Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65615 products of "Quinazoline and Quinoline Derivatives"
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4-Hydroxy Phenylbutazone
CAS:<p>Applications Impurity in the production of Phenylbutazone (P319570)<br>References Fricoteaux, R., et al.: J. Pharm. Biomed. Anal., 7, 1585 (1989), Segrestaa, J., et al.: Chem. Pharm. Bull., 50, 744 (2002),<br></p>Formula:C19H20N2O3Color and Shape:White To Off-WhiteMolecular weight:324.37m-Salicylic Acid
CAS:Controlled Product<p>Applications m-Salicylic Acid is widely used in organic synthesis. It is also an important active metabolite of aspirin (A187780).<br>References Haynes, M., et al.: CRC H.b Chem. Phys., 92, 306 (2011)<br></p>Formula:C7H6O3Color and Shape:Off-WhiteMolecular weight:138.12Gabapentin Ethyl Ester Hydrochloride
CAS:Controlled Product<p>Applications Protected Gabapentin (G117250). Amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Used as an anticonvulsant.<br>References Vollmer, K.-O. et al.: Arzneimittel-Forshc., 36, 830 (1986), Saletu, B., et al.: Int. J. Clin. Pharmacol. Ther. Toxicol., 24, 362 (1986)<br></p>Formula:C11H21NO2·ClHColor and Shape:NeatMolecular weight:235.75Perampanel-d5
CAS:Controlled Product<p>Applications Perampanel-d5, is the labeled analogue of Perampanel (P285520), an antiepileptic drug.<br>References Shih, J., et al.: Therap. Clinical Risk Management, 9, 285 (2013); Rogawski, M. A., et al.: Epilepsy Curr., 11, 56 (2011);<br></p>Formula:C23D5H10N3OColor and Shape:Light Orange Colour SolidMolecular weight:354.42Dapoxetine N-Oxide (90%)
CAS:Controlled Product<p>Applications The N-oxide impurity of the selective serotonin reuptake inhibitor Dapoxetine (D185700).<br></p>Formula:C21H23NO2Purity:90%Color and Shape:NeatMolecular weight:321.412-Chloro Loratadine
CAS:Controlled Product<p>Applications 2-Chloro Loratadine is an impurity of Loratadine (L469575), a nonsedating-type histamine H1-Receptor blocker.<br>References U.S. (1998), US 5719148 A 19980217. PCT Int. Appl. (1995), WO 9510515 A1 19950420.<br></p>Formula:C22H22Cl2N2O2Color and Shape:NeatMolecular weight:417.33Nilotinib 3-Imidazolyl N-oxide
CAS:Controlled Product<p>Applications 4-Methyl-3-(4-pyridin-3-yl)pyrimidin-2-yl]amino-N-(5-(3-oxo-4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamine is an impurity compound of Nilotinib (N465300), useful in the treatment of chronic myelogenous leukemia. It is a COVID19-related research product.<br>References Wei-Sheng H., et al.: Synthesis, 14, 2121 (2007); Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),<br></p>Formula:C28H22F3N7O2Color and Shape:NeatMolecular weight:545.522-(1-Amino-1-methylethyl)-N-(4-fluorobenzyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide
CAS:Controlled Product<p>Applications An intermediate in the preparation of HIV-integrase inhibitors<br>References Summa, V., et al.: J. Med. Chem., 51, 5843 (2008),<br></p>Formula:C16H19FN4O3Color and Shape:NeatMolecular weight:334.35Carmustine-D8-Nitroso
Controlled ProductFormula:C5HD8Cl2N3O2Color and Shape:NeatMolecular weight:193.101N-Benzyl Epinephrine-d3
CAS:Controlled Product<p>Applications Labelled analogue of N-Benzyl Epinephrine, an impurity of Epinephrine (E588580).<br></p>Formula:C16H16D3NO3Color and Shape:NeatMolecular weight:276.35Bis(3-methylthien-2-yl)methanone
