6-membered Rings

<p>Applications 2-((tert-bButoxycarbonyl)amino)-2-(hydroxymethyl)-4-(4-octylphenyl)butyl Acetate is the intermediate in the synthesis of Mono-O-acetyl Fingolimod TFA (F524600), which is an impurity of Fingolimod (F805000, HCl salt) which is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs.<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001). Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002). Mtaloubian, M., et al.: Nature, 427, 355 (2004)<br></p>

<p>Applications 2-Ethoxy-4-ethoxysulfonylbenzoic Acid is a derivative of Methyl 2-Ethoxybenzoate (M220113), a useful chemical reagent, used in the synthesis and antibacterial triazoles and oxadiazoles, as well as sulfonamide compounds.<br>References Shi, Z. et al.: Compt. Rend. Chim., 18, 1320 (2015);<br></p>

<p>Applications 4-(Dihydroxyborophenyl)acetylene is a reagent used in organic synthesis . It is used in the preparation of purine analogs as PI4K IIIβ inhibitors used in cancer treatment. As well, used in the preparation of demethylase inhibitors for their potential as anti-tumor drugs.<br>References Sala, M. et al. Bioorg. Med. Chem. Lett., 26, 2706 (2016); Wu, F. et al.: J. Med. Chem., 59, 253 (2016);<br></p>

<p>Applications 4,5,6,7-Tetrahydro-7-oxo-benzo[b]thiophene-4-carbonitrile is a useful synthetic intermediate.<br></p>

<p>Applications 1,4-Benzodioxan-2-carbonitrile (cas# 1008-92-0) is a compound useful in organic synthesis.<br></p>

<p>Applications m-Xylene is an organic solvent used in histology. It is also used after tissue sections have been stained to make them hydrophobic so a coverslip may be applied with a resin in solvent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Watanabe, M., et al.: Stain Technol., 50, 239 (1975); Wishe, H., et al.: Anat. Rec., 197, 283 (1980); Wolf, E.: Acta Histochem. Suppl., 35, 179 (1988); Dykewicz, M.: J. Allergy Clin. Immunol., 87 (1991)<br></p>

<p>Applications 1,1'-[Oxybis(3,1-propanediyloxymethylene)]bis-benzene is an intermediate in the synthesis of 3,3'-[Oxybis(3,1-propanediyloxy)]bis[1-propanol] (O870290). 3,3'-[Oxybis(3,1-propanediyloxy)]bis[1-propanol] is derived from 3-(Benzyloxy)propyl 4-Toluenesulfonate (B288830), which is used as a reagent in the synthesis of Silodosin (S465000); an antidysuria drug. 3-(Benzyloxy)propyl 4-Toluenesulfonate is also used as a reagent in the preparation of aryloxyalkyl derivatives of adenine which have antiviral activity.<br>References Calogero, F., et al.: Eur. J. Org. Chem., 2015, 6011 (2015); Petrov, V.I., et al.: Chem. Heterocyc. Compd., 39, 1218 (2003)<br></p>

<p>Applications 1-TERT-BUTYL-3-ETHYLBENZENE (cas# 14411-56-4) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Methyl 3-(Hydroxymethyl)benzoate is used in the synthetic preparation of N-acylhydrazone derivatives as lactate dehydrogenase A inhibitors.<br>References Rupiani, S., et al.: J. Med. Chem., 101, 70 (2015)<br></p>

<p>Applications 2-Aminomethylphenylacetic Acid is an intermediate of Ceforanide (C242930), a cephalosporin based antibiotic used in the sterilization in various medical procedures.<br>References Zhao, Y., et. al.: Res. Chem. Int. 40, 1637 (2014); Sifakis, S. et al.: Arch. Gyne. Obst., 272, 201 (2005); DiPiro, J. et al.: Antimicrob. Agents Chemother., 27, 287 (1985)<br></p>

<p>Applications 4-benzylcyclohexan-1-one (cas# 35883-77-3) is a useful research chemical.<br></p>

<p>Applications Perphenylcyclopentasilane is an intermediate in the synthesis of Cyclopentasilane (C988380), a reagent used for depositing silicon on surfaces for electronics applications.<br>References Morisaki, Y., et al.: Chem. Lett., 38, 498 (2009);<br></p>

