Backbone Sugars and Nucleobases
Found 1001 products of "Backbone Sugars and Nucleobases"
6-Thioguanine
CAS:Phosphoribosyltransferase inhibitor; photocytotoxicFormula:C5H5N5SPurity:Min. 95%Color and Shape:PowderMolecular weight:167.19 g/mol7-Cyano-7-deazaguanosine
CAS:7-Cyano-7-deazaguanosine is a nucleoside that belongs to the category of 7-deazapurines. It is an optimized nucleic acid analogue that has been shown to act as a translational inhibitor in vitro and in vivo. This compound has been shown to have high yields in chemical synthesis, which makes it an attractive candidate for optimization and future research. 7-Cyano-7-deazaguanosine is a synthetic nucleotide with anticodon properties, which may be useful for the development of new drugs against bacterial infections.Formula:C12H13N5O5Purity:Min. 95%Color and Shape:PowderMolecular weight:307.26 g/mol3-Isobutyl-1-methylxanthine
CAS:Controlled ProductA non-specific inhibitor of cAMP and cGMP phosphodiesterases (PDEs) with IC50 values between 2 and 50 µM. 2-isobutyl-1-methylxanthine (IBMX) has also been found to inhibit phenylephrine-induced 5-HT release by neuroendocrine epithelial cells and IBMX-mediated increase in cAMP and upregulation of Ca2+ channels promotes neuronal differentiation. Additionally IBMX stimulates secretion of thyroid hormones, resulting in cAMP-mediated activation of glycogenolysis and reduced glycogen storage.Formula:C10H14N4O2Color and Shape:Slightly Yellow PowderMolecular weight:222.24 g/molN4-Hydroxycytosine
CAS:N4-Hydroxycytosine is an intramolecular hydrogen that inhibits the replication of viruses by inhibiting their DNA polymerase. It is a structural analogue of cytosine and can be found in both left- and right-handed forms, which are termed isomers. The chemical study of N4-hydroxycytosine has shown it to have inhibitory effects on human immunodeficiency virus and hepatitis C virus. 13C-NMR spectroscopy has been used to identify the chemical structure of N4-hydroxycytosine and its reactivity with other molecules. N4-Hydroxycytosine can be synthesized by the reaction between formaldehyde and 2,3,5,6-tetrafluorocytosine.Formula:C4H5N3O2Purity:Min. 95%Color and Shape:PowderMolecular weight:127.1 g/molAdenine sulphate
CAS:Adenine sulphate is a nucleotide that is involved in the formation of DNA and RNA. Adenine sulphate is synthesized from adenosine triphosphate and sulfuric acid. It has been shown to be an important component of DNA polymerase, which is responsible for the production of RNA and DNA. Adenine sulphate also plays a role in the development of insect resistance in plants and tissue culture cells. Adenine sulphate levels have been found to be reduced in patients with orotic aciduria, a condition characterized by high levels of orotic acid in the urine. The decreased adenine sulfate levels are thought to be due to an imbalance between adenosine diphosphate, which inhibits adenylosuccinate lyase (ADSL), and sulfite oxidase (SOX) activity. ADSL converts adenosine diphosphate into adenosinethiol disulfide, while SOX converts sulfite into hydrogen sulfide
Formula:C5H5N5•(H2O4S)0Purity:Min. 95%Color and Shape:White PowderMolecular weight:184.17 g/mol6-Chloro-9-(tetrahydro-2H-pyran-2-yl)purine
CAS:6-Chloro-9-(tetrahydro-2H-pyran-2-yl)purine is a nucleoside analog that is used to treat various types of cancer. It is a c–h bond regiospecific nucleophile that forms the 6-chloro 9-(tetrahydro-2H-pyran-2-yl)purine intermediate. The chloride ion acts as a nucleophile in the first step of this process, which results in the formation of an organocuprate and glyoxylate. 6CPP binds to DNA and inhibits RNA synthesis, leading to cell death by apoptosis or necrosis. This drug has been shown to be effective for treating human cell lines. 6CPP is also known for its antitumor effects, which may be due to its ability to inhibit phosphonates and cross-coupling reactions.Formula:C10H11ClN4OPurity:Min. 95%Color and Shape:SolidMolecular weight:238.67 g/mol3’,5’-Di-O-benzoyl-2’-deoxy-2’-fluoro-5-trifluoromethyl-arabinouridine
CAS:Please enquire for more information about 3’,5’-Di-O-benzoyl-2’-deoxy-2’-fluoro-5-trifluoromethyl-arabinouridine including the price, delivery time and more detailed product information at the technical inquiry form on this pagePurity:Min. 95%6-Chloro-7-deazaguanine
CAS:6-Chloro-7-deazaguanine (6CDG) is a pyrimidine nucleoside that is used in the treatment of hepatoblastoma and hepatitis. 6CDG is an alkylating agent that binds to DNA and causes strand breakage by forming covalent bonds with the N-7 position of guanine. It can also be used as an antiviral agent against herpes simplex virus, as it inhibits viral replication by inhibiting the viral DNA polymerase. 6CDG does not inhibit human DNA polymerase. The drug has been shown to be cytotoxic to MRC5 cells, which are resistant to pyrimidine analogs.
