Antifungals

<p>Applications (5E)-5-(3-Bromopropylidene)-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol is an intermediate in the synthesis of 10-Hydroxy (E)-Amitriptyline (D462790). (5E)-5-[3-(dimethylamino)propylidene]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol is a metabolite of amitriptyline (A633350) which is a dibenzocycloheptadiene derivative and an antidepressant (1). Amitriptyline is also a TrkA and TrkB receptor agonist and exhibits neurotrophic and anti-inflammatory activities (2,3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA).<br></p>

<p>Applications Rhein Methylate 3-(2,3,4,6-Tetraacetate β-D-Glucopyranose) is an intermediate in synthesizing Rhein 8-Glucoside (R318520), which has been seen to exhibit cytotoxic and DNA-damaging properties towards tumor and normal human cells. In addition it has been shown to be an inhibitor of PTP1B (Human Protein Tyrosine Kinase 1B) in vitro. It is an analog of Rhein (318500) which is found in the free state and as glucoside in Rheum spp, Polygonaceae (rhubarb) and in Senna leaves. It is a potential antioxidant resource: endophytic fungi from medicinal plants.<br>References Wanitschke, Pharmacology, 20, Suppl. 1, 21 (1980); Raimondi, L., et al.: Pharmacol. Res. Commun., 14, 103 (1982); Franchi-Micheli, S., et al.: J. Pharm. Pharmacol., 35, 262 (1983); Li, S. et al.: J. Asian Nat. Prod. Res., 8, 281 (2006); Shi, Y.Q. et al.: Anticancer. Res., 21, 2847 (2001)<br></p>

<p>Antifungal agent 20 effectively combats various fungi, like Colletotrichum spp., Rhizoctonia, Phytophthora, Diplodia, and Fusarium.</p>

<p>Tecnazene is a giant myofibrillar protein. It also presents in invertebrate striated muscle.</p>

<p>Benzyl 2-hydroxy-6-methoxybenzoate exhibits potent antifungal activity, demonstrating an IC 50 of 25–26 μg/mL against fungal strains.</p>

<p>Amphotericin X1, Amphotericin B derivative, has potent antifungal effects against various fungi (MICs: 1-8 μg/mL).</p>

<p>Butenafine hydrochloride, a squalene epoxidase inhibitor, disrupts ergosterol synthesis, increasing cell membrane permeability.</p>

<p>Dicloran is an aromatic fungicide that delays spore germination and inhibits hyphal growth, effective against Botrytis, Monilinia, Rhizopus, Sclerotinia.</p>

<p>Antifungal agent 76 has broad-spectrum antifungal activity with a MIC value of 0.25-16 μg/mL.Antifungal agent 76 may act by disrupting fungal cell membranes and can be used to study fungal infections.</p>

<p>Anti-fungal; sterol demethylase inhibitor</p>

<p>Broad spectrum imidazole antifungal</p>

<p>Abafungin is an antifungal agent and is used for treating fungal infections.</p>

<p>(+)-Xylariamide A is a probe used for mycobacterial and fungal carbonic anhydrase.</p>

<p>Flusilazole (DPX6573) is an organosilicon fungicide with broad spectrum antifungal effects.</p>

<p>Prothioconazole (Proline 480 SC Fungicide) is a chiral triazole fungicide in plant pathogen control.</p>

<p>Pyrifenox is a pesticide and azole inhibitor.</p>

<p>Enoxastrobin is a reagent biochemical.</p>

<p>Triforine is an agent of biochemical.</p>

<p>Butoconazole (1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole) is an imidazole antifungal agent</p>

<p>Demethoxyencecalin is extracted from Helianthus annuus with antifungal activities.</p>