared for the use as porous polymeric monolith for the specific capture of cis-​diol-​containing flavone under neutral condition.<br>References Pan, J., et al.: Chem. Eng. J., 317, 317-330 (2017);<br></p>

<p>Applications 5-Chloro-2-fluorobenzoic Acid (cas# 394-30-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-Bromo-2-chloronicotinic acid<br></p>

<p>Applications 3-Oxohexanedioic Acid Diethyl Ester is an intermediate used to prepare CMPF (C595000) which is a drug-binding inhibitor which is also a constituent of urine. CMPF can inhibit specific T4 binding in serum by increasing the free concentration of direct competitors.<br>References Mabuchi, H., Nakahashi, H.: Nephron, 44, 277 (1986); Lim, C.F., et. al.: Metabolism Clin. Exp., 42, 1468 (1993)<br></p>

<p>Applications 3-Aminohydantoic Acid is an intermediate in the synthesis of new derivative of 5-Nitro-2-furfural, proved to be bactericidal.<br>References Swirska, A., et al.: Rocz. Chem., 31, 1335 (1957);<br></p>

<p>Applications 2-Mercapto-succinic acid diethyl ester (cas# 23060-14-2) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Magnesium acetate tetrahydrate (cas# 16674-78-5) is a useful research chemical.<br></p>

<p>Applications tert-Butyl carbamate is used to prepare N-Boc-protected anilines. It is also used in the synthesis of tetrasubstituted pyrroles, functionalized with ester or ketone groups at C-3 position.<br>References Bhagwanth, S., et al.: J. Org. Chem., 74, 4634 (2009); Cadierno, V., et al.: J. Heterocycl. Chem., 47, 233 (2010)<br></p>

<p>Applications 4-(Cyclopropylcarbonyl)-α,α-dimethylbenzeneacetic Acid is used for the preparation of Terfenadine ((T114500) analogs.<br>References Uchida., et al.: Chem. Pharm. Bull., 37, 958 (1989),<br></p>

<p>Applications (5-Formylfuran-2-yl)boronic Acid is a reagent used in Suzuki cross-couplings with deactivated aryl bromides and activated aryl chlorides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Trinh, T. N., et al.: Org. Biomol. Chem., 12, 9562-9571 (2014);<br></p>

<p>Applications 4-Acetylbutyric Acid is used in the synthesis of selective indomethacin analogues for AKR1C3 inhibition in the treatment of castrate-resistant prostate cancer. Also used to prepare PARP inhibitors for the treatment of cancer as well.<br>References Liedtke, A. et al.: J. Med. Chem., 56, 2429 (2013); Zhu, G. et al.: Bioorg. Med. Chem., 20, 4653 (2012);<br></p>

<p>Applications Dibromoacetic Acid is a halogenated disinfection byproduct. Dibromoacetic Acid was found to induce apoptotic changes and hydroxyl radical formation in human peripheral blood mononuclear cells (PBMCs). Dibromoacetic Acid also found to exhibit carcinogenic activity in which mice and rats were exposed to drinking water containing different concentrations of Dibromoacetic Acid that resulted in increased incidences of mononuclear cell leukemia, malignant mesothelioma, hepatocellular neoplasms, and hepatoblastoma.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Michalowicz, J., et al.: Toxicol. In Vitro 29, 1416 (2015); Natl Toxicol Program Tech Rep Ser. 537, 1 (2007)<br></p>

<p>Applications 2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid<br></p>

<p>Applications Methyl Dimethylbenzeneacetate (cas# 57625-74-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Azetidinecarboxylic acid, 1-ethyl- (cas# 106887-13-2) is a useful research chemical.<br></p>

<p>Applications 5-(Diphenylphosphinyl)pentanoic Acid, can be used for the preparation of praseodymium coordination polymers with diphenylphosphorylvalerate ligand. It is also a by product in the preparation of prostaglandin analogs.<br>References Spichal, Z., et al.: Polyhedron, 48, 99 (2012); Zhao Y. et al.: PCT Int. Appl. 43pp.Patent, 2016<br></p>

<p>Stability Moisture Sensitive<br>Applications 5,5-Dibromobarbituric Acid (cas# 511-67-1) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-(Aminosulfonyl)benzoic Acid can be used as reactant/reagent in synthesis and pharmacological activity of γ-(phenyloxamido)- and γ-(phenylsulfonyloxamido)butanoic acids.<br>References Georgiyants, V. A., et al.: Farmatsevtichnii Zhurnal, 2, 34 (2010);<br></p>

<p>Applications tert-Butyl N-(Benzyloxy)carbamate has been used in the synthesis of Deferoxamine Mesylate (D228980), an iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients<br>References Bergeron RJ, et al. 1992. J Med Chem. Dec 11;35(25):4739-44Inati A, et al. 2010. Am J Hematol. Oct;85(10):782-6 Selim M, et al. 2010. Transl Stroke Res. Mar;1(1):35-9<br></p>

<p>Stability Moisture Sensitive<br>Applications 2-(Dimethoxyphosphoryl)acetic acid<br></p>

<p>Applications 2-Ethylheptanoic Acid is used in the preparation of prostaglandin which is for for promoting bone growth<br>References Barrett, S., et al.: PCT Int. Appl., 331 (2015)<br></p>

<p>Applications B-(9-Phenyl-9H-carbazol-3-yl)boronic Acid is used in the synthesis of alkyl-functionalized organic dyes.<br>References Lee, E. et al.: Bull. Kor. Chem. Soc., 33, 293 (2012);<br></p>

<p>Applications 3-(4-Biphenyl)propionic Acid is a reactant in the preparation of 1,3,4-oxadiazole containing histone deacetylase inhibitors with anticancer activity.<br>References Valente, S., et. al.: J. Med. Chem., 57, 6259 (2014)<br></p>

<p>Stability Light Sensitive<br>Applications 1-Oxo-1H-isochromene-4-carboxylic acid (cas# 15868-29-8) is a useful research chemical.<br></p>