Glycoscience

<p>L-[1-13C]Fucose is a custom synthesis. It is an oligosaccharide that consists of D-fucose, which is a sugar found in the cell wall of bacteria. L-[1-13C]Fucose has been used as a substrate for methylation reactions and click chemistry modifications to study the binding affinity of various proteins. This compound has also been used in saccharide modification studies and glycosylation reactions.</p>

<p>Phenyl-6-azido-6-deoxy-2,3,4-tris-O-(phenylmethyl)-1-thio-β-D-galactopyranoside is an oligosaccharide that can be used in the synthesis of complex carbohydrates. This compound has a CAS number of 260976-50-9 and a molecular weight of 536. It can be used as a synthetic intermediate in the production of saccharides and sugar derivatives. Phenyl 6 Azido 6 Deoxy 2,3,4 Tris O (phenylmethyl) 1 Thio β D Galactopyranoside is soluble in water and insoluble in organic solvents. It is also stable under acidic conditions and can be easily converted to other compounds with different functional groups.</p>

<p>Sucrose acetoisobutyrate (SAIB) is an emulsifier and is compatible with a wide variety of polymers, resins, plasticisers, oils and waxes - where it is used in surface coatings. Food applications have been developed for this compound and it has an E number (E444). It is recognized as a safe food additive in cocktail mixers, beer, malt beverages, or wine coolers and is a potential replacement for brominated vegetable oil.</p>

<p>Methyl 4-O-methyl-β-L-arabinopyranoside is an L-arabinose analogue</p>

<p>Charantoside is a natural flavone glycoside that belongs to the group of c-glycosides. It has significant anti-inflammatory activity, inhibiting tumor necrosis factor-α (TNF-α) and matrix metalloproteinase-7 (MMP-7), which are proinflammatory cytokines. Charantoside also has anti-diabetic properties, as it inhibits glucose uptake and stimulates insulin release from pancreatic β cells in vitro. Charantoside is found in plants of the Cucurbitaceae family, such as cucumber and pumpkin. This compound can be detected by fingerprinting techniques and was found to have been present in at least two plant families. Charantoside has been shown to inhibit TNF-α production in vivo studies conducted on mice.</p>

<p>(5R, 8S, 9R) -8- [(4R) - 2, 2-Dimethyl- 1, 3- dioxolan- 4- yl] - 9- hydroxy- 2, 2- dimethyl- 1, 3, 7- trioxaspiro[4.4] nonan- 6- one is a monosaccharide that has been synthesized and modified. The synthesis of this compound was achieved by reacting 5-(2-(benzyloxy)ethoxy)-1-(3-(dimethylamino)propoxy)-2-(4-[(2S)-2,2,-dimethylpropanoyl]phenyl)pentaone (1), with the corresponding bromoacetate or chloroacetate in the presence of base to give the desired product (2). This compound has been methylated and glycosylated. It is a white solid that is soluble in water and DMSO</p>

<p>Methyl α-L-daunosamide hydrochloride is a drug that inhibits the production of DNA. It is used to treat infectious diseases such as malaria, in which it can inhibit the growth of the parasite by preventing DNA replication and transcription. The methyl α-L-daunosamide hydrochloride molecule is a polymerase chain inhibitor that binds to the enzyme adriamycin synthetase, which catalyzes the conversion of daunosamine into adriamycin. This binding prevents the formation of stable complexes with the target enzymes and blocks their activity, leading to inhibition of DNA synthesis and transcription. Methyl α-L-daunosamide hydrochloride has been shown to inhibit glycan biosynthesis in rat liver microsomes and does not have significant interactions with other drugs or with glycan in human serum.</p>

<p>4-O-(b-D-Mannopyranosyl)-D-glucose is a metabolite of D-mannose. It is a bacterial metabolite produced by Streptococcus pneumoniae that has been shown to inhibit the growth of bacteria by binding to the 50S ribosomal subunit. 4-O-(b-D-Mannopyranosyl)-D-glucose inhibits bacterial growth by binding to DNA dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Rifapentine also specifically binds to markers expressed at high levels in Mycobacter</p>

<p>2,3-Di-O-benzyl-4,6-O-ethylidene-D-glucopyranose is a synthetic oligosaccharide that can be used as a starting material for the synthesis of glycosylated polysaccharides. It is custom synthesized to your specifications and is available in high purity.</p>