CAS:Controlled Product<p>Applications Bis(3-methylthien-2-yl)methanone is an impurity of Tiagabine (T436400), a GABA uptake inhibitor and nticonvulsant agent.<br>References Zhang, J.G., et al.: Chem. Res. Chin. Uni., 22, 351 (2006); Callen, G., et al.: Heterocycles., 39, 293 (1994);<br></p>Formula:C11H10OS2Color and Shape:NeatMolecular weight:222.334-Oxo-1,4-dihydroquinoline Carboxylic Acid
CAS:Controlled Product<p>Applications 4-Oxo-1,4-dihydroquinoline Carboxylic Acid is a novel HIV-1 integrase strand transfer inhibitor.<br>References Shinkai, H. et al.: Antivir. Drugs. 197 (2011); Liao, C. et al.: ChemMedChem., 5, 1053 (2010);<br></p>Formula:C10H7NO3Color and Shape:NeatMolecular weight:189.173-Amino-2-chloro-propenal
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications 3-Amino-2-chloro-propenal is a chemical reagent in the synthesis of a COX-2 specific inhibitor.<br>References Davies, I. et al.: J. Org. Chem., 65, 8415 (2000);<br></p>Formula:C3H4ClNOColor and Shape:NeatMolecular weight:105.52Everolimus NHS-carbonate (>85%)
Controlled Product<p>Applications Everolimus NHS-carbonate is a derivative of Everolimus (E945400), a macrolide immunosuppressant.<br></p>Formula:C58H86N2O18Purity:>85%Color and Shape:NeatMolecular weight:1099.306Desacetyl Diltiazem-d3
CAS:Controlled Product<p>Applications A labelled metabolite of Diltiazem (D460620).<br>References Shallcross, H., et al.: Br. Med. J., 295, 1236 (1987), Yeung, P.K.F., et al.: Drug Metab. Dispos., 18, 1055 (1990), Cashman, J.R., et al.: J. Med. Chem., 34,2049 (1991),<br></p>Formula:C20H21D3N2O3SColor and Shape:NeatMolecular weight:375.5Indomethacin 1-Glycerin Ester
CAS:<p>Applications Indometacin 1-Glycerin Ester was synthesized and evaluated for anti-flammatory activity in the rate paw carrageenin edema essay.<br>References Paris, Gerard. , et al.: J. Med. Chem, 23, 9 (1980)<br></p>Formula:C22H22ClNO6Color and Shape:NeatMolecular weight:431.874-Chlorophenothiazine
CAS:Controlled Product<p>Applications Intermediate in the preparation of Prochlorperazine (P755800) and related compound.<br></p>Formula:C12H8ClNSColor and Shape:NeatMolecular weight:233.72rac Felodipine-d3
CAS:Controlled Product<p>Applications A labelled dihydropyridine calcium channel blocker.<br>References Berntsson, P.B., et al.: Acta Pharm. Suec., 18, 221 (1981), Kratochwil, N., et al.: Biochem. Pharmacol., 64, 1355 (2002), O'Brien, S., et al.: J. Med. Chem., 48, 1287 (2005), Castilho, M., et al.: Bioorg. Med. Chem., 14, 516 (2006),<br></p>Formula:C182H3H16Cl2NO4Color and Shape:NeatMolecular weight:387.27(E)-Thiothixene
CAS:Controlled Product<p>Applications (E)-Thiothixene is an antipsychotic agent used in the treatment of psychological disorders.<br>References Andorn, A. et al.: Brain Res., 971, 66 (2003); Seeman, P. et al.: Mol. Pharmacol. 28, 391 (1985);<br></p>Formula:C23H29N3O2S2Color and Shape:NeatMolecular weight:443.633,3'-Sulfonylbis(N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide)(Mixture of Diastereomers)
CAS:Controlled Product<p>Impurity Bicalutamide EP Impurity K / Bicalutamide EP Impurity L<br>Applications 3,3'-Sulfonylbis(N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide) is an impurity of Bicalutamide (B382000); a non-steroidal peripherally active antiandrogen. Also used as an antineoplastic (hormonal).<br>References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988); Cockshott, I.D., et al.: Eur. Urol., 18, Suppl. 3, 10 (1990); Cockshott, I., et al.: Br. J. Clin. Pharm., 36, 339 (1993); McKillop, D., et al.: Xenobiotica, 25, 623 (1995)<br></p>Formula:C24H20F6N4O6SColor and Shape:NeatMolecular weight:606.492’-Des(1-hydroxy-1-methylethyl)-2’-methycarboxy Montelukast Hydrochloride
