Hormones

<p>Expression system: E. coli&lt;br&gt;Length: 29-227, Full Length of Mature Protein&lt;br&gt;Activity: Enzyme activity</p>

<p>Glucagon is a secreted protein and belongs to the glucagon family.</p>

<p>Parathyroid hormone is the most important endocrine regulator of calcium and phosphorus concentration in extracellular fluid.</p>

<p>Adiponectin Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag.</p>

<p>Prolactin Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag.</p>

<p>Choriogonadotropin subunit beta is also known as CG-beta, Chorionic gonadotrophin chain beta.</p>

<p>AGRP Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>

<p>Resistin known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1) that seems</p>

<p>FSH Beta Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.</p>

<p>Chorionic Gonadotropin/CGA Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag.</p>

<p>Pancreatic derived factor, also known as FAM3B, is an islet-specific secreted cytokine specifically expressed at high levels in the islets of Langerhans of the</p>

<p>Fertility is dependent on follicle-stimulating hormone (FSH), a product of gonadotrope cells of the anterior pituitary gland.</p>

<p>Adiponectin Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag.</p>

<p>Chorionic Gonadotropin/CGA Protein, Human, Recombinant is expressed in HEK293 mammalian cells.</p>

<p>Parathyroid hormone (PTH) is a critical hormone in the regulation of Ca++ homeostasis.</p>

<p>The potential application of glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide, GIP) in the management of obesity and type 2 diabetes</p>

<p>CGB7 (chorionic gonadotropin, beta polypeptide 7) belongs to the glycoprotein hormones subunit beta family.</p>

<p>The potential application of glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide, GIP) in the management of obesity and type 2 diabetes</p>

<p>Glucose-dependent insulinotropic polypeptide (GIP) is an incretin that plays an important role in fat accumulation.</p>

<p>Procalcitonin/CALCA Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag.</p>

<p>Resistin is an adipocytokine, which has been studied for its role in insulin resistance and recently in inflammation.</p>

<p>Procalcitonin/CALCA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>

<p>Adiponectin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.</p>

<p>The potential application of glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide, GIP) in the management of obesity and type 2 diabetes</p>

<p>Prolactin Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag.</p>

<p>FSH alpha &amp; FSH beta Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.</p>

<p>Adiponectin Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag.</p>

<p>AGRP Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.</p>

<p>AGRP Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>

<p>Chorionic Gonadotropin/CGA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>

<p>AGRP Protein, Rhesus, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag.</p>

<p>FSH Beta Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>

<p>Adiponectin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>

<p>Fertility is dependent on follicle-stimulating hormone (FSH), a product of gonadotrope cells of the anterior pituitary gland.</p>

<p>AGRP Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.</p>

<p>Applications Pralmorelin is a growth hormone secretagogue that acts on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone release.<br>References Howard, A. D., et al.: Science, 273, 974 (1996)<br></p>

<p>Applications 5α-Pregnane-3β,20(S)-diol, is a metabolite of Progesterone (P755900).<br>References Beall, et al.: Biochem. J., 31, 35 (1937), Okuda, A., et al.: J. Biol. Chem., 259, 7519 (1984), Russell, D., et al.: Biochemistry, 31, 4737 (1992), Kondo, K., et al.: Eur. J. Biochem., 219, 357 (1994), Westerbacka, J., et al.: J. Clin. Endocrinol. Metab., 88, 4924 (2003),<br></p>

<p>Applications It is used as cholesterol-lowering agent.<br>References Bauer, D., et al.: Polym Deg. Stab., 48, 259 (1995), Nakahara, K., et al.: Chem. Physics Lett., 359, 351 (2002),<br></p>

<p>Applications A degradation and metabolic intermediate of Dexamethasone (D298800). A Dexamethasone enol aldehyde as inflammation inhibitor.<br>References Weiss, G., et al.: J. Clin. Endocrinol. Metab., 43, 696 (1976), Hirschmann R., et al.: Steroids, 57, 579 (1992),<br></p>

<p>Applications Enzalutamide Carboxylic Acid is used as hormone therapies to prevent androgen-fuled growth of castrate-resistant prostate cancer.<br>References Tomasz, M.B., et al.: New Engl, J. Med., 424, 371 (2014);<br></p>

<p>Applications Quillaic Acid an unglycosylated saponin from the Quillaja saponaria bark is used as a topical antiinflammatory.<br>References Arrau, S. et al.: J. Ethnopharm., 133, 164 (2011);<br></p>

<p>Applications Testololactone, is the derivative of Testolactone (T154800), which is an antineoplastic agent that is a derivative of progesterone and is used to treat advanced stage breast cancer.<br>References Dunkel, L.: Mol. Cell. Endocrinol., 254, 207 (2006); Eugster, E. A.: Treat. Endocrinol., 3, 141 (2004); Holbeck, S.L. et al.: Mol. Cancer Therap., 9, 1451 (2010);<br></p>