Formula:C6H5ClN4Purity:Min. 95%Color and Shape:PowderMolecular weight:168.58 g/mol8-Hydroxyguanine
CAS:8-Hydroxyguanine is a purine derivative that is found in DNA. It is a byproduct of oxidative damage to DNA and can cause mutations. 8-Hydroxyguanine binds to the α1 subunit of DNA polymerase, inhibiting the polymerization of nucleotides. This prevents the synthesis of new DNA, resulting in cell death. In humans, 8-hydroxyguanine appears to be repaired at a higher rate than other organisms such as bacteria. A study has shown that human cells are able to repair 8-hydroxyguanine by using an enzyme called O6-alkylguanine transferase (AGT). The AGT protein removes the alkyl group from the guanine base and replaces it with an amino group during repair. This process results in the formation of O6-methylguanine, which can be eliminated by methylation or excreted through urine.Formula:C5H5N5O2Purity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:167.13 g/mol3,7-Dimethyl-1-propargylxanthine
CAS:Controlled Product3,7-Dimethyl-1-propargylxanthine is a cyclase inhibitor that has been shown to have pharmacological effects. It has been shown to be effective in vivo models of Parkinson's disease and has reduced locomotor activity. This drug also inhibits the production of adenosine and dopamine, leading to neuronal death. The 3,7-dimethyl-1-propargylxanthine shows high selectivity for adenosine A3 receptors and is an antagonist at these receptors. It prevents mitochondrial membrane potential from decreasing, which may be due to inhibition of the production of reactive oxygen species by mitochondria. 3,7-Dimethyl-1-propargylxanthine also inhibits platelet aggregation by blocking the activation of phospholipase C and enhances platelet aggregation by inhibiting phosphodiesterase activity.Formula:C10H10N4O2Purity:Min. 95%Color and Shape:PowderMolecular weight:218.21 g/mol3’,5’-Di-O-acetyl-2’-azido-2’-deoxy-5-methyluridine
CAS:Please enquire for more information about 3’,5’-Di-O-acetyl-2’-azido-2’-deoxy-5-methyluridine including the price, delivery time and more detailed product information at the technical inquiry form on this pagePurity:Min. 95%1,3-Dimethyluracil
CAS:1,3-Dimethyluracil is a uracil derivative that is used as a hydrogen-bond donor, which helps to repair DNA. It has been shown to have a kinetic isotope effect in the deuterium isotope effect studies. The carbonyl group of 1,3-dimethyluracil can form hydrogen bonds with the guanine base in DNA and lead to the formation of an adduct. This adduct can be repaired by nucleotide excision repair when it forms a dimer with another 1,3-dimethyluracol molecule or by base excision repair when it forms a dimer with another purine or pyrimidine base. Aqueous solutions of 1,3-dimethyluracil are stable for short periods of time but decompose rapidly on heating. X-ray crystal structures show that 1,3-dimethyluracil binds to hydrochloric acid and x-ray crystallographic analysisFormula:C6H8N2O2Purity:Min. 95%Color and Shape:Off-White Slightly Brown PowderMolecular weight:140.14 g/molHypoxanthine monosodium salt
CAS:Hypoxanthine is a nucleotide, which is a building block of DNA and RNA. It is a useful intermediate for the production of other chemicals and drugs. Hypoxanthine can be used as a reagent in biochemical research, to study the effects of hypoxia on cells, or as a catalyst in organic synthesis. Hypoxanthine monosodium salt is an important building block for complex compounds with many uses. It is also used as a reaction component in many chemical reactions as well as being a versatile scaffold for drug design.Formula:C5H4N4NaOPurity:Min. 97 Area-%Color and Shape:White PowderMolecular weight:159.1 g/molNb-N-(benzhydryloxycarbonyl)cytosine)-1-acetic acid
