Others

<p>Applications Palbociclib-d4 is an isotope labelled compound of Palbociclib (P139900). Palbociclib (P139900) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.<br>References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009)<br></p>

<p>Stability Light Sensitive<br>Applications Bimatoprost is an antiglaucoma agent. Bimatoprost is an synthetic prostamide; structurally related to prostaglandin F2α.<br>References Brandt, J.D., et al.: Ophthalmology, 108, 1023 (2001), Woodward, D.F., et al.: J. Pharmacol. Exp. Ther., 305, 772 (2003), Quinones, R., et al.: J. Ocul. Pharmacol. Ther., 20, 115 (2004),<br></p>

<p>Applications Palbociclib N-Aldehyde is an intermediate in synthesizing Palbociclib N-β-D-Glucuronide Sodium Salt (P139910), a derivative of Palbociclib (P139900) which is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.<br>References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009)<br></p>

<p>Stability Hygroscopic<br>Applications An impurity of the antiparkinsonian and antispasmodic agent Memantine (M218000).<br>References Rystov, L. et al.: J. Pharmac. Biomed. Anal., 56, 887 (2011);<br></p>

<p>Stability Light Sensitive, Temperature Sensitive<br>Applications It is one of the two carotenoids contained within the retina.<br>References Karrer, et al.: Helv. Chim. Acta, 13, 268 (1930), Hlubucek, et al.: J. Chem. Soc. Perkin Trans., 1, 848 (1974), Maoka, T., et al.: Comp. Biochem. Physiol., 83B, 121 (1986),<br></p>

<p>Applications 2-CHLOROTOLUENE (cas# 95-49-8) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Impurity Eletriptan Impurity 14<br>Applications Tri-o-tolyl-Phosphine Oxide (Eletriptan Impurity 14) is an impurity of Eletriptan, a selective serotonin 5-HT1B and 5-HT1D receptor agonist and used to treat migraines.<br>References Willems, E., et al.: Arch. Pharmacol., 358, 212 (1998); Napier, C., et al.: Eur. J. Pharmacol., 368, 259 (1999); Goadsby, P.J., et al.: Neurology, 54, 156 (2000)<br></p>

<p>Impurity Atenolol EP Impurity E<br>Applications 4,4'-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis-benzeneacetamide is an impurity of Atenolol (A790075), a cardioselective β-adrenergic blocker. Atenolol EP Impurity E<br>References Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984);<br></p>

<p>Applications 5,6-Dimethylbenzimidazole (cas# 582-60-5) is a useful research chemical.<br></p>

<p>Applications A glucuronide of (Z)-4-Hydroxy Tamoxifen (or trans-4-hydroxytamoxifen), an active metabolite of Tamoxifen (T006000).<br>References Beaulieu, M., et al.: J. Biol. Chem., 271, 22855 (1996), Green, M., et al.: Drug Metab. Dispos., 26, 860 (1998), Nishiyama, T., et al.: Biochem. Pharmacol., 63, 1817 (2002),<br></p>

<p>Applications Gentisuric Acid is a metabolite that was found in hen plasma, tissues, and eggs as a result of the consumption of naturally occurring salicylates.<br>References Protasiuk, E., &amp; Olejnik, M.: Food Addit. Contam. Part A, 37, 946 (2020)<br></p>

<p>Stability Hygroscopic<br>Applications Food Red No. 102 is an artificial coloring food additive. Dye. Dyes and metabolites, Environmental Testing<br>References McCann, D. et al.: Lancet. 370, 1560 (2007); Kim, Y. et al.: Text. Res. J., 71, 318 (2001);<br></p>

<p>Applications 3-Methoxy-1,2-propanediol is used to prepare phosphorothioate analogs of sn-2 radyl lysophosphatidic acid as metabolically stabilized LPA receptor agonists. It is also used to synthesize diacylglycerol analogs as potential second-messenger antagonists.<br>References Jiang, G., et al.: Bioorg. Med. Chem. Lett., 23, 1865 (2013); Briggs, J., et al.: Bioorg. Med. Chem. Lett., 2, 127 (1992)<br></p>

<p>Stability Unstable in Methanol<br>Applications Used in the synthesis of cyanogen glycoside. A component contains in antiperspirants, deodorants, body soaps, shampoos, hair rinses, and hair; it inhibits volatile steroid formation by resident bacteria.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Marouf, A., et al.: Pharm. Biol., 39, 263 (2001), Fukuda, T., et al.: Biol. Pharm. Bull., 26, 271 (2003), Butler, M., et al.: J. Nat. Prod., 67, 2141 (2004), He, J., et al.: J. Nat. Prod., 69, 121 (2006),<br></p>