<p>Applications Juvenile Hormone B 3 is a sesquiterpenoid produced by the larval ring gland and adult corpus allatum (CA) of Drosophila melanogaster. Juvenile hormones regulate development, reproduction, diapause, and polyphenisms.<br>References Wang, Ch., et al.: Gen. Comp. Endocr., 176, 347 (2012); Bendena, W.G., et al.: Gen. Comp. Endocr., 172, 56 (2011); Wyatt, G., Davey, K.: Adv. Insect Physiol., 26, 1 (1996); Nijhout, H.: Insect Hormones (Princeton Univ. Press, Princeton) (1994)<br></p>

<p>Applications A metabolite of Indole-3-acetic acid in plants.<br>References Barratt, N., et al.: Physiol. Plant, 105, 207 (1999), Jackson, R., et al.: J. Biol. Chem., 276, 4350 (2001), Staswick, P., et al.: Plant Cell, 17, 616 (2005),<br></p>

<p>Applications N-Acetyl-cys(1)-calcitonin Salmon is a derivative of Calcitonin (salmon), is a 32-amino acid linear polypeptide hormone that is produced in thyroid in humans. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH).<br>References Boron, WF., et al.: Med. Physi., A Cellular and Molecular Approach (2004); Andreotti, G. et al.: J. Bio. Chem., 281, 24193 (2006);<br></p>

<p>Applications JHSB3 is an acyclic sesquiterpenoid that regulates many aspects of insect physiology. Juvenile Hormone regulate development, reproduction, diapause, and polyphenisms.<br>References Kotaki, T., et al.: Org. Let., 11, 5234 (2009); Riddiford, L.: Adv. Insect Physiol., 24, 213 (1994); Wyatt, G., Davey, K.: Adv. Insect Physiol., 26, 1 (1996); Nijhout, H.: Insect Hormones (Princeton Univ. Press, Princeton) (1994)<br></p>

<p>Stability Temperature Sensitive<br>Applications Anabolic steroid. Androgen.Controlled substance.<br>References Schanzer, W., et al.: Clin. Chem., 42, 1001 (1996), Kicman, A., et al.: Br. J. Pharmacol., 154, 502 (2008), Fragkaki, A., et al.: Steroids, 74, 172 (2009),<br></p>

<p>Applications Labelled Androgen. It has been used as an androgenic agent. Controlled substance (anabolic steroid).<br>References Bichet, N., et al.: Toxicol. Appl. Pharmacol., 106, 509 (1990), Gustafson, D., et al.: Toxicol. Sci., 53, 245 (2000), Copple, B., et al.: Toxicol. Sci., 77, 172 (2004), Takashima, K., et al.: Life Sci., 78, 2787 (2006),<br></p>

<p>Applications Androstenediol 3-Acetate is an intermediate in the synthesis of Pregnenolone (P712200) which is a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens.<br>References Stastna, E., et al.: Steroids., 75, 721 (2010);<br></p>

<p>Applications (R,S)-Equol is a human urinary metabolite of the soy isoflavones Daidzein (D103500).<br>References Heinonen, S., et al.: Anal. Biochem., 274, 211 (1999), Setchell, K., et al.: J. Nutr., 132, 3577 (2002), Thigpen, J., et al.: Comp. Med., 53, 607 (2003), Yee, S., et al.: Food Chem. Toxicol., 46, 2713 (2008),<br></p>

<p>Applications Abiraterone Ethyl Ether is an impurity of Abiraterone (A108490), a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.<br>References Denis, L., et al.: Cancer, 72, 3888 (1993); Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1995); Denmeade, S., et al.: Nat. Rev., 2, 389(2002); Scher, H., et al.: J. Clin. Oncol., 23, 8253 (2005)<br></p>

<p>Applications epi Dienogest, is metabolite of Dienogest (D441870), a derivative of 19-Nortestosterone, that in combination with estrogencan acts as oral contraceptive.<br>References Hubner, M., et al.: Arzneim.-Forsch., 30, 401 (1980), Spona, J., et al.: Contraception, 56, 185 (1997), Foster, R.H., et al.: Drugs, 56, 825 (1998),<br></p>

<p>Human Hepcidin peptide hormone product also know as LEAP-1 (liver-expressed antimicrobial peptide), where the disulfides are formed by random oxidation. Hepcidin is a peptide hormone that is synthesized in the liver and is an important regulator of iron homeostasis. Through binding to ferroportin Hepcidin prevents the exportation of iron thus reducing the amount of circulating iron. Furthermore through inflammatory cytokine induction Hepcidin leads to the internalization and degradation of ferroportin thus further reducing the amount of iron in circulation. This in turn make conditions unfavourable to invading pathogens. This demonstrates Hepcidin's ability as an anti-microbial peptide. This antimicrobial behaviour can be used in research into the elimination of pathogens but also in combatting diseases where iron dysregulation is prevalant.</p>

<p>Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR).</p>

<p>Expression System: E. coli&lt;br&gt;Length: 59-83, Full Length of Mature Protein&lt;br&gt;Activity: Not Tested</p>