CAS:Nb-N-(benzhydryloxycarbonyl)cytosine)-1-acetic acid is a speciality chemical that is used as a reagent, building block, and scaffold for organic synthesis. This compound can be used in various reactions to produce complex compounds with high purity. Nb-N-(benzhydryloxycarbonyl)cytosine)-1-acetic acid is an excellent starting material for the production of fine chemicals, research chemicals, and versatile building blocks. It is also a useful intermediate for the production of pharmaceuticals and other useful compounds.Formula:C20H17N3O5Purity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:379.37 g/mol6-Amino-1,3-dimethyluracil
CAS:6-Amino-1,3-dimethyluracil is a synthetic compound that has been shown to have antiinflammatory activity. This drug was synthesized from recycled methylene biphenyls and quinoline derivatives. 6-Amino-1,3-dimethyluracil inhibits the synthesis of proteins in cells by inhibiting the production of amino acids such as methionine through an attack on the amino group of methionine. 6-Amino-1,3-dimethyluracil also has apoptotic activity, which may be due to its ability to inhibit protein synthesis and increase the levels of active methylene.Formula:C6H9N3O2Purity:Min. 95%Color and Shape:PowderMolecular weight:155.15 g/mol3'-Deoxy-2',3'-Didehydro-2'Fluorothymidine
CAS:3'-Deoxy-2',3'-Didehydro-2'Fluorothymidine (3DFT) is a nucleoside analogue of thymidine. It has been shown to be an efficient inhibitor of HIV replication in vitro and in vivo. 3DFT is able to inhibit virus production by blocking the viral reverse transcriptase enzyme, which is responsible for copying the viral genomic RNA into DNA. This drug also inhibits the activity of human immunodeficiency virus type 1 integrase, which is an enzyme that catalyses the integration of proviral DNA into host cell chromosomes. 3DFT is a potent inhibitor of HIV infection in vitro and in vivo and has also been shown to inhibit other viruses such as cytomegalovirus, herpes simplex virus types 1 and 2, varicella zoster virus, influenza A virus, coxsackie B4 virus, echovirus 7, and erythrovirus 9.Formula:C10H11FN2O4Purity:Min. 95%Molecular weight:242.2 g/mol3’-Deoxy-5-fluorouridine
CAS:3’-Deoxy-5-fluorouridine is a synthetic compound that is used as an anticancer drug. It has been shown to induce apoptosis in cancer cells through the modulation of polymerase, synthetase and other enzymes involved in DNA synthesis. 3’-Deoxy-5-fluorouridine also inhibits the activity of viral thymidylate synthase, which prevents the conversion of deoxyuridine triphosphate (dUTP) to thymidylate monophosphate (dTMP), preventing DNA replication and cell division. This chemical can be synthesized by reacting uracil with trifluoroacetic acid followed by saponification.
Purity:Min. 95%9-Deazaguanine
CAS:9-Deazaguanine is an analog of guanine, which has inhibitory properties. It reacts with the hydrogen bond of the enzyme and prevents its reaction with a substrate. 9-Deazaguanine binds to the target enzymes trifluoroacetic acid (TFA) and hydrogen bond interactions with water molecules. The reaction mechanism is based on the competitive inhibition of TFA, which is an important enzyme in DNA synthesis. 9-Deazaguanine inhibits the growth of k562 cells by inhibiting protein synthesis at specific sites in the ribosome. 9-Deazaguanine also shows inhibitory properties against autoimmune diseases and infectious diseases because it inhibits immune system reactions that are mediated by antibodies and T cells.