CAS:Controlled Product<p>Applications 2’-Des(1-hydroxy-1-methylethyl)-2’-methycarboxy Montelukast Hydrochloride is an impurity of Montelukast (M568000), a selective leukotriene D4-receptor antagonist.<br>References Kumar, I.V. et al.: Asian J. Chem., 23, 4536 (2011)<br></p>Formula:C34H33Cl2NO4SColor and Shape:NeatMolecular weight:622.6(R)-1-Methyl-3-pyrrolidinol
CAS:Controlled Product<p>Applications (R)-1-Methyl-3-pyrrolidinol is a useful synthetic intermediate. It is used for asymmetric synthesis of constrained (-)-S-adenosyl-L-homocysteine (SAH) analogs as DNA methyltransferase inhibitors.<br>References Isakovic, L., et al.: Bioorg. Med. Chem. Lett., 19, 2742 (2009); Gobbini, M., et al.:J. Med. Chem., 51, 4601 (2008)<br></p>Formula:C5H11NOColor and Shape:NeatMolecular weight:101.15Deacetyl Racecadotril Disulfide
CAS:Controlled Product<p>Applications Deacetyl Racecadotril Disulfide is an impurity of Racecadotril (R070600); an antidiarrheal and enkephalinase inhibitor that reduces the amount of water and electrolytes into the intestine.<br>References Cezard, J., et al.: Gastroenterol., 120, 799 (2001); Sato, T., et al.: J. Med. Chem., 51, 7705 (2008); Lakshmana, P., et al.: J. Pharm. Res., 8, 39 (2009); Fournie-Zaluski, Marie Claude., et al.: J. Med. Chem., 35(13), 2473-81 (1992)<br></p>Formula:C38H40N2O6S2Color and Shape:NeatMolecular weight:684.86Clonidine
CAS:Controlled Product<p>Applications Clonidine is an α2-Adrenergic agonist. Antihypertensive; analgesic for neuropathic pain.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Roach, A.G., et al.: J. Pharmacol. Exp. Ther., 227, 421 (1983); Glassman, A.H., et al.: Science, 226, 864 (1984); Abounassif, A.M., et al.: Anal. Profiles Drug Subs. Excip., 21, 109 (1992);<br></p>Formula:C9H9Cl2N3Color and Shape:NeatMolecular weight:230.09[3-(9H-Carbazol-4-yloxy)-2-hydroxy]propyl Carvedilol
CAS:Controlled ProductFormula:C39H39N3O6Color and Shape:NeatMolecular weight:645.742,2'-((6,6'-(2,4-Di(pyridin-2-yl)cyclobutane-1,3-diyl)bis(1H-indazole-6,3-diyl))bis(sulfanediyl))bis(N-methylbenzamide)
CAS:Controlled Product<p>Applications 2,2'-((6,6'-(2,4-Di(pyridin-2-yl)cyclobutane-1,3-diyl)bis(1H-indazole-6,3-diyl))bis(sulfanediyl))bis(N-methylbenzamide) is an impurity of Axitinib (A794650), a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.<br>References Wasser, K., et al.: Eur. Radiol., 13, 80 (2003), Park, J., et al.: Clin. Cancer Res., 8, 1172 (2002), Bergers, G., et al.: J. Clin. Invest., 111, 1287 (2003),<br></p>Formula:C44H36N8O2S2Color and Shape:BeigeMolecular weight:722.946-Amino-1-methyl-5-nitrosouracil
CAS:Controlled Product<p>Stability Light and temperature sensitive<br>Applications 6-Amino-1-methyl-5-nitrosouracil is known to exhibit anitmicrobial activity and form complexation with platinum (II).<br>References Gaballa, A.S., et al.: Molec. Biomolec. Spectro. 75A, 146 (2010);<br></p>Formula:C5H6N4O3Color and Shape:NeatMolecular weight:170.131-(4-(4-(tert-Butyl)phenyl)-4-hydroxybutyl)piperidine-4-carboxylic Acid
Controlled ProductFormula:C20H31NO3Color and Shape:NeatMolecular weight:333.4653-Methylxanthine
CAS:Controlled Product<p>Impurity Pentoxifylline EP Impurity B<br>Applications 3-Methylxanthine (Pentoxifylline EP Impurity B) is a metabolite of Theophylline (58-55-9), which is a Xanthine (X499950) derivative with diuretic, cardiac stimulant and smooth muscle relaxant activities; isomeric with theobromine.They can also act as Bronchodilator.<br>References Cohen, J.L., et al.: Anal. Profiles Drug Subs., 4, 466 (1975); Svedmyr, K., et al.: Allergy, 37, 111 (1982);<br></p>Formula:C6H6N4O2Color and Shape:BeigeMolecular weight:166.14N-Nitroso-desethyl-Hydroxychloroquine