<p>Applications 1-​(3-​Hydroxyphenyl)​-​1-​propanone is a reactant used to synthesize tricyclic fused pyridines, a family of alkaloids with antimalarial activity.<br>References Zheng, L., et al.: J. Org. Chem., 81, 8911-8919 (2016)<br></p>

<p>Applications A hydroxy derivative of dibenzothiophene. Coal model compound used in chemical coal cleaning studies with molten hydroxides.<br>References Nowak, M.A. et al.: Coal Prep., 7, 29 (1989); Nishioka, M. et al.: Anal. Chem., 57, 1327 (1985);<br></p>

<p>Applications o-Iodochlorobenzene is a building block that has been used as a reactant for the synthesis of biaryl derivatives of seasamol used for their antioxidant activity against DPPH radical.<br>References Rodriguez, S.A., et. al.: Australian J. Chem., 66, 1334 (2013)<br></p>

<p>Applications 1,4-Cyclohexanedimethanol diglycidyl ether (cas# 14228-73-0) is a useful research chemical.<br></p>

<p>Applications Methyl 2-(Isocyanatosulfonyl)benzoate is an intermediate in the synthesis of Metsulfuron (M227745), a powerful herbicide used in the control of pests and protection of crops and produce.<br>References Anderson, J. et al.: J. Agric. Food Chem., 37, 1429 (1989); Ivany, J. et al.: Can. J. Plant Sci., 67, 1083 (1987);<br></p>

<p>Applications 2-Biphenylmethanol is a useful reactant in organic synthesis.<br>References Li, Zheng, et al.: Bioorg. &amp; Med. Chem., 25(24), 6647-6652 (2017);Shi, Guangfa, et al.: Org. Let., 18(12), 2958-2961 (2016)<br></p>

<p>Applications Cyclohexyl Vinyl Ketone is a reagent used in the synthesis of α,β-unsaturated carbonyl compounds which are aminotrifluoromethylathiolated.<br>References Xiao, Q. et al.: Org. LEtt., 17, 6090 (2015) ;<br></p>

<p>Applications N-benzyl-2,2-dichloroacetamide (cas# 6063-50-9) is a useful research chemical.<br></p>

<p>Applications 4'-Hydroxybiphenyl-3-carboxylic Acid is a biaryl compound that can be prepared via palladium bis[(dipiperidinylphosphino)amino]phenyl-catalyzed Suzuki-Miyaura cross coupling reactions of organoboronic acids or trifluoroborates and aryl bromides and can also be synthesized by simultaneous hydroxylation and carboxylation of biphenyls. 4'-Hydroxybiphenyl-3-carboxylic Acid is a useful building block with applications in various syntheses.<br>References Shibahara, F., et al.: Org. Lett., 6, 2437 (2004); Bolliger, J., Frech, C.: Adv. Synth. Catal., 352, 1075 (2010);<br></p>

<p>Applications Benzenesulfonyl Chloride is used in the synthesis of cecloprotoberberine derivatives as antitumor agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, Y. et al.: Eur. J. Med. Chem., 68, 463 (2013);<br></p>

<p>Applications 4-Nitrobenzyl Acetoacetate acts as a reagent in the preparation of panipenem via esterification of nitrobenzyl alcohol followed by substitution, cyclizations and hydrogenation. Panipenem I is a new carbapenem antibiotic for the treatment of inflammation.<br>References Fang, H., et al.: hongguo Yaowu Huaxue Zazhi, 21, 216 (2011)<br></p>

<p>Applications 3-Hydroxybenzyl Alcohol, is shown to have antioxidant and free radical scavenging activity.<br>References Dhiman, S., et al.: Chemi-Bio. Interac., 182, 119 (2009); Alfaro, C., et al.: Mutation Res., 539(1-2), 187 (2003);<br></p>

<p>Applications N-(4-Chlorophenyl)-2,6-Difluorobenzamide (cas# 122987-01-3) is a useful research chemical.<br></p>

<p>Applications Reagent used in the preparation of pharmaceutically active Dibenzocyclohenptenes.<br></p>

