Aminoacids and derivatives

<p>Applications D-Cysteine is a strong inhibitor of Escherichia coli growth and also functions to provide inorganic sulfates for the sulfation of xenobiotics. D-Cysteine is a non-physiological isomer of L-Cysteine (C995000), and is not involved in protein or glutathione synthesis.<br>References Glazenburg, E., et al.: Biochem. Pharm., 33, 625 (1984); Klassen, C. &amp; Boles, J.: FASEB J., 11, 404 (1997); Soutourina, J., et al.: J. Biol. Chem., 276, 40864 (2001);<br></p>

<p>Stability Hygroscopic<br>Applications Oleoyl-L-carnitine is a long-chain fatty ester of carnitine which is accumulated and released into the circulation, in fatty-acid oxidation defects. Pattern of Oleoyl-L-carnitine can be diagnostic for a number of ß-oxidation defects.<br>References Adams, S., et al.: J. Nutrition, 139, 1073 (2009); Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)<br></p>

<p>Applications S-Enantiomer of Baclofen. Specific GABA-B receptor agonist. Muscle relaxant (skeletal).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ahuja, S., et al.: Anal. Profiles Drug Subs., 14, 527 (1985), Brogden, R.N., et al.: Drugs, 8,1 (1974)<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Melatonin (M215000).<br>References Reiter, R.J., et al.: J. Biomed. Sci., 7, 444 (2000), Chen, Z., et al.: Am. J. Physiol, 284, 1618 (2003), Barrenetxe, J., et al.: J. Physiol. Biochem., 60, 61 (2004),<br></p>

<p>Impurity L-5-Hydroxytryptophan(Tryptophan EP Impurity D)<br>Applications 5-Hydroxy-L-Tryptophan (L-5-Hydroxytryptophan(Tryptophan EP Impurity D)) is a hydroxylated metabolite of L-Tryptophan (T947210).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gartside, S., et al.: Eur. J. Pharmacol., 179, 103 (1990); Gijsman, H., et al.: J. Clin. Psychopharmacol., 22, 183 (2002),; Schruers, K., et al.: Psychiatry Res., 113, 237 (2002);<br></p>

<p>Applications (S)-Carbidopa Methyl Ester N-cyclohexylideneis an impurity of Carbidopa (C175915), a prodrug inhibitor of aromatic amino acid decarboxylase.<br>References Sletzinger, M., et al.: J. Med. Chem., 6, 101 (1963)<br></p>

<p>Stability Hygroscopic<br>Applications L-Glutamic Acid, Magnesium Salt Hydrobromide is an metabolite of L-Glutamic acid, a non-essential amino acid. Its salt form (glutamate) is an important neurotransmitter that plays a key role in long-term potentiation and is important for learning and memory. It is also a key molecule in cellular metabolism. L-Glutamic Acid, Magnesium Salt Hydrobromide has also been investigated for sedative properties as a tranquilizer.<br>References McEntee, W., et al.: Psychopharmacology, 111, 391 (1993), Manev, H., et al.: Mol. Pharmacol., 36, 106 (1989), Hamanaka, T., et al.: Toho. Igakkai. Zasshi., 20, 663 (1973);<br></p>

<p>Applications L-Glutamine-2,3,3,4,4-d5 is the isotope labelled analog of L-Glutamine (G597000); an essential amino acid that is a crucial component of culture media that serves as a major energy source for cells in culture. L-Glutamine is very stable as a dry powder and as a frozen solution. In liquid media or stock solutions, however, L-glutamine degrades relatively rapidly. Optimal cell performance usually requires supplementation of the media with L-glutamine prior to use.<br>References Rivett, A., et al.: J. Biol. Chem., 260, 300 (1985); Watford, M., et al.: Metabolism, 49, 141 (2000); Wilmore, D., et al.: J. Nutr., 131, 2543S (2001)<br></p>

<p>Applications N-Glycylglycine is a derivative of Glycine (G615990), a non-essential amino acid that enhances N-methyl-D-aspartate (NMDA) receptor mediated synaptic potentials in the neocortex of rats. Glycine is also being used as adjuvant therapy for the treatment of schizophrenia.<br>References Logan, W. &amp; Snyder, S.: Brain Res., 42, 413 (1972); Rosse, R., et al.: Clin. Neuropharmacol., 12, 416 (1989)<br></p>

<p>Applications 2-Hydroxy L-Tryptophan is a metabolic intermediate in the biosynthesis of the neurotransmitters serotonin and melatonin from Tryptophan.<br>References Southan, M.D., et al.: Med. Chem. Res., 6, 343 (1996);<br></p>

