Antiparasitics
Antiparasitics are compounds designed to treat and prevent parasitic infections by inhibiting the growth and survival of parasites. This category includes a range of antiparasitic agents intended exclusively for laboratory use and not for human consumption. These products are essential for research purposes, allowing scientists to study parasitic life cycles, mechanisms of action, and the development of resistance. The use of antiparasitics in laboratory settings aids in the discovery and optimization of new treatments for parasitic diseases, contributing to advancements in medical and veterinary parasitology. Researchers rely on these products to enhance their understanding of parasitic infections and to develop more effective therapies.
Found 704 products of "Antiparasitics"
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Diethyl Isobutylmalonate
CAS:Controlled Product<p>Applications Diethyl Isobutylmalonate is used as a reagent in the synthesis of quinoline-based zinc metallo-aminopeptidase inhibitors which have antimalarial activity.<br>References Flipo, M., et al.: Bioorg. Med. Chem. Lett., 13, 2659 (2003)<br></p>Formula:C11H20O4Color and Shape:NeatMolecular weight:216.275-Nitro-1H-quinolin-2-one
CAS:Controlled Product<p>Applications 5-Nitro-1H-quinolin-2-one is used in the synthetic preparation of novel antileishmanial agents for Leishmania donovani promastigotes.<br>References Paloque, L., et al.: Europ. J. Med. Chem., 54, 75 (2012);<br></p>Formula:C9H6N2O3Color and Shape:NeatMolecular weight:190.163-Chloro-N-(3-methoxyphenyl)propanamide
CAS:Controlled Product<p>Applications 3-Chloro-N-(3-methoxyphenyl)propanamide acts as an inhibitor towards DOXP-reductoisomerase (DXR), a primary target for antimalarial drugs.<br>References Bodill, T. et al.: Bioorg. Med. Chem., 21, 4332 (2013);<br></p>Formula:C10H12ClNO2Color and Shape:NeatMolecular weight:213.6623-Des(methoxyimino)-23-hydroxy Moxidectin O-TBS
CAS:Controlled ProductFormula:C42H66O8SiColor and Shape:NeatMolecular weight:727.054-(Aminomethyl)-cyclohexanone Hydrochloride
CAS:Controlled Product<p>Applications 4-(Aminomethyl)-cyclohexanone Hydrochloride is used to prepare dispiro-1,2,4-trioxolanes with antimalarial activities. It is also used to synthesize aminopyrimidines as SYK inhibitors useful in the treatment of SYK-mediated diseases.<br>References Tang, Y., et al.: Bioorg. Med. Chem. Lett., 17, 1260 (2007); Altman, M., et al.: PCT Int. Appl. (2011), WO 2011075515 A1 20110623<br></p>Formula:C7H13NO·HClColor and Shape:NeatMolecular weight:127.18 + 36.463-Aminopropionitrile (Stabilized with K2CO3)
CAS:Controlled ProductFormula:C3H6N2Color and Shape:NeatMolecular weight:70.09Pseurotin A
CAS:Controlled Product<p>Applications Pseurotin A shows antiparasitic and anticancer activity. It exhibits inhibition towards IgE (immunoglobin E) production.<br>References Martinez-Luis, S. et al.: Nat. Prod. Comm., 7, 165 (2012); Bioorg. Med. Chem. Lett., 19, 1457 (2009);<br></p>Formula:C22H25NO8Color and Shape:NeatMolecular weight:431.444-Methoxy-6-(2-phenylethyl)-2H-pyran-2-one
CAS:Controlled Product<p>Applications 4-Methoxy-6-(2-phenylethyl)-2H-pyran-2-one is a Kawain (K145490) derivative that is known to exhibit antimalarial and antituberculosis activities. 4-Methoxy-6-(2-phenylethyl)-2H-pyran-2-one has been identified as a lead compound for the dual treatment of malaria and leishmaniasis.<br>References McCracken, S.T., et al.: Bioorg. Med. Chem., 20, 1482 (2012); Elzaawely, A.A.. et al.: Food. Chem., 103, 486 (2007); Xuan, T.D., et al.: J. Natural. Med., 62, 188 (2008);<br></p>Formula:C14H14O3Color and Shape:NeatMolecular weight:230.262'-O-(2-Methoxyethyl)-5-methylcytidine (~90%)
CAS:Controlled ProductFormula:C13H21N3O6Purity:~90%Color and Shape:NeatMolecular weight:315.324,4'-Dimethyldiphenylamine
