Complement System
The complement system is a crucial part of the immune response, consisting of a series of small proteins that enhance the ability of antibodies and phagocytic cells to clear pathogens from an organism. These proteins work together to opsonize pathogens, induce inflammatory responses, and directly lyse pathogen membranes, playing a vital role in innate immunity and overall immune function. At CymitQuimica, we provide high-quality complement system proteins to support your immunological studies and clinical research.
Found 156 products of "Complement System"
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Avdoralimab
CAS:<p>Avdoralimab (IPH 5401) is a humanized monoclonal antibody targeting complement C5a receptor 1 (C5aR1).</p>Purity:>95%Color and Shape:LiquidTesidolumab
CAS:<p>Tesidolumab, a fully human IgG1/λ anti-C5 monoclonal antibody, inhibits crovalimab and C5, preventing membrane attack complex formation.</p>Purity:99.72% (SEC-HPLC) - > 95%Color and Shape:LiquidMolecular weight:142 kDa (average)Lampalizumab
CAS:<p>Lampalizumab (RG 7417) is a humanized monoclonal antibody targeting Factor D, which can be used in cardiovascular disease research.</p>Purity:>95%Color and Shape:LiquidMolecular weight:46.96 (kDa)Sutimlimab
CAS:<p>Sutimlimab: monoclonal antibody, inhibits complement protein C1, treats cold agglutinin-induced hemolysis.</p>Purity:> 95%Color and Shape:LiquidMolecular weight:144.8 kDaVesencumab
CAS:<p>Vesencumab (MNRP-1685A) is an IG1 antibody targeting NRP-1 with anti-angiogenic and anti-tumor activity. Vesencumab can be used to study solid tumors.</p>Purity:99.2% (SDS-PAGE); 96.6% (SEC-HPLC) - 99.2% (SDS-PAGE); 96.6% (SEC-HPLC)Color and Shape:LiquidCyclosporin A
CAS:<p>Cyclosporin A is a Calcineurin Inhibitor Immunosuppressant, and a Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor.</p>Formula:C62H111N11O12Purity:99.00% - 99.92%Color and Shape:White PowderMolecular weight:1202.61Vilobelimab
CAS:<p>Vilobelimab (CaCP-29, IFX-1), a monoclonal antibody, inhibits C5a to reduce inflammation and is researched in sepsis and COVID-19 studies.</p>Purity:99% (SDS-PAGE); 98.9% (SEC-HPLC) - 99% (SDS-PAGE); 98.9% (SEC-HPLC)Color and Shape:LiquidDexamethasone
CAS:<p>Dexamethasone: a glucocorticoid agonist; modulates IL receptors; reduces inflammatory miRNA-155 exosomes in macrophage responses.</p>Formula:C22H29FO5Purity:98% - 99.91%Color and Shape:Crystals From Ether (Ntp 1992)Molecular weight:392.46SB290157 trifluoroacetate
CAS:<p>SB290157 trifluoroacetate is a potent and selective antagonist of C3a receptor(IC50 of 200 nM).</p>Formula:C24H29F3N4O6Purity:98.93% - 99.89%Color and Shape:SolidMolecular weight:526.51Ravulizumab
CAS:<p>Ravulizumab (ALXN1210) is a humanized antibody for blocking complement activation, treating PNH, aHUS, and myasthenia gravis.</p>Purity:> 95%Color and Shape:LiquidMolecular weight:145.80 kDaC3a (70-77)
CAS:<p>C3a (70-77) is an octapeptide corresponding to the COOH terminus of C3a.</p>Formula:C35H61N13O10Purity:98%Color and Shape:SolidMolecular weight:823.94Greziprubart
<p>Greziprubart is a humanized IgG1κ monoclonal antibody that targets C5a, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.</p>Color and Shape:Odour LiquidCK3 peptide
CAS:<p>CK3 peptide is an NRP-1-targeting peptide with the amino acid sequence CLKADKAKC. It specifically binds to NRP-1 to target breast cancer cells. Single-photon emission computed tomography (SPECT) and near-infrared fluorescence (NIRF) imaging demonstrate that CK3 peptide significantly accumulates in xenograft tumors in nude mice. CK3 peptide is applicable for molecular imaging studies of breast cancer.</p>Formula:C40H72N12O12S2Color and Shape:SolidMolecular weight:977.203Zilucoplan (PEG2)
<p>Zilucoplan(PEG2) is a derivative of Zilucoplan where the linker component has been substituted with PEG2 instead of PEG24. This compound acts as an effective inhibitor of complement component 5 (C5).</p>Formula:C128H190N24O33Color and Shape:SolidMolecular weight:2593.02Claseprubart
CAS:<p>Claseprubart is a monoclonal antibody that targets human complement C1s. It specifically binds to complement C1s, inhibiting the activation of the complement system and exerting immunosuppressive effects. Claseprubart shows potential for research in autoimmune diseases and inflammation-related conditions.</p>Color and Shape:LiquidPMX 205