<p>Applications 1,4-Cyclohexanediamine<br></p>

<p>Applications 5-Fluoro-2-mercaptobenzothiazole is used as a reagent in the synthesis of [[(benzothiazolyl)thio]methyl]phenyl]furanone derivatives with agrochemical fungicidal activities.<br>References Zhao, P., et al.: Youji Huaxue, 30, 1567 (2010);<br></p>

<p>Applications An intermediate in the preparation of Digallic Acid<br></p>

<p>Applications tert-Butyl N-(Benzyloxy)carbamate has been used in the synthesis of Deferoxamine Mesylate (D228980), an iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients<br>References Bergeron RJ, et al. 1992. J Med Chem. Dec 11;35(25):4739-44Inati A, et al. 2010. Am J Hematol. Oct;85(10):782-6 Selim M, et al. 2010. Transl Stroke Res. Mar;1(1):35-9<br></p>

<p>Applications 2-Cyclohexylethanol is a useful building block, and has recently been used in a green preparation of oxidative esterification of primary alcohols.<br>References Reddy, N.; et al.: Synth. Commun., 48, 1663 (2018).<br></p>

<p>Applications 4-tert-Butoxyphenylboronic Acid is a compound used in the preparation of nitrophenylphenol via cross-coupling reaction of nitrohalobenzenes with phenylboronic acids and deprotection.<br>References Kumamoto, N., et al.: Preparation of nitrophenylphenol, JP 2001055360 (2001);<br></p>

<p>Applications 8-chloro-2,3-dihydro-1,4-benzodioxine-5-carboxylic Acid (cas# 66411-24-3) is a useful research chemical.<br></p>

<p>Applications 5-formyl-2-(morpholin-4-yl)benzonitrile (cas# 1272756-61-2) is a useful research chemical.<br></p>

<p>Applications Benzyltriphenylphosphonium bromide is a useful reactant and reagent for organic reactions and synthesis.<br>References Hajra, S., et al.: Chem. Comm., 47, 3981-82 (2011); Smith, M.J., et al.: Org. Lett., 2011, 13, 3396-98;<br></p>

<p>Applications 1-Phenyl-2-(p-tolyl)ethylamine is an intermediate used to prepare γ-nitroaldehydes with quaternary stereogenic centers.<br>References Angewandte Chemie, International Edition, 52, 7228 (2013)<br></p>

<p>Applications Monobenzyl Miglustat is a useful synthetic intermediate.<br></p>

<p>Applications 2-(2-Benzyloxyphenoxy)ethylamine (cas# 72955-81-8) is a compound useful in organic synthesis.<br></p>

<p>Applications Methyl 2-Phenoxybenzoylformate is an intermediate in the synthesis of (Z)-Metominostrobin (M338758), a fungicide for rice plants.<br></p>

<p>Applications O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine can be used to treat fibrotic and inflammatory diseases.<br>References Gomer, R.H., et.al., PCT Int. Appl., 167, (2020);<br></p>

<p>Applications methyl 4-(bromomethyl)-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (cas# 1626407-50-8) is a useful research chemical.<br></p>

<p>Applications 1-(2-Phenylethynyl)cyclohexanamine is a reactant that functions as a catalyst in the cyclization of propargylamines.<br>References Zhao, D. et al.: ChemCatChem., 9, 4598 (2017); Yuan, R. et al.: J. Org. Chem., 82, 3639 (2017);<br></p>

<p>Stability Hygroscopic<br>Applications [3-(Ethoxycarbonyl)propyl]triphenylphosphonium Bromide is a reactant used in the preparation of maresin 1, a potent anti-inflammatory and pro-resolving lipid mediator.<br>References Tungen, J.E., et. al.: Tetrahedron Lett., 56, 1843 (2015)<br></p>

<p>Applications N-(4-Hydroxymethylbenzyl)trifluoroacetamide (cas# 171723-95-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-phenyloxolan-2-one (cas# 1008-73-7) is a useful research chemical.<br></p>

<p>Applications 2,5-Dimethylbenzene-1,4-diol is an intermediate used in the synthesis of β-Tocopherol (Racemic Mixture) (T625170), which is one of the naturally occurring forms of Vitamins E and is biologically less active than α-Tocopherol. This is the racemic mixture of all stereoisomers.<br>References Bianchi, G., et al.: Eur. J. Lipid Sci. Technology, 105, 229 (2003), Sakouhi, F., et al.: Food Chem., 108, 833 (2008)<br></p>