CAS:Controlled Product<p>Applications 4,4'-Dimethyldiphenylamine is a reagent used in the comparative studies of the analgesic and anti-inflammatory properties of N-phenylanthranilic acids and mefenamic acid, and the anti parasitic activities of some substituted diphenylamines.<br>References Izard-Verchere, C., et al.: Chimica Therapeutica, 6, 346 (1971)<br></p>Formula:C14H15NColor and Shape:NeatMolecular weight:197.282-Hydroxy-1-methyl-9,10-anthracenedione
CAS:Controlled ProductFormula:C15H10O3Color and Shape:NeatMolecular weight:238.242,5-Diacetoxy-2,5-dihydrofuran (Mixture of Isomers) (>90%)
CAS:Controlled Product<p>Applications 2,5-Diacetoxy-2,5-dihydrofuran is used as a reagent to synthesize Mexicanin H, a biologically active sesquiterpene lactone that exhibits antiparasitic activity against Trypanosoma cruzi (a parasite that causes Chagas disease)<br>References Jimenez-Ortiz, V., et al.: Parasitology, 91, 170 (2005); Romo, J., et al.: Tetrahedron Lett., No vol. given, 1029 (1966)<br></p>Formula:C8H10O5Purity:>90%Color and Shape:NeatMolecular weight:186.16PBD-5,11-dione
CAS:Controlled Product<p>Applications PBD-5,11-dione (cas# 18877-34-4) is a useful research chemical.<br></p>Formula:C12H12N2O2Color and Shape:NeatMolecular weight:216.243-[(Dimethylamino)methyl]-2-hexanone
CAS:Controlled ProductFormula:C9H19NOColor and Shape:ColourlessMolecular weight:157.25Benzenebutanoic Acid Ethyl Ester
CAS:Controlled Product<p>Applications Benzenebutanoic Acid Ethyl Ester is used in the synthesis of thiazolium salts with potent antimalarial activity. Also used in the preparation of novel lactate dehydrogenase A inhibitors. This compound is suitable for lactate dehydrogenase (LDH) related research.<br>References Hamze, A. et al.: J. Med. Chem., 48, 3639 (2005); Ward, R. et al.: J. Med. Chem., 55, 3285 (2012);<br></p>Formula:C12H16O2Color and Shape:NeatMolecular weight:192.25Tizoxanide - 98%
CAS:<p>Anti-parasitic; pyruvate ferredoxin oxidoreductase inhibitor</p>Formula:C10H7N3O4SPurity:Min. 95%Molecular weight:265.01573Oxfendazole
CAS:<p>Oxfendazole is a benzimidazole anthelmintic with action on microtubule formation in parasitic worms and is used for treating gastrointestinal parasites in livestock.</p>Formula:C15H13N3O3SPurity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:315.35 g/molAmoscanate
CAS:<p>Amoscanate is an antischistosomal agent, which is a synthetic compound with a broad spectrum of activity against parasitic infections. Its mode of action involves the disruption of parasite metabolism and structure, ultimately leading to the elimination of schistosomes. Schistosomes are trematode worms responsible for schistosomiasis, a significant parasitic disease affecting millions of people worldwide.</p>Formula:C13H9N3O2SPurity:Min. 95%Molecular weight:271.3 g/molIvermectin
CAS:<p>Naturally produced by the soil bacterium Streptomyces avermitili, it is clinically used in the treatment of parasitosis in both humans and animals. Ivermectin is commercially available as a mixture of 80% 22, 23-dihydroavermectin B1a and 20% 22, 23-dihydroavermectin B1b. In 2020, Ivermectin indicated that it was a good antiviral agent in the treatment of SARS-CoV-2 and a new mechanism of action has been suggested. Ivermectin would act on importin α/β heterodimer and affect nuclear transport and the translocation of viral proteins.</p>Formula:C48H74O14Purity:85%MinMolecular weight:875.1 g/mol4′-O-De(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-O-demethylavermectin A1a
CAS:<p>4′-O-De(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-O-demethylavermectin A1a is a semi-synthetic derivative of avermectin, which is a naturally occurring compound isolated from the fermentation broth of the soil bacterium *Streptomyces avermitilis*. This compound exhibits potent antiparasitic activity by targeting the glutamate-gated chloride channels in the nervous systems of parasitic organisms. By binding and activating these channels, it increases the permeability of the cell membrane to chloride ions, resulting in paralysis and death of the parasite.</p>Formula:C41H60O11Purity:Min. 95%Molecular weight:728.91 g/molPF 1022A
