Aminoacids and derivatives

<p>Applications 5-Aminolevulinic Acid Methyl Ester Hydrochloride, is the methyl ester of Aminolevulinic Acid (ALA) (A611780), which has been shown to have higher lipophilicity, and to be highly efficient at inducing protoporphyrin IX (PpIX) production in cell culture.<br>References Morrow, D. I. J., et al.: J. Pharmac. Sci., 99, 3486 (2010); Peng, Q., et al.: Cancer, 79, 2282 (1997);<br></p>

<p>Stability Decomposes under acidic condition, Hygroscopic<br>Applications 1,1’-Ethylidenebis[L-tryptophan] is a L-tryptophan (T947210) contaminant found in the peripheral blood mononuclear cells from patients with functional somatic syndromes.<br>References Barth, H., et al.: Clin. Experiment. Inmmunol., 126, 187 (2001); Simat, T.J., et al.: Adv. Experi. Med. Biol., 467, 469 (1999);<br></p>

<p>DEAC, SE (7-Diethylaminocoumarin-3-carboxy acid) is a blue fluorescent dye for labeling amine-containing organisms. λex of DEAC, SE is 330 nm and λem is 402</p>

<p>Applications Benzylamine has been used as a reactant in the preparation of diacetylated benzylamide which has shown to induce a G1/G0 arrest in tumor cells and cytotoxicity against human ovarian cancer cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Siewert, B., et. al.: Bioorg. Med. Chem., 22, 594 (2014)<br></p>

<p>Applications Cadaverine is a polyamine produced by the decarboxylation of L-lysine, and is also produced by Escherichia coli (E.coli) cells when grown in acidic pH. Cadaverine is known to inhibit porin-mediated outer membrane permeability in E.coli.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mimitsuka, T., et al.: Biosci., Biotech., Bioch., 71, 2130 (2007); Sanartzidou, H., et al.: J. Bacteriol., 185, 13 (2003)<br></p>

<p>Applications trans-4-Hydroxycyclohexylcarboxylic Acid acts as a reagent in the synthetic preparation of pyrazole-pyrimidine preparation as TTK inhibitors and potential antitumors, Preparation and Janus kinase 1 (JAK1)-selective inhibitory activity of benzimidazole derivatives.<br>References Liu, Y., et al.: ACS Med. Chem. Lett., 7, 671 (2016); Kim, H., et al.: Bioorg. Med. Chem. Lett., 26, 3213 (2016)<br></p>

<p>Applications (S)-Carbidopa Methyl Ester N-cyclohexylideneis an impurity of Carbidopa (C175915), a prodrug inhibitor of aromatic amino acid decarboxylase.<br>References Sletzinger, M., et al.: J. Med. Chem., 6, 101 (1963)<br></p>

<p>Applications Lacosamide is a medication used for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. Lacosamide is a potent anticonvulsant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lees, G., et al.: Brain Res., 612, 190 (1993), Kuo, C., et al.: Mol. Pharmacol., 51, 1077 (1997), Barton, M., et al.: Epilepsy Res., 47, 217 (2001), Beyreuther, B., et al.: Eur. J. Pharmacol., 539, 64 (2006), Beyreuther, B., et al.: CNS Drug Rev., 13, 21 (2007),<br></p>

<p>Applications Labelled Indole (I577320). Can be used in perfumes and in the synthesis of tryptophan.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Hygroscopic<br>Applications Essential amino acid.<br>References Liu, F., et al.: Bioorg. Med. Chem., 18, 4167 (2010), Kumar, R., et al.: Eur. J. Med. Chem., 45, 2265 (2010), Cai, W., et al.: Bioorg. Med. Chem., 18, 1899 (2010),<br></p>

