Nucleosides

<p>2'-Deoxy-5'-O-DMT-2'-fluorouridine is a medicament that belongs to the group of antineoplastic agents and is used in cancer treatment. It inhibits the synthesis of DNA by inhibiting the enzyme thymidylate synthetase, which is required for the formation of thymine nucleotides. This drug has been shown to be effective against some cancer cells in vitro and in vivo, but not all. 2'-Deoxy-5'-O-DMT-2'-fluorouridine can also inhibit terminal growth phases and induce programmed cell death. Solid phase synthesis has been used to synthesize this molecule as a phosphoramidite.</p>

<p>N3-Cyanoethyl-5’-O-DMT-2’-O-methyluridine is a nucleoside that is synthesized from 5'-O-DMT-2’-O-methyluridine. It has antiviral and anticancer properties, as well as an inhibitory effect on DNA synthesis. N3-Cyanoethyl-5’-O-DMT-2’-O methyluridine is a novel nucleoside with DMT and methylated uracil at the 3' position of the sugar moiety. Synthesis may be achieved by using phosphoramidites or modified nucleosides such as N3-(cyanoethyl)-5'-0-(dimethoxytrityl)thymidine. This product meets high purity standards, with a CAS number of 68719–77–8.</p>

<p>5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-N-isobutyrylguanosine is a synthetic nucleoside that is used as a building block in the synthesis of oligonucleotides. This chemical has an electronegativity value of 1.7, which means that it is more electronegative than guanine (1.0). It also has a conjugated system and is stable under a range of conditions. 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-N-isobutyrylguanosine reacts with tetrazole in the presence of phosphoramidite, yielding the corresponding 5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-N-isobutyrylguanosine, which can then be used to</p>

<p>3'-(N-Methyl-anthraniloyl)-2'-deoxy-adenosine-5'-triphosphate triethylammonium salt is an antiviral agent that inhibits the synthesis of viral RNA. It is a modified nucleoside monophosphate with antiviral activity, which has been shown to be effective against HIV and other retroviruses. 3'-(N-Methyl-anthraniloyl)-2'-deoxy-adenosine-5'-triphosphate triethylammonium salt is also used as a building block for novel anticancer drugs that inhibit cell proliferation by inhibiting DNA synthesis and inducing programmed cell death (apoptosis). This compound has been shown to be an activator of transcription factors, including NFκB, AP1, and SP1.</p>

<p>2'-Azido-2'-deoxyadenosine is a synthetic nucleoside analog of adenosine in which the 2'-hydroxyl group of the ribose sugar is replaced by an azido group (–N₃), and the 3'- and 5'-hydroxyl groups remain intact. This modification confers unique chemical properties, including the ability to participate in bioorthogonal "click" chemistry reactions, particularly azide-alkyne cycloadditions, making it useful for labeling and tracking nucleic acids in biochemical studies. Additionally, the azido substitution can influence enzymatic recognition and incorporation by polymerases, allowing its use in studying nucleic acid metabolism, drug design, and therapeutic nucleoside analog development.</p>

<p>1-(2R,3R,4R,5R)-3-Hydroxy-5-(hydroxymethyl)-4-methoxytetra hydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione is a nucleoside that is a novel anticancer drug. It has been shown to have potent antineoplastic activity in vitro and in vivo. This compound is an activator of the p53 tumor suppressor gene and may also act as a transcriptional inhibitor of NF-κB.</p>

<p>2',3',5'-Tri-O-acetyl-2-fluoroadenosine is nucleoside analog of adenosine for use in research. The addition of a fluorine to an adenosine can change adenosine's properties such as its hydrogen bonding ability and how it interacts with water and other biological molecules. It can also increase the stability of adenosine and increase its half-life in biological systems.</p>

<p>3'-Azido-N6-benzoyl-2',3'-dideoxyadenosine is an antiviral drug that inhibits the synthesis of viral DNA and RNA. This antiviral drug is a novel synthetic nucleoside analogue that is phosphorylated to form monophosphate, which inhibits the synthesis of RNA. 3'-Azido-N6-benzoyl-2',3'-dideoxyadenosine has been shown to be effective against cancer cells by inhibiting ribonucleotide reductase and DNA synthesis. 3'-Azido-N6-benzoyl-2',3'-dideoxyadenosine also inhibits DNA synthesis by blocking the enzymes DNA polymerase and deoxyribonucleoside kinase.</p>

<p>2'-O-Acetyl-3'-azido-3'-deoxy-5'-O-(p-toluoyl)-6-azauridine is a novel, modified nucleoside. It has antiviral activity and can be used as a building block for the synthesis of oligonucleotide analogues. 2'-O-Acetyl-3'-azido-3'-deoxy-5'-O-(p-toluoyl)-6-azauridine is a monophosphate that is phosphorylated to form an active ribonucleoside. It can be used in high purity as a building block for the synthesis of oligonucleotide analogues. This compound has been shown to have anticancer effects and DNA binding activities.</p>

<p>3'-O-Aminothymidine is an isomer of thymidine, a nucleoside that is found in DNA and RNA. It has a neutral charge and belongs to the category of nucleosides. 3'-O-Aminothymidine is synthesized by the coupling of an amino group with a hydroxyl group. This reaction is efficient and can be used to produce dimers. 3'-O-Aminothymidine can also be used as a precursor for other nucleotides or as a synthetic intermediate in other chemical reactions.</p>

