Carboxylic Acids

<p>Applications Fumaric Acid is a compound that occurs in many plants. It is essential to vegetable and tissue respiration and also used as an antioxidant. Fumaric Acid is also a metabolite of Dimethyl Fumarate (D464965), a compound used as a treatment for the relapsing forms of multiple sclerosis and psoriasis.<br>References Jelitto, T., et al.: Planta, 188, 238 (1992); Schimrigk, S., et al.: Eur. J. Neurol., 13, 604 (2006); Son, H., et al.: J. Agric. Food Chem., 56, 8007 (2008);<br></p>

<p>Applications 4-Sulfamoylbenzoic Acid is used as a reagent in the synthesis of carbonic anhydrase inhibitors anticonvulsant agents.<br>References Singh, S. et al.: J. Enz. Inhib. Med. Chem., 31, 417 (2016);<br></p>

<p>Applications 2-Amino-2-phenylbutyric acid 96% (cas# 5438-07-3) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Methanesulfonic acid is a strong acid and is an important intermediate in the cycling process of sulfur in the environment. Methanesulfonic acid is an oxidation product of Dimethyl sulfide (T348000), and is also used as a sole source of carbon and energy for some gram-negative methylotropic bacteria.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References de Marco, P., et al.: J. Bacteriol., 181, 2244 (1999); Kolaitis, L., et al.: Env. Sci. Tech., 23, 236 (1989); Saltzman, E., et al.: Geophys. Res. Lett., 12, 437 (1985)<br></p>

<p>Applications 2-Hydroxybutanoic Acid is an analyte used in the diagnoses of colorectal cancer as well as Type II diabetes. It is also used in the purification of the major Vibrio autoinducer and the study of its role in virulence factor production for cholera.<br>References Qiu, Y. et al.: J. Proteome Res., 8, 4844 (2009); Salek, R.. et al.: Phys. Genom., 29, 99, (2007); Higgins, D. et al.: Nature, 450, 883 (2007);<br></p>

<p>Applications 3,4-Secocholest-5-ene-3,4-dioic Acid Dimethyl Ester is an intermediate used in the synthesis of 3,4-Seco-solanidine-3,4-dioic Acid (S682410), which is a derivative of Solanidine (S682410).<br></p>

<p>Applications Cyclopropanecarboxylic Acid is used as a reagent in the synthesis of substituted 4-(thiophen-2-ylmethyl)-2H-phthalazin-1-ones as potent PARP-1 inhibitors. Also used as a reagent in the synthesis of 2-alkyloxazoles as potent and selective PI4KIIIβ inhibitors demonstrating inhibition of HCV replication.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, L., et al.: Bioorg. Med. Chem. Lett., 24, 3739 (2014); Keaney, E.P., et al.: Bioorg. Med. Chem. Lett., 24, 3714 (2014)<br></p>

<p>Applications Syringic Acid is used in biological studies for electron transfer from plant phenolates to carotenoid radical cations with antioxidant interaction entering the Marcus theory inverted region.<br>References Cheng, H., et al.: J. Agric. Food Chem., 62, 942 (2014)<br></p>

<p>Applications 1,4-dibutyl benzene-1,4-dicarboxylate (cas# 1962-75-0) is a useful research chemical.<br></p>

<p>Applications Trimellic Acid is a reagent used in the preparation of coordination polymers containing various luminescent properties.<br>References Zhang, Z. et al.: Crys. Grow. Des., 13, 4338 (2013); Qin, L. et al.: Trans. Met. Chem., 38, 627 (2013);<br></p>

<p>Applications 1,3-Dihydro-1,3-dioxo-5-isobenzofurancarboxylic Acid is an analog of Trioctyl Trimellitate (T804400) which is a plasticizer that was evaluated for endocrine disrupting activities through estrogen receptor alpha binding assay.<br></p>

<p>Applications DL-2,4-Diaminobutyric Acid Dihydrochloride (cas# 65427-54-5) is a useful research chemical.<br></p>

<p>Applications ACETOACETIC ACID ISOAMYL ESTER (cas# 2308-18-1) is a useful research chemical.<br></p>

<p>Applications (1-acetyl-2,3-dihydro-1H-indol-5-yl)boronic acid (cas# 905971-97-3) is a useful research chemical.<br></p>

<p>Applications Fendizoic Acid is a reagent in the synthesis of fluorinated polyphthalazinone ethers containing perfluorophenylene moieties.<br>References Lu, Z., et al.: J. Polym. Sci. A1, 42, 925 (2004)<br></p>

