6-membered Rings

<p>Applications A benzoic acid derivative used in the preparation of potent, selective, orally bioavailable matrix metalloproteinase inhibitors.<br>References Wada, C. et al.: J. Med. Chem., 45, 219 (2002)<br></p>

<p>Applications 2,4-Dinitrobenzenesulfonic Acid (cas# 89-02-1) is a useful research chemical.<br></p>

<p>Applications Cyclohexanecarbonyl Chloride is used to prepare 1,2,3-triazoles as inhibitors of human immunodeficiency virus type 1 protease. It was also used to synthesize benzothiazole as potent antitumor agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Whiting, M., et al.: J. Med. Chem., 49, 7697 (2006); Yoshida, M., et al.: Bioorg. Med. Chem. Lett., 15, 3328 (2005)<br></p>

<p>Stability -20°C Freezer<br>Applications Useful reagent for preparing amino acid pentachlorophenol active esters.<br>References Kovacs, J., et al.: J. Am. Chem. Soc., 89, 183 (1967)<br></p>

<p>Applications 3,3-Diphenylpropionic Acid is used in the preparation of steroid 5α-reductase inhibiting acylpiperidines. It can also be used in the preparation of calpain-inhibitory piptidyl α-ketoacids and esters.<br>References Picard, F. et al.: J. Med. Chem., 45, 3406 (2002); Donkor, I. et al.: J. Med. Chem., 51, 4346 (2008);<br></p>

<p>Applications Tetrabenzylpentaerythritol is used as a reagent in the preparation of esters via esterification of carboxylic acids with alcohols using uronium-based coupling agents. It is also an intermediate in B536540.<br>References Twibaniere, J. K., et al.: Org. Lett., 13, 2988 (2011);<br></p>

<p>Applications α-Hydroxy-3,4-bis(phenylmethoxy)benzeneacetic Acid Phenylmethyl Ester is an protected intermediate in the synthesis of metabolites of Catecholamines.<br></p>

<p>Applications Methyl 2-(3-Nitrobenzylidene)-3-oxobutanoate is a useful reactant in organic synthesis.<br>References Miao, Chun-Bao, et al.: Heterocycles, 87(4), 853-859 (2013);Kang, Soosung, et al.: Bioorg. &amp; Med. Chem., 21(14), 4365-4373 (2013);Li, Wan, et al.: Archiv der Pharmazie (Weinheim, Germany), 346(9), 635-644 (2013)<br></p>

<p>Applications Methyl 5-(2,2-Dibromoacetyl)-2-hydroxybenzoate is a by-product in the synthesis of Labetalol-1-carboxylic Acid (L096510), an impurity of the α-and β-adrenergic, Labetalol (L096500).<br></p>

<p>Applications 4-Phenylmorpholine, is a biochemical reagent used in various chemical synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications TRIPHENYLSILANE (cas# 789-25-3) is a useful research chemical.<br></p>

<p>Applications rac-trans-[3-Hydroxycyclohexyl]benzamide (cas# 177366-90-4) is a compound useful in organic synthesis.<br></p>

<p>Applications (2-Cyclobuten-1-ylseleno)-benzene is an intermediate used in synthesizing 2-Cyclobutenyl-3-trifluoromethyl-5-chloro-1H-indole-1-carboxylic Acid Ethyl Ester, which is synthesized from 5-chloro-2-oxindole (C375030), that is used in the preparation of novel GSK-3β inhibitors as anticancer agents.<br>References Choi, M.J., et al.: Bull. Korean. Chem. Soc., 32, 2015 (2011); Otani, M., et al.: Bioorg. Med. Chem. Lett.. 20, 4259 (2010); Jhan, Y.H., et al.: Tetrahedron. Lett., 54, 1155 (2013); Hsieh, J.C., et al.: Org. Biomolec. Chem., 10, 6404 (2012);<br></p>

<p>Applications 4,4'-Diethylbiphenyl (cas# 13049-40-6) is a useful research chemical.<br></p>

<p>Applications 5-Amino-2-chlorobenzoic Acid is a reagent in the preparation of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.<br>References Sleebs, B.E., et al.: J. Med. Chem., 56, 5514, (2013)<br></p>

<p>Applications 4-Benzyloxy-2-(2’-carbomethoxy)thiophenylaniline (cas# 329217-05-2) is a compound useful in organic synthesis.<br></p>

