Glycoscience

<p>Trifucosyl (1-2,1-2,1-3)-iso-lacto-N-octaose is a custom synthesis that is a complex carbohydrate. It is an oligosaccharide that contains three monosaccharides linked by alpha glycosidic bonds. This compound has been modified using methylation and glycosylation reactions. Trifucosyl (1-2,1-2,1-3)-iso-lacto-N-octaose has been fluorinated at the C6 position of the sugar ring to increase its solubility in water and enhance its stability in acid conditions. The product is a high purity synthetic compound.</p>

2-Acetamido-1,3,4,6-tetra-O-benzyl-2-deoxy-a-D-glucopyranoside is a modification of the natural carbohydrate. It is an oligosaccharide synthesized with custom synthesis. The synthetic process involves the methylation and glycosylation of the monosaccharides. Fluorination and saccharide linkages are also used in the production of this compound. 2-Acetamido-1,3,4,6-tetra-O-benzyl-2-deoxyglucopyranoside can be used as a building block for complex carbohydrates or as a research reagent for glycobiology.

<p>Isorhamnetin 3-glucoside-7-rhamnoside is a type of flavonoid that is found in plants and has the chemical formula C14H12O5. It is a glycoside that is converted to its aglycone, rhamnetin, in the body. Isorhamnetin 3-glucoside-7-rhamnoside has shown potential as an antiinflammatory agent by inhibiting the ubiquitin proteasome pathway and Cox2 inhibitory activity. It also inhibits protease activity and can be used to treat inflammatory diseases such as arthritis. Isorhamnetin 3-glucoside-7-rhamnoside is synergistic with other molecules, so it can be used to prevent or treat inflammation when combined with other drugs.</p>

<p>4- C- Methyl- 2, 3- O-isopropylidene -4-O-tert-butyldimethylsilyl-D- lyxono-1,5- lactone is a Fluorinated Monosaccharide. It is a Synthetic Monosaccharide. It is an Oligosaccharide. It is a complex carbohydrate. It has been Custom synthesized.<br>It has been Glycosylated and Polysaccharided. It has been Click modified and Methylated.<br>This compound's CAS number is A8BX04A9R1Z6.<br>This compound's sugar type is Carbohydrate. This compound has been Modified for High purity purposes.</p>

Fully acetylated laminaritriose

<p>5-Azido-5-deoxy-2,3-O-isopropylidene-L-lyxono-1.4-lactone is a carbohydrate that is a modification of the saccharide, oligosaccharide, sugar, and fluorinated complex carbohydrate group. It is synthesized from 5-(azidomethyl)-5'-deoxyfuranose by methylation and glycosylation followed by click modification. 5-(Azidomethyl)-5'-deoxyfuranose can be synthesized from L-(+)-glyceraldehyde and methyl azide in the presence of sodium hydride via a sequence of reactions involving hydrolysis, reduction, and hydrogenation.</p>

<p>Used as enzyme substrates, analytical standards and for in vitro diagnostics</p>

<p>Penta-O-benzoyl-D-glucopyranoside is a carbohydrate that has been prepared in a preparative scale. It is an organic compound and the structural formula is C12H22O11. The diameter of this molecule is around 1.5 nm, which makes it mesoporous. Penta-O-benzoyl-D-glucopyranoside has been analysed by high performance liquid chromatography (HPLC) and mass spectrometry (MS). The tree ring processability of this product is good and can be processed thermally.</p>

<p>6-Azido-6-deoxy-D-fructose is a piperidine that condenses with glyceraldehyde in the presence of aldolase and produces D-glyceraldehyde. This reaction is stereospecifically catalyzed by aldolase, which converts the product to D-glyceraldehyde 3-phosphate. 6Azido-6deoxy-D-fructose has been shown to exhibit polyhydroxylated properties.</p>

<p>D-Fructose-1,6-diphosphate dicalcium salt is an inorganic compound that is used as a pharmaceutical ingredient. It is the calcium salt of D-fructose-1,6-diphosphate. D-Fructose-1,6-diphosphate dicalcium salt can be isolated from a variety of sources, including by reprecipitation from ethanol and isolation from impurities in monophosphates. This product is obtained through ion exchange with alkali and calcium. The purity of this compound is confirmed by its free acidity (pH less than 1) and the absence of contaminating phosphate ions.</p>

<p>D-Galactosamine (GalN) is an aldohexose (2-Amino-2-deoxygalactose) in which the hydroxyl group at position 2 is replaced by an amino group (Collins, 2006). Galactosamine (as the N-Acetyl derivative) forms a key part of both N- and O-linked glycoproteins, glycolipids and glycosaminoglycans. Treatment of experimental animals with D-galactosamine / lipopolysaccharide causes lethal liver injury characterized by apoptosis of the hepatocyte and it is used as a laboratory model to study the effect of therapeutic agents (Hirono, 2001).</p>

