Carboxylic Acids

<p>Applications 9-Oxo-10(9H)-acridineacetic acid is a reagent for pre-column derivatization of amino acids for fluorescent determination in HPLC and it is also a building block in pharmaceutics.<br></p>

<p>Applications Cyclopropanecarboxylic Acid is used as a reagent in the synthesis of substituted 4-(thiophen-2-ylmethyl)-2H-phthalazin-1-ones as potent PARP-1 inhibitors. Also used as a reagent in the synthesis of 2-alkyloxazoles as potent and selective PI4KIIIβ inhibitors demonstrating inhibition of HCV replication.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, L., et al.: Bioorg. Med. Chem. Lett., 24, 3739 (2014); Keaney, E.P., et al.: Bioorg. Med. Chem. Lett., 24, 3714 (2014)<br></p>

<p>Stability Volatile<br>Applications Methyl Acetate is used as an organic chemical solvent for a multitude of organic processes. Also used in the production of biodiesel.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Xu, Y. et al.: J. mol. Cat., 32, 241 (2005); Ogino, H. et al.: J. Biosci. Bioeng., 89, 451 (2000);<br></p>

<p>Applications Trimellic Acid is a reagent used in the preparation of coordination polymers containing various luminescent properties.<br>References Zhang, Z. et al.: Crys. Grow. Des., 13, 4338 (2013); Qin, L. et al.: Trans. Met. Chem., 38, 627 (2013);<br></p>

<p>Applications 3-Oxohexanedioic Acid is a degradation product of catechol in the presence of hydrogen peroxide; Also, it is derived from 3-Oxohexanedioic Acid Diethyl Ester (O856830), which is an intermediate used to prepare CMPF (C595000) which is a drug-binding inhibitor which is also a constituent of urine. CMPF can inhibit specific T4 binding in serum by increasing the free concentration of direct competitors.<br>References Gogoi, A., et al.: Chem. Eng. J., 311, 153-162 (2017); Mabuchi, H., Nakahashi, H.: Nephron, 44, 277 (1986); Lim, C.F., et. al.: Metabolism Clin. Exp., 42, 1468 (1993)<br></p>

<p>Applications 2-Ethylbutyric Acid is used in biological studies as a possible descriptor for toxicity prediction through electrophilicity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Roy, D.R., et al.: Bioorg. Med. Chem., 13, 3405 (2005); Parthasarathi, R., et al.: J. Phys. Chem. A., 107, 10346 (2003)<br></p>

<p>Applications (3E,7E)-4,8,12-Trimethyl-3,7,11-tridecatrienoic Acid is a compound involved in a study on ligand-controlled regiodivergent Ni-catalyzed reductive carboxylation of allyl esters with CO2.<br>References Moragas, T., et al.: J. Am. Chem. Soc., 136, 17702-17705 (2014)<br></p>

<p>Applications Sebacic Acid is a urinary metabolite that has been identified as an anti-fatigue biomarker.<br>References Ma, C. et. al.: J. Pharmaceut. Biomed. Anal. 105, 84 (2015)<br></p>

<p>Applications 3-Isopropoxybenzoic acid is a useful reagent for organic synthesis and other chemical processes.<br>References Chiong, H. A., et al.: J. Am. Chem. Soc., 129, 9879 (2007); Kingston, D. G. I., et al.: J. Med. Chem., 41, 3715 (1998)<br></p>

<p>Applications Perfluorohexanoic Acid is a perfluorinated compound (FPC) that can cause acute toxicity to humans and the environment. Perfluorohexanoic Acid is also used as a reagent in the synthesis of 3,3,4,4,5,5,6,6,7,7,7-Undecafluoro-2-heptanol (U787500).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Latala, A., et al.: Environ. Toxicol. Phar., 28, 167 (2009); Mulkiewicz, E., et al.: Environ. Toxicol. Phar., 23, 279 (2007)<br></p>

