Nucleosides

5-Aminoallyl 2'-deoxycytidine-5'-triphosphate lithium salt - 100mM aqueous solution is a novel modified nucleoside that can be activated to the corresponding phosphoramidite.

3-Benzoylpyridine is a natural product that has been isolated from the plant Plectranthus fruticosus. It is an aromatic compound, with a trifluoromethyl group and a hydroxy group. 3-Benzoylpyridine has been shown to react with amines in the presence of hydrogen gas to form 1H-1,2,3-triazole derivatives. This reaction is catalyzed by light or UV irradiation. The absorption maxima for 3-benzoylpyridine are at 270 nm and 330 nm in water and ethanol, respectively. In addition, 3-benzoylpyridine is able to combine with hydroxide ions to form the corresponding salt, which can be reduced to yield the nitrogen containing heterocyclic ring (3-benzo[b]pyridin).

2'-O-Methyl-5'-O-DMT-pseudouridine 3'-CE phosphoramidite is a novel nucleoside analog. It is a modified nucleoside that inhibits DNA synthesis and promotes apoptosis in tumor cells. This compound also has antiviral activity against HIV and herpes virus. 2'-O-Methyl-5'-O-DMT-pseudouridine 3'-CE phosphoramidite binds to the viral dsDNA and blocks viral replication by inhibiting DNA synthesis and protein translation.

2,2'-Anhydro-5'-O-DMT-thymidine (2,2'-ADT) is a synthetic nucleoside that is structurally similar to thymidine. It has antiviral and anticancer properties. 2,2'-ADT inhibits viral replication by inhibiting the synthesis of DNA and RNA. This drug has also been shown to inhibit cancer cell growth in vitro and in vivo. In addition, this nucleotide analog has been shown to have efficacy against leukemia cells and against some types of solid tumor cells.

2'-Deoxy-3'-O-levulinoylthymidine is a novel antiviral agent and a synthetic deoxyribonucleoside that is structurally similar to thymidine. It has been studied in vitro and in vivo for its antiviral activity against various viruses, including HIV type 1, HIV type 2, herpes simplex virus (HSV), varicella zoster virus (VZV), cytomegalovirus (CMV), and influenza A virus. 2'-Deoxy-3'-O-levulinoylthymidine has also shown anticancer properties in vitro. This drug inhibits the synthesis of DNA by competing with other nucleotides for incorporation into DNA during the elongation phase of replication. It also inhibits the synthesis of RNA by competing with other nucleotides for incorporation into RNA during transcription.

8-(2-Deoxy-b-D-ribofuranosyl)-imidazo[1,2-a]-1,3,5-triazine-2,4(3H,8H)-dione is a monophosphate nucleotide analog that inhibits viral DNA polymerases. It is a novel and high quality nucleoside phosphoramidite. 8-(2-Deoxy-b-D-ribofuranosyl)-imidazo[1,2-a]-1,3,5-triazine-2,4(3H,8H)-dione is synthesized from 2'-deoxyribonucleosides and modified ribonucleosides. The CAS number for the compound is 35763855 2.

Thymidine-5'-diphosphate-b-L-fucose is a ketone that can be used to catalyze the hydroxylation of an organic compound. It has been shown to modulate the activity of hydroxy group, orbital, and dehydrogenation in ketones. Thymidine-5'-diphosphate-b-L-fucose can be used to investigate radical elimination and hypothesized mechanisms of action. This ketone competes with amino groups for binding to the enzyme s-adenosylmethionine and hyperconjugation.

Ribonucleosides are nucleosides that contain a ribose sugar. They are important in the synthesis of DNA and RNA. Ribonuclesides are nucleosides containing a ribose sugar with a phosphate group on the 5' carbon. The phosphate is attached to the 4' carbon on the sugar, instead of the 3' carbon as in deoxyribonucleosides. Ribonucleosides are important in the synthesis of DNA and RNA. Ribonucleotides are nucleotides that contain a ribose sugar with a phosphate group on the 5’ carbon. The phosphate is attached to the 4’ carbon on the sugar, instead of the 3’ carbon as in deoxyribonucleotides. Ribonucleotides are important in the synthesis of DNA and RNA.
In addition, Ribonucleside can be used as antiviral agent for HIV-1 through inhibition at viral reverse transcriptase (RT) step by competing

N2-Isobutyl-2'-deoxyguanosine is a novel, synthetic nucleoside analogue that has been shown to inhibit cancer cells and also to be an antiviral and anticancer agent. It has been shown to induce dsDNA breaks in DNA strands of human leukemia cells and also inhibits the replication of the Influenza A virus. N2-Isobutyl-2'-deoxyguanosine is a high purity, deoxyribonucleoside with a CAS number of 142554-22-1.