CAS:<p>PMX 205 is an effective complement antagonist of the C5a receptor.</p>Formula:C45H62N10O6Purity:98%Color and Shape:SolidMolecular weight:839.04ATWLPPR Peptide TFA
<p>ATWLPPR Peptide TFA inhibits neuropilin-1 and VEGF165-NRP-1 binding; may reduce diabetic retinal damage.</p>Formula:C42H62F3N11O11Purity:98%Color and Shape:SolidMolecular weight:954EG01377 2HCl
CAS:<p>EG01377 2HCl is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1) with a Kd value of 1.32 μM and an IC50 value of 609 nM for both EG01377</p>Formula:C26H32Cl2N6O6S2Purity:98.91%Color and Shape:SoildMolecular weight:659.6ARC186
<p>ARC186 is a highly potent aptamer that serves as a complement inhibitor by blocking the convertase-catalyzed activation of C5.</p>Color and Shape:SolidMolecular weight:120702.76AMY-101
CAS:<p>AMY-101 TFA is a C3 complement inhibitor with high affinity (KD: 0.5 nM) and promising anti-inflammatory effects in severe COVID-19.</p>Formula:C83H117N23O18S2Purity:98%Color and Shape:SolidMolecular weight:1789.11PIC1 PA TFA
<p>PIC1 PATFA is the trifluoroacetate form of PIC1 PA. PIC1 PA TFA is a peptide composed of 15 amino acids and serves as an effective PIC1 analog capable of inhibiting complement activation mediated by the classical pathway.</p>Formula:C71H123N19O21S2·xC2HF3O2Color and Shape:SolidPozelimab
CAS:<p>Pozelimab (REGN 3918) is a humanized antibody targeting component 5 (C5), used for research on Pozelimab disease.</p>Purity:98.94% (SEC-HPLC) - 98.94% (SEC-HPLC)Color and Shape:Liquid3-Phenoxybenzaldehyde
CAS:<p>3-Phenoxybenzaldehyde is a complement (classical pathway) inhibitor with IC50 of 1388μM.</p>Formula:C13H10O2Purity:99.01%Color and Shape:SolidMolecular weight:198.22CP-289
CAS:<p>CP-289 is a potent C5a receptor antagonist with IC50 of 1 μM.</p>Formula:C30H35ClN2O2Purity:99.97%Color and Shape:SoildMolecular weight:491.06tLyP-1 peptide
CAS:<p>tLyP-1 peptide is an NRP-1 targeting peptide with an IC50 of 4 μM, and its amino acid sequence is CGNKRTR. It can specifically bind to NRP-1 to target tumor cells.</p>Formula:C31H59N15O10SColor and Shape:SolidMolecular weight:833.96AMY-101 TFA
CAS:<p>AMY-101 TFA is an inhibitor of complement C3 and an immunomodulator, gingivitis and periodontitis. reduces inflammation and lowers levels of MMP-8 and MMP-9</p>Formula:C85H118F3N23O20S2Color and Shape:SolidMolecular weight:1903.11C5aR2 agonist P32 acetate
<p>C5aR2 agonist P32 acetate (Ac-RHYPYWR-OH), a selective agonist for C5aR2, has been shown to induce various immunomodulatory activities both in vitro and in vivo. It modulates cell signaling via the downregulation of C5aR1-mediated pathways and can also function independently of C5aR1.</p>Formula:C54H70N16O11·xC2H4O2Color and Shape:SolidMolecular weight:1119.23 (free base)Olendalizumab
CAS:<p>Olendalizumab (ALXN1007) is a humanized antibody targeting C5a for research on COVID-19-related inflammation.</p>Color and Shape:LiquidFactor B-IN-5
CAS:<p>Factor B-IN-5 is a complement factor B inhibitor, which can be used to study immune-related diseases.</p>Formula:C27H32N2O4Purity:98.19%Color and Shape:SoildMolecular weight:448.553-O-(2'E,4'Z-Decadienoyl)ingenol
<p>3-O-(2'E,4'Z-Decadienoyl)ingenol is a useful organic compound for research related to life sciences and the catalog number is T124104.</p>Formula:C30H42O6Color and Shape:SolidMolecular weight:498.66NH2-C6-ARC186
<p>NH2-C6-ARC186 is a derivative of the aptamer ARC186, featuring an NH2-C6 moiety that enables coupling to various peptides or molecules.</p>Purity:98%Color and Shape:SolidMolecular weight:12881Human Immunoglobulin M
<p>Human Immunoglobulin M (IgM) is an antibody secreted by the adaptive immune system in response to foreign antigens. It is a primary type of immunoglobulin released into circulation during the early stages of the primary antibody response. Human Immunoglobulin M forms a pentamer comprising five IgG equivalents, with 10 Fab fragments, allowing for 10 antigen binding sites. Additionally, Human Immunoglobulin M acts as a complement (complement) activator.</p>Color and Shape:Odour SolidPMX 205 Trifluoroacetate
<p>PMX 205 Trifluoroacetate is a potent complement C5a receptor ( C5aR ; CD88 ) antagonist.</p>Formula:C47H63F3N10O8Color and Shape:SolidMolecular weight:953.06Vemircopan
CAS:<p>Vemircopan is a complement factor D inhibitor.</p>Formula:C29H28BrN7O3Color and Shape:SolidMolecular weight:602.493PMX-53
