Purines and Pyrimidine Derivatives
Purines have a bicyclic structure, consisting of a six-membered ring fused to a five-membered ring, both containing nitrogen atoms in key positions. Purine derivatives, such as adenine and guanine, are essential for the formation of DNA and RNA. These compounds have therapeutic applications in cancer and viral disease treatments by inhibiting cell replication. Pyrimidines, on the other hand, have a monocyclic six-membered structure with two nitrogen atoms. Their derivatives, such as cytosine, thymine, and uracil, are also essential components of DNA and RNA and are used in chemotherapy and antiviral treatments.
At CymitQuimica, we offer purine and pyrimidine derivatives for research in molecular biology, genomics, and the development of innovative therapies.
Found 8902 products of "Purines and Pyrimidine Derivatives"
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(R)-Methotrexate
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications R-Methotrexate is an enantiomer of Methotrexate (M260675), a folic acid antagonist. Used as a antineoplastic and antirheumatic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>Formula:C20H22N8O5Color and Shape:Dark YellowMolecular weight:454.545-Diazoimidazole-4-carboxamide
CAS:Controlled Product<p>Impurity Temozolomide USP Related Compound A<br>Applications Temozolomide USP Related Compound A<br></p>Formula:C4H3N5OColor and Shape:NeatMolecular weight:137.101,7-Dimethyluric Acid
CAS:Controlled Product<p>Applications A metabolite of Caffeine.<br>References Kalow, W., et al.: Clin. Pharmacol. Ther., 53, 503 (1993), Sharma, S., et al.: Cancer Res., 54, 5848 (1994), Sugawara, M., et al.: J. Biol. Chem., 275, 16473 (2000), Takeda, M., et al.: J. Pharmacol. Exp. Ther., 302, 666 (2002),<br></p>Formula:C7H8N4O3Color and Shape:NeatMolecular weight:196.168-Descarboxamido-8-cyano Temozolomide
CAS:Controlled Product<p>Applications 8-Descarboxamido-8-cyano Temozolomide is a useful synthetic intermediate in the synthesis of Temozolomide (T017775); an imidazotetrazine alkylating agent and antineoplastic.<br>References Newlands, E.S., et al.: Cancer Treat. Rev., 23, 35 (1997); Kim, C., et al.: J. Biol. Chem., 274, 1233 (1999); Hait, W., et al.: Cancer Res., 69, 1263 (2009); Wang, Y., et al.: J. Org. Chem., 62, 7288 (1997)<br></p>Formula:C6H4N6OColor and Shape:Light Yellow To Light BrownMolecular weight:176.141-(3-(BENZO[D]THIAZOL-2-YL)-4-HYDROXYPHENYL)-3-PHENYLUREA
CAS:Purity:95.0%Molecular weight:361.42001342773441-Methyluric Acid
CAS:Controlled Product<p>Applications A metabolite of Theophylline.<br>References Chen, Y., et al.: Clin. Exper. Pharmacol. Physiol., 36, 828 (2009), Yu, C., et al.: J. Bacteriol., 191, 4624 (2009), Jetter, A., et al.: Eur. J. Clin. Pharmacol., 65, 411 (2009),<br></p>Formula:C6H6N4O3Color and Shape:Light Yellow To Light BrownMolecular weight:182.142-Fluoroadenosine
CAS:Controlled Product<p>Applications 2-Fluoroadenosine is a fluorinated analog of Adenoside (A280400) nucleotide.<br>References Long, X., et al.: J. Pharmacol. Exper. Ther., 335, 781 (2010); Ham, M., et al.: J. Pharmacol. Exper. Ther., 335, 607 (2010);<br></p>Formula:C10H12FN5O4Color and Shape:NeatMolecular weight:285.234-(3-fluorophenyl)-6-(thiophen-2-yl)pyrimidin-2-amine
CAS:Purity:95.0%Molecular weight:271.30999755859375Allopurinol-d2
CAS:Controlled Product<p>Applications Labelled xanthine oxidase inhibitor; decreases uric acid production. Used in treatment of hyperuricemia and chronic gout. Antiurolithic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Benezra, S.A., et al.: Anal. Profiles Drug Subs., 7, 1, (1978), Dalbeth, N., et al.: Rheumatology, 44, 1090 (2005), Dinarello, C., et al.: J. Exp. Med., 201, 1355 (2005),<br></p>Formula:C52H2H2N4OColor and Shape:Light BrownMolecular weight:138.121,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one