<p>Applications Methyl 2-benzylhydrazinecarboxylate is an intermediate for the synthesis of CFM 1571 Hydrochloride (C291720), which acts as a soluble guanylyl cyclase (sGC) activator while ignoring adenylyl cyclase. Inhibits collagen-stimulated platelet aggregation in vitro.<br>References Kotzki, S. et al.: J. Pharm. Exp. Ther., 346, 424 (2013); Selwood, D&gt; et al.: J. Med. CHem., 44, 78 (2001)<br></p>

<p>Applications Perfume and flavoring material.<br></p>

<p>Applications Reagent used in the preparation of carbazole derivatives<br>References Dong, Y., et al.: J. Med. Chem., 48, 4953 (2005),<br></p>

<p>Applications Tetraethylammonium P-Toluenesulfonate (cas# 733-44-8) is a useful research chemical.<br></p>

<p>Applications p-Xylene is a colorless organic solvent. It is used in the production of benzoic, isophthalic and tetraphillic acids.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bramucci, M., et al.: Appl. Microbiol. Biotechnol., 58, 255 (2002)<br></p>

<p>Applications α-Chlorophenylacetyl Chloride is a reagent used for dehydrohalogenation of ketones.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Brady, W.T., et al.: J. Org. Chem., 45, 3525 (1980); Brady, W.T., et al.: J. Org. Chem., 45, 2025 (1980);<br></p>

<p>Applications tert-Butyl (Triphenylphosphoranylidene)carbamate is used in the preparation of ketimines.<br>References Yan, W., et. al.: Organic Lett., 14, 2512 (2012)<br></p>

<p>Applications 5-Amino-2-chloro-4-fluorobenzoic Acid is an intermediate in the synthesis of Saflufenacil-d7 (S081802). Saflufenacil-d7 is the labeled version of Saflufenacil (S081800), which is a herbicide of the pyrimidinedione chemical class used for the preplant burndown and selective preemergence dicot weed control in different field crops. It was found to inhibit protoporphyrinogen IX oxidase (PPO) enzyme.<br>References Knezevic, S., et al.: Crop Prot., 29, 148 (2010); Grossmann, K., et al.: Weed Sci., 58, 1 (2010)<br></p>

<p>Applications 1-Methyl-2-nitrobenzene is a toxic pollutant of the environment because of its large scale use in the production of explosives. It is a useful synthetic intermediate. It shows carcinogenic activity in rats.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sikandar, M., et al.: Chemosphere, 90, 1920 (2013); Jones, C., et al.: Carcinogen., 24, 779 (2003)<br></p>

<p>Applications N-(β-Cyanoethyl)-N-(ethoxycarbonylethyl)benzylamine is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications E-3-(4-Benzyloxy)-1-(2.4-bisbenzyloxy-6-hydroxy)phenyl)propenone (cas# 88607-79-8) is a compound useful in organic synthesis.<br></p>

<p>Applications Tetrahydropyran is a useful synthetic intermediate. Tetrahydropyranyl (THP-) ethers derived from the reaction of alcohols and dihydropyran are common intermediates in organic synthesis. In organic synthesis, the 2-tetrahydropyranyl group is used as a protecting group for alcohols.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Earl, R., et al.: Org. Synth., 7, 334 (1990); Kluge, A.: Org. Synth., 7, 160 (1990)<br></p>

<p>Applications 2-Benzylaniline was used to study efficient and convenient heterogeneous palladium-catalyzed regioselective deuteration at the benzylic position.<br>References Kurita, T., et al.: Chem. Eur. J., 14, 664 (2008);<br></p>

<p>Applications Intermediate in the preparation of alkoxycarbonylthiazolethione derivatives.<br></p>

<p>Applications 1-(3,4-Dimethoxyphenyl)-2-butanone (cas# 884-06-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-Ethynylcyclohexanol is used in the preparation of 9-methyladenines used as adenosine receptor antagonists. Also used in the cycloadition of alkynes to organic azides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Harada, H. et al.: J. Med. Chem. 44, 170 (2001); Zhang, L. et al.: J. Am. Chem. Soc., 127, 15998 (2005);<br></p>

<p>Applications [3-[(Trimethylsilyl)oxy]-2-cyclohexen-1-yl]-benzene (cas# 108643-81-8) is a compound useful in organic synthesis.<br></p>

