Lignans

Applications Schisantherin B is a bioactive of lignans isolated from Schisandra chinesis which protect against cognitive deficits and neurodegeneration induced by Aβ1-42 in mice.
References Xu, M., et al.: Physiol. Behav., 167, 265-273 (2016)

Applications A metabolite of Tamoxifen (T006000), a nonsteroidal estrogen antagonist of interest in the treatment of some forms of breast cancer. Tamoxifen is a Protein Kinase C inhibitor, and induces apoptosis in human malignant glioma cell lines.
References Brandt, S., et al.: Anticancer Res., 23, 223 (2003), Coller, J., et al.: Br. J. Clin. Pharmacol., 57, 105 (2004), Parte, P., et al.: Drug Metab. Dispos., 33, 1446 (2005),

Applications Isotope labelled Terameprocol (T104200) is a semi-synthetic lignan which inhibits the transcription of several inflammatory and oncogenic genes.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ho, S. et al.: Bioorg. med. Chem. Lett., 23, 6127 (2013); Lopez, A. et al.: Anti-Canc. Drugs, 18, 933 (2007);

Magnolin is a bioactive compound, which is a lignan isolated from the plant Magnolia officinalis. It functions as a natural product with various modes of action, primarily interacting with multiple signaling pathways in biological systems. Magnolin primarily inhibits the phosphorylation of key proteins involved in processes such as inflammation and cancer cell proliferation.

(-)-Nortrachelogenin is a bioactive lignan compound, which is a type of secondary metabolite derived from various plant sources, including Forsythia species. This compound is predominantly isolated from the stems and leaves of these plants and is recognized for its potential pharmacological properties.

Prestegane B is a bioactive compound, which is a natural product extracted from the plant Hewittia sublobata. This compound is sourced from the leaves and stems of the plant, which have been traditionally used in various folk medicines. The extraction process involves detailed phytochemical analysis to isolate the active constituents.

Dimethyl epipodophyllotoxin is a semisynthetic anticancer agent, which is a derivative of the naturally occurring compound podophyllotoxin, isolated from the rhizomes of Podophyllum species, typically sourced from North American and Himalayan caustic plants. This compound functions primarily as a topoisomerase II inhibitor, disrupting DNA replication and transcription by stabilizing the DNA-enzyme complex and preventing the re-ligation of DNA strands.

Applications SK-216 is a plasminogen activator inhibitor-1 (PAI-1) that limits tumor progression and angiogenesis, a therapeutic target in the management of malignancy.
References Masuda, T., et al.: Mol. Cancer Ther., 12, 2378 (2013)