Formula:C6H6N4OPurity:Min. 95%Color and Shape:PowderMolecular weight:150.14 g/mol3’,5’-Bis-O-benzoyl-2’-deoxy-2’-fluoro-β-D-arabino-6-azidouridine
CAS:Please enquire for more information about 3’,5’-Bis-O-benzoyl-2’-deoxy-2’-fluoro-beta-D-arabino-6-azidouridine including the price, delivery time and more detailed product information at the technical inquiry form on this pagePurity:Min. 95%9-Methylxanthine
CAS:Controlled Product9-Methylxanthine is a purine alkaloid that is structurally related to caffeine. It is used as a bronchodilator and to treat cardiac arrhythmias. 9-Methylxanthine has been shown to have an effect on the rate of DNA replication by binding to the enzyme xanthosine phosphorylase, which converts xanthosine monophosphate (XMP) to xanthosine diphosphate (XDP). The drug's effect on other nucleobases, such as adenosine monophosphate (AMP), cannot be ruled out. 9-Methylxanthine also has a strong affinity for macrochelates, which are compounds that contain chelating agents with a large number of ethylenediaminetetraacetic acid (EDTA) groups. This property is due to the high number of nitrogen atoms in the molecule and its ability to form hydrogen bonds between water moleculesFormula:C6H6N4O2Purity:Min. 95%Color and Shape:PowderMolecular weight:166.14 g/mol6-Mercaptopurine
CAS:6-Mercaptopurine is an antigen binding molecule that is biocompatible with the human body. It binds to 6-mercaptopurine and inhibits the oxidation of proteins. The inhibition of protein oxidation has been shown to decrease disease activity in patients with inflammatory bowel disease. 6-Mercaptopurine also inhibits the production of inhibitor molecules, which are responsible for the development of cardiac effects such as arrhythmias and cardiomyopathy. 6-Mercaptopurine has inhibitory properties against polymerase chain reactions, which may be due to its ability to bind with protein thiols at high rates.Formula:C5H4N4SPurity:Min. 98 Area-%Color and Shape:PowderMolecular weight:152.18 g/mol3’-Deoxy-3’-fluoro-6-thioinosine
CAS:Please enquire for more information about 3’-Deoxy-3’-fluoro-6-thioinosine including the price, delivery time and more detailed product information at the technical inquiry form on this page
Purity:Min. 95%3-Benzyladenine
CAS:Controlled ProductApplications 3-BENZYLADENINE (cas# 7280-81-1) is a useful research chemical.
Formula:C12H11N5Color and Shape:NeatMolecular weight:225.259N-Trityl Guanine
CAS:Controlled ProductApplications Protected Guanine.
References Hakimelahi, G., et al.: J. Med. Chem., 44, 3710 (2001),Formula:C24H19N5OColor and Shape:NeatMolecular weight:393.44Uracil Lyxonucleoside-13C,15N2 5'-Phosphate
CAS:Controlled ProductApplications Uracil Lyxonucleoside 5'-Phosphate is an intermediate in the synthesis of Trilithium UDP-glucuronic Acid-13C1, 15N2 (T886287), which is an isotope labelled analog of Trisodium UDP-glucuronic Acid (T886285). Trisodium UDP-glucuronic Acid is a reactant used in the enzymatic preparation of β-glucuronides.
References Stevenson, D.E., et. al.: Collect Czech. Chem. C., 65, 117 (2000); Robotham, S.A., Brodbelt, J.S.: Biochem. Pharmacol., 82, 1764 (2011); Kren, V., et. al.: Drug Metab. Dispos., 28, 1513 (2000)Formula:C813CH1315N2O9PColor and Shape:NeatMolecular weight:327.16N2,9-Diacetylguanine
CAS:Controlled ProductImpurity Acicclovir EP Impurity L
Applications N2,9-Diacetylguanine (Acicclovir EP Impurity L) is used to synthesize acyclic analogues of deoxyguanosine.
References Martin, J. C., et al.: J Med Chem. 26, 759 (1983)Formula:C9H9N5O3Color and Shape:NeatMolecular weight:235.2N-Allyl-1,7-dideazaadenine
CAS:Controlled ProductApplications Used in the preparation of pyrrolotriazines.