<p>Applications Phenyl 2-Chloroethyl Ether (cas# 622-86-6) is a compound useful in organic synthesis.<br></p>

<p>Applications (R)-6-Benzyloxy-8-(oxiran-2-yl)-4H-benzo[1,4]oxazin-3-one is an intermediate in the synthesis of Olodaterol (O262000), a novel inhaled β2-adrenoceptor agonist with a 24h bronchodilatory efficacy.<br>References Bouyssou, T., et al.: Bioorg. Med. Chem. Lett., 20, 1410 (2010);<br></p>

<p>Applications 6-Amino-5-(1,1-dimethylethyl)-3,3-dimethyl-2(3H)-benzofuranone is an intermediate in synthesizing Ivacaftor Carboxylic Acid (I940605). It is an impurity of Ivacaftor (I940600); a drug used in the treatment of cystic fibrosis.<br>References Clancy, J. et al.: Am. J. Resp. Crit. Care. Med., 186, 593 (2012)<br></p>

<p>Applications 4-Oxocyclohexanecarboxylic Acid is used in the preparation of Indomethacin (I641000) analogues used in the treatment of prostate cancer. In addition it is used in the synthesis of β-alanine derivatives as glucagon receptor antagonists.<br>References Liedtke, A. et al.: J. Med. Chem., 56, 2429 (2013); Lau, J. et al.: J. Med. Chem., 50, 113 (2007);<br></p>

<p>Applications 9-Chloro-dibenzo[b,f][1,4]thiazepin-11(10H)-one is an intermediate in the synthesis of 9-Chloro Quetiapine (C366040). 9-Chloro Quetiapine is an impurity of Quetiapine hemifumarate (Q510000), a dibenzothiazepine antipsychotic medication used in the treatment of schizophrenia.<br>References Kumar, K., et al.: Org. Chem.: An Indian Journal, 8, 164 (2012); Raju, I., et al.: Chromatographia, 70, 545 (2009)<br></p>

<p>Applications 2,6-Dimethoxytoluene is an organic synthesis intermediate.<br>References Liu, C., et al.: Bioorg. Med. Chem., 24, 4263 (2016); Della S., et al.: J. Org. Chem., 81, 5726 (2016); Zhang, M., et al.: Asian J. Org. Chem., 4, 1047 (2015); Peixoto, P. A., et al.: J. Am. Chem. Soc., 136, 15248 (2014)<br></p>

<p>Applications (R)-(-)-2,2-Dimethyl-1,3-dioxolan-4-ylmethyl p-Toluenesulfonate is a chiral building block. It is used to prepare the antifungal agent ketoconazole. It is also used to prepare acyclic Nucleotide Analogs Derived from 8-Azapurines with antiviral activities.<br>References Rotstein, D., et al.: J. Med. Chem., 35, 2818 (1992); Holy, A., et al.: J. Med. Chem., 39, 4073 (1996)<br></p>

<p>Applications Benzyl 4-Fluorophenyl Ketone is used in the preparation and evaluation of 2,3-diarylpyrazines and quinoxalines as selective COX-2 inhibitors.<br>References Singh, S. et al.: Bioorg. Med. Chem., 12, 1881 (2004);<br></p>

<p>Applications Benzyl 6-Oxohexanoate is an intermediate in the synthesis of N-5-Carboxypentyl-1-deoxynojirimycin (C181200), which is a ligand used for the preparation of an affinity resin highly specific for glucosidase I purification. Glucosidase I is involved in the post-translational processing of N-linked glycoproteins.<br>References HettKamp, H., et al.: Eur. J. Biochem., 142, 85 (1984); Shailubhai, K., et al.: Biochem. J., 247, 555 (1987); Bause, E., et al.: FEBS, 278, 167 (1991)<br></p>

<p>Applications 9-Hydroxydecanoic Acid Benzyl Ester is an intermediate in the synthesis of Monocarboxyisodecyl Phthalate (M525575), a metabolite of Dibutyl phthalate (DBP) (D429495), which is found widely in consumer products.<br>References Weber, A. E., et al.: J. Med. Chem., 35, 3755 (1992);<br></p>