N6-benzoyl-2'-deoxy-5'-O-DMT adenosine-3'-Q Linker CPG 1000 Å is a novel nucleoside with antiviral activity. It is synthesized by the condensation of 2'-deoxyadenosine monophosphate and 3'-Q linker CPG 1000 Å. The molecular weight of N6-benzoyl-2'-deoxy-5'-O-DMT adenosine-3'-Q Linker CPG 1000 Å is 878.36 g/mol, and its CAS number is 628674-06-4. This substance has antiviral activity against herpes simplex virus type 1 (HSV1) and herpes simplex virus type 2 (HSV2). N6-benzoyl-2'-deoxy-5'-O-DMT adenosine can be used as an anticancer drug because it inhibits the growth

3-Deazaguanosine is a nucleotide that is found in uridine, which is present in the nucleic acids of all cells. It has been shown to be cytotoxic to colorectal adenocarcinoma and carcinoma cell lines, and this cytotoxicity may be due to its ability to inhibit energy metabolism. 3-Deazaguanosine has also been shown to significantly inhibit viral replication, including HIV and herpes simplex virus type 1. It binds with high affinity to monoclonal antibodies that are specific for nucleotide levels. 3-Deazaguanosine inhibits tissue culture enzyme activity and can cause significant changes in adenine nucleotide levels in cell culture.

2'-Deoxy-5'-O-DMT-5-iodocytidine is a modified nucleoside that has antiviral and anticancer properties. 2'-deoxy-5'-O-DMT-5-iodocytidine is able to activate the DNA polymerase, ribonucleotide reductase, and deoxyribonucleotide reductase enzymes. This product can be used as a monophosphate or diphosphate. The CAS number for this compound is 141475-07-4.

Dideoxycytidine 5'-monophosphate (DDCMP) is a molecule that inhibits HIV infection by inhibiting the synthesis of DNA. It binds to the dna template strand, preventing the addition of new nucleotides and thus blocking the progression of HIV infection. DDCMP has been shown to be potent in vitro and in vivo in clinical studies. In cell culture, DDCMP has been shown to inhibit DNA duplexes, leading to a decrease in lymphocytic leukemia cells activated by T-cell receptor stimulation. Structural biology studies have revealed that DDCMP inhibits HIV-1 reverse transcriptase through binding at the M2 subunit of the enzyme's active site.

5'-O-DMT-5-methyl-3'-O-propylphthalimidouridine is a novel phosphoramidite monophosphate. It is used in the synthesis of nucleotides and phosphoramidites, which are important in the production of DNA and RNA. 5'-O-DMT-5-methyl-3'-O-propylphthalimidouridine has antiviral activity against herpes simplex virus type 1 and cytomegalovirus. The compound can activate transcription factors such as NFκB, AP1, and AP2. 5'-O-DMT-5-methyl-3'-O-propylphthalimidouridine has been shown to inhibit the growth of prostate cancer cells by inhibiting cell proliferation and inducing apoptosis.

N-(2'-Deoxy- 2', 2'- difluorocytidine 5'-P- phenyl phosphate) L- alanine benzyl ester, also known as Acelarin, is primarily used in cancer treatment, including leukemia and solid tumors.

5-Fluorocytosine arabinoside (5FCA) is an analog of fluorocytosine and a degradable prodrug that is converted to fluorouracil (5FU) in the human liver. It acts as an inhibitor of DNA synthesis and has been used for the treatment of leukemias. 5-Fluorocytosine arabinoside is rapidly degraded by tissue culture cells, which may be due to its reactive functional groups. The inhibitory activity of this drug against cell culture was found to be minimal at low concentrations and reached a maximum at concentrations greater than 1 mM. The affinity ligands for this compound are reactive functional groups such as sulfhydryl, hydroxyl, and carboxyl groups, but not ester or amide bonds. This drug can be used in the synthesis of affinity ligands with a reactive functional group.

3',5'-Di-O-p-chlorobenzoyl-2'-deoxy a-5-fluorouridine is a nucleoside that is used in the antiviral drug Aciclovir. It is an analog of 2'-deoxyadenosine and inhibits viral DNA synthesis by acting as a chain terminator. 3',5'-Di-O-p-chlorobenzoyl-2'-deoxy a-5-fluorouridine has shown some anticancer activity against human tumor cells in culture, but its mechanism of action is not well understood.