Controlled ProductFormula:C16H21ClN4O3Color and Shape:NeatMolecular weight:336.817Everolimus Isomer C (>60%, contains everolimus)
CAS:Controlled Product<p>Stability Unstable in solution, revert back to Everolimus<br>Applications Everolimus Isomer C is an isomer of Everolimus (E945400), a derivative of Rapamycin (R124000). Everolimus inhibits cytokine-mediated lymphocyte proliferation.<br>References Dumont, F.J., et al.: Curr. Opin. Invest. Drugs, 2, 1220 (2001); Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001); Nashan, B., et al.: Ther. Drug Monit., 24, 53 (2002)<br></p>Formula:C53H83NO14Color and Shape:NeatMolecular weight:958.225-(4'-Methyl-2-biphenyl)tetrazole-d4
CAS:Controlled Product<p>Applications Labelled Valsartan (V095750) impurity.<br>References Thai, H., et al.: J. Cardiovasc. Pharmacol., 50, 703 (2007), Lukas, J., et al.: Science, 313, 662 (2006),<br></p>Formula:C14H8D4N4Color and Shape:Off-WhiteMolecular weight:240.301Methyl 4-Methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]benzoate
CAS:Controlled Product<p>Applications Methyl 4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]benzoate is an intermediate used in the synthesis of 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzamide (M326838), which is an impurity of Nilotinib (N465300), a possible agent in the treatment of chronic myelogenous leukemia.<br>References Corbin, A., et al.: J. Biol. Chem., 277, 32214 (2002); Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005); Gleixner, K., et al.: Blood, 107, 752 (2006); Nicolini, F., et al.: Leukemia, 20, 1061 (2006)<br></p>Formula:C18H16N4O2Color and Shape:NeatMolecular weight:320.35(R)-(+)-α-Methylbenzylamine (>85%)
CAS:Controlled ProductFormula:C8H11NPurity:>85%Color and Shape:NeatMolecular weight:121.182-Nitroso Riluzole
Controlled Product<p>Applications 2-Nitroso Riluzole is an impurity of Riluzole (R510000); is a neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant. Neuroprotective agent.<br>References Mizoule, J., et al.: Neuropharmacology, 24, 767 (1985), Wahl, F., et al.: Eur. J. Pharmacol., 230, 209 (1993) Bensimon, G., et al.: N. Engl. J. Med., 330, 585 (1994)<br></p>Formula:C8H3F3N2O2SColor and Shape:Dark GreenMolecular weight:248.182Mosapride-d5
CAS:Controlled Product<p>Applications A labelled selective 5-HT4 receptor agonist. Gastroprokinetic.<br>References Yoshida, N., et al.: Arch. Int. Pharmacodyn. Ther., 300, 51 (1989), Yatera, S., et al.: Japan. Pharmacol. Ther., 21, 21 (1993), Ruth, M., et al.: Aliment Pharmacol. Ther., 12, 35 (1998),<br></p>Formula:C21H20D5ClFN3O3Color and Shape:NeatMolecular weight:426.92N-[1-(4-Chlorophenyl)cyclobutylmethyl]-N,N-dimethylamine Hydrochloride
CAS:Controlled Product<p>Applications N-[1-(4-Chlorophenyl)cyclobutylmethyl]-N,N-dimethylamine Hydrochloride is an impurity of Sibutramine Hydrochloride (S422500), a serotonin and noradrenaline reuptake inhibitor.<br>References Hanotin, C., et al.: Int. J. Obesity, 22, 32 (1998)<br></p>Formula:C13H19Cl2NColor and Shape:NeatMolecular weight:260.2Ofloxacin N-Oxide Hydrochloride
CAS:Controlled ProductFormula:C18H20FN3O5·ClHColor and Shape:Off-WhiteMolecular weight:413.83Famotidine Acetaldehyde Adduct Maleate