<p>Applications 1-(Phenylmethoxy)-3-(2-propen-1-yloxy)-2-propanol (cas# 83016-75-5) is a compound useful in organic synthesis.<br></p>

<p>Applications An intermediate in the preparation of Digallic Acid<br></p>

<p>Applications Diphenyliodonium chloride &gt;=98.0% (AT) (cas# 1483-72-3) is a useful research chemical.<br></p>

<p>Applications 1-(Benzyloxy)-3-[[bis(benzyloxy)phosphoryl]oxy]propan-2-ol is an intermediate in the synthesis of Dihydroxyacetone Phosphate Lithium Salt (D450538), which is a metabolic intermediate involved in involved in a wide variety of metabolic pathways including glycolysis and lipid biosynthesis. In plants, Dihydroxyacetone phosphate is involved with the synthesis of vitamin B6.<br>References Jun Ogawa et. al.: et al.: Bioscience, biotechnology, and biochemistry, 67(4), undefined (2003-6-6); John P Richard, Biochemistry, 51(13), undefined (2012-3-14);<br></p>

<p>Applications 5-(4-Hydroxypentyl)-1,3-benzenediol is an intermediate used in the synthesis of 4''-Hydroxycannabidiol (H824830), which is a metabolite of Canabidiol (C175300), a major constituents in marijuana. 4''-Hydroxycannabidiol be used to investigate canabidiol metabolism and human liver microsomes that metabolize Canabidiol into 6α-Hydroxycannabidiol.<br>References Jiang, R., et al.: Life Sci. 89, 165 (2011); Lander, N., et al.: Science 169, 611 (1970)<br></p>

<p>Applications Phenylselenyl Bromide is used as a reagent in the synthesis of the antihyperglycemic agent, (+)-Antroquinonol. Phenylselenyl Bromide is also used in the preparation of 9-epi-Artemisinin (A777505); the chiral isomer of Artemisinin (A777500) which is an antimalarial.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sulake, R.S., et al.: J. Org. Chem., 80, 6044 (2015); Orabi, K.Y. et al.: Phytochem., 51, 257 (1999); Jefford, C.W. et al.: Helv. Chim. Acta, 83, 1239 (2000); Klayman, D.L., et al.: Science, 228, 1049 (1985)<br></p>

<p>Applications 1-(Benzyloxy)propan-2-one (cas# 22539-93-1) is a useful research chemical.<br></p>

<p>Applications Wittig reagent.<br></p>

<p>Applications N-(Methoxymethyl)-N-[(trimethylsilyl)methyl]benzenemethanamine is used in the synthesis of pyrrolidine derivatives as novel sodium channel blockers used to treat ischemic related ailments.<br>References Seki, M. et al.: Bioorg. Med. Chem. Lett., 23, 4230 (2013);<br></p>

<p>Applications 1-(4-sec-Butylphenyl)ethanone is a useful synthetic intermediate in the synthesis of 2-(p-sec-Butylphenyl)propionic Acid (B692720); an impurity of Ibuprofen (I140000) which is a selective cyclooxygenase inhibitor (IC50=14.9uM) that inhibits PGH synthase-1 and PGH synthase-2 with comparable potency.<br>References Busson, M., et al.: J. Int. Med Res., 14, 53 (1986); Meade, E.A., et al.: J. Biol. Chem., 268, 6610 (1993); Davies, N.M., et al.: Clin. Pharmacokinet., 34, 101 (1998)<br></p>

<p>Applications Chlorobis(4-fluorophenyl)methane is a compound involved in the synthesis of 1-[bis(4-fluorophenyl)methyl]-4-cinnamylpiperazine, a T-type calcium channel blocker and anti-ischemic drug.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Narsaiah, A.V., et al.: Indian J. Chem., 7, 105-107 (2011)<br></p>

<p>Applications 2-(4-Nitro-2-ethoxyphenyl)pthalimide (cas# 106981-60-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Methyl 3-(4-Hydroxy-benzyl)-3-oxopropanoate (cas# 1391053-46-5) is a compound useful in organic synthesis.<br></p>

<p>Applications α-Hydroxy-4-(2-oxiranylmethoxy)-benzeneacetamide is an intermediate in the synthesis of hydroxyatenolol (H802480), which is a metabolite of Atenolol (A790075); a cardioselective β-adrenergic blocker, antihypertensive, antianginal, and antiarrhythmic (class II).<br>References Escher, B., et al.: Environ. Sci. Technol., 40, 7402 (2006); Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984)<br></p>