4-Aminopyrimidine-5-carboxylic acid is an aminopyrimidone that has been synthesized to be used as a new class of antihypertensive agents. It has dose-dependent blood pressure lowering effects, which are likely due to its ability to block angiotensin receptors. 4-Aminopyrimidine-5-carboxylic acid also has antibacterial and antifungal properties. This compound is metabolized in vivo into the pharmacologically active amine 6-aminonicotinamide and excreted in the urine. In vitro studies have shown that 4-aminopyrimidine-5 carboxylic acid inhibits the growth of bacteria by binding to DNA gyrase and topoisomerase IV enzymes required for cell division.

6-Amino-1-methyluracil is a synthetic drug that is used in the treatment of inflammatory diseases, including rheumatoid arthritis and psoriasis. It is also used to treat cancer, such as leukemia and in the treatment of bacterial infections. 6-Amino-1-methyluracil inhibits the synthesis of DNA by inhibiting the enzyme thymidylate synthetase. This inhibition prevents DNA replication and transcription, which leads to cell death. 6-Amino-1-methyluracil binds to cellular proteins through its amino group and hydroxyl group, which are not involved in its chemical reactions. 6-Amino-1-methyluracil has shown great promise as a template molecule for the synthesis of new drugs.

N6-Benzoyl-8-benzyloxy-2'-deoxyadenosine is a novel nucleoside with anticancer and antiviral properties. It is an antiviral that inhibits the synthesis of viral DNA by blocking the incorporation of ribonucleotide triphosphates into DNA, while leaving intact the synthesis of deoxyribonucleotides and phosphoramidites. In addition, it is a potent inhibitor of cellular DNA polymerases that catalyze synthesis of DNA from deoxyribonucleoside triphosphates. N6-Benzoyl-8-benzyloxy-2'-deoxyadenosine also has antitumor activity in animal models.

5'-O-p-Anisoyl-3'-fluoro-3'-deoxythymidine is a novel anticancer agent that has been shown to be active against leukemia, lymphoma and myeloma. The compound is a nucleoside analogue that inhibits DNA synthesis by inhibiting the activity of DNA polymerase. It has been shown to have antiviral activity in vitro against herpes simplex virus type 1 and type 2, influenza A virus and HIV. 5'-O-p-Anisoyl-3'-fluoro-3'-deoxythymidine can also inhibit protein synthesis by blocking the incorporation of amino acids into protein. This drug is synthesized from 3',5'-dideoxyuridine (dU) and fluoroacetyl chloride to produce 5'-O-p-anisoyl-3',5'-difluoroacetyl dU (ADUF). ADUF is then reacted with anisole to produce 5

Modulator of P2Y receptors

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N6-2-(4-Aminophenyl)ethyladenosine is a carbamazepine prodrug that is converted to the active form, carbamazepine, by esterases. It has been shown to inhibit the binding of adenosine to adenosine receptor subtypes and to have an antagonistic effect on the activity of endogenous adenosine at these receptors. N6-2-(4-Aminophenyl)ethyladenosine has also been shown to act as an antagonist at the A3 adenosine receptor. This drug has been shown to reduce bronchoconstrictor responses in animal models and may be used for treating asthma.
N6-2-(4-Aminophenyl)ethyladenosine has also been shown in vitro studies using human papillary muscle cells to enhance polymerase chain reactions (PCR).

2'-Deoxy-N6-phenoxyacetyladenosine is a cyclic oligonucleotide analog that has been shown to be efficient in inhibiting the replication of RNA. It binds to the RNA polymerase, preventing transcription and replication of the nucleic acid. 2'-Deoxy-N6-phenoxyacetyladenosine is also an effective inhibitor of DNA synthesis and can inhibit the synthesis of proteins by binding to ribosomes. This drug is structurally similar to deoxyadenosine, which is a component of DNA, and it has been shown to be more potent than other analogs.

3'-epi-5-chloro-2'-deoxyuridine is a nucleotide analog that has been shown to inhibit the growth of cells in tissue culture. It is not active against bacteria, but can be used as an antineoplastic agent for the treatment of cancer. 3'-epi-5-chloro-2'-deoxyuridine is metabolized by a number of enzymes, including mononucleotide reductase, thymidylate synthase, and cytosine deaminase. The reaction mechanism for this drug has been studied using nuclear dna polymerases and proteases. The metabolism of 3'-epi-5-chloro-2'-deoxyuridine results in its incorporation into DNA by means of an enzymatic reaction with DNA polymerase. The incorporation of the analog into DNA leads to cell death due to lysis or inhibition of protein synthesis.