2-Chloroethyl-b-D-fructopyranoside is a stable reagent that is used to prepare 2,4-dichloroacetophenone (2,4-DAAP), which can be used as a crosslinking agent. This reagent is reactive and should be handled with care. It forms a hemoglobin adduct by reacting with the amino groups of hemoglobin. The reaction can be catalyzed by dialdehydes. Affinities for tissue proteins are created through stepwise reactions involving ring-opening reactions or methemoglobin formation. 2-Chloroethyl-b-D-fructopyranoside can be used to synthesize a polymerized affinity column by using the ring opening reaction in an affinity chromatography process.

<p>N-[2-(3'-Nitrophenylacetonitrile)]-2,3,4,6-tetra-O-pivaloyl-D-glucopyranoside is a high purity custom synthesis sugar. It is synthesized through Click modification and fluorination. This chemical has been used as a building block for glycosylation and methylation. The CAS number is 95825-78-8.</p>

7-Deoxy-1,2:4,5-di-O-isopropylidene-L-glycero-D-glucoheptitol is a high purity synthetic compound that can be custom synthesized to order. It is a white powder with a molecular weight of 264.27 grams per mole and is soluble in water and DMSO. The CAS No. for this compound is 2206188-76-3. It has been fluorinated at the C2 position and has been modified with a click chemistry reaction to create an oligosaccharide or polysaccharide. This product is available for purchase from our store at www.sigmaaldrichchemicals.com/7deoxy1,2:4,5diOisopropylideneLglyceroDglucoheptitol

<p>Allyl 2,3,4-tri-O-benzyl b-D-galactopyranoside is a custom synthesis of an oligosaccharide with a complex carbohydrate and a high purity. Allyl 2,3,4-tri-O-benzyl b-D-galactopyranoside can be used for a variety of applications including as an intermediate for the production of other chemicals or as a food additive. It is also used in the synthesis of other carbohydrates and saccharides. This compound has been shown to be effective in methylation reactions and glycosylation reactions.</p>

<p>2-Azido-2-deoxy-3,5-O-isopropylidene-D-xylono-1,4-lactone is a methylated saccharide that has been synthesized from D-xylonolactone. It has a CAS Number of 122758-81-6 and is available for custom synthesis. This molecule is a modified form of the natural product xyloglucan. It can be used as a glycosylation or fluorination reagent to create more complex carbohydrates.<br>2-Azido -2 deoxy -3,5 O -isopropylidene -D -xylono -1,4 lactone is prepared by the reaction of 2 moles of nitrous acid with 1 mole of D -xylonolactone in an organic solvent such as ethanol or acetone at room temperature. The product can then be purified by recrystallization from a mixture of</p>

<p>Produced by the fast pyrolysis of cellulose</p>

<p>3-C-Methyl-1-deoxy-psicose is a sugar that is used in the synthesis of complex carbohydrates. This synthetic sugar is synthesized by the click modification of 3,4-dihydroxybenzaldehyde with 1,2,3,4-tetraacetylated benzyl chloride. The compound has a molecular weight of 228.22 and an empirical formula of C6H8O6F2. It's CAS number is 52714-32-0 and it's Oligosaccharide number is 976.</p>

<p>N-Acetylallolactosamine is a lectin that has been shown to have an acceptor for the oligosaccharide, n-acetylllactosamine. It is synthesized by alkaline hydrolysis of allolactose, which is a lactose metabolite. N-Acetylallolactosamine can be used as a growth factor in the treatment of wounds and burns. This protein can also be used as a diagnostic tool to detect different types of cells in the blood stream.</p>

<p>Sedoheptulose anhydride is a derivative of sedoheptulose, a seven-carbon atoms carbohydrate.</p>

<p>Glucose 6-phosphatase substrate</p>

<p>1-O-Methyl-β-D-glucopyranoside is a β-glucosidase inducer.</p>

<p>Please enquire for more information about a,a-D-Trehalose dihydrate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>N-(Succinyl)-O-b-D-lactosylhydroxylamine is a methylation product of b-D-lactosylhydroxylamine. It has a CAS number and can be modified with Click chemistry, which is a method of chemical modification using copper (II) ions. N-(Succinyl)-O-b-D-lactosylhydroxylamine can also be modified with other chemicals, such as an amine or carboxylic acid, to create an oligosaccharide. This product is synthesized in high purity and has a high glycosylation yield. It is used for research purposes and can be custom synthesized for any desired sugar.</p>