CAS:<p>PMX-53: MrgX2 agonist; C5aR antagonist; lessens atherosclerotic lesions & metastasis in mice; blocks rat hypernociception.</p>Formula:C47H65N11O7Purity:98%Color and Shape:SolidMolecular weight:896.09Factor B-IN-1
CAS:<p>Factor B-IN-1 is a Factor B inhibitor.</p>Formula:C19H16N4O2Color and Shape:SolidMolecular weight:332.3559JPE-1375
CAS:<p>JPE-1375: a C5aR1 antagonist, blocks leukocyte mobilization (EC50=6.9 µM), lowers TNF in mice (EC50=4.5 µM), useful for autoimmune/inflammation research.</p>Formula:C49H63FN10O9Color and Shape:SolidMolecular weight:955.08TLQP-21
CAS:<p>TLQP 21, a VGF-derived peptide, guards CGCs against apoptosis and combats early diet-induced diabetes by boosting energy spend.</p>Formula:C107H170N40O26Purity:98%Color and Shape:SolidMolecular weight:2432.75L-156,602
CAS:<p>L-156,602 has a wide range of applications in life science related research.</p>Formula:C38H64N8O13Color and Shape:SolidMolecular weight:840.973Certepetide
CAS:<p>Certepetide, or iRGD, is a cyclic peptide that enhances tumor penetration and researches solid cancers.</p>Formula:C37H60N14O14S2Color and Shape:SolidMolecular weight:989.09Compstatin TFA
<p>Compstatin TFA: 13-residue cyclic peptide, inhibits primate complement C3, species-specific, protease-resistant, IC50=63μM (classical), 12μM (alternative).</p>Formula:C68H100F3N23O19S2Color and Shape:SolidMolecular weight:1664.79Pegcetacoplan acetate
<p>Pegcetacoplan acetate is a pegylated complement C3 inhibitory peptide that functions by binding to complement component 3 (C3) and its activation fragment C3b. This compound is utilized in the study of complement-mediated diseases, including age-related macular degeneration, C3 glomerulopathy, geographic atrophy (GA), and autoimmune hemolytic anemia.</p>Color and Shape:Odour SolidComplement C1s-IN-1
CAS:<p>Complement C1s-IN-1 is a selective inhibitor of complement C1s，oral and brain penetrable, inhibit human serum-induced formation of membrane attack complexes</p>Formula:C22H20F2N6OPurity:97.77%Color and Shape:SoildMolecular weight:422.43Vensobafusp alfa
CAS:<p>Vensobafusp alfa (KP-104) is a fusion protein composed of an IgG4 monoclonal antibody targeting complement protein C5, combined with the domains 1-5 of complement factor H (FH1-5). It exhibits anti-inflammatory and immunomodulatory properties. The isotype control for Vensobafusp alfa can be referred to as human IgG4(S228P) kappa.</p>Color and Shape:LiquidC1s-IN-1 trihydrochloride
CAS:<p>C1s-IN-1 trihydrochloride (Compound A1) is a selective inhibitor of C1s protease with a Ki of 5.8 μM. This compound inhibits the cleavage of C2 by C1s with an IC50 of 85 μM and prevents activation of the classical pathway, with an IC50 of 22 μM. Additionally, C1s-IN-1 trihydrochloride acts as a competitive inhibitor of thrombin, exhibiting a Ki of 51.2 μM.</p>Formula:C16H22Cl3N5Color and Shape:SolidMolecular weight:390.74CP-447697
CAS:<p>CP-447697, a lipophilic C5a receptor antagonist, exhibits an IC50 of 31 nM. It is utilized in inflammation research.</p>Formula:C29H26ClF2N3O2SPurity:99.90%Color and Shape:SoildMolecular weight:554.05Complement C5 Protein, Cynomolgus, Recombinant (His)
<p>Complement C5 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>Color and Shape:Lyophilized PowderMolecular weight:188.1 kDa (predicted); 106.3 and 75.8 kDa (reducing conditions)Complement C2 Protein, Cynomolgus, Recombinant (His)
<p>Single nucleotide polymorphism (SNP) of complement component 2 (C2) has been found to be significantly associated with hepatocellular carcinoma (HCC).</p>Color and Shape:Lyophilized PowderMolecular weight:82.18 kDa (predicted). Due to glycosylation, the protein migrates to 90-110 kDa based on Tris-Bis PAGE result.Complement factor I Protein, Human, Recombinant (His)
<p>Complement factor I (CFI) is a serine protease which plays a key role in the modulation of complement system and the induced-fit factor responsible for</p>Color and Shape:Lyophilized PowderMolecular weight:64.58 kDa (predicted). Due to enzyme lysis and glycosylation, the protein migrates to 75-95 kDa based on Tris-Bis PAGE result.Complement Factor MASP3 Protein, Human, Recombinant (His)
<p>MASP3 is a member of the MASPs involved in mannan-binding lectin (MBL) complement pathway.</p>Color and Shape:Lyophilized PowderMolecular weight:95-120 KDa (reducing condition)
