Antifungals

Tolindate, a potent PXR agonist, demonstrates antifungal activity and possesses an EC50 value of 8.3 µM.

Chlorothalonil (DAC 2787): Broad-spectrum, efficient, low-toxicity fungicide for fruits, vegetables, rice, wheat, cotton.

Antifungal Agent 70 (Compound 13), a dihydroeugenol-imidazole, exhibits efficacy against multi-resistant Candida auris with a minimum inhibitory concentration (

Tropesin is a non-steroidal anti-inflammatory agent (NSAIA) that has inhibitory effects on the growth of Xylaria green.

P163-0892: potent, specific antifungal for Cryptococcus; moderate blood-brain barrier penetration.

Antifungal agent 68 (compound 10) effectively combats fungal infections caused by Candida and Cryptococcus gattii through the inhibition of ergosterol

CID-4785700 is a potent pan-GTPase inhibitor that inhibits Rab7 and inhibits the fungal histone acetyltransferase Rtt109 that binds to Asf1 and Vps75

Hexamide is a protein inhibitor.

Silthiofam effectively combats Ggt, a wheat take-all fungus, now widely used for control in China.

Oosponol is a dopamine beta-hydroxylase inhibitor exhibiting hypotensive effects.

Apogossypolone (ApoG2) is a semi-synthesized derivative of gossypol which is a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins with K i

Penflufen, a broad-spectrum succinate dehydrogenase inhibitor (SDHI), serves effectively as a fungicide.

BI-10, paired with fluconazole, hinders fungal growth, increases ROS, decreases MMP, and changes membrane permeability.

Antifungal agent 74 (compound 3c), is a potent substance that exhibits excellent fungicidal activity against C.

Vibunazole is an antifungal agent.

Furalaxyl is an fungicide of acyl amino chiral.

Inz-4 is a fungal-selective inhibitor of mitochondrial cytochrome bc1.

Succinate dehydrogenase-IN-1 (Compound 34) acts as an inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 value of 0.94 μM and a KD of 22.4 μM. This compound also demonstrates antifungal activity, with EC50 values against Rhizoctonia solani, Sclerotinia sclerotiorum, Monilinia fructicola, and Botrytis cinerea measured at 0.04 μM, 1.13 μM, 1.61 μM, and 1.21 μM, respectively.

Chaetochromin (4548-G05, NSC 345647) is an oral, selective insulin receptor agonist with potent, lasting antidiabetic effects in mice.

BHBM, an acylhydrazone antifungal, halts C. neoformans growth (MIC80 = 1 μg/ml) by blocking glucosylceramide synthesis.

Posaconazole: broad-spectrum antifungal, second-gen triazole, strong C14α demethylase inhibitor (IC50: 0.25 nM).

Bivittoside A is a non-sulfated hexoside analog obtained from Bovine sea cucumber with antifungal activity and potential antitumor activity.

Compound 9 (Antifungal agent 67), an imidazole class antifungal, exhibits efficacy against Candida and possesses a CC50 value of 33.6 μM in neonatal rat

RO-09-4609 is a potent and selective inhibitor of Candida albicans N-myristoyltransferase (CaNmt).

Chitin Synthase Inhibitor 13 (compound 12g), a non-competitive antagonist of chitin synthase, demonstrates broad-spectrum antifungal activity and has an

Fenhexamid (Elevate), a sterol biosynthesis inhibitor, shows antifungal activity against the plant pathogenic fungus.

Nifuroxime, an anti-infective agent, is utilized in researching fungal infections.

Orally active antifungal D16 (IC50: 0.5 μg/mL) passes blood-brain barrier, stable, low toxicity, targets C. neoformansH99 cells.

Ofurace is a fungicide.

Diethofencarb: a fungicide effective against Botrytis cinerea and resistant Botryis strains.

Fosravuconazole is a ravuconazole prodrug. It has antifungal activity.

Chitin Synthase Inhibitor 10: potent antifungal with 0.11 mM IC50, effective against resistant C. albicans and C. neoformans. Used in IFI research.