<p>2-Naphthoxyacetic acid is an endogenous metabolite that is an inhibitor of firefly luciferase (Potency=40 μm).</p>

<p>Applications Decanoic acid is used in manufacturing of esters for artificial fruit flavors and perfumes.<br>References Oro, L., et al.: Acta Pharmacol. Toxicol., 18, 141 (1961),<br></p>

<p>Applications Benzyl Acetate, is found naturally in many flowers, It has pleasant sweet aroma reminiscent of jasmine, and thus is used widely in perfumery industry, and also as a flavouring agent. It is also used as a solvent.<br>References Schiestl, F. P., et al.: J. Chem. Ecology, 29 (2004); Qian-qian, M., et al.: Jingxi Huagong, 30, 442 (2013);<br></p>

<p>Applications 3-Carboxyphenylboronic Acid is used in phenylboronic acid-decorated gelatin nanoparticles for enhanced tumor targeting and penetration.<br>References Wang, X., et al.: Nanotechnology, 27, 385101 (2016); Wang, X., et al.: Eur. J. Pharm. Biopharm., 113, 168 (2017)<br></p>

<p>Applications Ethyl Nitroacetate is an ester of nitrocarboxylic acid used as an intermediate in the preparation of unsubstituted amino acids.<br>References Sidorin, G.I.: Gig. Aspe. Okhr. Zdor. Nasel., 144 (1977);<br></p>

<p>Applications Propiolic Acid is a compound used in the synthesis of haloalkyl propiolates, halopropenoates, and transition metal complexes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References J. Organomet. Chem., 456, 271 (1993); Tetrahedron, 49, 4229 (1993); Tetrahedron, 48, 3413 (1992); J. Org. Chem., 57, 709 (1992)<br></p>

<p>Applications 7H-Dodecafluoroheptanoic Acid is a derivative of Heptanoic Acid (H998455) which can be used as an organic building blocks for the synthesis of variety of chemical compounds. Heptanoic Acid is used in the synthesis of 17-epi-Testosterone Enanthate (T155095). It is used in the preparation of esters, such as ethyl heptanoate, which are used in fragrances and as artificial flavors. It is also one of many additives in cigarettes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anneken, D. et al.: Fatty Acids, Ullmann's Encyclopedia of Industrial Chemistry (2006); Wudy, S., et al.: Steroids, 66, 759 (2001); Kootstra, P., et al.: Anal. Chim. Acta., 586, 82 (2007); Sten, T., et al.: Drug Metab. Dispos., 37, 417 (2009)<br></p>

<p>Applications Antioxidant.<br>References Arnous, A., et al.: J. Agr. Food Chem., 49, 5736 (2001), Guendez, R., et al.: Food Chem., 89, 1 (2005), Proestos, C., et al.: Food Control,16, 319 (2005)<br></p>

<p>Applications 2,6-Diaminopimelic Acid is useful in biological studies involving amino acids and amino sugars as molecular indicators of the origins of organic matter in buried tephra soils.<br>References Hobara, S., et al.: Geoderma, 373, 114449 (2020)<br></p>

<p>Stability Moisture Sensitive<br>Applications Perfluorobutanesulfonic acid (PFBS) is a stable fluorosurfactant because of the strength of carbon–fluorine bonds. PFBS has served as a replacement for the persistent, toxic, and bioaccumulative perfluorooctanesulfonic acid (PFOS) in 3M's Scotchgard stain repellents. PFBS is neither toxic nor bioaccumulative.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Renner R., et al.: Environ. Sci. Technol., 40, 12 (2006), Betts, K.S., et al.: Environ. Health Perspect., 115, 250 (2007),<br></p>

<p>Applications 5-Formylfuran-2-carboxylic Acid is a compound useful in organic synthesis.<br>References Nocito, F., et al.: ACS Omega, 3, 18724 (2018); Chen, G., et al.: Ind. Eng. Chem. Res., 57, 16172 (2018)<br></p>