<p>Applications An impurity of Nintedanib, which is an antifibrotic drug.<br>References Holdsworth, G.; et al.: Scientific Reports, 7, 1 (2017)<br></p>

<p>Applications Tetramethylurea is an excellent solvent for organic substances, in particular aromatic compounds.<br>References Lüttringhaus, A., et al.: Angew. Chem. Int. Ed. Engl., 3, 260 (1964)<br></p>

<p>M01914 - myo-Inositol</p>

<p>Impurity Atenolol EP Impurity D<br>Applications 4-(3-Chloro-2-hydroxypropoxy)benzeneacetamide is an impurity of Atenolol (A790075), a cardioselective β-adrenergic blocker. Atenolol EP Impurity D<br>References Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984); Pai, N.R., et al.: J. Chem. Pharma. Rsch., 4, 375 (2012);<br></p>

<p>Applications Delorazepam 4-Oxide is an N-oxide of Delorazepam (D230675) and an intermediate in the synthesis of Lorazepam (L469850).<br>References Cepanec, I. et al.: Org. Proc. Res. Dev., 10, 1192 (2006); Guerrato, A. et al.: Boll. Chim. Farm., 126, 170 (1987);<br></p>

<p>Applications Lindane-d6 is very toxic. It was an effective insecticide on mosquitoes, house flies, and on German and American cockroaches.<br>References Tanaka, K., et al.: Pestic. Biochem. Physiol., 6, 386-391 (1976)<br></p>

<p>Bestatin (Ubenimex) competitively inhibits many aminopeptidases. Bestatin is a microbial metabolite and dipeptide with immunomodulatory and antitumor effects.</p>

<p>Applications Selective non-benzodiazepine GABAA receptor agonist.<br>References Allen, D., et al.: Eur. J. Clin. Pharmacol., 45, 313 (1993), Beer, B., et al.: J. Clin. Pharmacol., 34, 335 (1994), Rosen, A.S., et al.: Biopharm. Drug Dispos., 20, 171 (1999), Elie, R., et al.: J. Clin. Psychiatry, 60, 536 (1999), Heydorn, W.E., et al.: Expert Opin. Invest. Drugs, 9, 841 (2000)<br></p>

<p>Applications Desmethyl Nintedanib is an impurity of Intedanib (I666650), which is an antitumor agent. Desmethyl Nintedanib was used in the study of synthesizing indolinones as triple angiokinase inhibitors.<br>References Roth, G., et al.: J. Med. Chem., 52, 4466 (2009);<br></p>

<p>Folinic acid (Leucovorin) is a biofolic acid that can be used in the treatment of methotrexate, often in combination with Methotrexate (MTX) to reduce MTX-</p>

<p>Applications Lindane is an insecticide that is used as a treatment for scabies and lice. Lindane has been used as a broad-spectrum insecticide for seed and soil treatment, foliar applications, tree and wood treatment and against ectoparasites in both veterinary and human applications. Lindane is persistent, bioaccumulates easily in the food chain and bioconcentrates rapidly. There is evidence for long-range transport and toxic effects (immunotoxic, reproductive and developmental effects) in laboratory animals and aquatic organisms. One of the new POPs under the Stockholm Convention.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bist, R., et al.: Int. J. Pharm. Pharma. Sci., 4, 117 (2012); Heinz, M., et al.: Human. Health. Handbook., 1, 355 (2012); Bay, S.M., et al.: Enviro. Toxciol. Chem., 31, 2711 (2012);<br></p>

<p>Applications N-Acetyl Memantine is an intermediate used for preparation of Memantine (M218000).<br>References Gerzon, K., et al.: J. Med. Chem., 6, 760 (1963), Reddy, J., et al.: Org. Process Res. Dev., 11, 268 (2007),<br></p>

<p>Impurity Diazepam EP Impurity E<br>Applications 6-Chloro-1-methyl-4-phenyl-2(1H)-quinazolinone (Diazepam EP Impurity E) is an impurity of Temazepam (T017200), which is a pharmacologically active metabolite. It is used as a sedative and hypnotic drug.<br>References Sarteschi, P., et al.: Arzneim.-Forsch., 22, 93 (1972), Schwandt, H.J., et al.: Xenobiotica, 4, 733 (1974), Curry, S.H., et al.: Br. J. Pharmacol., 57, 427 (1976), Heel, R.C., et al.: Drugs, 21, 321 (1981)<br></p>

<p>Impurity Abiraterone Impurity 5<br>Applications 17-Iodo-androsta-5,16-diene-3β-ol is an analog of Abiraterone (A108490) and is used as a reagent in the synthesis of C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens which exhibit antitumor activity. Abiraterone Impurity 5<br>References Handratta, V.D., et al.: J. Med. Chem., 48, 2972 (2005)<br></p>