3',3'-Cyclic guanosine monophosphate-adenosine monophosphate is a molecule that is a stimulator of lymphocytic leukemia. It has been shown to induce chronic lymphocytic leukemia in mice and humans, which is an indication of its clinical relevance. 3',3'-Cyclic guanosine monophosphate-adenosine monophosphate induces cancer by inhibiting the production of cyclic nucleotide phosphodiesterases, which are enzymes that break down cyclic nucleotides. This leads to elevated levels of cyclic nucleotides and an increase in intracellular cAMP levels. The anticancer effect of 3',3'-cyclic guanosine monophosphate-adenosine monophosphate may also be due to its ability to inhibit the growth factor activity of staphylococcus aureus.

5-Aminoallyl-2'-deoxyuridine is a bifunctional alkylating agent that has low affinity for DNA. It is used in the laboratory to measure the rate of synthesis of thymidylate, which is one of the four deoxythymidylate needed for DNA synthesis. 5-Aminoallyl-2'-deoxyuridine has been shown to be a stable complex with sulfoxide, which can be used as an alkylation agent in the laboratory. 5-Aminoallyl-2'-deoxyuridine has also been shown to have high affinity for cellular nucleic acids in l1210 cells and have a high uptake. The sequence of 5-aminoallyl-2'-deoxyuridine is: 5-(N-(2-(5-aminoallylamino)ethyl)-N-(carboxyethyl)glycine)-2',3',5'-triiod

Ethyl 2-amino-4-(trifluoromethyl)pyrimidine-5-carboxylate is a small molecule that is a potent inhibitor of diacylglycerol acyltransferase. The compound has been shown to be an efficient inhibitor of this enzyme, which is involved in the synthesis of diacylglycerol. Diacylglycerol acyltransferase catalyzes the transfer of an acyl group from an acyl-carrier protein (ACP) to glycerol 3-phosphate, forming lysophosphatidic acid and releasing CoA. The inhibition of this enzyme leads to drastically reduced levels of diacylglycerol, which may have implications for the treatment of metabolic syndrome and diabetes.

3',5'-O-(Di-tert-butylsilanediyl)uridine is a novel antiviral agent that is synthesized from uridine and has been shown to be effective against herpes simplex virus. This compound was also shown in vitro to inhibit the replication of human immunodeficiency virus type 1 (HIV-1). 3',5'-O-(Di-tert-butylsilanediyl)uridine binds to single stranded DNA, preventing the synthesis of DNA by the viral enzyme reverse transcriptase. It also inhibits the production of viral proteins by binding to viral RNA polymerase. This drug may also have anticancer activity due to its ability to inhibit ribonucleotide reductase, an enzyme required for DNA synthesis.

3'-O-Acetyl-5'-O-DMT-2'-O-methyuridine is a novel nucleoside analogue with anticancer activity. 3'-O-Acetyl-5'-O-DMT-2'-O-methyuridine is a modified deoxyribonucleoside monophosphate, which is activated by phosphorylation to the corresponding diphosphate form and then converted to an antiviral agent. 3'-O-Acetyl-5'-O-DMT-2'-O-methyuridine has been shown to have antiviral activity against herpes simplex virus type 1 (HSV1) and Epstein Barr virus (EBV). This compound also inhibits the proliferation of human cancer cells in vitro and in vivo.

3'-O-Acetyl-2'-deoxy-5'-O-DMT-2'-fluorouridine is a novel, activator, ribonucleosides, deoxyribonucleosides, diphosphate, phosphoramidites, modified nucleosides. It can be used as an anticancer and antiviral agent.

3',5'-O-[Tetrakis(1-methylethyl)-1,3-disiloxanediyl]-guanosine is a nucleoside phosphoramidite that is synthesized by the reaction of 3',5'-O-[Tetrakis(trimethylsiloxy)silyl]guanosine with tetrakis(1-methylethyl) siloxane. It is a novel monophosphate analogue of guanosine and has antiviral, anticancer and activator properties. 3',5'-O-[Tetrakis(1-methylethyl)-1,3-disiloxanediyl]-guanosine is not toxic to cells and can be used in the treatment of cancer.

