Benzimidazole and Imidazole Derivatives
Benzimidazole is a compound consisting of a benzene ring fused to an imidazole ring, a five-membered structure containing two nitrogen atoms. Benzimidazole derivatives, such as albendazole, are known for their antiparasitic and antifungal activity, used in the treatment of parasitic infections and certain parasitic diseases in animals and humans. Imidazole, on the other hand, is a five-membered structure with two nitrogen atoms found in various biologically active compounds. Imidazole derivatives, such as metronidazole, have antimicrobial and antiparasitic properties. These compounds are also used in the pharmaceutical industry for treating bacterial infections, parasitic diseases, and some fungal infections, as well as in organic chemistry as catalysts.
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Found 10376 products of "Benzimidazole and Imidazole Derivatives"
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2,4-Dicyano-3-(2-methylpropyl)-pentanediamide (Mixture of Diastereomers)
CAS:Controlled Product<p>Stability Hygrscopic<br>Applications 2,4-Dicyano-3-(2-methylpropyl)-pentanediamide is an impurity of Pregabalin (P704800), a GABA (A602920) analogue used as an anticonvulsant.<br>References Hoekstra, M.S., et al.: Org. Proc. Rec. Deve., 1, 26 (1997); Lowry, O., et al.: J. Biol. Chem., 193, 265 (1951); Gerlach, M., et al.: Brain Res., 741, 142 (1996); Taylor, C.P., at al.: Epilepsy Res., 14, 11 (1993), Field, M.J., et al.: Pain, 80, 391 (1999)<br></p>Formula:C11H16N4O2Color and Shape:NeatMolecular weight:236.272-(Chloromethyl)-3,5-dimethylpyridine Hydrochloride
CAS:Controlled Product<p>Applications Intermediate in the preparation of Omeprazole metabolites<br></p>Formula:C8H10ClN·ClHColor and Shape:NeatMolecular weight:192.09(R)-4,5-Dehydro Pregabalin
CAS:Controlled Product<p>Applications (R)-4,5-Dehydro Pregabalin is derived from rac 4,5-Dehydro Pregabalin (D230050), which is an impurity of the anti-convulsnat, Pregabalin.<br>References Dousa, M, et al.: J. Pharmac. Biomed. Anal., 53, 717 (2010);<br></p>Formula:C8H15NO2Color and Shape:NeatMolecular weight:157.21Lurasidone Opened Imide (Mixture of Diastereomers)
CAS:Controlled Product<p>Applications Lurasidone Opened Imide is an impurity in the synthesis of Lurasidone (L474920) which is antipsychotic used for treatment of schizophrenia.<br>References Ishiyama, T., et al.: Eur. J. Pharmacol., 572, 160 (2007); Cole, P., et al.: Drugs of the Fut., 33, 316 (2008);<br></p>Formula:C28H38N4O3SColor and Shape:NeatMolecular weight:510.69Varenicline-d2,15N2 Dihydrochloride
CAS:Controlled Product<p>Applications Varenicline-d2,15N2 Dihydrochloride, is the labelled dihydrochloride salt of Varenicline (V098492), a nicotinic α4β2 acetylcholine receptor partial agonist. Aids in smoking cessation.<br>References Benowitz, N., et al.: Clin. Pharmacol. Ther., 44, 23 (1988), Cohen, C., et al.: J. Pharmacol. Exp. Ther., 306, 407 (2003), Tapper, A., et al.: Science, 306, 1029 (2004), Coe, J., et al.: J. Med. Chem., 48, 3474 (2005), Obach, R., et al.: Drug Metab. Disp., 34, 121 (2006),<br></p>Formula:C13H13D2Cl2N15N2Color and Shape:Light Beige SolidMolecular weight:288.18Omeprazole Sodium Salt
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Omeprazole Sodium Salt is the salt analogue of Omeprazole (O635000), which binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative.<br>References Muller, P., et al.: Arzneimittel-Forsch., 33, 1685 (1983); Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984); Morii, M., et al.: J. Biol. chem., 268, 21553 (1993); Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)<br></p>Formula:C17H18N3O3S·Na·H2OColor and Shape:Off-WhiteMolecular weight:385.41Prazepam
CAS:Controlled Product<p>Applications Prazepam, is a benzodiazepine derivative drug having anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.<br>References Shader R. I., et al.: Ciba. Found. Symp., (74), 141 (1979); Jacqmin, P., et al.: Neuropsychobiology, 19 (4), 186 (1988);<br></p>Formula:C19H17ClN2OColor and Shape:Off-WhiteMolecular weight:324.80N-Methyl Omeprazole-d3 (Mixture of isomers with the methylated nitrogens of imidazole)