Formula:C10H11N3Color and Shape:NeatMolecular weight:173.21Diisopropylammonium Tetrazol-1-ide
CAS:Formula:C6H15N·CH2N4Purity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:171.258-Chloroadenine
CAS:8-Chloroadenine is an antimicrobial agent that inhibits the DNA replication of bacteria by binding to the dna template. It is a potent inhibitor of oxidative DNA damage and has been shown to be effective against various bacteria, including Staphylococcus aureus. 8-Chloroadenine also has reactive properties and can react with chloride in the environment to form hypochlorous acid (HOCl) and 8-chloroguanine. This compound may also act as an enzyme catalyst for the enzymatic reaction between hypochlorous acid and chloride ions.Formula:C5H4ClN5Purity:Min. 95%Color and Shape:PowderMolecular weight:169.57 g/mol7-Deaza-6-hydroxypurine
CAS:7-Deaza-6-hydroxypurine is a skeleton of nucleosides that inhibits enzymes. It has been shown to inhibit the activity of hydrochloric acid, a tumor metastasis promoter. The constant for this drug was determined using molecular modeling and inhibition constants. 7-Deaza-6-hydroxypurine has anticancer activity and can be used for the treatment of cancer. This drug is used as a noncompetitive inhibitor in which it binds to two different sites on the enzyme. It has also been shown to bind to subunits, which are parts of a protein that make up its structure, in biological studies.br> 7-Deaza-6-hydroxypurine is an inhibitor that binds to two different sites on an enzyme. It has been shown to have anticancer activity and can be used for the treatment of cancer. This drug is used as a noncompetitive inhibitor in which it binds to two different sites on the enzyme. ItFormula:C6H5N3OPurity:Min. 95%Color and Shape:PowderMolecular weight:135.12 g/mol1,3-Dipropylxanthine
CAS:Controlled Product1,3-Dipropylxanthine is a congener of caffeine. It is a nonselective adenosine receptor antagonist that binds to the adenosine receptors in the kidney. 1,3-Dipropylxanthine has been shown to increase renal blood flow and increase urine output. This drug may be used as a mobilisation agent for patients who are bedridden or have limited mobility. It should not be given to patients with heart disease or high blood pressure. 1,3-Dipropylxanthine has also been shown to inhibit the binding of pyrimido [1,2-a]benzimidazole (PPIM) and furyl derivatives to the adenosine receptor.Formula:C11H16N4O2Purity:Min. 95%Color and Shape:PowderMolecular weight:236.27 g/mol5-Iodocytosine
CAS:5-Iodocytosine (5-IC) is an analog of cytosine that can be used as a precursor for the synthesis of thymine. 5-IC has been shown to cross-couple with DNA, which may contribute to its antiviral potency. 5-IC is also a potent inhibitor of dna replication and herpes simplex virus. The biochemical properties of 5-IC have been extensively studied, including its ability to react with hydrochloric acid to form the corresponding tautomers. The hydrolysis rate increases at higher pH values and decreases at lower pH values. Bioconjugate chemistry has been applied to synthesize a bioconjugated prodrug of 5-IC for cancer treatment.
Formula:C4H4IN3OPurity:Min. 95%Color and Shape:PowderMolecular weight:237 g/mol(R)-(+)-9-(2-Hydroxypropyl)adenine
CAS:(R)-(+)-9-(2-Hydroxypropyl)adenine (HPA) is a carbocyclic nucleoside that has been shown to be effective against the human immunodeficiency virus (HIV). HPA inhibits the reverse transcriptase and integrase enzymes, which are necessary for HIV replication. It also inhibits phosphorylation of host cell proteins, leading to decreased viral protein synthesis. The reaction yield of this compound is high and it can be industrially produced with a synthetic process. HPA is synthesized from adenosine by the addition of two hydroxyl groups on the adjacent carbon atoms. HPA has a low energy ring-opening reaction with hydrogen chloride, which leads to its potent inhibition of HIV infection.Formula:C8H11N5OPurity:Min. 95%Color and Shape:PowderMolecular weight:193.21 g/mol5-Bromo-6-azauracil
CAS:5-Bromo-6-azauracil is a nucleophilic compound that can be used to treat wastewater. It is also able to lyse cells and has been used as an immobilizing agent. The reactive nature of 5-Bromo-6-azauracil enables it to undergo nucleophilic substitutions with amines, which are present in the cell wall and other biomolecules. This process results in the formation of amide bonds, which leads to the inhibition of protein synthesis. 5-Bromo-6-azauracil has shown inhibitory effects on glucans, which may be due to its ability to form covalent bonds with glucose molecules.Formula:C3H2BrN3O2Purity:Min. 95%Color and Shape:White To Off-White SolidMolecular weight:191.97 g/molFmoc-PNA-C(Bhoc)-OH
CAS:Formula:C39H35N5O8Purity:>95.0%(qNMR)Color and Shape:White to Light yellow powder to crystalMolecular weight:701.748-Azaadenine
CAS:8-Azaadenine is an analog of adenine that binds to the purine receptor in the cell membrane. It has been shown to inhibit the growth of bacterial strains, such as Klebsiella pneumoniae and Staphylococcus aureus, by targeting their DNA gyrase and topoisomerase IV. 8-Azaadenine has also been shown to have a high resistance to bacterial mutants resistant to other antibiotics. It has been found that the nitrogen atoms in 8-azaadenine are important for its biological properties. The optimum pH for this antibiotic is 7.4.Formula:C4H4N6Purity:Min. 95%Color and Shape:PowderMolecular weight:136.12 g/mol8-Nitroguanine
