Nucleosides

<p>Supplied as a 10mM solution (150uL).λmax 255 nm, ε 23.3 L mmol-1 cm-1Sold by weight of solid</p>

<p>2-Amino-9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)purine is a novel nucleoside with anticancer and antiviral properties. It has been shown to inhibit replication of human immunodeficiency virus and herpes simplex virus type 1 in vitro. The drug also inhibits the growth of tumor cells in vitro. 2-Amino-9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)purine is an analog of adenosine, which is phosphorylated by the enzyme ribonucleoside diphosphate kinase to form 2'-deoxyadenosine monophosphate, a common building block for DNA synthesis.</p>

<p>Ribonucleosides are a class of compounds that contain the nucleoside ribose and the phosphate group. Ribonuclesides are modified ribonucleosides that have been synthesized and modified to be more stable than standard ribonucleotide analogs. The compound 5-Trimethylstannyl-1-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)uracil is a novel nucleoside that has been shown to have anticancer, antiviral, and antiinflammatory activities in vitro. It is also an activator for phosphoramidites, which are used to modify DNA or RNA molecules. This chemical is available at high purity and quality with CAS No. 213136-14-2.</p>

<p>N6-Benzoyl-7'-hydroxy-N-trityl morpholino adenine is a novel Ribonucleoside, which is a synthetic nucleoside with antiviral properties. It has been shown to inhibit the growth of cells in culture by inhibiting the synthesis of DNA and RNA. N6-Benzoyl-7'-hydroxy-N-trityl morpholino adenine has shown cytotoxicity against various cancer cells, including human leukemia cells, human lung cancer cells, and human breast cancer cells. The cytotoxic effects are thought to be due to inhibition of DNA synthesis and RNA synthesis.</p>

<p>5'-O-DMT-5-methyl-3'-O-propylphthalimidouridine is a novel phosphoramidite monophosphate. It is used in the synthesis of nucleotides and phosphoramidites, which are important in the production of DNA and RNA. 5'-O-DMT-5-methyl-3'-O-propylphthalimidouridine has antiviral activity against herpes simplex virus type 1 and cytomegalovirus. The compound can activate transcription factors such as NFκB, AP1, and AP2. 5'-O-DMT-5-methyl-3'-O-propylphthalimidouridine has been shown to inhibit the growth of prostate cancer cells by inhibiting cell proliferation and inducing apoptosis.</p>

<p>3'-Azido-N4-benzoyl-5'-O-trityl-2',3'-dideoxyadenosine is a novel nucleoside that has been described as an activator of diphosphate. It is a modified deoxyribonucleoside, with the amino group in the ribose moiety replaced by an azido group. This nucleotide inhibits viral and cellular DNA synthesis by blocking DNA polymerase. 3'-Azido-N4-benzoyl-5'-O-trityl-2',3'-dideoxyadenosine can also be used for anticancer purposes, where it has been shown to inhibit cancer cell growth.</p>

<p>2'-O-Methyluridine-5'-triphosphate lithium salt is a modified ribonucleoside which is used as an activator for nucleic acid synthesis. It has antiviral properties and can be used to inhibit the replication of DNA and RNA viruses. 2'-O-Methyluridine-5'-triphosphate lithium salt inhibits the viral polymerase, preventing the transcription of viral genetic material. This product is also considered novel because it is not found in nature and has not been previously described in the literature.</p>

<p>7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine is a palladium catalyst that catalyzes the cross-coupling reaction of aryl bromides and organoboronic acids with good efficiency. This method is an efficient and general procedure for the synthesis of various substituted pyrimidines. The cross-coupling reaction can be achieved in high yields without the need for purification of intermediates.</p>

<p>2',3'-O-Isopropylidene-adenosine-5-N-methylcarbamide is an activator that has anticancer and antiviral properties. It is a synthetic nucleoside, which is a modified form of the natural nucleosides adenosine and cytidine. 2',3'-O-Isopropylidene-adenosine-5-N-methylcarbamide inhibits the replication of DNA by binding to the deoxyribonucleoside triphosphate (dNTP) in DNA synthesis. The drug also inhibits viral RNA transcription by blocking the action of diphosphate reductase, an enzyme required for the conversion of ribonucleosides to ribonucleotides. 2',3'-O-Isopropylidene-adenosine-5-N-methylcarbamide has shown antiproliferative effects on human cancer cells in vitro and may be effective against leukemia and lymph</p>

<p>P1,P5-Di(adenosine-5')pentaphosphate trilithium salt is a diphosphate nucleoside that has antiviral and anticancer activities. It also inhibits DNA synthesis by competitively inhibiting the incorporation of dATP into DNA. This product is an activator of phosphoramidite chemistry. P1,P5-Di(adenosine-5')pentaphosphate trilithium salt is a novel monophosphate nucleoside with modified phosphorus linkages in the sugar backbone and a high purity of &gt; 98%.</p>