CAS:Controlled ProductFormula:C10H17N7O2S3·C4H4O4Color and Shape:NeatMolecular weight:479.553-Chloro-1,2-propanediol-d5 (10 ug/mL in methanol)
CAS:Controlled ProductFormula:C32H5H2ClO2Color and Shape:ColourlessMolecular weight:115.57Dimenhydrinate
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications An antihistamine with antiemetic properties used to prevent nausea and motion sicknes composed of two drugs 8-Chlorotheophylline (C411440) and Diphenhydramine (D486900).<br>References Sibel, K. et al.: Arzneim.-Forsch. , 52, 529 (2002); Pytel, J. et al.: Clin. Therap., 29, 84 (2007); Scholtz, A.W. et al.: Clin. Therap., 26, 866 (2004);<br></p>Formula:C17H21NO·C7H7ClN4O2Color and Shape:NeatMolecular weight:469.96rac O-Acetyl Pseudoephedrine Hydrochloride
CAS:Controlled Product<p>Applications rac O-Acetyl Pseudoephedrine is a racemic O-acetylated analogue of the non-selective adrenergic agonist Pseudoephedrine (P839350).<br>References Snopek, J. et al.: J. Chrom., 438, 211 (1988);<br></p>Formula:C12H17NO2·ClHColor and Shape:WhiteMolecular weight:243.732-Amino-3-benzyloxypyridine
CAS:Controlled Product<p>Applications 2-Amino-3-benzyloxypyridine is used in preparation of pyridinyl/pyridazinyloxymethyl substituted Raf kinase inhibitors.<br>References Jen, T., et al.: J. Med. Chem., 20, 1258 (1977), Chung, D., et al.: Antican. Res., 11, 1373 (1991),<br></p>Formula:C12H12N2OColor and Shape:NeatMolecular weight:200.243-O-Benzyl-4,5-O-(1-methylethyldiene)-β-D-fructopyranose
CAS:Controlled Product<p>Applications Intermediate in the preparation of 2,3-Desisopropylidene Topiramate, a metabolite of Topiramate<br></p>Formula:C16H22O6Color and Shape:NeatMolecular weight:310.34Eltenac-13C,d3
CAS:Controlled Product<p>Applications Labelled Eltenac (E507000). A nonsteroidal anti-inflammatory drug.<br>References Allen, A., et al.: Gut, 21, 249 (1980), Tobin, T., et al.: J. Vet. Pharmacol. Therap., 9, 1 (1986),<br></p>Formula:CC11H7Cl2D2NO2SColor and Shape:NeatMolecular weight:302.18Lornoxicam-d4
CAS:Controlled Product<p>Applications Labelled Lornoxicam. Cyclooxygenase inhibitor; structurally similar to tenoxicam. Anti-inflammatory; analgesic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ankier, S.I., et al.: Postgrad. Med. J., 64, 752 (1988), Tricerri, M., et al.: Chem. Phys. Lipids, 71, 61 (1994), Santos, N., et al.: Biochemistry, 37, 8674 (1998), Pellicano, A., et al.: Infect. Immun., 75, 1738 (2007),<br></p>Formula:C132H4H6ClN3O4S2Color and Shape:NeatMolecular weight:375.84Tadalafil-13C2,d3
CAS:Controlled Product<p>Applications Tadalafil-13C2,d3 is labelled Tadalafil (T004500) which is used for the treatment of erectile dysfunction. It is a phosphodiesterase 5 inhibitor.<br>References Carrier, S., et al.: Can. J. Urol., 10(1), 12 (2003), Doggrell, S.A., et al.: Expert Opin. Pharmacother., 6, 75 (2005), Forgue, S.T., et al.: Br. J. Clin. Pharmacol., 61, 280 (2005)<br></p>Formula:C2013C2H16D3N3O4Color and Shape:White PowderMolecular weight:394.41Ambroxol Cycloimine Impurity
CAS:Controlled Product<p>Applications 4-(6,8-Dibromo-3(4H)-quinazolinyl)-cyclohexanol is an impurity of Ambroxol (A575900), a bronchosecretolytic drug.<br>References Jauch, R., et al.: Arzneim-Forsch., 13, 474 (1963)<br></p>Formula:C14H16Br2N2OColor and Shape:NeatMolecular weight:388.09764-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