CAS:<p>PF 1022A is a cyclooctadepsipeptide, which is a type of cyclic peptide composed of amino acids and hydroxy acids. It is derived from the fermentation products of the fungus *Mycelia sterilia*, a member of the *Rosellinia* genus. Its mode of action involves disrupting glutamate-gated chloride channels in parasitic nematodes, which leads to paralysis and eventual death of the parasite.</p>Formula:C52H76N4O12Purity:Min. 95%Molecular weight:949.18 g/molHalofuginone
CAS:<p>Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.</p>Formula:C16H17BrClN3O3Purity:99.53%Color and Shape:Off-White SolidMolecular weight:414.68Satranidazole
CAS:<p>Satranidazole is an antimicrobial agent that falls under the category of synthetic nitroimidazoles. It is derived from chemical synthesis and is designed to combat infections caused by specific organisms. The mode of action involves the reduction of the nitro group within the organism, creating reactive intermediates that disrupt DNA synthesis and lead to cell death. This mode of action is notably effective against protozoal infections and anaerobic bacterial infections.</p>Formula:C8H11N5O5SPurity:Min. 95%Molecular weight:289.27 g/molICA
CAS:<p>ICA (N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine) is a SK channel inhibitor and exhibits antileishmanial activity (IC50: 2.1 µM).</p>Formula:C13H10N4SPurity:99.68%Color and Shape:SolidMolecular weight:254.31Piperaquine
CAS:<p>Piperaquine is a bisquinoline antimalarial compound and a companion compound to artemisinin.</p>Formula:C29H32Cl2N6Purity:98%Color and Shape:SolidMolecular weight:535.51BPH-715
CAS:<p>BPH-715 inhibits the liver-stage growth of P. falciparum with an IC50 of 10 μM for P. falciparum exoerythrocytic forms in HepG2 cells.</p>Formula:C17H31NO7P2Purity:98.91%Color and Shape:SolidMolecular weight:423.38Quinfamide
CAS:<p>Quinfamide is a compound with the potential to treat tropical parasitic infections such as Amoebiasis and Helminthiasis.</p>Formula:C16H13Cl2NO4Purity:99.92%Color and Shape:SolidMolecular weight:354.18Halofuginone hydrobromide
CAS:<p>Halofuginone specifically inhibits collagen type I and MMP-2 gene expression, which may result in the suppression of angiogenesis and tumor cell growth.</p>Formula:C16H17BrClN3O3·HBrPurity:97.01% - 99.73%Color and Shape:SolidMolecular weight:495.59Antimalarial agent 26
CAS:<p>Antimalarial agent 26, a derivative of 1,4-naphthoquinones, demonstrates antimalarial properties through oral administration.</p>Formula:C20H22N4O3Purity:98%Color and Shape:SolidMolecular weight:366.41Antiparasitic agent-18
CAS:<p>Antiparasitic agent-18 (compound 3a) exhibits potent and selective antiprotozoal activity, demonstrating effective inhibition of T.</p>Formula:C25H21N7OPurity:98%Color and Shape:SolidMolecular weight:435.48Antimalarial agent 19
CAS:<p>Compound 6e, an antimalarial, targets P. falciparum K1 (EC50 0.3 µM) and P. berghei (EC50 15.3 µM); has high solubility and stability.</p>Formula:C22H33Cl2N5SPurity:98%Color and Shape:SolidMolecular weight:470.5Antimalarial agent 24
CAS:<p>Compound 24 (Compound 7), an in vitro antimalarial agent, demonstrates inhibitory activity against the Plasmodium falciparum W2 strain with an IC50 of 0.81 μM</p>Formula:C20H16N4O2Purity:98%Color and Shape:SolidMolecular weight:344.37Antimalarial agent 29
CAS:<p>Compound 29 (also known as Compound 16) is an antimalarial agent that demonstrates inhibition of the P.</p>Formula:C18H10ClF3N2Purity:98%Color and Shape:SolidMolecular weight:346.73Antileishmanial agent-14