CAS:Controlled Product<p>Applications Labelled Omeprazole (O635000) impurity.<br>References Allenmark, S., et al.: Anal. Biochem., 136, 293 (1984), Besancon, M., et al.: J. Biol. Chem., 272, 22438 (1997),<br></p>Formula:C18H18D3N3O3SColor and Shape:NeatMolecular weight:362.46(S)-Modafinil-d10
CAS:Controlled Product<p>Applications Labelled (S)-Modafinil. Used for treatment of excessive sleepiness, α1-adrenoceptor agonist.<br>References Saletu, B., et al.: Int. J. Clin. Pharmacol. Res., 9, 183 (1989), Chemelli, R.M., et al.: Cell, 98, 437 (1999), Purnell, M., et al.: J. Sleep Res., 11, 219 (2002), Dinges, D., et al.: Curr. Med. Res. Opin., 22, 159 (2006)<br></p>Formula:C15D10H5NO2SColor and Shape:NeatMolecular weight:283.41Benzofuran-6-carboxylic Acid
CAS:Controlled Product<p>Applications Benzofuran-6-carboxylic Acid is a reagent in the development of potent LFA-1/ICAM antagonist SAR 118 as an opthalmic solution for treating dry eyes. Preparation of piperidinylpyrimidine derivatives as inhibitors of HIV-1 LTR activation.<br>References Zhong, M., et al.: ACS Med. Chem., 3, 203 (2012); Fujiwara, N., et al.: Bioorg. Med. Chem., 16, 9804 (2008)<br></p>Formula:C9H6O3Color and Shape:NeatMolecular weight:162.14Lansoprazole Sulfone N-Oxide
CAS:Controlled Product<p>Applications An impurity of Lansoprazole.<br>References Barradell, L., et al.: Drugs, 44, 225 (1992), Aydogmus, Z., et al.: Acta Pharm. Sci., 48, 45 (2006), El-Sherif, Z., et al.: Chem. Pharm. Bull., 54, 814 (2006),<br></p>Formula:C16H14F3N3O4SColor and Shape:WhiteMolecular weight:401.361-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid Sodium Salt
CAS:<p>Applications 1-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid is an impurity of Rabeprazole. It is also a degradation product formed in stressed tablets of Rabeprazole sodium.<br>References Kommanaboyina, B., et al.: Drug Dev. Ind. Pharm., 25, 857 (1999); Carswel, C., et al.: Drugs, 61, 2327 (2001); Garcia, C., et al.: J. Pharm. Biomed. Anal., 46, 88 (2008)<br></p>Formula:C14H10N3NaO3Color and Shape:NeatMolecular weight:291.24Prazepam-d5
CAS:Controlled Product<p>Applications Prazepam-d5, is the labeled analogue of Prazepam (P702250), a benzodiazepine derivative drug having anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.<br>References Shader R. I., et al.: Ciba. Found. Symp., (74), 141 (1979); Jacqmin, P., et al.: Neuropsychobiology, 19 (4), 186 (1988);<br></p>Formula:C192H5H12ClN2OColor and Shape:NeatMolecular weight:329.832-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Hydrochloride
CAS:Controlled Product<p>Impurity Omeprazole EP Impurity XI<br>Applications 2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Hydrochloride (Omeprazole EP Impurity XI) is an intermediate in the production of the antiulcer agent Omeprazole.<br>References Roma, G., et al.: J. Med. Chem., 50, 2886 (2007), Hoffmann, S., et al.: Toxicol. Lett., 180, 9 (2008),<br></p>Formula:C9H12ClNO·ClHColor and Shape:WhiteMolecular weight:222.11trans-Itraconazole
CAS:Controlled Product<p>Impurity Itraconazole EP Impurity E<br>Applications trans-Itraconazole (Itraconazole EP Impurity E) is a geometrical isomer of Itraconazole (I937500). It is a COVID19-related research product.<br>References Ahn, C., et al.: J. Korean Chem. Soc., 43, 676 (1999),<br></p>Formula:C35H38Cl2N8O4Color and Shape:NeatMolecular weight:705.63N-Ethylcarbamic Acid 3-[(1S)-1-(Dimethylamino)ethyl]phenyl Ester
CAS:Controlled ProductFormula:C13H20N2O2Color and Shape:NeatMolecular weight:236.314-Desmethoxypropoxyl-4-chloro Rabeprazole Sulfide
CAS:Controlled Product<p>Applications A process impurity of Rabeprazole (R070500).<br>References Pingili, R.R., et al.: Pharmazie, 60, 814 (2005),<br></p>Formula:C14H12ClN3SColor and Shape:NeatMolecular weight:289.78cis-Hydroxy Solifenacin N-Oxide(Mixture of Diastereomers)
Controlled Product<p>Applications Solifenacin (S676700) metabolite.<br></p>Formula:C23H26N2O4Color and Shape:NeatMolecular weight:394.46
![1-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid Sodium Salt](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FB203965.webp&w=3840&q=75)
![N-Ethylcarbamic Acid 3-[(1S)-1-(Dimethylamino)ethyl]phenyl Ester](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FE900885.webp&w=3840&q=75)