<p>Applications Ethyl Diazoacetate is used in the synthesis of Arteludovicinolide A as well as pyrimidoazepine analogs as seritonin 5-HT2A/C receptor ligands for treatment of obesity. This compound contains solvent for added stability.<br> E0<br>References Yang, H. et al.: Eur. J. Med. Chem., 63, 558 (2013); Kreuzer, A. et al.: Org. Lett., 15, 3420 (2013);<br></p>

<p>Applications Boric Acid is a common chemical component in insecticides, specifically for flea erradication. Also has the properties of an effective flame retardant.<br>References Hinkle, N. et al.: J. Med. Entomol., 32, 424 (1995); Dogan, M. et al.: Polym. Degrad. Stab., 99, 12 (2014);<br></p>

<p>Stability Hygroscopic<br>Applications Used in the manufacturing of L-tryptophan by enzymic reaction.<br>References Franke, L., et al.: J. Med. Chem., 48, 6997 (2005), Fox, T., et al.: Curr. Top Med. Chem., 6, 1579 (2006),<br></p>

<p>Applications Fumaric Acid is a compound that occurs in many plants. It is essential to vegetable and tissue respiration and also used as an antioxidant. Fumaric Acid is also a metabolite of Dimethyl Fumarate (D464965), a compound used as a treatment for the relapsing forms of multiple sclerosis and psoriasis.<br>References Jelitto, T., et al.: Planta, 188, 238 (1992); Schimrigk, S., et al.: Eur. J. Neurol., 13, 604 (2006); Son, H., et al.: J. Agric. Food Chem., 56, 8007 (2008);<br></p>

<p>Applications 2-Hydroxyphenylacetic Acid (cas# 614-75-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Chloronicotinic Acid is used as reagent/reactant luminescence and hydrothermal preparation of cobalt/cadmium/lead chloronicotinate phenanthroline MOF.<br>References Gao, Z.Q., et al.: J. Solid State Chem., 241, 121-130 (2016)<br></p>

<p>Applications (2E)-3-Phenyl-2-propenoic Acid is used in the synthesis of amides and esters through coupling reactions involving carboxylic acids and amines. Also used in the N-methylation of amides and O-methylation of carboxylic acids.<br>References Kunishima, M. et al.: Tetrahedron, 55, 13159 (1999); Xia, Q. et al.: Org. Lett., 15, 3326 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications Perfluorobutylphosphonic Acid, is a surfactant or antifoaming agent.<br></p>

<p>Applications 3-O-Ethyl-L-ascorbic Acid could be a useful stabilizing agent for a para-​hydroxyacetophenone solution.<br>References Zhang, H., et al.: Faming Zhuanli Shenqing (2020), CN 111937874 A<br></p>

<p>Applications Nicotinic Acid 2-Diethylamino-Ethyl Ester (cas# 3099-52-3) is a useful research chemical.<br></p>

<p>Applications Maleic Acid is used in the synthesis of pyridoindolones as potent inhibitors of Aurora kinases. Also is a reagent in the preparation of TiO2/carbon nanotube composites.<br>References Le, L. et al.: ChemMedChem., 8, 289 (2013); Yao, Y. et al.: Env. Sci. Tech., 42, 4952 (2008)l<br></p>

<p>Applications Dithiocarbamate complexes serve as hosts for the specific binding of various metal cations.<br>References Bourson, J., et al.: J. Phys. Chem., 97, 4552 (1993), Lai, S., et al.: Inorg. Chem., 38, 4262 (1999),<br></p>

<p>Applications 18-(tert-Butoxy)-18-oxooctadecanoic Acid is used to engineer long-acting, potent exendin-4 based GLP-1 analog for microstructure-based transdermal delivery for glycemic control.<br>References Yang, P., et al.: Proc. Natl. Acad. Sci. USA, 113, 4140 (2016);<br></p>

<p>Applications 2-butoxyacetic acid (cas# 2516-93-0) is a useful research chemical.<br></p>