<p>Applications DL-3-phenyllactic acid had been identified as a urinary food intake biomarker for milk, cheese and soy-based drinks.<br>References Munger, L.H.; et al.: J. Proteome Res., 16, 3321 (2017)<br></p>

<p>Applications 3-Hydroxyphenylacetic Acid (cas# 621-37-4) is a compound useful in organic synthesis.<br></p>

<p>Stability Stench<br>Applications 2,2-Dimethylcyclopropylcarboxylic acid<br></p>

<p>Applications Hydrazine acetate (cas# 7335-65-1) is a useful research chemical.<br></p>

<p>Applications 5-Aminolevulinic Acid Hydrochloride (cas# CAS:5451-09-2) is a useful research chemical.<br></p>

<p>Applications Tert-butyl Acetate is a common solvent used in the production of various industrial cleansers, thinners and adhesives and is also known as a VOC.Environmental contaminants; Food contaminants<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mackay, D., et al.: SAR. QSAR. Enviro. Res., 23, 205 (2012); Yang, Y.S., et al.: Toxicol. Res., 26, 293 (2010);<br></p>

<p>Applications Dithiocarbamate complexes serve as hosts for the specific binding of various metal cations.<br>References Bourson, J., et al.: J. Phys. Chem., 97, 4552 (1993), Lai, S., et al.: Inorg. Chem., 38, 4262 (1999),<br></p>

<p>Applications 3-Hydroxymandelic Acid is used in the synthesis of an enzyme activity-based labeling molule.<br>References Komatsu, T. et al.: J. Am. Chem. Soc., 128, 15946 (2006);<br></p>

<p>Applications Boric Acid, Pinacol Ester was a useful reagent in the study of hydrogen peroxide inducible DNA croslsinking agents as anticancer prodrugs.<br>References Kuang, Y., et al.: J. Am. Chem. Soc., 133, 19278 (2011);<br></p>

<p>Applications 5-(tert-butoxy)-5-oxo-4-(4,7,10-tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanoic Acid has been used in synthesis of; GdDOTAGA(C18)2: an efficient amphiphilic Gd(III) chelate for the preparation of self-assembled high relaxivity MRI nanoprobes; bifunctional prochelators for coupling to bioactive peptides for radiometal labeling; DOTAGA-anhydride, building block for prepn. of DOTA-like chelating agents.<br>References Filippi M., et al., ChemComm., 51, 17455-17458 (2015); Eisenwiener K. P., et al., Bioorg. Med. Chem. Lett., 10, 2133-2135 (2000); Bernhard C., et al., Chem. Eur. J., 18, 7834-7841 (2012)<br></p>

<p>Applications o-Arsanilic Acid is an organoarsenic compound. o-Arsanilic Acid is a highly toxic contaminant and can be found in plants growing in contaminated soil.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Schmidt, A.-C. et al.: Chemosphere, 73, 1781 (2008);<br></p>

<p>Applications 2,2-dimethyl-4-oxo-4-(propan-2-yloxy)butanoic acid (cas# 1803601-41-3) is a useful research chemical.<br></p>

<p>Applications 1-Cyclohexenylcarboxylic Acid is a reagent used in the synthesis and optimization of small-molecule HIV-1 entry inhibitors. Also used in the stereoselective synthesis of diazabicyclic β-lactams for antimicrobial activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tuyishime, M. et al.: Bioorg. Med. Chem. Lett., 24, 5439 (2014); Zhang, S. et al.: J. Org. Chem., 81, 956 (2016);<br></p>

<p>Applications 2,4-Dihydroxybenzoic acid is a useful synthetic intermediate. An organic building block for plastics and rubber products.<br>References Gautam, R., et al.: Cryst. Growth Des., 18, 1501 (2018); Shvedene, N. V., et al.: J. Anal. Chem., 72, 95 (2017);<br></p>

<p>Applications 4-​Hydrazinobenzoic acid hydrochloride (cas# 24589-77-3) is a useful research chemical.<br></p>

<p>Applications 4-(4,6-Bis(4-((2-ethylhexyloxy)carbonyl)phenylamino)-1,3,5-triazin-2-ylamino)benzoic Acid is an impurity in the synthesis of Ethylhexyl Triazone (E918810), used in sunscreen formulations as a UV filter to block out harmful ultraviolet light.<br>References Potard, G. et al.: Int. J. Pharm., 189, 249 (1999); Couteau, C. et al.: J. Pharm. Biomed. Anal., 44, 270 (2007);<br></p>