CAS:<p>Antileishmanial agent-14, a sulfuretin analog, exhibits potential activity against Leishmania donovani promastigotes (IC 50 = 4.1 μM) and inhibits infection by</p>Formula:C23H26ClNO5Purity:98%Color and Shape:SolidMolecular weight:431.91Insecticidal agent 2
CAS:<p>Insecticidal agent 2 (example 2) is an effective pesticide that significantly inhibits pest growth [1].</p>Formula:C16H8ClF7N2O2Purity:98%Color and Shape:SolidMolecular weight:428.69Antileishmanial agent-15
CAS:<p>Antileishmanial agent-15 (compound 13c) exhibits potent activity against L.</p>Formula:C28H39N5O4Purity:98%Color and Shape:SolidMolecular weight:509.64Epsiprantel
CAS:<p>Epsiprantel is an orally active antiparasitic drug that inhibits various tapeworms, including Echinococcus granulosus (granular echinococcus), in dogs.</p>Formula:C20H26N2O2Purity:98.09%Color and Shape:SolidMolecular weight:326.43CRK12-IN-2
CAS:<p>CRK12-IN-2, a potent CRK12 inhibitor, has EC50 of 3.2 nM for T. congolense and 0.08 nM for T. vivax; treats trypanosomiasis in animals.</p>Formula:C23H33F2N5O3S2Purity:99.26% - 99.70%Color and Shape:SolidMolecular weight:529.67Symetine
CAS:<p>Symetine（L 16726） is a small molecule compound with antiparasitic activity that can be used to study amoebic liver abscesses in guinea pigs.</p>Formula:C30H48N2O2Purity:99.79%Color and Shape:SolidMolecular weight:468.71(Rac)-ACT-451840
CAS:<p>(Rac)-ACT-451840 is an isomer of ACT-451840 exhibiting antimalarial activity against Plasmodium falciparum NF54.</p>Formula:C47H54N6O3Purity:99.25%Color and Shape:SolidMolecular weight:750.97Chalcone 4 hydrate
CAS:<p>Chalcone 4 hydrate, an anti-parasite compound, inhibits the growth of Theileria and Babesia.</p>Formula:C16H15ClO4Purity:99.54%Color and Shape:SolidMolecular weight:306.74Phosphodiesterase-IN-1
CAS:<p>Phosphodiesterase-IN-1 (Compound 7), a phosphodiesterase (PDE) inhibitor, exhibits anti-Plasmodium and antiproliferative activities. It effectively inhibits P. falciparum (strain 3D7) with an IC 50 value of 0.64 μM [1].</p>Formula:C15H15FN4OColor and Shape:SolidMolecular weight:286.3MMV006833
CAS:<p>MMV006833 is an inhibitor of Plasmodium falciparum. It targets the lipid transfer protein PfSTART1, inhibiting the ring-stage development of Plasmodium falciparum.</p>Formula:C19H27ClN2O4SColor and Shape:SolidMolecular weight:414.95Topoisomerase II inhibitor 16
CAS:<p>Topoisomerase II Inhibitor 16 (compound CT3) is a selective, orally bioavailable, and irreversible inhibitor of trypanosomal topoisomerase II, possessing the</p>Formula:C19H12F4N6OPurity:98%Color and Shape:SolidMolecular weight:416.33SQ109
CAS:<p>SQ109 (NSC-722041) is an effective inhibitor of the trypomastigote form of the parasite (IC50 = 50 nM). SQ109 is an antitubercular agent and targets MmpL3.</p>Formula:C22H38N2Purity:99.70% - 99.91%Color and Shape:SolidMolecular weight:330.55Antitrypanosomal agent 2
CAS:<p>Antitrypanosomal agent 2 shows potent and specific antiparasite activities against Trypanosoma brucei.</p>Formula:C17H13N5O3Purity:99.2%Color and Shape:SolidMolecular weight:335.32Artelinic acid
CAS:<p>Artelinic acid is an artemisinin analog with antimalarial activity and is used for the treatment of multi-drug resistant strains of Plasmodium falciparum.</p>Formula:C23H30O7Purity:97.49% - 97.69%Color and Shape:SolidMolecular weight:418.48Bithionol sulfoxide
CAS:<p>Bithionol sulfoxide (Bithionoloxide) is a compound with inhibitory effects against parasites, inhibiting Fasciola hepatica and Schistosoma mansoni.</p>Formula:C12H6Cl4O3SPurity:98.76%Color and Shape:Off White To Tinch Pink Crystalline PowderMolecular weight:372.05Rufigallol
CAS:<p>Rufigallol, an anthraquinone with six OH groups, induces DLC and fluoresces when aggregated, showing antimalarial effects with vitamin C and ketones.</p>Formula:C14H8O8Purity:98.92% - 99.27%Color and Shape:SolidMolecular weight:304.21
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