Aminoacids and derivatives

<p>Applications Glutamine analog.<br>References Hellberg, S., et al.: J. Med. Chem., 30, 1126 (1987), Blondelle, S., et al.: Antimicrob. Agents Chemother., 38, 2280 (1994), Jiracek, J., et al.: J. Biol. Chem., 270, 21701(1995),<br></p>

<p>Applications Labelled analogue of Glycine, a non-essential amino acid for human development. Glycine is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.<br>References Scott, D. et al.: J. Neurosci., 21, 3063 (2001); Laube, B. et al.: Neuropharmacology, 47, 994 (2004); Papadakis, M. et al.: J. Biol. Chem., 279, 14703 (2004); Chen, P. et al.: Mol. Pharmacol., 67, 1470 (2005); Wolosker, H. et al.: Mol. Neurobiol., 36, 152 (2007);<br></p>

<p>Applications sn-Glycero-3-phosphocholine (Choline Alfoscerate) is a phospholipid; precursor in choline biosynthesis. sn-Glycero-3-phosphocholine is an intermediate in catabolic pathway of phosphatidylcholine. sn-Glycero-3-phosphocholine is used as an Nootropic.<br>References Schmidt, G., et al.: J. Biol. Chem., 161, 523 (1945), Frattola, L., et al.: Curr. Ther. Res., 49, 683 (1991), Olson, D., et al.: Science, 270, 1967 (1995),<br></p>

<p>Applications Tranexamic-d2 acid is deuterium labelled tranexamic acid (T714505), which is an antifibrinolytic agent that blocks lysine binding sites of plasminogen. Hemostatic.<br>References Andersson, et al.: Scand. J. Haematol. 2, 230 (1965), Melander, B., et al.: Acta Pharmacol. Toxicol., 22, 340 (1965), Bonnar, J., et al.: Br. Med. J., 313, 579 (1996), Dunn, C.J., et al.: Drugs, 57, 1005 (1999),<br></p>

<p>Impurity Baclofen EP Impurity A<br>Applications 4-(4-Chlorophenyl)-2-pyrrolidinone is used in the preparation of potential and selective antagonists of the α1A adrenergic receptor (1,2). It is an impurity of Baclofen (B108000), a specific GABA-B receptor agonist. Muscle relaxant (skeletal).<br>References (1) Whitlock, G. et al.: Bioorg. med. Chem. Lett., 19, 3118 (2009)(2) Brogden, R.N., et al.: Drugs, 8,1 (1974)<br></p>

<p>Impurity Tranexamic EP Impurity C<br>Stability Hygroscopic<br>Applications 4-(Aminomethyl)-1-cyclohexene-1-carboxylic Acid (Tranexamic EP Impurity C) is an impurity of Tranexamic acid (T714505).<br></p>

<p>Applications Specific GABA-B receptor agonist. Muscle relaxant (skeletal).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ahuja, S., et al.: Anal. Profiles Drug Subs., 14, 527 (1985), Brogden, R.N., et al.: Drugs, 8,1 (1974)<br></p>

<p>Stability Hygroscopic<br>Applications Biogenic polyamine formed from spermidine and occurring in almost all tissues. Essential for both normal and neoplastic tissue growth. Involved in the modulation of calcium-dependent immune processes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Israel, et al.: J. Med. Chem., 7, 710 (1964), Janne, J., et al.: Biochim. Biophys. Acta, 473, 241 (1978). Theoharides, T.C., et al.: Life Sci., 27, 703 (1980), Horn, Y., et al.: Cancer Res., 42, 3248 (1982),<br></p>

<p>Applications A labelled, essential amino acid.<br>References Liu, F., et al.: Bioorg. Med. Chem., 18, 4167 (2010), Kumar, R., et al.: Eur. J. Med. Chem., 45, 2265 (2010), Cai, W., et al.: Bioorg. Med. Chem., 18, 1899 (2010),<br></p>

<p>Applications 5-Aminolevulinic Acid Methyl Ester Hydrochloride, is the methyl ester of Aminolevulinic Acid (ALA) (A611780), which has been shown to have higher lipophilicity, and to be highly efficient at inducing protoporphyrin IX (PpIX) production in cell culture.<br>References Morrow, D. I. J., et al.: J. Pharmac. Sci., 99, 3486 (2010); Peng, Q., et al.: Cancer, 79, 2282 (1997);<br></p>

<p>Applications Labelled Indole (I577320). Can be used in perfumes and in the synthesis of tryptophan.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>