<p>Applications L-Glutamic-2,4,4-d3 Acid (CAS# 203805-84-9) can be used for rapid and sensitive quantitation of amino acids in malaria biological samples using LC-EI/MS. It can also be used to determine thyroxine levels in blood samples using mass spectrometry.<br>References Armenta, J.et.al., Anal.Chem., 82,548-5548,(2010); Chace, D., et.al., U.S. Pat. Appl Publ., 10,(2008);<br></p>

<p>Applications Labelled sym-Homospermidine (H625000). sym-Homospermidine is an analogue of Spermidine. sym-Homospermidine is used as antineoplastic.<br>References Pegg, A., et al.: Cancer Res., 48, 759 (1988), Bergeron, R., et al.: J. Med. Chem., 37, 3464 (1994), Bergeron, R., et al.: Drug Metab. Dispos., 23, 1117 (1995),<br></p>

<p>Applications It is used as labelled biomarker for metabolic age.<br>References Selmer, T., et al.: Eur. J. Biochem., 268, 1363 (2001), Connelly, J., et al.: Drug Metab. Dispos., 30, 1357 (2002), Lindon, J., et al.: Pharm. Res., 23, 1075 (2006), Monteagudo, E., et al.: Xenobiotica, 37, 1000 (2007),<br></p>

<p>Applications Labelled analogue of an essential amino acid found in naturally produced peptides. Unlike its stereoisomer, L-tryptophan, it is not used in structural or enzyme proteins.<br>References Karunakaran, S.et al.: Bochem. J., 414, 343 (2008); Pallaghy, P.K. et al.: Biochem., 38, 11553 (1999);<br></p>

<p>Applications Desacetyl Desmethyl Lacosamide is an impurity of Lacosamide (L098500) which is a potent anticonvulsant.<br>References Lees, G., et al.: Brain Res., 612, 190 (1993), Kuo, C., et al.: Mol. Pharmacol., 51, 1077 (1997), Barton, M., et al.: Epilepsy Res., 47, 217 (2001), Beyreuther, B., et al.: Eur. J. Pharmacol., 539, 64 (2006), Beyreuther, B., et al.: CNS Drug Rev., 13, 21 (2007),<br></p>

<p>Stability Moisture Sensitive<br>Applications 3-(4-Chlorophenyl)glutaric Anhydride (cas# 53911-68-5) is a compound useful in organic synthesis.<br></p>

<p>Applications N-Descarboxymethyl-N-carboxyethyl Lacosamide is an impurity of Lacosamide (L098500), an anticonvulsant drug that enhances sodium channel slow inactivation, and is used to treat patients with epilepsy.<br>References Doty, P., et al.: Neurotherapeutics, 4, 145 (2007); Perucca, E., et al.: Nat. Rev. Drug Discov., 7, 973 (2008); Sake, J., et al.: CNS Drugs, 24, 1055 (2010)<br></p>

<p>Applications N,N-Dimethylaminoethanol Phosphate is a metabolite of Dimethylaminoethanol, a precursor to the neurotransmitter acetylcholine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ansell, G.B. et al.: Zhur. Evol. Biochim, Fiziol., 15, 249 (1979): Miyazaki, H. et al.: Chem. Pharm. Bull., 24, 763 (1976); Haidar, N.E. et al.: Neurochem. Res., 19, 457 (1994);<br></p>

<p>Applications N-Acetyl-cysteine is a reagent that is used in the synthesis of phenylalkyl isoselenocyanates which has anticancer activity.<br>References Sharma, A. K., et al.: J. Med. Chem., 24, 7820 (2008);<br></p>

<p>Applications Labelled analogue of Glycine (G615990), a non-essential amino acid for human development. Glycine (G615990) is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.<br>References Scott, D., et al.: J. Neurosci., 21, 3063 (2001), Laube, B., et al.: Neuropharmacology, 47, 994 (2004), Papadakis, M., et al.: J. Biol. Chem., 279, 14703 (2004), Chen, P., et al.: Mol. Pharmacol., 67, 1470 (2005), Wolosker, H., et al.: Mol. Neurobiol., 36, 152 (2007),<br></p>