CAS:Controlled Product<p>Applications 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine is a reagent in the synthesis of (+)-tofacitinib, a selective Janus kinase 3 inhibitor (JAK3) and an immunosuppressant drug.<br>References Liao, H., et al.: Tetrahedron: Asymmetry, 28, 105, (2017)<br></p>Formula:C13H10ClN3O2SColor and Shape:NeatMolecular weight:307.76(7-(4-{4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butoxy}butoxy)-3,4-dihydroquinolin-2(1H)-one)
CAS:Controlled Product<p>Impurity Aripiprazole USP Related Compound H<br>Applications (7-(4-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}butoxy)-3,4-dihydroquinolin-2(1H)-one) is an impurity of Aripiprazole (A771000), a selective dopamine D2-receptor antagonist with dopamine autoreceptor agonist activity. Aripiprazole USP Related Compound H.<br>References Zeidan, T.A., et al.: Crystal. Growth. Design., 13, 2036 (2013); Nagasaka, Y., et al.: Biopharma. Drug. Dispo., 33, 304 (2012); Chen, X., et al.: J. Med. Chem., 55, 7141 (2012);<br></p>Formula:C27H35Cl2N3O3Color and Shape:WhiteMolecular weight:520.495'-Hydroxyphenyl Carvedilol-d5
CAS:Controlled Product<p>Applications A Labelled metabolite of Carvedilol which is a multiple-action, neurohormonal antagonist that is used in the treatment of hypertension.<br>References Schaefer, W.H., et al.: Drug Metab. Dispos., 26, 958 (1998).<br></p>Formula:C24H21D5N2O5Color and Shape:NeatMolecular weight:427.55-Ethoxy-2-pyrrolidone
CAS:Controlled Product<p>Applications 5-Ethoxy-2-pyrrolidone is an intermediate in the synthesis of rac-Vigabatrin (V253005), a novel antiepileptic drug. Antidepressant; antipsychotic; anxiolytic.<br>References Vajda, F., et al.: Clin. Neurosci., 7, 88 (2000), Beghi, E., et al.: Lancet. Neurol., 3, 618 (2004), Sagirli, O., et al.: J. Pharmaceut. Biomed., 42, 618 (2006),<br></p>Formula:C6H11NO2Purity:>90%Color and Shape:NeatMolecular weight:129.16N-Nitroso Moxonidine
Controlled ProductFormula:C9H11ClN6O2Color and Shape:NeatMolecular weight:270.6764-Chloro-6,7-dimethoxyquinoline
CAS:<p>Applications 4-Chloro-6,7-dimethoxyquinoline, can be used as an intermediate for the synthesis of various pharmaceutical and biologically active compounds. It is used for the preparation of Tivozanib (T447205), and Cabozantinib (C051500), acting as anticancer agents.<br>References Fu, Y., Zhongguo Xinyao Zazhi, 22, 26 (2013); Liu, M., Adv. Mat. Res., 396, 1490 (2012); Camp, R., et al.: Cancer, 86, 2259 (1999);<br></p>Formula:C11H10ClNO2Color and Shape:NeatMolecular weight:223.662,4-Difluorobenzoic Acid
CAS:Controlled Product<p>Applications 2,4-Difluorobenzoic Acid (cas# 1583-58-0) is a compound useful in organic synthesis.<br></p>Formula:C7H4F2O2Color and Shape:NeatMolecular weight:158.10Riociguat Nitroso Impurity 1
Controlled ProductFormula:C18H16FN9OColor and Shape:NeatMolecular weight:393.15Valdecoxib Sulfonyl Chloride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Valdecoxib Sulfonyl Chloride is an impurity in the preparation of the cyclooxygenase-2 inhibitor, Valdecoxib (V090000) and its metabolites.<br>References Erdelyi, P. et al.: Bioorg. Med. Chem., 16, 5322 (2008);<br></p>Formula:C16H12ClNO3SColor and Shape:NeatMolecular weight:333.79(S)-Hydroxy Timolol
CAS:Controlled Product<p>Applications (S)-(-)-Hydroxy Timolol is a metabolite of the non-selective beta-adrenergic receptor blocker, Timolol (T443710).<br>References Volotinen, M. et al.: Basic Clin. Pharmacol. Toxicol., 106, 302 (2010);<br></p>Formula:C13H24N4O4SColor and Shape:NeatMolecular weight:332.42(±)-2-Phenylpropanoic Acid
