Aminoacids and derivatives

<p>M01802 - G-418.Sulfate, Sterile-Filtered Solution</p>

<p>Cy 3 (Non-Sulfonated) is a CY3-derived dye. CY3 is an amine-reactive cyanine orange dye for fluorescent labelling of proteins and nucleic acids.</p>

<p>Nordalbergin, a coumarin isolated from the bark of Dalbergia sissoo, can significantly induce the differentiation of HL-60 cells.</p>

<p>Applications O-Methyl-3,3',5,5'-tetraiodothyronamine is a derivative of p-Tyramine (T898500); an adrenergic.<br>References Brandacher, G., et al.: Curr. Drug Metab., 8, 289 (2007); Oresic, M., et al.: J. Exp. Med., 205, 2975 (2008)<br></p>

<p>Applications Betaine-15N is an isotopically labelled analog of Betaine (B325005), which is an endogenous zwitterioin present in many biological systems and referred to as Glycine Betaine. It can be used as an organic osmolyte, a methyl donor and it can also be used for the treatment of homocystinuria, an inherited disorder of the metabolism of amino acid methionine.<br>References Ashraf, M. &amp; Foolad, M.: Environ. Exp. Bot., 59, 206 (2006);Yancey, P.: J. Exp. Biol., 208, 2819 (2005);Rees, W., et. al.: Biochem., 32, 137 (1993)<br></p>

<p>Applications Glycine-d2, is the labeled analogue of Glycine (G615990), a non-essential amino acid for human development. Glycine is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.<br>References Scott, D., et al.: J. Neurosci., 21, 3063 (2001); Laube, B., et al.: Neuropharmacology, 47, 994 (2004); Papadakis, M., et al.: J. Biol. Chem., 279, 14703 (2004), Chen, P., et al.: Mol. Pharmacol., 67, 1470 (2005), Wolosker, H., et al.: Mol. Neurobiol., 36, 152 (2007);<br></p>

<p>Applications N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-5,6-dihydro-1-Naphthalenecarboxamide is an impurity of Palonosetron (P165800), a serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.<br>References Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993), Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995), Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003), Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004), Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004),<br></p>

<p>Applications N-Carbobenzoxy-S-phenyl-L-cysteine methyl ester is used in the preparation of γ-amino β-ketoesters by cross-Claisen condensation of α-amino acid derivatives with alkyl acetates.<br>References Honda, Y., et al.: Tetrahedron, Lett., 44, 3163 (2003);<br></p>

<p>Applications 1-Methyl-D-tryptophan is used in biological studies to determine the effect of IDO2 enzyme (indoleamine-(2,3)-dioxygenase) activity and IDO2-mediated arrest of human T cell proliferation. It reverses IDO-mediated immune suppression<br>References Qian, F., et al.: Cancer Immunology Immunothrapy, 61, 2013 (2012)<br></p>

<p>Applications Serotonin-13C215N Hydrochloride, is a labelled Serotonin (S274980). Serotonin is a monoamine neurotransmitter.<br></p>

<p>Applications Carbidopa Monohydrate (cas# 38821-49-7) is a useful research chemical.<br></p>