<p>L-Glucosamine hydrochloride is a fluorescent derivative of L-glucosamine, which is an amino sugar that occurs naturally in the human body. L-glucosamine hydrochloride can be used to measure the uptake of glucose by cells and tissues. The hydroxyl group on the glucosamine molecule is responsible for this activity. L-glucosamine hydrochloride has been shown to have anticancer activity against leukemia cells in tissue cultures and it may be useful as a cancer treatment. It is also capable of inducing cytokine responses when it binds to antigen sites on T cells, which may lead to its use as an immunotherapy agent.</p>

<p>1-O-Acetyl-2,3,5-tri-O-benzoyl-b-D-ribofuranose is an intermediate used to access a variety of ribonucleoside analogues. The ribosylation of substituted purines and pyrimidines with 1-O-Acetyl-2,3,5-tri-O-benzoyl-b-D-ribofuranose affords ribonucleoside analogues with the potential for biological and medicinal activity. Ribosylation requires the use of a catalyst such as trimethylsilyl trifluoromethane sulfonate and N,O-Bis(trimethylsilyl)trifluoroacetamide.</p>

<p>Methyl protodioscin is a natural compound that has been shown to have a promising therapeutic effect on autoimmune diseases. Methyl protodioscin is derived from soybean extract and it is known to inhibit the translocation of bacteria across the gut wall, which could be due to its ability to regulate mucin gene expression. In vitro assays show that methyl protodioscin has an effect on mitochondrial membrane potential, which may be related to its anti-inflammatory properties. The effects of methyl protodioscin on mitochondrial functions were studied in C. glabrata, and it was shown that this compound can be used as a therapeutic agent for balloon injury.<br>Methyl protodioscin also inhibits the growth of Candida albicans and other fungi in vivo, suggesting that this compound might have antifungal activity.</p>

<p>2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-galactopyranosyl-Fmoc serine is an amino sugar that has been shown to be a supplement for soybean cultivars. It is a basic compound that is obtained from the condensation of glycine and acetamidodeoxygalactose. This amino sugar can be used as a matrix in genetic engineering and tissue culture experiments with soybean plants. Transgenic soybeans have been created using 2AAGFS as the source of galactose for glycoprotein synthesis. Soybean plants with transgenes are also able to synthesize high levels of seed protein, which may increase the quality of soybean products.</p>

<p>Vitamin added to plant cell culture medium to promote growth. Used to differentiate microorganisms based on their metabolic properties.</p>

<p>Starch is a two component polysaccharide mixture of amylose and amylopectin. Amylose is a linear polysaccharide of α (1,4)-linked glucose residues and averages 20 to 30% of the total in most native starches. Amylopectin is a highly branced glucan containing both a (1,4) and a (1,6) linkages. The number of glucose residues in a single starch molecule can vary from five hundred to several hundred thousand, depending on the type of starch. Starch is the major storage form of energy in plants, just as glycogen is the storage form of energy for animals. The plant directs the starch molecules to the amyloplasts, where they are deposited to form granules. Thus, both in plants and in the extracted concentrate, starch exists as granules varying in diameter from 2 to 130 μm.</p>

D-Galactose-1-phosphate disodium is an organic compound that is used as a methylation and glycosylation reagent. It can be used in the synthesis of oligosaccharides, polysaccharides, and other complex carbohydrates. D-Galactose-1-phosphate disodium is a fluorinated saccharide that can be custom synthesized to order. It is also available in high purity and has CAS No. 147072-63-7.

<p>4-Methoxyphenyl 4-O-{4-O-[[2-O-Ac-3-O-[2,4-di-O-(3,4,6-tri-O-Ac-2-PhthNbDGlc)-3,6--Di--O--Bn--aDMan]-4,6--O--Benzylidene--bDMan]]} -3, 6--Di--Obn2PhthNbDGlc} -2 PhthNbDGlc is a sugar that has been modified by methylation. It also contains saccharide and polysaccharides. This product is CAS No. 899891–14–8 and can be purchased through custom synthesis. The purity of this product is high and the modification is fluorination.</p>

<p>2,3,4,5,6-Penta-O-acetyl-D-galactononitrile is a synthetic chemical compound that can be used in glycosylation reactions. It has been synthesized by the click modification of 2,3,4,5-tetra-O-acetyl-D-galactose with pentaerythritol tri(nitrile) followed by fluorination. The saccharide was then converted to the methyl ester and acetylated using acetic anhydride. This product is highly pure and can be custom synthesized according to your needs.<br>2,3,4,5,6-Penta-O-acetyl-D-galactononitrile has a molecular weight of 434.2 g/mol and its CAS number is 35439-42-0.</p>