<p>Applications 6-Chlorohexanoic Acid is used as the starting material in the synthesis of 2,6-Dichloro-N-(2,6-dimethylphenyl)hexanamide (D434225); an impurity of the local anesthetic Levobupivacaine (B689546). 6-Chlorohexanoic Acid is also used as a reagent in the synthesis of novel types of polyester glycodendrimers as potential inhibitors of urinary tract infections.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tullar, B., et al.: J. Med. Chem., 14, 891 (1971); Schmidt, A., et al.: Pharm. Res., 22, 2121 (2005); Twibanire, J.K., et al.: New J. Chem., 39, 4115 (2015)<br></p>

<p>Applications Cyclohexanecarboxylic acid<br></p>

<p>Applications 4-octylbenzoic acid (cas# 3575-31-3) is a useful research chemical.<br></p>

<p>Applications Pentafluorobenzoic acid (cas# 602-94-8) is a useful research chemical.<br></p>

<p>Applications 3,3-Dimethylbutyric Acid is used in the synthesis of imidazo[4,5-c]pyridine derivatives as anitmicrobial agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jose. G., et. al.: Eur. J. Med. Chem., 77, 288 (2014)<br></p>

<p>Applications 4-hydroxy-2-nitrobenzoic acid (cas# 74230-08-3) is a useful research chemical.<br></p>

<p>Applications Hexanedioic Acid Mono(4-hydroxybutyl) Ester is an intermediate in the synthesis of aliphatic polyesters.<br>References McCabe, R. W., et al.: Tetrahedron., 60, 765 (2004);<br></p>

<p>Applications Citric Acid Monohydrate is a useful buffer component for antigen and epitope unmasking.<br></p>

<p>Applications Acetylpyruvic acid is a derivative of pyruvic acid (P998900) which is an intermediate in sugar metabolism and in enzymatic carbohydrate degradation (alcoholic fermentation) where it is converted to acetaldehyde and CO2 by carboxylase. In muscle, Pyruvic acid (derived from glycogen) is reduced to lactic acid during exertion, which is reoxidized and partially retransformed to glycogen during rest. The liver can convert Pyruvic acid to alanine by amination. A diagnostic agent for Parkinson disease.<br>References Wenzel, A., et al.: J. Neurosci., 21, 53 (2001), Martinez., et al.: Development, 6, 851 (2002), Nakayama, K., et al.: J. Biochem., 146, 757 (2009), Tanaka, T., et al.: J. Pharmacol. Sci., 109, 24 (2009),<br></p>

<p>Applications Phenylglyoxylic Acid (cas# 611-73-4) is a compound useful in organic synthesis.<br></p>

<p>Applications Phosphoric acid, ammonium salt (1:1) is a useful reagent for organic synthesis.<br></p>

<p>Applications Ethyl 4-Phenylacetoacetate is a useful synthetic intermediate. It is used to prepare pyrazolone derivatives as antiprion compounds. It is also used to prepare pyrrolinylaminopyrimidine analogs as inhibitors of AP-1 and NF-κB mediated gene expression.<br>References Kimata, A., et al.: J. Med. Chem., 50, 5053 (2007); Palanki, M., et al.: Bioorg. Med. Chme. Lett., 12, 2573 (2002)<br></p>

<p>Applications Polymaleic acid (cas# 26099-09-2) is a useful research chemical.<br></p>

<p>Applications 1,3-Adamantanedicarboxylic acid, is a monomer that can be used in polymer science, self assembly and lithography.<br></p>

<p>Applications Ethyl 2-Mercaptoacetate is an off-odor compound in white wine and an eye irritant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nikolantonaki, M., Darriet, P.: J. Agr. Food Chem., 59, 10191 (2011); Bagley, D.M., et. al.: Toxicol. in vitro, 13, 505 (1999)<br></p>

<p>Applications Di-β,β'-Chloroethylphosphoric Acid, is a dialkyl hydrogen phosphates, that can undergo the electrophilic trifluor- omethylation to produce trifluoromethyl phosphates in order to increase the lipophilicity of functional groups.<br>References Santschi, N., et al.: J. Fluorine Chem., 135, 83 (2012);<br></p>

<p>Stability Light Sensitive<br>Applications TRANS-2-OCTENOIC ACID (cas# 1871-67-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Phthalanilic acid is a compound that is useful in the production of fertilizers.<br>References Liang, S., et al.: Faming Zhuanli Shenqing.,4 (2019)<br></p>