6-membered Rings

<p>Applications 2,5-Dimethoxybenzyl Alcohol can be used as a self-indicating standard for the determination of organolithium reagents<br>References Winkle, M.R. et al.: J. Chem. Soc. Chem. Comm., 3, 1980 (1980):<br></p>

<p>Applications 1-(3,5-Bis(benzyloxy)phenyl)pentan-2-ol is an intermediate for the synthesis of 2''-Hydroxycannabidiol (H824820), which is a metabolite of Canabidiol (C175300), a major constituents in marijuana. 2''-Hydroxycannabidiol can be used to investigate canabidiol metabolism and human liver microsomes that metabolize Canabidiol into 6α-Hydroxycannabidiol.<br>References Jiang, R., et al.: Life Sci. 89, 165 (2011); Lander, N., et al.: Science 169, 611 (1970)<br></p>

<p>Applications Ethyl 3,5-dichloro-4-hydroxybenzoate (cas# 17302-82-8) is a useful research chemical.<br></p>

<p>Applications 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxide is used in the preparation of antihypertensive agents.<br>References Topliss, J. G., et al.: Journal of Medicinal Chemistry, 6, 122 (1963);<br></p>

<p>Applications 1-(1-phenylcyclobutanecarbonyl)piperidine-4-carboxylic acid (cas# 1099048-69-7) is a useful research chemical.<br></p>

<p>Applications [4-[3-[[(Methylamino)methylene]amino]phenyl]-2-thiazolyl] Guanidine is a guanidino heterocyclic phenylamidines with pharmaceutical properties.<br>References Bietti, G., et al.: Eur. Pat. Appl. (1983), EP 89730 A2 19830928<br></p>

<p>Applications 1,2-Dimethylcyclohexane is used in the preparation of rhodium nanoparticles as recyclable catalysts.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Stratton, S.A., et. al.: Catalysis Today, 183, 96 (2012)<br></p>

<p>Applications Dibenzo[b,d]furan-2-sulfonic acid (cas# 83863-63-2) is a useful research chemical.<br></p>

<p>Applications [1-(3-Fluorophenyl)-1-tosyl]methyl isocyanide (cas# 321345-36-2) is a useful research chemical.<br></p>

<p>Applications 3-Formylphenylboronic Acid is a reactant in the synthesis of I-BET726 (GSK1324726A), a potent tetrahydroquinoline ApoA1 up-regulator and selective BET bromodomain inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gosmini, R., et. al.: J. Med. Chem., 57, 8111 (2014)<br></p>

<p>Applications 3,5-Dimethylbenzyl Cyanide (cas# 39101-54-7) is a compound useful in organic synthesis.<br></p>

<p>Applications (2S,2aR,2aS,8aR)-2a-(2-((Cyclopropylmethyl)(methyl)amino)ethyl)-2,4,8a-trihydroxy-2,2a,8a-tetrahydro-1H-indeno[1,7,6-bcd]benzo-2-carboxylic Acid is an intermediate used in the synthesis of (4R,4aS,6S,6aR,11bS)-6-Carboxy-3-(cyclopropylmethyl)-1,2,3,4,4a,5,6,6a-octahydro-4a,6,8-trihydroxy-3-methyl-4,11-methanobenzofuro[3',2':2,3]cyclopenta[1,2-c]pyridinium, Inner Salt (C176953), which is an impurity/degradation of N-methyl Naltrexone (M320350), a metabolite of Naltrexone (N285750).<br>References Wall, M., et al.: Drug Metab. Dispos., 12, 677 (1984), Jones, D., et al.: .: Bioorg. Med. Chem., 13, 6727 ( 2005), Chen, T., et al.: Drugs Future, 32, 771 (2007); Chem. and Eng. News p.4 Jan. 23, (2017)<br></p>

<p>Applications 4-(2-Amino-3,3-dimethyl-1-oxobutyl)benzonitrile hydrochloride is used as a reagent to synthesize phenyloxobutanylpyridinylpiperazinecarboxamide derivatives, compounds that have TRPA1 receptor antagonistic properties.<br>References Svensson, M. &amp; Weigelt, D. Preparation of Phenyloxobutanylpyridinylpiperazinecarboxamide Derivatives for Use as TRPA1 Receptor Antagonist. PCT Int. Appl. 2012050512. Apr 19, 2012.<br></p>

<p>Applications 4-phenyl-2,3-dihydroquinazolin-2-one (cas# 23441-75-0) is a useful research chemical.<br></p>

<p>Applications A useful synthetic intermediate.<br></p>

<p>Applications 5-Amino-2-chlorobenzenesulfonamide (cas# 2015-19-2) is a compound useful in organic synthesis.<br>References Somers, F., et al.: Pharm. Pharmacol. Commun., 6, 89 (2000), D'Ambrosio, K., et al.: J. Med. Chem., 51, 3230 (2008),<br></p>

<p>Applications N-Benzylformamide is a useful synthetic intermediate. It is used to prepare thiadiazolidinone derivatives as possible glycogen synthase kinase 3 inhibitors. It can also be used to synthesize selective antitubercular agents.<br>References Martinez, A., et al.: J. Med. Chem., 48, 7103 (2005); Karabanovichi, G., et al.: Eur. J. Med. Chem., 82, 324 (2014)<br></p>