<p>Applications 6,7-Dinitro-2,3-dihydro-benzo[1,4]dioxime (cas# 57356-48-6) is a compound useful in organic synthesis.<br></p>

<p>Applications N-(3-Chloro-4-fluorophenyl)-2-cyanoacetamide (cas# 219529-31-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 4,5-Dimethyl-o-phenylenediamine is used in biological processes as a substrate for CobT nicotinate-mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase from Salmonella typhimurium LT2.<br>References Trzebiatowski, J.R., et al.: J. Biol. Chem., 272, 17662 (1997); Johnson, M.G., et al., J. Biol. Chem., 267, 13302 (1992); Cheong, C., et al.: J. Biol. Chem., 277, 41120 (2002)<br></p>

<p>Applications N-(3-Acetylphenyl)-N-ethylacetamide is a reactant used in the preparation of 5-Oxo-Zaleplon (O870470), a metabolite of Zaleplon (Z145000).<br></p>

<p>Applications Intermediate in the production of Bufuralol Hydrochloride<br></p>

<p>Applications 2-(2,6-Dimethyl-3-hydroxyphenyl)-3-oxo-2-azaindolizidine (cas# 1796881-08-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(((10-(Benzyloxy)-10-oxodecan-2-yl)oxy)carbonyl)benzoic Acid is an intermediate in the synthesis of Monocarboxyisodecyl Phthalate (M525575), a metabolite of Dibutyl phthalate (DBP) (D429495), which is found widely in consumer products.<br></p>

<p>Applications N-(2-Chloroethyl)benzenesulfonamide is an intermediate for the synthesis of Bensulide (B166000), which is an organophosphate acetylcholinesterase inhibitor used as an herbicide (1) in the protection of crops through pesticides (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br></p>

<p>Applications 9-(Benzyloxy)-3,7-dimethylnona-1,7-dien-4-ol is an intermediate in the synthesis of Menaquinone 6 (M218590). Menaquinones are isoprenoid quinones of the naphthalene series and belongs to the K2 Vitamin homologs. Menaquinones were originally discovered as the anti-hemorrhagic factor and now encompasses a variety of physiological processes. Menaquinone-6 were the major isoprenoid quinones found in membrane preparations of Campylobacter jejuni and Campylobacter fetus.<br>References Kiesel, B., et al.: Biodegradation, 19, 435 (2008), Suhara, Y., et al.: Bioorg. Med. Chem., 16, 3108 (2008), Gast, G., et al.: Nut., Metab., Cardiovas., Diseases, 19, 504 (2009); Carlone G.M., et al.: J. Gen. Microbiol., 129, 3385 (1983);<br></p>

<p>Applications 2-Nitrobenzylcyanide (cas# 610-66-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 5,7-Bis-(benzyloxy)-2-(4-(benzyloxy)phenyl)-4H-chromen-4-one (cas# 96333-59-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Benzoylbenzoic acid is a reagent that is used in the synthesis of BzATP Triethylammonium Salt, which is a selective P2X purinergic agonist. It is more potent than ATP at homodimeric P2X7 receptors.<br>References Cole, D., Yount, R.: J. Biol. Chem., 265, 22537 (1990); Atarashi, K., et al.: Nature, 455, 808 (2008)<br></p>

<p>Applications 2-Phenylpropionitrile (cas# 1823-91-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Nitrobenzonitrile (cas# 619-72-7) is a useful research chemical.<br></p>

<p>Applications N-[2-[3,4-Bis(phenylmethoxy)phenyl]ethyl]-3,4,5-trimethoxybenzeneacetamide is an intermediate used in the synthesis of S-(-)-Tretoquinol Hydrochloride (T798100), which belongs to the class of adrenergic inhalants, selective β-2-adrenoreceptor agonists. S-(-)-Tretoquinol is used in the treatment of obstructive airway diseases. S-(-)-Tretoquinol is a bronchodilator.<br>References Meshi, et al.: Biochem. Pharmacol., 19, 2937 (1970), Satoh, et al.: Chem. Pharm. Bull., 19, 667 (1971),<br></p>

