Aminoacids and derivatives

<p>Nordalbergin, a coumarin isolated from the bark of Dalbergia sissoo, can significantly induce the differentiation of HL-60 cells.</p>

<p>Cy 3 (Non-Sulfonated) is a CY3-derived dye. CY3 is an amine-reactive cyanine orange dye for fluorescent labelling of proteins and nucleic acids.</p>

<p>Applications Betaine-15N is an isotopically labelled analog of Betaine (B325005), which is an endogenous zwitterioin present in many biological systems and referred to as Glycine Betaine. It can be used as an organic osmolyte, a methyl donor and it can also be used for the treatment of homocystinuria, an inherited disorder of the metabolism of amino acid methionine.<br>References Ashraf, M. &amp; Foolad, M.: Environ. Exp. Bot., 59, 206 (2006);Yancey, P.: J. Exp. Biol., 208, 2819 (2005);Rees, W., et. al.: Biochem., 32, 137 (1993)<br></p>

<p>Stability Unstable in Solution<br>Applications (S)-(-)-Carbidopa is a peripheral decarboxylase inhibitor that is commonly used in combination with L-DOPA (D533751) for treatment of Parkinsonism. S(-)-Carbidopa ( has also been shown to prolong the elimination half-life of L-DOPA from blood plasma and skeletal muscle.<br>References Henry, G.M. et al.: Psychosom. Med., 38, 95 (1976); Leguire, L.E. et al.: Invest. Ophthalmol. Vis. Sci. 34, 3090 (1993); Deleu, D. et al.: Naun. Schmied. Arch. Pharmacol. 348: 576 (1993);<br></p>

<p>Applications Labelled Dapoxetine (D185700). Selective serotonin reuptake inhibitor (SSRI).<br>References Feret, B., et al.: Formulary, 40, 227 (2005),<br></p>

<p>Applications 1-Methyl-D-tryptophan is used in biological studies to determine the effect of IDO2 enzyme (indoleamine-(2,3)-dioxygenase) activity and IDO2-mediated arrest of human T cell proliferation. It reverses IDO-mediated immune suppression<br>References Qian, F., et al.: Cancer Immunology Immunothrapy, 61, 2013 (2012)<br></p>

<p>Applications N-Carbobenzoxy-S-phenyl-L-cysteine methyl ester is used in the preparation of γ-amino β-ketoesters by cross-Claisen condensation of α-amino acid derivatives with alkyl acetates.<br>References Honda, Y., et al.: Tetrahedron, Lett., 44, 3163 (2003);<br></p>

<p>Applications O-Methyl-3,3',5,5'-tetraiodothyronamine is a derivative of p-Tyramine (T898500); an adrenergic.<br>References Brandacher, G., et al.: Curr. Drug Metab., 8, 289 (2007); Oresic, M., et al.: J. Exp. Med., 205, 2975 (2008)<br></p>

<p>Applications (S)-Ethyl 2-amino-3-(1H-indol-3-yl)propanoate hydrochloride (cas# 2899-28-7) is a useful research chemical.<br></p>

<p>Applications Antifibrinolytic agent. Used in the preparation of Tranexamic Acid (T714505).<br></p>

<p>Applications A labelled metabolite of Tryptophan (T947200).<br>References da Prada, M., et al.: Biochem. Pharmacol., 14, 1721 (1965), Curzon, G., et al.: Br. J. Pharmacol., 63, 627 (1978), Fukumori, R., et al.: J. Pharm. Pharmacol., 33, 586 (1981), Aasmoe, L., et al.: Biochem. Pharmacol., 57, 1067 (1999), Karamanakos, P., et al.: Pharmacol. Toxicol., 88, 106 (2001),<br></p>

<p>Applications Labelled cis-Tranexamic Acid (T714500). Antifibrinolytic agent; blocks lysine binding sites of plasminogen. Hemostatic.<br>References Andersson, et al.: Scand. J. Haematol. 2, 230 (1965), Melander, B., et al.: Acta Pharmacol. Toxicol., 22, 340 (1965), Bonnar, J., et al.: Br. Med. J., 313, 579 (1996), Dunn, C.J., et al.: Drugs, 57, 1005 (1999),<br></p>