<p>Applications 2-amino-3-hydroxy-3-phenylpropanoic acid (cas# 7695-56-9) is a useful research chemical.<br></p>

<p>Applications 4-Cyanocyclohexanone is used to prepare nicotinamides as PDE4 D isoenzymes inhibitors. It is also used as an anthranilic acid replacement in niacin receptor agonist.<br>References Marfat, A., et al.: PCT Int. Appl. (1998), WO 9845268 A1 19981015; Schmidt, D., et al.: Bioorg. Med. Chem. lett., 20, 3426 (2010)<br></p>

<p>Applications Methyl 4-Chlorobenzoate is a reactant used in the synthesis of ataxia-telangiectasia mutated (ATM) kinase, a target for novel radiosensitizing agents. As well, used as a reactant in the synthesis of aminopyridine functionalized polyacrylonitrile fibers.<br>References Min, J. et al.: J. Med. Chem., 59, 559 (2016);<br></p>

<p>Applications Tetrahydro-4-pyranol is a building block of various organic compounds and pharmaceuticals.<br>References Chan, A.W., et al.: J. Med. Chem., 53, 3086 (2010); Desjardins, A.E.. et al.: Phytochem., 27, 767 (1988);<br></p>

<p>Applications (s)-2-phenyl-1-propanamine (cas# 17596-79-1) is a useful research chemical.<br></p>

<p>Applications N-[(2,4-Difluorophenyl)methyl]-2,4-difluoro-benzenemethanamine is derived from 2,4-Difluorobenzylamine (D45085), which acts as a reagent for the design of pyrazole derivatives as non-nucleoside heptatitis B virus inhibitors. It is also used as a reagent in the preparation, HIV antiviral activity, SAR, and molecular modelling of hydroxypyridonecarboxylic acids as HIV reverse transcriptase inhibitors.<br>References Jia, H., et al.: Eur. J. Med. Chem., 123, 202 (2016); Kankanala, J., et al.: J. Med. Chem., 59, 5051 (2016)<br></p>

<p>Applications Used as an intermediate in the Saliniketal A, B formal synthesis desymmetrization.<br>References Francke, W., et al.: Bioorg. Med. Chem., 4, 363 (1996), Basuroy, U., et al.: J. Biochem., 139, 27 (2006), Williams, P., et al.: J. Nat. Prod., 70, 83 (2007),<br></p>

<p>Applications 2-Aminomethyl-1,4-benzodioxane is used in the synthesis of N-substituted (dihydrobenzodioxinyl)methylamine derivatives as D2 antagonists/5-HT1A partial agonists with potential as atypical antipsychotic agents in relation to affinity for α1 adrenoceptors.<br>References Birch, A. M., et al.: J. Med. Chem., 42, 3342 (1999);<br></p>

<p>Stability Moisture Sensitive<br>Applications 1-(2-oxopropyl)-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione (cas# 57384-79-9) is a useful research chemical.<br></p>

<p>Stability Air Sensitive<br>Applications Can be used as a building block for chiral ligands.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-Isobutyrylcyclohexanone (cas# 39207-65-3) is a useful research chemical.<br></p>

<p>Applications Ethyl α-Bromo-β-phenylpropionate 90% (cas# 39149-82-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 4,5-Dimethoxy-2-nitrobenzoic Acid (cas# 4998-07-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Benzofuran-3(2H)-one is a useful research chemical, an intermediate used in the catalytic asymmetric synthesis of chiral benzofuranones.<br>References Li, Y., et al.: Adv. Synth. Catal., 356, 1172 (2014); Huang, Z., et al.: Org. Lett., 19, 3524 (2017)<br></p>

<p>Applications 3-PHENYLISONICOTINIC ACID (cas# 104096-15-3) is a useful research chemical.<br></p>

<p>Applications 3,4-Diaminobenzenesulfonic Acid is a useful organic synthetic reagent and a sulfonate-aminium zwitterion.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liu, J., et al.: Acta Crystallogr. B., 66, 3281 (2010)<br></p>

<p>Applications 5-Nitro-1-benzofuran is a chemical reagent used in the synthesis of internal alkynes. Also used in the preparation of anti-oxidants quinolines.<br>References Lu, L. et al.: Eur. J. Org. Chem., 2013, 1644 (2013); Kuzmin, V. et al.: Russ. Chem. Bull., 57, 2405 (2008);<br></p>

<p>Applications 2-CYCLOPENTYL-2-PHENYLACETIC ACID (cas# 3900-93-4) is a useful research chemical.<br></p>

<p>Applications b-Phenylethyl Furoate (cas# 7149-32-8) is a useful research chemical.<br></p>

<p>Applications 4-Hydroxyphenylacetone (cas# 770-39-8) is a useful research chemical.<br></p>

<p>Applications trans-2-(Chloromethyl)cyclohexanemethanol is an impurity of Lurasidone Hydrochloride (L474920), an antipsychotic used for treatment of schizophrenia.<br>References Ishiyama, T., et al.: Eur. J. Pharmacol., 572, 160 (2007); Cole, P., et al.: Drugs of the Fut., 33, 316 (2008)<br></p>