<p>2,3-O-Isopropylidene-L-ribonic acid-1,4-lactone is a fluorinated glycoside that can be used as a monosaccharide or modified to form an oligosaccharide. It is synthesized by the addition of fluorine to an alpha position of D-ribose, followed by lactonization. This product has been shown to have high purity and can be used as a sugar substitute in foods. This compound has been used for the synthesis of saccharides with click modification and oligosaccharides with polymerization.</p>

<p>Potent and specific inhibitor of α-mannosidase I. It is active against the Golgi isoform (GMI) of the enzyme and blocks carbohydrate branch elongation from immature to complex and hybrid N-glycans. Its anti-viral activity against HIV-1 is characterized by the alteration of N-glycan pattern and shift to high-mannose glycans on viral glycoprotein gp120, resulting in decreased infectivity of newly synthesized virions.</p>

<p>This beta-cyclodextrin (β-CD) derivative is a functionalized cyclic oligosaccharide composed of seven glucose units, characterized by a hydrophilic exterior and a lipophilic cavity (bigger than α-CD and smaller than γ-CDs), which allows it to encapsulate various guest molecules. This structural feature facilitates its use in multiple applications, including pharmaceuticals, food enhancement, and cosmetics. In the pharmaceutical industry, it enhances the solubility and stability of poorly water-soluble drugs, improving their bioavailability and efficacy while also masking unpleasant tastes. The food sector utilizes it as a stabilizer for flavors, colors, and nutrients, extending shelf life by protecting sensitive ingredients from degradation. In cosmetics, it serves as a complexing agent for fragrances and active components, ensuring their stability and controlled release. Its use expands to many other fields, including nanotechnology for drug delivery systems, environmental remediation for extracting organic pollutants, textiles for slow-release fragrances, and analytical chemistry for chiral separation.</p>

<p>Tri-mannuronic acid sodium salt (b-1,4-linked sodium mannuronotriose) is one of a number of oligosaccharides obtained from alginate which is a polysaccharide in brown seaweeds containing: blocks of repeating mannuronic acid sequences (M-M-M-M etc), repeating guluronic acid sequences (G-G-G-G etc), and alternating M-G-M-G sequences.Oligosaccharides can be released using several methods (Lua, 2015; Yanga, 2004) and claims have been published that mannuronic acid oligosaccharides for example, can be effective in the prophylaxis and treatment of Alzheimer's disease, or for the prophylaxis and treatment of diabetes (USP 8835403B2, 2014).</p>

<p>2,4-Anhydro-3,5:6,7-di-O-isopropylidene-D-glycero-D-gulo-heptonic acid benzylamide is a glycosylation agent that is used in the synthesis of complex carbohydrate. It can be methylated and fluorinated to produce saccharides with desired properties. It also has a variety of chemical modifications for use as a synthetic sugar or oligosaccharide. 2,4-Anhydro-3,5:6,7-di-O-isopropylidene-D-glycero-D -gulo heptonic acid benzylamide is typically synthesized in high purity for use in pharmaceuticals or other applications requiring high purity.</p>

<p>3,4-Di-O-acetyl-D-arabinal is a spiroketal monofluoride that is known to be an efficient method for the synthesis of β-unsaturated aldehydes. It can be prepared by the hydration of enantiopure allyl chloroformate followed by reductive elimination with triflic acid and acidic hydrolysis. 3,4-Di-O-acetyl-D-arabinal has been used in the synthesis of biologically active molecules such as polyketides, peptides and natural products.</p>

<p>NGA3 N-Glycan is a high purity, custom synthesis, sugar-containing glycoprotein. It is synthesized by Click modification of the glycopeptide backbone with a fluorinated amino acid and then glycosylated with an acetylated sugar. The acetylation of the sugar allows for selective labeling of the glycan. This product can be used in research applications such as Fluorination, Glycosylation, Synthetic, Methylation, Modification and Carbohydrate. It has CAS No. 110387-63-8 and is available in both Monosaccharide and Oligosaccharide form.</p>

<p>Allyl 2,4,6-tri-O-(3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-b-D-glucopyranosyl)-3-O-benzyl a -D -mannopyranoside is a glycosylated oligosaccharide. It is synthesized from 3,4,6 tri O acetyl 2 deoxy 2 phthalimido b D glucopyranosyl chloride and allyl alcohol by the click reaction with sodium azide in the presence of palladium catalysis. This product has been fluorinated at the 6 position of allose. The purity of this product is high and it has been modified on the saccharide chain with methyl groups at the C1 and C2 positions of glucose. Allyl 2,4,6 tri O (3 4 6 tri O acetyl 2 deoxy 2 phthalimido b D gluc</p>

Cotinine-N-b-glucuronide-D3 is a modification of the natural product cotinine, which is a methylated form of nicotine and can be synthesized from the plant Nicotiana tabacum. Cotinine-N-b-glucuronide-D3 is a complex carbohydrate that has been custom synthesized for the purpose of modifying an oligosaccharide. This modification will allow for the synthesis of high purity monosaccharides. Cotinine has been shown to have antiinflammatory properties, which may be due to its inhibition of prostaglandin synthesis.

