Antivirals
Found 767 products of "Antivirals"
N-[5-[3-[(4-Hydroxyphenyl)sulfamoyl]-4-methoxyphenyl]-4-methyl-1,3-thiazol-2-yl]-2,2-dimethylpropanamide
CAS:PI4KIII beta inhibitorFormula:C22H25N3O5S2Purity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:475.58 g/molRaltegravir
CAS:Raltegravir is an antiretroviral agent, which is a synthetic integrase inhibitor sourced from pharmaceutical research. Its mode of action involves the inhibition of the HIV-1 integrase enzyme, which is essential for the viral replication process. By blocking the strand transfer step of the integration of viral DNA into the host cell genome, Raltegravir prevents the proliferation of the virus within the host.
Formula:C20H21FN6O5Purity:Min. 98 Area-%Color and Shape:White Off-White PowderMolecular weight:444.42 g/molPimodivir
CAS:Pimodivir is a non-nucleoside-derived inhibitor of the polymerase basic protein 2 (PB2) subunit found in the polymerase complex of the influenza A virus. In general, pimodivir is indicated for the treatment of patients with severe influenza although knowledge about possible rise of resistance is not available.Formula:C20H19F2N5O2Purity:Min. 95%Color and Shape:Slightly Yellow PowderMolecular weight:399.39 g/mol3- Phenyl- N- [1- (phenylmethyl) - 4- piperidinyl] -tricyclo[3.3.1.13, 7] decane- 1- carboxamide
CAS:A compound with antiviral activity against Ebola virus that targets the surface-exposed glycoprotein and inhibits viral entry into host cells. In vitro studies in Vero cells revealed the compound inhibits the viral replication with EC50 of 0.38 µM.Formula:C29H36N2OPurity:Min. 95%Color and Shape:Off-White To Yellow SolidMolecular weight:428.61 g/molLopinavir - Bio-X ™
CAS:Chemically derived from ritonavir, Lopinavir belongs to the amphetamines. Lopinavir is clinically used in the prevention and treatment of HIV infections as it acts as HIV-1 protease inhibitor. In 2020, lopinavir was tested to treat COVID-19 patients and although it led to a higher rate of gastrointestinal side effects, the Lopinavir-treated group had a lower incidence of severe complications. Overall it was deemed not to work as a treatment.Formula:C37H48N4O5Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:628.8 g/molBrivudine
CAS:Anti-viral; thymidine analogue; DNA plymerase inhibitorFormula:C11H13BrN2O5Purity:Min. 95%Color and Shape:White PowderMolecular weight:333.14 g/molDelavirdine mesylate
CAS:Non-nucleoside reverse transcriptase inhibitor; antiviral agent against HIV
Formula:C23H32N6O6S2Purity:Min. 95%Color and Shape:White To Yellow SolidMolecular weight:552.18248Dasabuvir
CAS:Dasabuvir is a non-nucleoside NS5B polymerase inhibitor with action on hepatitis C virus RNA replication and is used for treating hepatitis C in combination therapies.Formula:C26H27N3O5SPurity:Min. 95%Color and Shape:Off-White PowderMolecular weight:493.58 g/molZanamivir hydrate - Bio-X ™
CAS:Potent and selective inhibitor of influenza A and B sialidases. Zanamivir belongs to the class of drugs known as neuraminidase inhibitors. This compound is a sialic acid analogue that occupies viral neuraminidase active site, inhibits enzyme’s hydrolytic activity and cleavage of sialic acid residues from host cell surface glycans. It therefore prevents shedding newly produced virions from infected cell surface and reduces infection of surrounding cells. In in vitro studies with influenza A and B virus isolates, zanamivir inhibited the plaque formation by 50% in canine cells (MDCK) with concentrations between 0.004 and 0.014 μM and 0.02 and 16 μM, respectively. Zanamivir hydrate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formula:C12H22N4O8Purity:(%) Min. 98%Color and Shape:PowderMolecular weight:350.33 g/molTelaprevir
CAS:Inhibitor of hepatitis C viral enzyme NS3-4A serine protease
Formula:C36H53N7O6Purity:Min. 98 Area-%Molecular weight:679.85 g/mol2-Hydroxy-2-methylpropanethioamide
CAS:Controlled ProductApplications 2-Hydroxy-2-methylpropanethioamide is an thioamide compound integrated as an constituent in the synthesis of Ritonavir (R535000) and its derivatives.