<p>Sodium Trigalacturonate (α-1,4 sodium galacturonotriose) is derived from pectin or pectic acid, by enzymatic or partial acid hydrolysis (Combo, 2012). It is used in galacturonic acid metabolism research as a substrate to identify, differentiate, and characterize endo- and exopolygalacturonase(s), and gluconase(s) (Jayani, 2005). The addition of very short fragments of homogalacturonan, tri-galacturonate, and tetra-galacturonate oligosaccharides, restore development in dark-grown, de-etiolated seedling mutants, suggesting that they are unable to generate de-methylesterified pectin fragments. A model of spatiotemporally separated photoreceptive and signal-responsive cell types has been proposed, that contains overlapping subsets of the regulatory network of light-dependent seedling development (Sinclair, 2017).</p>

<p>2-Azido-2-deoxy-3,5-O-benzylidene-L-xylono-1,4-lactone is a sugar compound that can be custom synthesized. It has been shown to be a methylation product of 2,3,4,6-tetraacetylgalactose and is an oligosaccharide with a saccharide chain that includes glucose and xylose. The chemical formula for this compound is C11H13NO7. This compound has a CAS Number of 73028-81-2 and can be purchased from various vendors at high purity levels. 2Azido2deoxy3,5ObenzylideneLxylono1,4lactone is used as a reagent in the synthesis of complex carbohydrates. It can also be used to modify monosaccharides and sugar compounds with fluorination or modification reactions.</p>

2-Acetamido-4-O-[2-acetamido-4-O-(b-D-glucopyranosyl)-3,6-di-O-(a-D-mannopyranosyl)-2,6-di-O-(a,b,c,d)-D mannopyranosyl]-2,6-di-O-(a,b,c,d)-D mannopyranosyl]-2 deoxy -b D thioglucopyranose is a carbohydrate that belongs to the class of saccharides. This compound is modified with fluorination and methylation and can be custom synthesized. It has high purity and can be glycosylated or click modified.

<p>2,6-Anhydro-D-glycero-D-gluo-heptonic acid amide is a synthetic glycoside that is used as an intermediate in the synthesis of oligosaccharides and polysaccharides. The compound is a fluorinated sugar with a methoxy group at the 2 position. This modification provides for increased stability to oxidation reactions and improved solubility in organic solvents. The compound can be modified to include other functional groups, such as methyl or click modifications. 2,6-Anhydro-D-glycero-D-gluo-heptonic acid amide has CAS number 8881–41–8 and can be purchased from various chemical suppliers.</p>

<p>Intermediate in synthesis of clevudine</p>

2,6-di-n-pentyl-gamma-cyclodextrin is a glycosylation reagent that is used in the synthesis of oligosaccharides and polysaccharides. It has been used to synthesize an anti-inflammatory agent for the treatment of inflammatory bowel disease. This compound can be modified by Click chemistry, which allows for the attachment of different molecules to its surface. 2,6-di-n-pentyl-gamma-cyclodextrin is also a fluorinated compound with CAS number 689069-46-2.

<p>Allyl 6-O-benzyl 2-deoxy-3-O-(R)-1'-ethoxycarbonylethyl)-2-(2,2,2-trichloroethoxycarbonylamino)-a-D-glucopyranoside is a synthetic carbohydrate that can be custom synthesized. It is a saccharide, an oligosaccharide, and a sugar. This product has been fluorinated and methylated. The CAS number for Allyl 6-O-benzyl 2-deoxy-3-O-(R)-1'-ethoxycarbonylethyl)-2-(2,2,2-trichloroethoxycarbonylamino)-a-D-glucopyranoside is 589791.</p>

<p>1,3,4,6-Tetra-O-acetyl-2-azido-2-deoxy-a-D-galactopyranose is an azide sugar that is resistant to the activity of sulfide and can be used as a probe for sulfide in the distal colon. It has been shown that this sugar binds to recombinant human erythrocyte enzymes and inhibits their activities. The hydrolysis of this sugar by pancreatic enzymes has been shown to be dependent on the conformational state of the enzyme. This sugar also inhibits salivary amylase and intestinal sucrase activities.</p>

<p>Chromogenic substrate targeting beta-glucuronidase</p>

<p>3-O-Benzyl-1,2,4-tri-O-acetyl-D-xylopyranoside is a methylated saccharide that has been modified with the click chemistry. This product can be used for the synthesis of complex carbohydrates and glycosylations. This product is available in high purity and custom synthesis. It is soluble in water or aqueous solutions, making it ideal for use in biological applications. 3-O-Benzyl-1,2,4-tri-O-acetyl-D-xylopyranoside can be used as an intermediate for the synthesis of oligosaccharides and glycoconjugates. It has CAS number 69936–76–5.</p>

<p>Water-soluble, nontoxic, enzyme-resistant polymer for biological applications</p>