<p>Applications Lacosamide impurity I: (R)-N-benzyl-2-(3-benzylureido)-3-methoxypropanamide is an impurity of lacosamide (L098500), a medication used for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. Lacosamide is a potent anticonvulsant.<br>References Lees, G., et al.: Brain Res., 612, 190 (1993), Kuo, C., et al.: Mol. Pharmacol., 51, 1077 (1997), Barton, M., et al.: Epilepsy Res., 47, 217 (2001), Beyreuther, B., et al.: Eur. J. Pharmacol., 539, 64 (2006), Beyreuther, B., et al.: CNS Drug Rev., 13, 21 (2007),<br></p>

<p>Applications Glycyl-glycyl-glycine is used as a model peptide for studies of physicochemical parameters and molecular associations of small peptides. It is also used as a copper chelator.<br></p>

<p>Applications Baclofen-d4, is the labeled analogue of Baclofen (B108000), a specific GABA-B receptor agonist. Muscle relaxant (skeletal).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ahuja, S., et al.: Anal. Profiles Drug Subs., 14, 527 (1985), Brogden, R.N., et al.: Drugs, 8,1 (1974)<br></p>

<p>Applications A lipid biomarker for stable and unstable heart disease.<br>References Gaziano, J., et al.: Circulation, 96, 2520 (1997), Thomas, A., et al.: Anal. Chem., 82, 6687 (2010),<br></p>

<p>Applications 6-Aminocaproic Acid Dimer is a reactant with citric acid in the formation of 3-hydroxy-3,4-dicarboxy-butanamide-N-hexanoic acid.<br>References Schou-Pedersen, A. V., et al.: J. Pharm. Biomed. Anal., 107, 333-340 (2015)<br></p>

<p>Applications 4-(4-Chlorophenyl)-2,6-piperidinedione (cas# 84803-46-3) is a compound useful in organic synthesis.<br></p>

<p>Stability Decomposes under acidic condition, Hygroscopic<br>Applications 1,1’-Ethylidenebis[L-tryptophan] is a L-tryptophan (T947210) contaminant found in the peripheral blood mononuclear cells from patients with functional somatic syndromes.<br>References Barth, H., et al.: Clin. Experiment. Inmmunol., 126, 187 (2001); Simat, T.J., et al.: Adv. Experi. Med. Biol., 467, 469 (1999);<br></p>

<p>Applications Isotope labelled Glycine is a non-essential amino acid for human development. Glycine is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.<br>References Scott, D., et al.: J. Neurosci., 21, 3063 (2001), Laube, B., et al.: Neuropharmacology, 47, 994 (2004), Papadakis, M., et al.: J. Biol. Chem., 279, 14703 (2004), Chen, P., et al.: Mol. Pharmacol., 67, 1470 (2005), Wolosker, H., et al.: Mol. Neurobiol., 36, 152 (2007),<br></p>

<p>Applications N-Methyl-p-tyramineúHCl (cas# 370-98-9) is a useful research chemical.<br></p>

<p>Applications CEL and CML are two stable, nonenzymatic chemical modifications of protein lysine residues resulting from glycation and oxidation reactions.<br>References Fu, M.X., et al.: J. Biol. Chem., 271, 9982 (1996), Ahmed M.U., et al.: Biochem.J., 324, 565 (1997), Schleicher, E.D., et al.: J. Clin. Invest., 99, 457 (1997), Shibayama, R., et al.: Diabetes, 48, 1842 (1999),<br></p>

<p>Applications L-Lysine is an essential amino acid for human development. Lysine residues are useful in many cellular processes, due to their ability to accept a wide variety of post-translational modifications.<br>References Tosha, L. et. al.: Biochem. J. 435, 509 (2011);<br></p>

<p>Applications A metabolite of Malatonin.<br>References Young, I., et al.: J. Clin. Endocrinol. Metab., 60, 114 (1985), Barrenetxe, J., et al.: J. Physiol. Biochem., 60, 61 (2004),<br></p>

<p>Applications Labelled analogue of Glycine, a non-essential amino acid for human development. Glycine is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.<br>References Scott, D. et al.: J. Neurosci., 21, 3063 (2001); Laube, B. et al.: Neuropharmacology, 47, 994 (2004); Papadakis, M. et al.: J. Biol. Chem., 279, 14703 (2004); Chen, P. et al.: Mol. Pharmacol., 67, 1470 (2005); Wolosker, H. et al.: Mol. Neurobiol., 36, 152 (2007);<br></p>