<p>P3-(1-(2-Nitrophenyl)ethyl) adenosine 5'-triphosphate disodium salt (P3-ANP-Na2) is an anticancer drug that belongs to the group of nucleosides. It is a phosphoramidate prodrug that is converted to adenosine 5'-triphosphate (ATP) by intracellular esterases. This prodrug has been shown to inhibit the growth of various types of cancer cells in vitro and in vivo, including leukemia and breast cancer cells. P3-ANP-Na2 binds to DNA by intercalation, inhibiting DNA synthesis and transcription. It also inhibits protein synthesis by inhibiting ribonucleotide reductase and deoxyribonucleotide reductase, which are enzymes responsible for synthesizing DNA precursors from RNA precursors.</p>

<p>LDA is a technique for extracting spectral features from a set of spectra. It uses the probabilistic model of discriminant analysis to discriminate between groups of spectra. LDA has been shown to outperform other techniques, such as PCA and MDA, in analyzing datasets with a small number of variables. The algorithm is incrementally updated with new data points and parameters, which makes it an attractive choice for real-time applications.</p>

<p>5'-Deoxy-5-fluoro-N-[(3-methylbutoxy)carbonyl]cytidine is a novel nucleoside phosphoramidite. It is synthesized by the reaction of 5'-deoxy-5-fluoro cytidine with 3-methylbutanol in the presence of an activator (e.g., tetrazole). The methyl group on the 3′ position of cytidine has been shown to improve antiviral activity, as well as DNA and RNA synthesis. The chemical purity of 5'-deoxy-5-fluoro-N-[(3-methylbutoxy)carbonyl]cytidine is &gt;99% with no detectable impurities. This product is a white powder that is soluble in water and organic solvents.</p>

<p>Biotin-16-uridine-5'-triphosphate, lithium salt - 1 mM aqueous solution is a synthetic nucleotide that contains the natural nucleoside uridine and the modified nucleoside 5-biotin. It is an activator of DNA polymerase. Biotin-16-uridine-5'-triphosphate, lithium salt - 1 mM aqueous solution has antiviral properties as it inhibits HIV reverse transcriptase and human cytomegalovirus (HCMV) DNA polymerase. It also inhibits human telomerase activity by preventing telomeric DNA synthesis. The high purity of this product allows for its use in many different research applications.</p>

<p>3'-Azido-3'-deoxy-5-fluorocytidine is an activator with novel antiviral and anticancer properties. It is a high quality, modified nucleoside that can be used to synthesize deoxyribonucleosides and ribonucleosides. 3'-Azido-3'-deoxy-5-fluorocytidine has been shown to inhibit the growth of cancer cells in vitro and in vivo.</p>

<p>TFA-aa-dC is a novel anti-cancer drug that has been shown to have both antiviral and anticancer activities. It is a modified phosphoramidite of 2'-deoxyadenosine 5'-triphosphate with a 3'-amino group (TFA-aa-dC) and an acetyl group at the 2' position. TFA-aa-dC blocks viral replication by inhibiting the activity of viral DNA polymerase, which is required for DNA synthesis. The compound also inhibits cell growth by blocking RNA synthesis and protein production, leading to cell death. TFA-aa-dC has shown efficacy in preclinical studies against cervical cancer and leukemia cells.</p>

<p>N4-Acetyl-5'-O-DMT-cytidine 3'-succinyl CPG 1000 Å (RNA) is a novel, high quality, high purity, synthetic nucleoside analogue. It has antiviral and anticancer properties.</p>

<p>3'-O-Azidomethyl 2'-deoxycytidine 5'-O-triphosphate sodium salt is a modified nucleoside that inhibits the synthesis of DNA. It has been shown to be an effective antiviral agent and can be used to treat cancer. 3'-O-Azidomethyl 2'-deoxycytidine 5'-O-triphosphate sodium salt is synthesized by reacting cytidine monophosphate with sodium azide in the presence of a triphosphorylating reagent. <br>3'-O-Azidomethyl 2'-deoxycytidine 5'-O-triphosphate sodium salt also inhibits DNA polymerase, which prevents the synthesis of RNA and proteins. The phosphoramidites are commercially available, high quality, and have a purity greater than 99%. This product is not currently approved by the FDA for use in humans or animals.</p>

<p>2’,3’-Bis-O-tert-butyldimethylsilyl-2-thiouridine is a modified nucleoside composed of 2-thiouracil (2-thiopyrimidine), a modified uracil where the oxygen at the 2-position is replaced by sulfur. Possible applications as its use as an intermediate in the chemical synthesis of RNA oligonucleotides.</p>

<p>6-Methylthioinosine-5’-triphosphate sodium salt - 10 mM aqueous solution is a synthetic, modified ribonucleoside that is an activator of the antiviral response. It has been shown to inhibit the replication of both DNA and RNA viruses in vitro. 6-Methylthioinosine-5’-triphosphate sodium salt - 10 mM aqueous solution is also used as a precursor in the synthesis of phosphoramidites. The CAS number for this product is 51464-82-5.</p>