<p>Applications 4-(Benzyloxy)-2-hydroxy-5-(sulfooxy)benzoic Acid is an intermediate used in the synthesis of 4-Hydroxy Flecainide (H942485), which is an analogue of Flecainide (F390000).<br>References Blom, Y., et al.: J. Chromatogr., 653, 138 (1993),<br></p>

<p>Applications 4-Benzoylbiphenyl is a reagent used in the synthesis of multicolored mechanochromic luminogen molecules.<br>References Zhao, Z. et al.: J. Mat. Chem. C. Mat. Opt. Elec. Dev., 4, 4800 (2016);<br></p>

<p>Applications p-Toluenesulfonyl Isocyanate has been used to react with a prepolymer with the OH-functionality.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Muenker, A.H., Hudson, B.E.: J. Macromol. Sci. Chem., 3, 1465 (1969)<br></p>

<p>Applications An intermediate used in the production of various ectoparasiticides, drug metabolites and analgesic agents.<br>References Rastogi, S., et al.: J. Med. Chem., 16, 797 (1973), Maguire, J., et al.: Drug Metab. Disposition, 9, 393 (1981),<br></p>

<p>Applications 3-(4-Aminophenyl)propionic acid (cas# 2393-17-1) is a useful research chemical.<br></p>

<p>Applications 2-(4-Octylphenyl)ethyl Acetate (cas# 162358-04-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,3,5-Trimethylbenzonitrile is an methyl-substituted benzonitrile is an intermediate in the synthesis of Ketoprofen (K200800) related compounds.<br></p>

<p>Applications rac-cis-[3-Hydroxycyclohexyl]benzamide (cas# 177366-89-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-(4-Benzylphenyl)ethanone is used in the preparation of di- and triarylmethanes through palladium-catalyzed reductive coupling of N-tosylhydrazones and aryl bromides.<br>References Xia, Y., et al.: Synthesis., 49, 1073-1086 (2017)<br></p>

<p>Applications 2-(4-Acetoxyphenyl)ethanol is an intermediate in synthesizing Oleocanthal (O524540). It is a compound of olive oil with potential use as anti-inflammatory and chemotherapeutic agents.<br>References Scotece, M., et. al.: Drug Discovery Today, 20, 406 (2015)<br></p>

<p>Applications 3-(3-(3-(Benzyloxy)propoxy)propoxy)propan-1-ol is an intermediate in the synthesis of 3,3'-[Oxybis(3,1-propanediyloxy)]bis[1-propanol] (O870290). 3,3'-[Oxybis(3,1-propanediyloxy)]bis[1-propanol] is derived from 3-(Benzyloxy)propyl 4-Toluenesulfonate (B288830), which is used as a reagent in the synthesis of Silodosin (S465000); an antidysuria drug. 3-(Benzyloxy)propyl 4-Toluenesulfonate is also used as a reagent in the preparation of aryloxyalkyl derivatives of adenine which have antiviral activity.<br>References Calogero, F., et al.: Eur. J. Org. Chem., 2015, 6011 (2015); Petrov, V.I., et al.: Chem. Heterocyc. Compd., 39, 1218 (2003)<br></p>

<p>Applications 5,6-Dihydro-6-ethenyl-4-hydroxy-2H-pyran-2-one is an intermediate in the synthesis of 4’-Hydroxy rac-Kavain (H944520), which is a metabolite of Kavain (K145490), shown in recent research to exhibit protective properties on anaerobic glycolysis, ATP content and intracellular calcium and sodium of anoxic brain vesicles.<br>References Gleitz, J., et al: Neuropharmacol., 35, 1743 (1997); Hashimoto, T., et al.: Phytomedicine, 10, 309 (2003); Mulholland, P.J., et al.: Brain. Res., 945, 106 (2002);<br></p>

<p>Applications Phosphorylating reagent<br></p>

<p>Applications (3-(((2-Hydroxyethyl)(methyl)amino)methyl)phenyl)(phenyl)methanone-d3 is an intermediate in the synthesis of Nefopam-d3 (N389402), a cyclized labelled analog of orphenadrine and diphenhydramine; representative of a new class of centrally acting skeletal muscle relaxants.<br>References Bassett, et al.: Br. J. Pharmacol., 37, 69 (1969), Klohs, et al.: Arzneim.-Forsch., 22, 132 (1972), Hell, et al.: Drugs, 19, 249 (1980),<br></p>