NSC-670224 blocks HDAC6 and NF-κB, is toxic to yeast at low µM concentrations, similar to tamoxifen's action.

SDH-IN-5 (compound 7d), a potent inhibitor of succinate dehydrogenase (SDH) with an IC50 of 3.293 μM, additionally demonstrates antifungal efficacy, exhibiting

Pyrisoxazole is a novel fungicide inhibitor of Sterol 14α-demethylase.

Potent antifungal, works against Candida albicans (MIC: 0.03 μg/mL) & Aspergillus fumigatus (MIC: 0.5 μg/mL) via CYP51 interactions.

Iodiconazole, an azole antifungal, is used potentially for the treatment of fungal infection.

Tolciclate is an agent of antifungal medication.

Brassilexin is a cyclobrassinin hydrolase inhibitor, a unique enzyme from the fungal pathogen Alternaria brassicicola.

Mollugogenol A: a Gammacerane saponin from Mollugo pentaphylla with antifungal and spermatocidal properties; damages sperm membrane.

NB-598 hydrochloride is a competitive squalene epoxidase (SE) inhibitor.

Iprovalicarb is a fungicide aimed at oomycetes.

Metyltetraprole: potent fungicide, effective against Zymoseptoria, low EC50 (0.002 ppm), inhibits respiratory chain.

Antibacterial agent 67 blocks succinate dehydrogenase more effectively than haloperidol, with IC50 of 0.03 μM vs 4.40 μM.

Pyribencarb, a benzylcarbamate-type fungicide, exhibits broad-spectrum activity against various plant pathogenic fungi.

Isobellidifolin, a xanthone compound, serves as a free radical scavenger and antioxidant. It exhibits a potent antifungal effect.

Diamthazole (Dimazole) hydrochloride, an antifungal agent, is utilized in infection research.

Albaconazole, a small fungal CYP51A1 inhibitor, treats fungal infections and some musculoskeletal disorders.

Rustmicin is a 14-membered macrolide identified as an inhibitor of plant pathogenic fungi.

Aliconazole is an imidazole derivative with antifungal activity for the study of skin infections.

Benthiavalicarb isopropyl is a fungicide, specifically targeting downy mildew and blight.

Orally active CYP51/HDAC-IN-1 dual inhibitor targets virulence factors and resistance genes; effective against Candidiasis and Cryptococcal meningitis.

β-Nor-lapachone is an antibiofilm agent of Candida glabrata.

Sch 39304 is an oral triazole antifungal.

Compound 2f (Antifungal Agent 46) is a potent antifungal that inhibits Ras signaling by targeting protein farnesyltransferase [1].

Pramiconazole (R126638), an oral antifungal, treats dermatophyte and yeast infections in seborrheic dermatitis.

Flutrimazole: a dual-action imidazole with anti-inflammatory and antifungal effects; ideal for topical use due to limited skin penetration.

Olorofim（F-901318）is a new selective antifungal compound that inhibits Aspergillus fumigatus DHODH (IC50: 44 nM). Cost-effective and quality-assured.

Dihydropenicillin F potassium is a novel antibiotic compound, which is semisynthetic in nature, derived from the penicillin family. It is sourced through the modification of natural penicillins, bringing about enhanced stability and efficacy against certain resistant bacterial strains. The mode of action involves the inhibition of bacterial cell wall synthesis, primarily targeting the penicillin-binding proteins (PBPs). This disruption consequently leads to cell lysis and the eventual bacterial death.

ME1111, a succinate dehydrogenase inhibitor of Trichophyton species, serves as an antifungal agent effective against dermatophytes.

PC945 (Opelconazole) is an antifungal compound that inhibits CYP51A/CYP51B and can be used to study fungal infections of the lungs.