<p>Expression system: E. coli&lt;br&gt;Length: 71-132, Partial&lt;br&gt;Activity: Not Tested</p>

<p>CGRP induces vasodilation.</p>

<p>Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile.</p>

<p>Adiponectin Protein, Feline, Recombinant is expressed in E.</p>

<p>Adiponectin Protein, Bovine, Recombinant (His) is expressed in yeast with N-6xHis tag.</p>

<p>Expression System: E. coli&lt;br&gt;Length: 24-51, Ghrelin&lt;br&gt;Activity: Not Tested</p>

<p>Expression System: E. coli&lt;br&gt;Length: 90-84, Hepcidin-25&lt;br&gt;Activity: Not Tested</p>

<p>Meteorin-like/METRNL Protein, Rat, Recombinant (His) is expressed in E.</p>

<p>Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of</p>

<p>Plays an important role in growth control.</p>

<p>Plays an important role in growth control.</p>

<p>Insulin-1 Protein, Mouse, Recombinant (E. coli, His &amp; Myc) is expressed in E. coli.</p>

<p>PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion.</p>

<p>PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion.</p>

<p>Insulin-1 Protein, Mouse, Recombinant (His &amp; Myc) is expressed in Yeast.</p>

<p>Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased</p>

<p>Glycoprotein hormones alpha chain Protein, Canine, Recombinant (His &amp; Myc) is expressed in E. coli.</p>

<p>Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals.</p>

<p>Meteorin-like/METRNL Protein, Mouse, Recombinant (His) is expressed in E.</p>

<p>Endothelins are endothelium-derived vasoconstrictor peptides.</p>

<p>PTHLH Protein, Human, Recombinant (His) is expressed in E.</p>

<p>Glycoprotein hormones alpha chain Protein, Canine, Recombinant (His) is expressed in Yeast.</p>

<p>Hormone induced following exercise or cold exposure that promotes energy expenditure.</p>

<p>Endothelins are endothelium-derived vasoconstrictor peptides.</p>

<p>Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells.</p>

<p>Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased</p>

<p>Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism.</p>

<p>Hepcidin Protein, Larimichthys crocea, Recombinant is expressed in E.</p>

<p>Expression System: HEK293 Cells&lt;br&gt;Length: 25-54 90-110, Partial&lt;br&gt;Activity: Not Tested</p>

<p>Applications The labelled epimer of Medroxyprogesterone acetate (M203560). Progesterone impurity.<br>References Tang, M., et al.: Endocrinol., 151, 1320 (2010), Lee, K., et al.: Mol. Cell. Endocrinol., 319, 109 (2010), Rodgers, A., et al.: Chem., Res. Toxicol., 23, 724 (2010), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),<br></p>

<p>Applications Intermediate in the synthesis of a cholesterol absorption inhibitor.<br>References Kambara, T. et al.; J. Org. Chem. 64, 9282 (1999); Wu, G. et al.; J. Org. Chem. 62, 6412 (1997)<br></p>

<p>Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of</p>

<p>Applications Testosterone-2,2,4,6,6-d5 Heptanoate is a useful isotopically labeled compound of Testosterone Enanthate (T155080)<br></p>

<p>Applications 5-Androstenediol is a steroid androgen metabolite of Testosterone (T155000), the principal hormone of the testes, produced by the interstitial cells.<br>References Miller, M., et al.: Steroids., 78, 15 (2013); Baker, M.E., et al.: Steroids., 77, 1192 (2012); Ronis, M.J.J. et al.: Comp. Biochem. Physiol.-C: Pharmacol. Toxicol. Endocrinol., 121C, 221 (1998);<br></p>

<p>Applications 5α-Pregnane-3-one-20α-ol, is a steroid metabolome, that can be used for in studies of a possible tool for laboratory diagnosis of schizophrenia. It is also a metabolite of Progesterone (P755900) in adipose cells.<br>References Bicikova, M., et al.: J. Steriod Biochem. Mol. Bio., 77, 133 (2013); Zhang, Y., et al.: Mol. Cell. Endocrinology, 298, 76 (2009);<br></p>

<p>Applications 17α-Methyl-5α-androstane-2β,3α,17β)-triol is a derivative of Madol (M108000, which is an anabolic steroid recently identified to be misused as a doping agent. The potency of Madol (DMT) to transactivate androgen receptor (AR) dependent reporter gene expression was two times lower as compared to dihydrotestosterone (DHT).<br>References Zierau, O., et al.: Planta Med., 69, 856 (2003), Takahashi, M., et al.: Endocr. J., 51, 425 (2004), Labrie, F., et al.: J. Endocrinol., 184, 427 (2005),Friedel, A., et al.: Toxicol. Lett., 164, 16(2006),<br></p>

<p>Applications Testosterone-16,16,17-d3 Hexanoate is a useful isotopically labeled compound of Testosterone Hexanoate (T155125)<br></p>