<p>2'-Deoxyadenosine-5'-monophosphate disodium salt (DAP) is a white crystalline powder. It is soluble in water and insoluble in ethanol. DAP can be neutralised by aqueous solutions of hydroxide, such as sodium hydroxide or ammonium hydroxide. DAP is also reactive with aluminium oxide, which can be used for drying the compound to form anhydrous particles. DAP reacts with chloride ions to form 2',3'-diacetylpyridine-5'-diphosphate dibasic chloride, which has been shown to inhibit bacterial growth and act as an antibacterial agent. Autoclaving may be required for preparation of this drug due to its sensitivity to heat energy.</p>

<p>Cyclopentenyl cytosine is a cytotoxic drug that inhibits the synthesis of DNA, RNA, and proteins. It is a nucleoside analogue that inhibits the enzyme activity of ribonucleotide reductase. Cyclopentenyl cytosine has significant cytotoxicity against hl-60 cells, as well as squamous carcinoma and MDA-MB-231 breast cancer cells. It also has significant activity against cyclopentenyl, dextran sulfate, and mitochondrial functions in vivo in human cells. Cyclopentenyl cytosine binds to the response element on the DNA strand, preventing transcription of genes for protein synthesis and cell division.</p>

<p>5'-O-DMT-2'-O-methyl-N6-phenoxyacetyladenosine 3'-CE phosphoramidite is a monophosphate, which is a phosphate group that is attached to the 5' carbon on the ribose ring of RNA. This monophosphate has been modified with a 2'-O-methyl group at the 6 position of the adenosine moiety. It has also been modified with a phenoxyacetyl group at the 2 position of the adenosine moiety. The phosphoramidite backbone is an ester bond between phosphorus and nitrogen atoms, and it can be used to make DNA or RNA in vitro. This compound has anticancer properties and antiviral activities against HIV, HSV, and HBV.<br>5'-O-DMT-2'-O-methyl-N6-phenoxyacetyladenosine 3'-CE phosphoramidite has novel properties that have not</p>

<p>1-(5-O-Acetyl-2,3-dideoxy-ß-L-glycero-pent-2-enofuranosyl)-5-fluorouracil is a modified nucleoside analog with structural alterations that enhance its biological properties and stability. The compound features 5-fluorouracil as the nucleobase, a fluorinated pyrimidine often used in chemotherapy due to its ability to interfere with DNA replication. The sugar component is 2,3-dideoxy-β-L-glycero-pent-2-enofuranose and has a specific glycerol and enol configuration, which alters its interactions with enzymes involved in nucleic acid metabolism. The compound includes a 5-O-acetyl protecting group at the 5'-position, which shields the hydroxyl group during synthesis.</p>

<p>8-Benzyloxy-9-(beta-D-xylofuranosyl)guanine (8BXG) is a novel nucleoside analog that inhibits the growth of cancer cells. It binds to the ribonucleotide reductase enzyme and inhibits the synthesis of DNA, thus preventing cell proliferation. 8BXG has been shown to inhibit viral replication in vitro with high potency. This compound is a monophosphate, which can be phosphorylated by adenosine kinase to form its active form. 8BXG is also an activator of ribonucleotide reductase in vitro, leading to increased anticancer activity.</p>

<p>2’-O-Acetyl-3,5-bis-O-(2,4-dichlorobenzyl)adenosine (OAAD) is a novel nucleoside that has been modified to be phosphorylated by the enzyme ribonucleotide kinase. It is an antiviral and anticancer agent that affects the synthesis of DNA. OAAD inhibits viral replication in vitro and in vivo by inhibiting DNA synthesis.</p>

<p>Adenosine 3',5'-diphosphate disodium salt is a nucleotide that is found in all cells and is involved in the regulation of many physiological processes, including energy metabolism and blood flow. It has inhibitory effects on platelets and calcium ion channels. Adenosine 3',5'-diphosphate disodium salt also inhibits the synthesis of prostaglandins by blocking the conversion of arachidonic acid to prostaglandin H2, which leads to an anti-inflammatory effect. Adenosine 3',5'-diphosphate disodium salt has been shown to be effective in treating primary pulmonary hypertension and bowel disease. The reaction solution can be used for polymerase chain reactions, multivariate logistic regression, or other applications.</p>

<p>N4-Acetyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-5-methylcytidine 3'-CE phosphoramidite is a novel monophosphate nucleotide that can be used for the synthesis of DNA and RNA. It has antiviral, anticancer, and activating properties. N4-Acetyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-5-methylcytidine 3'-CE phosphoramidite is synthesized by modifying cytosine with an acetyl group at the 4th position in the ribose ring, a tertiary butyldimethylsilyl group at the 2nd position on the 5' carbon atom, and a DMT group at the 5' position on the 5' carbon atom. The CAS number for this compound is 868312050.</p>

<p>5'-(R)-C-Methyl-2-thiouridine is an antiviral agent that inhibits the synthesis of viral RNA by acting as a substrate for thymidine kinase, which converts it to 5'-(R)-C-methyluracil. This drug also has anticancer properties and may be useful in the treatment of leukemia.</p>

<p>2'-Azido-2'-deoxy-5'-O-DMT-uridine is a nucleoside that has been modified with an azido group at the 2' position. The azido group is used to modify DNA and RNA nucleosides, which are monophosphate, ribonucleosides, and deoxyribonucleosides. This drug may be used as an activator of DNA synthesis or as a antiviral agent. It has been shown to inhibit HIV replication in vitro.</p>