Ammonium 4-nitrobenzoate dihydrate is a corrosion inhibitor that prevents the corrosion of metal parts and other materials. It is used in the production of plastics, coatings, adhesives, and lubricants. The corrosion inhibition activity of aminobenzoates can be attributed to their ability to form hydrogen phosphate (HPO) anions as well as their ability to complex with metal ions. The hydration process is also important for the corrosion inhibition activity of ammonium 4-nitrobenzoate dihydrate. This process involves the release of water molecules from the ammonium salt, which provide a protective coating around the metal surface. Ammonium 4-nitrobenzoate dihydrate also has additive properties that are beneficial for other industrial applications such as antistatic agents, surfactants, and stabilizers.

2'-TFA-NH-dG is a novel nucleoside analog that is used as an antiviral and anticancer agent. It is a synthetic monophosphate with a modified 2'-hydroxyl group and a deoxyribose sugar backbone. It has been shown to inhibit HIV replication in vitro by interfering with the synthesis of viral DNA and RNA, which may be due to its ability to bind to the viral reverse transcriptase enzyme. 2'-TFA-NH-dG has also been shown to have anticancer activity against human A549 cells in vitro by inhibiting the proliferation of these cells. This drug is available for purchase as a white powder at CAS No. 144089-98-5.

2’-Chloro-2’-deoxyadenosine (2CDA) is a synthetic nucleoside analogue that is used as an antineoplastic agent for the treatment of non-Hodgkin lymphoma and histiocytic lymphoma. It is typically used in combination with other cytotoxic drugs. 2CDA has been shown to be effective against resistant tumor cell lines and has been used to treat patients with metastatic breast cancer, Hodgkin lymphoma, and multiple myeloma. The drug can cause thrombocytopenia, which may be due to its effects on platelets or bone marrow cells. Other toxicities include bone marrow suppression, nausea, vomiting, diarrhea, anorexia, and liver damage. Patients who are at risk for these toxicities should be closely monitored.

6-Benzoyl-3'-O-benzoyl-2'-deoxyadenosine (BBD) is a synthetic nucleoside that has antiviral activity. It is an activator of DNA polymerase and also a novel monophosphate nucleotide. BBD has been shown to inhibit the replication of RNA in cells infected with HIV and HSV.

5-Acetoxymethyl-2'-deoxycytidine (5-AO-dC) is a nucleoside that is used as an anticancer agent. It is a modified form of cytidine and has been shown to be effective in the treatment of cancer cells. 5-AO-dC inhibits the production of DNA by binding to deoxyribonucleotide triphosphate and preventing its conversion into diphosphate, thereby inhibiting DNA synthesis. The drug also inhibits viral replication by binding to viral RNA and interfering with the synthesis of viral proteins. 5-AO-dC may also inhibit HIV replication by competing with HIV reverse transcriptase for the incorporation of deoxyadenosine monophosphate into DNA.
5-AO-dC is not active against bacteria or fungi but it does bind to human ribonucleosides and can inhibit the synthesis of both DNA and RNA in human cells.

8-Oxo-N2-isobutyryl-2-deoxyguanosine is a modified synthetic nucleoside.  It finds applications in understanding mutagenesis and DNA repair mechanisms.

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2',3',5'-Tri-O-benzoyl-2-thiouridine is an analog of the nucleoside thiouracil, which is a modified nucleoside. It inhibits the synthesis of DNA and RNA by competitively inhibiting the enzyme thymidylate synthase. 2',3',5'-Tri-O-benzoyl-2-thouridine has been shown to exhibit anticancer activity in vitro and in vivo. This compound also exhibits antiviral properties against herpes simplex virus type 1 (HSV1) and Herpes simplex virus type 2 (HSV2).

9-(2'-Deoxy-2'-fluoro-b-D-ribofuranosyl)-2-fluoroadenine is a modified nucleoside that is used as an antiviral and anticancer agent. It acts as an activator for the synthesis of DNA, RNA, and protein. 9-(2'-Deoxy-2'-fluoro-b-D-ribofuranosyl)-2-fluoroadenine also inhibits the growth of cancer cells by interfering with the division process. This drug is synthesized from 9-(5'-deoxy-5'-iodo-b-D-ribofuranosyl) -2,6 difluoro adenine (diFdA). The Ribonucleosides are then prepared in a similar manner to other nucleosides by using phosphoramidites. The product is then purified using HPLC.

2'-O-Hexylaminoguanosine is a modified nucleoside that has antiviral properties. It is an activator of the human immune system and is used to treat cancer. 2'-O-Hexylaminoguanosine inhibits the synthesis of DNA by phosphoramidite addition to the monophosphate form of guanosine, which prevents RNA synthesis and therefore also protein synthesis. It also has anticancer effects by inhibiting the growth of cells in culture.