<p>Applications 3-Cyclohexenylcarboxylic Acid has been found to be an oxidizable, nongrowth substrate and induces the metabolism of cyclohexanecarboxylic acid and benzoic acid in a strain of Pseudomonas putida. 3-Cyclohexenylcarboxylic Acid has been used as food for cultures of Streptomyces sp.  KCTC 11604BP fkbO deletion mutant to make 32-dehydroxy-FK506, a FK506 analogue containing a non-natural starter unit.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Blakley, E.R., Papish, B.: Can. J. Microbiol., 28, 1324 (1982); Ban, Y.H., et. al.: Mol. bioSystems, 9, 944 (2013)<br></p>

<p>Applications 2-Amino-4-(methylsulfonyl)benzoic Acid is a reagent used in the synthesis of anthranilic diamides containing fluorinated groups as potential ryanodine receptors activators.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wu, C. et al.: Chem. Lett., 28, 1248 (2017);<br></p>

<p>Applications 3,4,9,10-Perylenetetracarboxylic diimide (cas# 81-33-4) is a useful research chemical.<br></p>

<p>Applications Veratric Acid is a derivative of Protocatechuic Acid. Veratric Acid is a reagent used in the production of antimicrobial agents, antifeedants, and a variety of other biologically active compounds.<br>References Alissandrakis, E., et al.: Eur. Food Res. Technol., 229, 365 (2009), Spaccini, R., et al.: Soil Biol. Biochem., 41, 1164 (2009), Narasimhan, B., et al.: Eur. J. Med. Chem., 44, 689 (2009), Pereira, L., et al.: J. Biotechnol., 139, 68 (2009),<br></p>

<p>Applications Adipic Acid Dihydrazide is used to functionalize magnetic nanoparticles for gylcopeptitde enrichment and identification. Adipic Acid Dihydrazide can also be used as a chain extension for liquid rubber.<br>References Cao, Q., et. al.: Analyst, 139, 603 (2014); Cutts, E.: Chem. Industry, 7, 280 (1974)<br></p>

<p>Applications 3,5-DINITRO-4-HYDROXYBENZOIC ACID (cas# 1019-52-9) is a useful research chemical.<br></p>

<p>Applications (1-acetyl-2,3-dihydro-1H-indol-5-yl)boronic acid (cas# 905971-97-3) is a useful research chemical.<br></p>

<p>Applications Monohydrazide Adipic Acid is a synthetic reagent and a plant growth retarding agent.<br>References Ye, W-L., et al.: J. Pharm. Sci, 104, 2293-2303 (2015);<br></p>

<p>Applications 5-(3-hydroxyphenyl)pentanoic acid (cas# 31129-95-0) is a useful research chemical.<br></p>

<p>Applications Ethyl Acetate is generally used as a solvent in organic reactions.Environmental contaminants; Food contaminants<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Reyes L et al. J Org Chem. 2013 Mar 15;78(6):2327-35.<br></p>

<p>Applications N-Undecylbenzenesulfonic Acid is an anionic surfactant.<br>References Mottaleb, M. A.: Anal. Sci., 15, 1137 (1999), Kolb, M., et al.: LaborPraxis, 22, 56 (1998); Ferrer D., et al.: Tenside, Surfact., Det., 34, 278 (1997)<br></p>

<p>Applications Citric Acid Monohydrate is a useful buffer component for antigen and epitope unmasking.<br></p>

<p>Applications A metabolite of pyrethroid insecticides such as: Deltamethrin, Permethrin, Cypermethrin, Fenvalerate, Decamethrin.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Woollen, B., et al.: Xenobiotica, 22, 983 (1992), Saito, K., et al.: Toxicol. Sci., 57, 54 (2000), Fang, H., et al.: Chem. Res. Toxicol., 14, 280 (2001), Andersen, H., et al.: Toxicol. Appl. Pharmacol., 179, 1 (2002),<br></p>