<p>Applications (2S,3R,4E)-3-Benzoyl-2-tert-butyloxycarbonylamino-4-octadecen-1,3-diol (cas# 299172-59-1) is a compound useful in organic synthesis.<br>References Kinjo, Y., et al.: Chem. Biol., 15, 654 (2008),<br></p>

<p>Applications Glycidyl 4-Toluenesulfonate is used in the development and validation of a chiral HPLC method for rapid screening of allylic alcohol asymmetric epoxidation processes. Glycidyl 4-Toluenesulfonate is a reagent for organic displacement, additional and ring-opening reactions.<br>References Morante-Zarcero S., et al.: Analytica chimica acta, 618, 102 (2008); Bittman, R., et al.: e-EROS Encyclopedia of Reagents for Organic Synthesis; 1, (2001)<br></p>

<p>Applications (Methyl)triphenylphosphonium Iodide is the precursor to a wittig reagent.<br></p>

<p>Applications Methyl 2-cyanobenzoate<br></p>

<p>Applications 2-(diphenylacetyl)-3-hydrazino-1H-Inden-1-one is a useful chemical reagent.<br></p>

<p>Applications 5-Hydroxy-3-phenylbenzoic Acid can be used in biological study of preparation and identification of hydroxybenzoic acids as lactate receptor agonists and antilipolytics. It can also be used in discovery of new series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design.<br>References Duffy, B. C., et al.: Bioorg Med Chem Lett, 25, 2818 (2015), Dvorak, C. A., et al.: ACS Med Chem Lett, 3, 637 (2012)<br></p>

<p>Applications 4-(2,4,4-trimethylpentan-2-yl)benzene-1,2-diol (cas# 1139-46-4) is a useful research chemical.<br></p>

<p>Applications 5-Phenyl-1,2,5-thiadiazolidin-3-one 1,1-Dioxide is used in the structure-based design of protein tyrosine phosphatase-1B inhibitors.<br>References Black, E. et al.: Bioorg. Med. Chem. Lett., 15, 2503 (2005);<br></p>

<p>Applications 2-((Tetrahydrofuran-2-yl)methoxy)phenoxy)tetrahydro-2H-pyran is an intermediate used in the synthesis of Bufetolol (B689435), a β-adrenergic blocking agent and it inhibits the activation of adenyl cyclase.<br>References Ikegami, K., and Imamura, H.: Yakugaku Zasshi 96, 614 (1976); Yamaji, A., et al.: Yakugaku Zasshi 105, 1179 (1985)<br></p>

<p>Applications 4,4'-Dimethoxydiphenylamine is a diphenylamine derivative used as a chemical additive for cured rubber. 4,4'-Dimethoxydiphenylamine is highly toxic and may potentially induce chromosome abberation.<br>References Kel'man, G.Y. et al.: Kauch. Rez., 26, 28 (1967); Sofuni, T. et al.: Mutat. res. Gen. Toxicol. Test., 24, 175 (1990);<br></p>

<p>Applications 7-Benzyloxy-10,11-dihydrodibenzo[b,f[[1,4]thiazepin-11-one (cas# 329217-07-4) is a compound useful in organic synthesis.<br></p>

<p>Applications [2-(4-Fluorophenyl)cyclopropyl]amine hydrochloride is a synthetic intermediate in the preparation of thiazolinone 4-monosubstituted quinolines as CDK1-Cyclin B inhibitors for use as anti-cancer agents.<br>References Tsai, T.Y., et al.: Bioorg. Med. Chem., 17, 2388 (2009); Vallgaarda, J., et al.: J. Med. Chem., 39, 1485 (1996);<br></p>

<p>Applications N-[1-[3-(2-Ethoxyphenyl)-2,5-dihydro-5-oxo-1,2,4-triazin-6-yl]ethyl]acetamide is an intermediate in the synthesis of Vardenafil (V098001) related compounds.<br>References Olszewska, T., et al.: Tetahedron., 69, 474 (2013);<br></p>

<p>Applications METHYL 2-HYDROXY-4-IODOBENZOATE (cas# 18179-39-0) is a useful research chemical.<br></p>