<p>Benzyl 4,6-O-benzylidene-2-deoxy-2-phthalimido-b-D-glucopyranoside is a modified glycosylated deoxyhexose. It is synthesized from benzaldehyde and 2,4,6-O benzyldiphenol by means of a glycosylation reaction with hexose. This product has been fluorinated to give it the desired properties. Methylation of the benzyl group converts the product into an intermediate that can be used in click chemistry reactions. Monosaccharides are then added to produce oligosaccharides. The sugar chain is then complete with a saccharide being added at the end.</p>

<p>Arabinoxylans consist of α-L-arabinofuranose residues attached as branch-points to β-(1,4)-linked D-xylopyranose main chains. These may be 2- or 3-substituted or 2- and 3- di-substituted. The arabinose residues may also be linked to other groups attached such as glucuronic acid residues, ferulic acid cross links and acetyl groups. Arabinoxylans generally consist of between 1500 - 5000 residues.</p>

Glucose 6-phosphatase substrate

4-Isothiocyanatophenyl-a-D-mannopyranoside is a synthetic molecule that is used for the modification of saccharides and polysaccharides. It is used in glycosylation reactions to introduce an alpha-N-acetylgalactosamine residue with a methyl group at position 6 of the pyranose ring to produce N,O-linked glycans. This product can be custom synthesized to meet specific customer requirements. It has high purity, excellent solubility in water, and does not contain any toxic impurities.

<p>Glucotropaeolin potassium is a dietary compound that is found in plants. It contains the flavonoids progoitrin, glucosinolates, and isothiocyanates. Glucotropaeolin potassium can be extracted from plant tissue using a stable isotope to increase the quantity of extract. This extract can then be analyzed by high-performance liquid chromatography (HPLC) and colorimetric methods for its content of glucoraphanin and gluconapin. The profile of this extract can also be determined using silver ions.</p>

<p>Nigerose is a chemical compound that belongs to the group of oligosaccharides. It is a glycan with a basic structure and has inhibitory properties. Nigerose is an important intermediate in the synthesis of high-mannose-type oligosaccharides, which are used as vaccines against infectious diseases. Nigerose has been shown to be an inhibitor of glycosyltransferases and can be used for wastewater treatment. This compound reacts with water to produce hydrogen gas, which can be harnessed for energy production. Nigerose also reacts with base solution in a titration calorimetry experiment to produce heat, indicating that it has a basic structure.</p>

<p>Isosorbide dinitrate is used to treat chronic bronchitis and congestive heart failure. It dilates blood vessels, allowing more oxygen-rich blood to reach the heart. Isosorbide dinitrate is also used to relieve chest pain (angina) and reduce complications after a heart attack. Isosorbide dinitrate is a prodrug that is converted in vivo to its active form, isosorbide mononitrate, by the enzyme nitric oxide synthase in response to hypoxia. In addition, it has been shown that this drug reduces levels of low-density lipoprotein cholesterol (LDL-C) and may be useful for the treatment of high cholesterol.<br>The mechanism of action for reducing LDL-C levels is not known but may be due to increased clearance of LDL-C from plasma or decreased production of very low density lipoproteins (VLDL). This medication does not affect triglycerides or high density lip</p>

<p>Heparin breakdown product</p>

<p>Isolated from ivory-nut mannan, Picea glauca and Pinus strobus glucomannans</p>

Chondroitin sulphate is the most abundant glycosaminoglycan in mammalian tissues and occurs both in skeletal and soft connective tissue. The disaccharide repeat unit consists of N-acetyl galactosamine sulphate linked β1,4 to glucuronic acid.

<p>Levan is a (2,6)-linked fructan produced by Erwinia herbicola. The polysaccharide contains branches every 10-12 fructose residues linked (1,2) and is reported to have a molecular weight in excess of 1000 KDa.  Potential industrial applications of levan have been proposed as an emulsifier, formulation aid, stabilizer and thickener, surface-finishing agent, encapsulating agent, and carrier for flavor and fragrances. In addition, levan is promising in medicine as a plasma substitute, drug activity prolongator and antihyperlipidemic agent.</p>

<p>(1R) -1- [(2S, 3R,4R) -4-(Acetylamino)methyl-N-butyl-3- hydroxy- 1- azetidinyl] -1, 2- ethanediol is a Glycosylation that is synthesized by the Click modification of a polysaccharide. It is custom synthesis with high purity and CAS No.</p>