Micafungin is an antifungal drug that inhibits the synthesis of ergosterol, a vital component of fungal cell membranes. It is a cyclic peptide with a lipophilic fatty acid chain that has been modified to allow penetration into cells. Micafungin is active against Candida and Aspergillus species and has shown activity against some strains of Cryptococcus neoformans. The MIC (minimum inhibitory concentration) for this drug ranges from 0.06 to 1 microgram/mL, depending on the bacterial strain being tested. Micafungin FR-179642 impurity (acid) is an impurity in micafungin that can be present as trace amounts in the final product and may contribute to hemolytic activity. This impurity is formed by hydrolysis during the synthesis process.

Phosphatase-IN-1 is a phosphatidic acid phosphatase (Pah) inhibitor with antifungal activity for the study of rice blast and ruderalia.

Rilopirox is a synthetic fungicidal antimycotic with hydrophobic characteristics.

Compound 5k (Antiproliferative Agent-18) is an antiproliferative agent that exhibits moderate antibacterial and antifungal activities [1].

HDAC/HSP90-IN-3, a dual inhibitor targeting fungal Hsp90 (IC50: 0.83 μM) & HDAC (IC50: 0.91 μM), counters azole-resistant C. albicans.

Dihydroaltenuene B inhibits mushroom tyrosinase (IC50: 38.33µM) and binds His244, Met280, Gly281 via hydrogen bonds.

VT-1598 is a novel, selective, orally active fungal CYP51 inhibitor. VT-1598 exhibits antifungal effects against Candida albicans.

Chitin Synthase Inhibitor 14 (compound 4n), a potent chitin synthase (CHS) inhibitor, exhibits antifungal activity and is effective against drug-resistant

Alteconazole is an antifungal drug.

Azaconazole, an agricultural fungicide, is used for controlling powdery mildew on crops and bean rust.

Laxifloran possesses antibacterial and antifungal properties.

FR194738 free base inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM. 

FT895 is a selective and potent HDAC11 inhibitor with antifungal and antitumor activity that inhibits HDAC11 expression and limits EV71 replication in vitro.

TMV-IN-5 (compound 1a) serves as an antiviral/antifungal agent, specifically targeting and inhibiting the assembly of the tobacco mosaic virus (TMV) by binding

Pradimicin A derivative 26 exhibits antifungal, antiviral, and antiparasitic properties by attaching to d-mannose (Man)-rich glycans in pathogenic organisms [1

Icofungipen is an oral antifungals with active against Candida species.

Antiproliferative Agent-33 (Compound 2g) serves as an anti-proliferative, antifungal, and antibacterial agent, effectively inhibiting the proliferation of MDA-

Methyl 3,4-dimethoxycinnamate impedes uredospore germination and concurrently inhibits global DNA methylation in Hep3B cells [1] [2].

PF-184563 is an effective and selective non-peptide antagonist of the V1a receptor with oral activity, suitable for studying Raynaud's disease dysmenorrhoea.

Inz-1 is an effective and fungal-selective inhibitor of mitochondrial cytochrome bc1 with IC50s of 8.092 and 45.320 μM for yeast and human.

Byssochlamic acid, a mycotoxin identified in the agricultural fungal pathogen B. fulva, exhibits lethality in mice with an LD50 of 94 mg/kg.

6-Chloro-7-deazapurine-β-D-riboside shows antifungal activity.

Zoxamide (RH-7281) is an oomycete-specific fungicide that impedes nuclear division in Phytophthora capsici germlings and disrupts the microtubule cytoskeleton [

Inz-5 is a fungal-selective inhibitor of mitochondrial cytochrome bc1. Inz-5 impairs fungal virulence. It also prevents the evolution of drug resistance.

N,O-Diacetyltyramine, isolated from the actinomycete Pseudonocardia endophytica VUK-10, exhibits both antibacterial activity against Gram-positive and Gram-negative bacteria, alongside fungi, and demonstrates cytotoxicity towards MDA-MB-231, HeLa, MCF-7, and OAW-42 cells [1].

Antifungal agent 24 (Compound 6) is an antifungal agent that inhibits Candida albicans (MIC: 0.03 μg/ml).