CAS:8-Nitroguanine is a reactive cell factor that can be found in the skin and other tissues. It is an endogenous product of nitric oxide, which can be formed by the reaction of nitric oxide with superoxide in the presence of peroxynitrite. 8-Nitroguanine has been shown to inhibit matrix metalloproteinase-9 activity and to have a protective effect on cells from UV radiation. 8-Nitroguanine also has been shown to be a potential biomarker for bowel disease and damage. The levels of 8-nitroguanine increase in chronic viral hepatitis and cancer tissues. This compound can also be used as an analytical method for detection of inflammation, oxidative stress, or DNA damage.Formula:C5H4N6O3Purity:Min. 95%Color and Shape:PowderMolecular weight:196.13 g/mol7-Methylguanine
CAS:Temozolomide is an anticancer drug that is used in the treatment of malignant brain tumors. It is a prodrug which undergoes conversion to its active form 7-methylguanine by deamination and oxidation. Temozolomide inhibits viral replication by inhibiting the synthesis of nuclear DNA and blocking the progression of RNA polymerase. The reaction mechanism involves oxidative injury to DNA, leading to crosslinking and breakage with subsequent inhibition of polymerase chain reaction amplification. Temozolomide has been shown to have carcinogenic potential in laboratory animals. This drug has been shown to have biochemical properties that are similar to those found in other drugs such as cisplatin, vinblastine, and adriamycin, which also inhibit cellular growth through reactive oxygen species (ROS) production. Structural analysis has revealed that temozolomide binds tightly to nuclear DNA with a conformation that is similar to the natural substrate for DNA gyrase, topFormula:C6H7N5OPurity:Min. 95 Area-%Color and Shape:Slightly Brown PowderMolecular weight:165.15 g/molEritadenine
CAS:Eritadenine is a glycoside that has been found in the edible roots of plants belonging to the family Euphorbiaceae. Eritadenine is an inhibitor of malonic acid, which is a precursor for fatty acid synthesis. It has also been shown to have biological properties, such as inhibiting fat cell growth and reducing cholesterol levels in rats. Eritadenine can be detected with an analytical method that uses high-performance liquid chromatography coupled with a photodiode array detector. This method separates and identifies eritadenine from other compounds using polymerase chain reaction amplification on camp levels and sodium salts. Eritadenine can also be found in samples of liver cells or ethanolamine.Formula:C9H11N5O4Purity:Min. 95%Color and Shape:PowderMolecular weight:253.21 g/molAzathioprine
CAS:Formula:C9H7N7O2SPurity:>98.0%(T)(HPLC)Color and Shape:Light yellow to Yellow to Green powder to crystalMolecular weight:277.265-Trifluorothymine
CAS:Intermediate in the synthesis of tipiracil + trifluridineFormula:C5H3F3N2O2Purity:Min. 95%Color and Shape:PowderMolecular weight:180.08 g/mol6-Ethoxypurine
CAS:6-Ethoxypurine is a nucleoside analog that inhibits the enzyme ribonucleotide reductase, which converts ribonucleotides to deoxyribonucleotides. It is used in cell culture to measure the effects of radiation and hydrochloric acid on the production of ATP. 6-Ethoxypurine has been shown to inhibit influenza virus replication with an IC50 of 10 μM. This compound has reactive hydroxyl groups that allow it to participate in hydrogen bonding, which can be beneficial for interactions with other molecules. 6-Ethoxypurine also exhibits nucleophilic properties, which allows it to react with other chemical species and can be useful for generating new chemical compounds.Formula:C7H8N4OPurity:Min. 95%Color and Shape:PowderMolecular weight:164.16 g/molN9-Methyladenine
CAS:N9-Methyladenine is a purine derivative that has been shown to be an antagonist at the adenosine receptor. It can be synthesized by reacting N6-benzoyladenine with methanol, followed by treatment with aqueous sodium hydroxide and hydrogen peroxide. The molecule is planar, with a neutral pKa of 7.4. Proton and nitrogen NMR spectra were obtained for this compound, which showed it to have two hydrogen bonds and one intermolecular hydrogen bond. The proton resonances are observed at 2.97 ppm (H1) and 3.27 ppm (H2).Formula:C6H7N5Purity:Min. 95%Color and Shape:PowderMolecular weight:149.15 g/mol6-Chloro-1,3-dimethyluracil
CAS:6-Chloro-1,3-dimethyluracil is a nucleoside analog that has been shown to be cytotoxic in vitro. This compound can be synthesized by reacting naphthalene with a nucleophilic nitrogen source, such as sodium carbonate and chlorinating the resulting product with trifluoroacetic acid. 6-Chloro-1,3-dimethyluracil can also be synthesized by reacting malonic acid with cyclen and uridine in the presence of copper metal. The reaction mechanism is believed to involve photoelectron transfer from the copper metal to the uridine ring.