<p>Applications 3,4-Bis(isobutoxycarbonyl)benzoic Acid is a useful reagent in organic synthesis.<br></p>

<p>Applications 3,5-Dibenzyloxybenzyl alcohol (cas# 24131-31-5) is a useful research chemical.<br></p>

<p>Applications Intermediate in the production of Cyclophosphamide metabolites.<br>References Hashizume, H., et al.: Chem. Pharm. Bull., 42, 2097 (1994), Wu, L., et al.: Bioorg. Med. Chem., 15, 7434 (2007),<br></p>

<p>Applications 5-Chloro-2-fluorobenzoic Acid (cas# 394-30-9) is a compound useful in organic synthesis.<br></p>

<p>Applications An intermediate for the preparation of (+/-)-Taxifolin.<br></p>

<p>Applications N-Octyl 4-Hydroxybenzoate is a useful plasticizer.<br>References Shen, J., et al.: Faming Zhuanli Shenqing (2020), CN 111073279 A<br></p>

<p>Applications 2-Nitro-5-phenylthioaniline is a useful synthetic intermediate. It was used to synthesize methyl 5(6)-phenylsulfinyl-2-benzimidazolecarbamate as a potent anthelmintic.<br>References Averkin, E., et al.: J. Med. Chem., 18, 1164 (1975);<br></p>

<p>Applications Nitrosobenzene (cas# 586-96-9) is a useful research chemical.<br></p>

<p>Applications N-(3,4-dimethylphenyl)acetamide (cas# 2198-54-1) is a useful research chemical.<br></p>

<p>Applications 5-(Chloromethyl)-3-[1-(4-chlorophenyl)cyclopropyl]-1,2,4-oxadiazole is an intermediate used to prepare substituted oxadiazole analogs as calcium channel antagonists.<br>References Cai, C., et al.: PCT Int. Appl., WO 2008117148 A1 20081002 (2008)<br></p>

<p>Applications 4-Biphenylcarboxylic acid (cas# 92-92-2) is a useful research chemical.<br></p>

<p>Applications Benzyltrimethylammonium dichloroiodate is used in the mechanism of oxidation.<br>References Srinivasan, N., et al.: Tetrahedron, 30, 419 (1974), Sankhla, R., et al.: J. Chem. Res., 0465 (2002),<br></p>

<p>Applications 5-Amino-2-bromobenzoic acid (cas# 2840-02-0) is a useful research chemical.<br></p>

<p>Applications PROPYL 3,5-DICHLORO-4-HYDROXYBENZOATE (cas# 101003-80-9) is a useful research chemical.<br></p>

<p>Applications 2-amino-6-hydroxybenzoic acid (cas# 567-62-4) is a useful research chemical.<br></p>

<p>Applications Used for the preparation of dihydrouracils as anti-ictogenic or anti-epileptogenic agents.<br>References Akoulitchev, S., et al.: Nature, 377, 557 (1995), Marshall, N., et al.: J. Biol. Chem., 270, 12335 (1995), Marshall, N., et al.: J. Biol. Chem., 271, 27176 (1996), Shapiro, G., et al.: J. Clin. Oncol., 24, 1770 (2006),<br></p>

<p>Applications Methyl 4-Bromophenylacetate (cas# 41841-16-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-(2H-1,3-benzodioxol-5-yl)prop-2-en-1-ol (cas# 5208-87-7) is a useful research chemical.<br></p>

<p>Applications 4-Nitrotoluene is an explosive material.<br>References Wollseifen, Rainer, et al.: Separation, 35(1), 28-30 (2015);Cao, Anping, et al.: Nano Letters, 17(1), 1-7 (2017)<br></p>

<p>Applications 1-(2-AMINO-5-HYDROXYPHENYL)ETHANONE (cas# 30954-71-3) is a useful research chemical.<br></p>

<p>Applications Benzyl (2S)-2-carbobenzyloxyamino-6-hydroxyhexanoate (cas# 84246-49-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 3,4-dihydro-2H-1-benzopyran (cas# 493-08-3) is a useful research chemical.<br></p>

<p>Applications Tetrahydro-2H-pyran-2-ol (cas# 694-54-2) is a useful research chemical.<br></p>

<p>Applications 5-[2-(Trifluoromethyl)phenyl]-2-furoic Acid is a chemical reagent used in the preparation of novel TRPV1 antagonists. Also used in the preparation of potent inhibitors of FeII and MnII E, coli Methionine Aminopeptidase as antibacterial agents.<br>References Huguet, F. et al.: ChemMedChem. 7, 1020 (2012); Kim, N. et al.: Chem. Asian J., 8, 400 (2013);<br></p>

<p>Applications 6-Cyclohexylhexanoic Acid (cas# 4354-56-7) is useful for the preparation of N-​Acylethanolamine Acid Amidase (NAAA) inhibitors, which exhibit anti-inflammatory and analgesic activities.<br>References Ren, J., et al.: RSC Advances, 7, 12455 (2017)<br></p>