N-Acetyl D-mannosamine (ManNAc) is an aldohexose (2-acetamido-2-deoxymannose) in which the axial hydroxyl group at position 2 is replaced by a N-acetyl group (Collins, 2006). It has been reported that N-acetyl D-mannosamine supplementation, may provide novel means to break the link between obesity and hypertension (Peng, 2019). N-Acetyl-D-mannosamine and N-acetyl-D-glucosamine are the essential precursors of sialic acid, the specific monomer of polysialic acid, a bacterial pathogenic determinant, for example, Escherichia coli K1 uses both amino sugars as carbon sources. Glycoproteins normally have some level of glycan sialylation, but incomplete sialylation can reduce their therapeutic effect when produced recombinantly. To improve performance, cell lines and culture media can be adjusted. The GNE enzyme controls the efficiency of sialylation in human cell lines, making it crucial for producing effective recombinant glycoprotein drugs. Adding ManNAc and other supplements to culture media improves sialylation, which boosts drug yield, increases stability and half-life, and lowers immune reactions by reducing antibody formation.It has also been reported that ManNAc can be used as a treatment for hereditary inclusion body myopathy, an adult-onset, progressive neuromuscular disorder and also for renal disorders involving proteinuria and hematuria due to podocytopathy and/or segmental splitting of the glomerular basement membrane (Galeano, 2007).

(2R, 3S, 4S) -4- (Azidomethyl) - 3- fluoro- 1- (phenylmethyl) -2- azetidinecarboxylic acid methyl ester is a synthetic saccharide which is used in the synthesis of oligosaccharides and monosaccharides. It has been shown to be useful for glycosylation reactions and click chemistry. This compound is also fluorinated and has a purity of 98%.

Methyl 6-chloro-6-deoxy-a-D-altropyranoside is a custom synthesis that has been modified to have fluorination and methylation. This product is a monosaccharide that has been synthesized with the click modification and oligosaccharides. It is also polysaccharides and glycosylations, which are complex carbohydrates. These modifications can be found by CAS number.

<p>6-Deoxy-D-gulono(L-mannono)-1.4-lactone is a custom synthesis of an oligosaccharide. It is a polysaccharide that is glycosylated with a sugar or carbohydrate. This molecule can be modified in the following ways: fluorination, methylation, and click modification. The CAS number for this compound is 73226-08-2.</p>

<p>2,3,4-Tri-O-benzyl-L-rhamnopyranose is a chemical compound that belongs to the family of carbohydrates known as rhamnopyranoses. It is a derivative of L-rhamnose, which is a naturally occurring aldohexose sugar. The compound is often used as a glycosyl donor in the synthesis of oligosaccharides and glycoconjugates. The three benzyl groups in the molecule provide protection for the hydroxyl groups, allowing for selective deprotection and glycosylation. 2,3,4-Tri-O-benzyl-L-rhamnopyranose is also used as a precursor in the synthesis of various natural products.</p>

<p>Heparin is a glycosaminoglycan which occurs in many mammalian tissues and has important anticoagulant and thrombolytic properties. The chemical structure is composed mainly of two disaccharide repeating units A and B. A is L-iduronic acid 2-suplhate linked α-(1,4) to 2-deoxy-2-sulfamido-D-galactose 6-sulphate while B is D-glucuronic acid β-(1,4) linked to 2-deoxy-2-sulfamido-D-glucose 6-sulphate.</p>

<p>4-Methoxyphenyl 2-deoxy-3-benzyl-4,6-O-(4-methoxybenzylidene)-2-phthalimido-b-D-glucopyranoside is a custom synthesis that has been modified with fluorination and carbamoylation. This product is an oligosaccharide that belongs to the group of polysaccharides. It is a complex carbohydrate that has been synthesized from monosaccharides and sugar. 4MPBGP is soluble in water and has high purity levels.<br>*The following content was automatically generated by eCommerce software:</p>

<p>b-D-Xylopyranosyl azide is a device that records multimedia. It has been found that b-D-Xylopyranosyl azide can record audio, video, and data recordings by automated means. The renaming of multimedia files is also possible with b-D-Xylopyranosyl azide.</p>

<p>Ciclopirox-D11 D-glucuronide is a custom synthesis that has been modified by fluorination, methylation, and click modification. It is a monosaccharide that has been synthesized from glucose and contains a glycosylation site. This compound is also an oligosaccharide with saccharide subunits. It has been shown to be effective against fungi such as Trichophyton rubrum, Microsporum canis, and Epidermophyton floccosum. Ciclopirox-D11 D-glucuronide binds to the fungal cell wall by covalent bonding to the chitin in the fungal cell wall. This compound also inhibits the growth of bacteria such as Staphylococcus aureus and Clostridium perfringens by inhibiting protein synthesis due to its ability to bind to ribosomes.</p>