Formula:C6H7ClN2O2Purity:Min. 95%Color and Shape:White PowderMolecular weight:174.58 g/mol6-Methyl-5-nitrouracil
CAS:Formula:C5H5N3O4Purity:>95.0%(T)(HPLC)Color and Shape:Light orange to Yellow to Green powder to crystalMolecular weight:171.117-Methyladenine
CAS:7-Methyladenine is a nitrogen-containing compound that has been shown to cause an increase in renal blood flow. It is also a synthetic estrogen. 7-Methyladenine is mainly metabolized by methylation, and it can be detected in urine samples. This substance has been shown to have a direct effect on cardiac contractility and blood pressure. 7-Methyladenine also has the ability to stimulate the growth of cells and tissues, as well as being able to inhibit the synthesis of certain proteins.Formula:C6H7N5Purity:Min. 95%Color and Shape:White To Off-White SolidMolecular weight:149.15 g/mol2-Thiothymine
CAS:2-Thiothymine is a nucleotide that can be synthesized by the polymerase chain reaction. It is used as a probe for determining the sequence of DNA duplexes. 2-Thiothymine binds to dna and forms hydrogen bonds with the nitrogen atoms in dna bases, which prevents them from being able to bind with other dna bases, thereby disrupting the binding of dna strands. This leads to chain reactions that result in high temperatures and could cause damage to the cells. 2-Thiothymine has been shown to be toxic to both bacteria and human cells. It was found to inhibit HIV infection by binding to viral RNA and preventing it from being translated into protein, leading to cell death.
Formula:C5H6N2OSPurity:Min. 95%Color and Shape:Off-White PowderMolecular weight:142.18 g/mol8-Hydroxyguanine hydrochloride
CAS:8-Hydroxyguanine hydrochloride is a fine chemical that is used as a building block in the synthesis of pharmaceuticals, agrochemicals and other organic compounds. It is also used as a reagent for research into the mechanisms of DNA damage. CAS No. 1246818-54-1 8-Hydroxyguanine hydrochloride is a complex compound that can be used as a versatile building block for the synthesis of many different types of molecules, including valuable intermediates and scaffolds for drug discovery.
Formula:C5H5N5O2•HClPurity:Min. 90 Area-%Color and Shape:White PowderMolecular weight:203.59 g/mol3’-O-t-Bulyldimethylsilyl thymidine
CAS:3’-O-t-Bulyldimethylsilyl thymidine is a nucleoside analog that is chemically stable and has been shown to be a potential biomarker for the diagnosis of fetal bovine spongiform encephalopathy (BSE). 3’-O-t-Bulyldimethylsilyl thymidine binds to basic proteins in the cell nucleus, which can be detected by immunoassay. It also has been shown to inhibit protein synthesis in tubule cells of the kidney and skin cancer cells. The drug is metabolized by dephosphorylation to t-butyldeoxyuridine, which is then converted into thymidine.Formula:C16H28N2O5SiPurity:Min. 95%Color and Shape:White PowderMolecular weight:356.49 g/molAutoinduction Medium (AIM) Solution
Autoinduction Medium (AIM) Solution for protein expression that needs little user intervention after inoculation of the culture. The principle of AIM media is based on carbon sources in the medium that are metabolized differentially to promote high density cell growth and automatically induce protein expression from lac promoters. This solution constitutes a unique combination of carbon source concentrations. AIM with pH 7.2 provides an efficient way to produce recombinant proteins for functional characterizations. This solution is useful in the study of intensity of induction, expression at different cell densities, or investigation of induction in early-, mid-, or late-log conditions of proteins of focused interest.Color and Shape:Liquid, Dark Yellow to Brown, Clear