CAS:<p>Impurity Ondansetron EP Impurity C<br>Applications 1,2,3,9-Tetrahydro-9-(methyl-d3)-4H-carbazol-4-one (Ondansetron EP Impurity C) is used in the preparation of 5-HT3 modulators useful in the treatment and prevention of 5-HT3 receptor-mediated diseases. 1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one is an impurity of Ondansetron (O655000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Huang, W. et al.: Zhong. Yao. Dax. Xueb., 30, 1 (1999); Kim, M. et al.: Heterocycles, 45, 2041 (1997); Feng, R. et al.: Zhong. Yaox. Zaz., 46, 1436 (2011);<br></p>Formula:C13H13NOColor and Shape:Off-WhiteMolecular weight:199.256,6’-Methylenebis[(3RS)-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-one(Ondansetron Impurity B)
CAS:<p>Impurity Ondansetron EP Impurity B<br>Applications Ondansetron EP Impurity B.<br></p>Formula:C37H38N6O2Color and Shape:NeatMolecular weight:598.74Tenofovir Monohydrate
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Tenofovir Monohydrate is an HIV-1 RT inhibitor and antiretroviral drug.<br>References Zhao, Z., et al.: Method for preparing medical salts and/or derivatives of tenofovir disoproxil, and their application for preventing and/or treating HBV and HIV/AIDS infections, CN 101574356 (2009);<br></p>Formula:C9H14N5O4P·H2OColor and Shape:NeatMolecular weight:305.23Paraxanthine-d3
CAS:Controlled Product<p>Applications Paraxanthine-d3, is the labeled analogue of Paraxanthine (P192500), an adenosine receptor ligand and a major metabolite of caffeine.<br>References Proc. Natl. Acad. Sci. USA 78, 3260 (1981); Cell Mol. Neurobiol., 3, 69 (1983); Eur. J. Pharmacol., 179, 295 (1990)<br></p>Formula:C72H3H5N4O2Color and Shape:NeatMolecular weight:183.182-[3-(Aminocarbonyl)-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid
CAS:Controlled Product<p>Applications 2-[3-(Aminocarbonyl)-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid is an impurity of Febuxostat (F229000), an xanthine oxidase/xanthine dehydrogenase inhibitor used for the treatment of hyperuricemia and chronic gout.<br>References Kadivar, M.H., et al.: J. Pharma. Biomed. Anal., 56, 749 (2011);<br></p>Formula:C16H18N2O4SColor and Shape:White To Off-WhiteMolecular weight:334.39Zolmitriptan
CAS:Controlled Product<p>Applications Zolmitriptan is a serotonin 5HTID-receptor agonist and used to treat migraine (1,2,3).<br>References (1) Glen, R.C., et al.: J. Med. Chem., 38, 3566 (1995)(2) Seaber, E., et al.: Brit. J. Clin. Pharmacol., 41, 141 (1996)(3) Tepper, S.J., et al.: Curr. Med. Res. Opin., 15, 254 (1999)<br></p>Formula:C16H21N3O2Color and Shape:NeatMolecular weight:287.364-Hydroxythiobenzamide
CAS:<p>Applications 4-Hydroxythiobenzamide is used in the synthesis of PPARα agonists used in increasing HDLc levels. Also used in the synthesis of potent CDK5 inhibitors in the treatment of Alzheimer’s disease.<br>References Sierra, M. et al.: J. Med. Chem., 50, 685 (2007); Zhong, W. et al.: Bioorg. Med. Chem. Lett., 17, 5384 (2007);<br></p>Formula:C7H7NOSColor and Shape:NeatMolecular weight:153.2Iso Rizatriptan
CAS:Controlled Product<p>Impurity Rizatriptan EP Impurity C<br>Applications Iso Rizatriptan (Rizatriptan EP Impurity C) is a potential impurity of Rizatriptan. A regioisomer of Rizatriptan.<br>References Dill, K., et al.: J. Phys. Chem., 91, 1980 (1987), Cole, L., et al.: Anal. Chem., 64, 1317 (1992), Street, L., et al.: J. Med. Chem., 1995, 38, 1799<br></p>Formula:C15H19N5Color and Shape:NeatMolecular weight:269.34
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