<p>3'-Sialyl Lewis X 16-sp - biotin is a modified oligosaccharide that is synthesized by the addition of a sialic acid residue to the terminal position of the carbohydrate. This product has a CAS number and can be custom synthesized to meet specific customer requirements. 3'-Sialyl Lewis X 16-sp - biotin is an important glycosylation site for many proteins, including CD45 and CD47, which are present in erythrocytes and leukocytes respectively. It is also used as an important substrate for methylation reactions due to its susceptibility to S-adenosyl methionine. 3'-Sialyl Lewis X 16-sp - biotin is soluble in water and has a high purity. The structure of this oligosaccharide includes a complex carbohydrate composed of mono-, di-, tri-, tetra-, penta-, hexa-, hepta-, octa-, nona-, deca-sac</p>

<p>2-Azidomethyl-2-deoxy-D-ribono-1.5-lactone is a custom synthesis of an oligosaccharide with a carbohydrate chain that has been modified by methylation and glycosylation. It is a high purity product that can be used in the synthesis of complex carbohydrates, such as polysaccharides, and has been fluorinated to create a click modification. This compound has an CAS number and can be used in the synthesis of saccharides or sugars. It can also be used for the preparation of complex carbohydrates, such as polysaccharides, and has been fluorinated to create a click modification.</p>

D-ribulose 1,5-bisphosphate sodium hydrate (DRBP) is a naturally occurring sugar that is found in plants. It is synthesized by the action of ribulose bisphosphate carboxylase on ribulose 1,5-bisphosphate, with ATP as a cofactor. DRBP has been shown to be an important intermediate in many biochemical pathways and enzymes. DRBP has been shown to inhibit HIV replication in vitro by binding to the enzyme reverse transcriptase and blocking its activity. As an inhibitor of HIV replication, DRBP is activated by a number of factors including p-nitrophenyl phosphate (pNPP), and the presence of hydrogen bond donors such as ATP or NADP+. This chemical also inhibits protease activity and increases the transport rate for D-ribulose 1,5-bisphosphate.

<p>Myo-inositol 1,2,4,5,6-pentakisphosphate (IP) is a phosphate of inositol that is found in the cytosol. It is an important component of polyphosphates and can be used for oxygen transport. It has been shown to inhibit the growth of cancer cells by binding to monoclonal antibodies that are targeted against CD20 and CD22 on cancer cells. IP also inhibits the activity of kinases and phosphatases in mammalian cells. This may be due to the inhibition of cytokine release from macrophages treated with IL-1β. Inositol phosphates are involved in many cellular responses including platelet-derived growth factor activation, cell proliferation, and protein synthesis.</p>

<p>Intermediate in the synthesis of prostaglandins</p>

<p>Dextran sulphate is a dextran derivative whose ulcer (colitis) -causing properties were first reported in hamsters and extrapolated a few years later to mice and rats. The exact mechanisms through which dextran sulphate induces intestinal inflammation are unclear but may be the result of direct damage of the monolayer of epithelial cells in the colon, leading to the crossing of intestinal contents (for e.g. commensal bacteria and their products) into underlying tissue and therefore induction of inflammation.  The dextran sulphate sodium-induced ulceration model in laboratory animals has some advantages when compared to other animal models of colitis due to its simplicity and similarities to human inflammatory bowel disease. <br>MW is in the range of 40,000Da</p>

<p>(2R, 3R, 4R) -2- (Hydroxymethyl) - 2- methyl- 3, 4- pyrrolidinediol is a modification of oligosaccharides. It is synthesized from monosaccharides or disaccharides and can be modified with fluorine or methyl groups. This product has the highest purity available on the market and can be used in a variety of applications such as glycosylation, polysaccharide synthesis, sugar fluorination, saccharide click modification and more.</p>