Formula:C4H9NOSColor and Shape:NeatMolecular weight:119.191-Oxyl-2,2,5,5-tetramethyl-∆3-pyrrolinyl-4-pyridine Disulfide
Controlled ProductApplications A highly reactive thiol-specific spin-label. A specific conformational probe of thiol site structure by virtue of its minimal rotational freedom and distance from the covalent disulfide linkage to the macromolecule under study.
Formula:C14H19N2OS2Color and Shape:NeatMolecular weight:295.443Abacavir Triphosphate TEA Salt
CAS:Controlled ProductFormula:C14H21N6O10P3·xCH15NColor and Shape:NeatMolecular weight:526.27 + (101.19)xT-705RMP TEA Salt >80% (contain inorganics)
CAS:Applications T-705RMP TEA Salt is a metabolite of T-705RMP (CAS# 356783-08-9), which is a reagent used for the preparation of pyrazine-ribofuranose derivatives as antiviral agents that are useful in the treatment of viral infections. T-705 (Favipiravir) [F103350] gets converted to T-705RMP by host cells, but T-705RMP has little inhibitory effect on the replication of the host cells based on biological studies.
References Zhong, B., et al.: Faming Zhuanli Shenqing, 2014:924257 (2014); Yousuke, F., et al.: Antimicrob Agent Chemother., 49, 981 (2005)Formula:C10H13FN3O9P•xC6H15NColor and Shape:NeatMolecular weight:369.20 + x(101.19)1-[2-O-(Phenoxythioxomethyl)-3,5-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-β-D-ribofuranosyl]-1H-1,2,4-triazole-3-carboxamide
CAS:Controlled ProductApplications 1-[2-O-(Phenoxythioxomethyl)-3,5-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-β-D-ribofuranosyl]-1H-1,2,4-triazole-3-carboxamide is an intermediate in the synthesis of 2’-Deoxyribavirin-5’-triphosphate (D2149940) Triethylamine Salt, a potential new inhibitor for HIV-1 replication.
References Vivet-Boudou, V., et al.: Nucleos. Nucleot. Nucl., 26, 743 (2007);Formula:C27H42N4O7SSi2Color and Shape:NeatMolecular weight:622.88(S)-2-(3-((2-(2-Hydroxypropan-2-yl)thiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic Acid
CAS:Controlled ProductApplications (S)-2-(3-((2-(2-Hydroxypropan-2-yl)thiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic Acid is an intermediate in the synthesis of Ritonavir (R535000) derivatives.
Formula:C14H23N3O4SColor and Shape:NeatMolecular weight:329.422’,3’-O-Isopropylidene-1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxylic Acid Methyl Ester 5’-O-Acetate
Controlled ProductApplications Intermediate in the preparation of Ribavirin.
Formula:C14H19N3O7Color and Shape:NeatMolecular weight:341.322’,3’-O-Isopropylidene-1-Alpha-D-ribofuranosyl-1,2,4-triazole-3-carboxylic Acid Methyl Ester 5’-O-Acetate
Controlled ProductApplications Intermediate in the preparation of α-Ribavirin.
Formula:C14H19N3O7Color and Shape:NeatMolecular weight:341.32(R)-(((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic Acid Methyl Ester Trimethylamine
Controlled ProductApplications (R)-(((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic Acid Methyl Ester Trimethylamine is an intermediate in the synthesis of Tenofovir (T018500), is an acyclic phosphonate nucleotide analogue.
References Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),Formula:C16H31N6O4PColor and Shape:NeatMolecular weight:402.43(4R)-3-[[(1S,2S)-2-Hydroxy-3-cyclopenten-1-yl]carbonyl]-4-(phenylmethyl)-2-oxazolidinone
CAS:Controlled ProductApplications Used in the synthesis of enantioselective synthesis of carbocyclic ribavirin, its analogs and other antiviral agents.
References Kuang, R. et al.; Tetrahedron Lett. 41, 9575 (2000)Formula:C16H17NO4Color and Shape:NeatMolecular weight:287.31
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