<p>Kestoheptaose is a long-chain inulin with a molecular weight of 1,000 Da. It is found in the plant family Asteraceae and is the only natural polysaccharide with seven glucose units. Kestoheptaose has been shown to be involved in the regulation of muscle glycogen levels and can be used as a supplement for athletes or those who are active. The biochemical functions of Kestoheptaose have been validated using an oral ethanol extract, which was shown to increase muscle glycogen levels by up to 132%. This extract also decreased malondialdehyde concentrations by up to 41% and increased urea nitrogen levels by up to 89%.</p>

<p>1,4:3,6-Dianhydro-D-iditol is an organic compound. It is the L-enantiomer of 1,4:3,6-dianhydro-L-iditol. This compound can be used as a substrate for the cytochrome P450 system and soluble guanylate cyclase. 1,4:3,6-Dianhydro-D-iditol has been shown to have an inhibitory effect on both tissues and guanylate cyclase in vitro. This compound also inhibits the production of reactive oxygen species by oxidases.</p>

<p>2,3,4,6-Tetra-O-pivaloyl-b-D-galactopyranosyl isothiocyanate is a custom synthesis that has complex carbohydrate as its main component. It is a modified saccharide with chemical modifications such as methylation, glycosylation, and fluorination. It also contains one or more sugars. The CAS number for this product is 147948-52-5. This product has high purity and can be synthesized according to customer specifications.</p>

<p>Methyl 3-O-[(6-O-b-D-galactopyranosyl)-b-D-galactopyranosyl]-b-D-galactopyranoside is a white crystalline powder that is soluble in water. It can be custom synthesized to order, and has been shown to have high purity with no detectable impurities. This product can be used in Click chemistry, fluorination, glycosylation, or synthesis of complex carbohydrates. The CAS number for this product is <br>56919-86-4.</p>

<p>D-Gluconic acid lithium salt is a cationic compound that has been shown to inhibit the growth of bacteria by forming a covalent linkage with the ribose in RNA. This inhibits the enzyme activity of the cell and prevents transcription and replication. The chemical formula for this compound is CH3CH2OH-CH2COOH+Li+→CH3CH2OLi+H2O, where D-gluconic acid is carboxylate anion and lithium ion is cation. Electrophoresis studies have shown that this compound binds to proteins, which may be due to its hydrophilic properties. X-ray diffraction data has revealed that it forms a crystalline structure. This compound can be used as an antimicrobial agent against Group P2 Gram-positive cocci (e.g., Enterococcus faecalis) and other infectious diseases such as Staphylococcus aureus, Streptococcus pneumonia</p>

<p>Raffinose-sp-biotin is a Custom synthesis, Modification, Fluorination, Methylation, Monosaccharide, Synthetic, Click modification, Oligosaccharide, saccharide. It is available in CAS No. and has the molecular formula C6H14O6. Raffinose-sp-biotin is a polysaccharide with a complex carbohydrate structure.</p>

<p>This compound is a custom synthesis, modification and fluorination of an acetylated glycoside. It is a methylated monosaccharide with a saccharide at the reducing end. This product can be used in the synthesis of oligosaccharides, glycosylation and sugar modifications. The CAS number for this compound is 58907-27-3.</p>

<p>7-(2-(2-((N-2-Deoxy-acetamido-beta-D-glucopyranosyl)-(N-methyl)-aminooxy)ethoxy)ethoxy)-naphthalene-1,3-disulfonate is a synthetic compound that can be custom synthesized. It has been specifically designed for the modification of complex carbohydrates by click chemistry. The binding site of 7-(2-(2-((N-2-Deoxy-acetamido-beta-D-glucopyranosyl)-(N-methyl)-aminooxy)ethoxy)ethoxy)-naphthalene 1,3 disulfonate is the anomeric carbon of the sugar moiety. This compound has a CAS number of 2365081–65–6 and can be used in many different applications including glycosylation, oligosaccharide synthesis, and methylation.</p>

<p>A tetra-O-acetyl-6-O-(2,3,4,6-tetra-O-acetyl-a-D-galactopyranosyl)-b-D-thioglucopyranose is a 1,2,3,4 tetraol. It is synthesized by the modification of a disaccharide that has been modified with fluorine and methyl groups on the C1 and C4 positions of the sugar. The complex carbohydrate is a glycosylated sugar that is composed of one monosaccharide and one oligosaccharide. This product is CAS No. 1820574-50-2.</p>

Ethyl 3-O-allyl-4-O-levulinoyl-2-O-(2-naphthylmethyl)-b-D-thioglucuronide benzyl ester is a custom synthesis that has been modified with fluorination, methylation and click chemistry. It is a water soluble polysaccharide that consists of monosaccharides, oligosaccharides and saccharides. This product is a glycosylated carbohydrate that can be used as an additive in food products or as an excipient for drug delivery systems.