CAS:<p>Applications Used in the preparation of ibuprofen derivatives for their anti-inflammatory activity. Also used in nucleation inhibitors in Dutch resolution of diastereomers.<br>References Leeman, M. et al.: Angew. Chem. Int. Ed., 47, 1287 (2008); Eur. J. Med. Chem., 45, 3564 (2010);<br></p>Formula:C9H10O2Color and Shape:Light Yellow LiquidMolecular weight:150.17rac Methotrimeprazine Sulfoxide
CAS:Controlled Product<p>Applications A metabolite of Methotrimeprazine (M260785).<br>References Haddad, P., et al.: Drugs, 62, 1649 (2002),<br></p>Formula:C19H24N2O2SColor and Shape:NeatMolecular weight:344.473-(Trifluoromethoxy)aniline
CAS:Controlled Product<p>Applications 3-(Trifluoromethoxy)aniline is reactant in the synthesis of pyrazolone-quinazolone hybrids as human hydroxyphenylpyruvate dioxygenase inhibitors which is a potential treatment for type I tyrosinemia.<br>References Xu, Y., et. al.: Bioorg. Med. Chem., 22, 5194 (2014)<br></p>Formula:C7H6F3NOColor and Shape:NeatMolecular weight:177.124-(4-Amino-1-oxoisoindolin-2-yl)-4-carbamoyl Butyric Acid
CAS:Controlled ProductFormula:C13H15N3O4Color and Shape:Off WhiteMolecular weight:277.28Fingolimod Stearoate Amide
CAS:Controlled Product<p>Applications Fingolimod Stearoate Amide is an impurity of Fingolimod (F805000, HCl salt), a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),<br></p>Formula:C37H67NO3Color and Shape:NeatMolecular weight:573.932-(2,4-Difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-1,2-propanediol
CAS:Controlled Product<p>Impurity Fluconazole EP Impurity F<br>Stability Hygroscopic<br>Applications 2-(2,4-Difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-1,2-propanediol (Fluconazole EP Impurity F) is a diol impurity of the antifungal agent Fluconazole (F421000).<br>References Dongre, V.G. et al.: J. Pharmac. Biomed. Anal., 42, 334 (2006):<br></p>Formula:C11H11F2N3O2Color and Shape:Light YellowMolecular weight:255.225-Acetyl-2-propyl-1H-Imidazole-4-carboxylic Acid Ethyl Ester
CAS:Controlled Product<p>Applications 5-Acetyl-2-propyl-1H-Imidazole-4-carboxylic Acid Ethyl Ester is used in the synthetic preparation of imidazole-5-carboxylic acids bearing alkyl, alkenyl, and hydroxyalkyl substituents at the 4-position and their related compounds.<br>References Yanagisawa, H., et al.: J. Med. Chem., 39, 323 (1996);<br></p>Formula:C11H16N2O3Color and Shape:NeatMolecular weight:224.26N-Aminocarbonyl Felbamate
CAS:Controlled Product<p>Applications N-Aminocarbonyl Felbamate is an impurity of Felbamate (F231000), an antiepileptic, structurally similar to meprobamate.<br></p>Formula:C12H15N3O5Color and Shape:NeatMolecular weight:281.26(2R,6S)-rel-2,6-Dimethyl-4-(2-methyl-3-phenylpropyl)morpholine Hydrochloride
CAS:<p>Impurity Amorolfine EP Impurity C<br>Stability Hygroscopic<br>Applications (2R,6S)-rel-2,6-Dimethyl-4-(2-methyl-3-phenylpropyl)morpholine Hydrochloride (1:1), is used in the preparation of Amorolfine (A634170), a morpholine antifungal drug.<br>References Rotta, I., et al.: JAMA Dermatol., 149, 341 (2013); Espinel-Ingroff, A., et al.: Antimicrob. Agents Ch., 26, 5 (1984)<br></p>Formula:C16H26ClNOColor and Shape:NeatMolecular weight:283.844'-Nitro-3'-(trifluoromethyl)acetanilide
CAS:<p>Applications 4’-Nitro-3’-(trifluoromethyl)acetanilide is a metabolite of the nonsteroidal antiandrogen drug, Flutamide (F598850).<br>References Kang, P. et al.: Drug Metab. Dispos., 36, 1425 (2008); Takashima, E. et al.: Biol. Pharmac. Bull., 26, 1455 (2003); Katchen, B. et al.: J. Invest. Dermatol., 66, 379 (1976);<br></p>Formula:C9H7F3N2O3Color and Shape:NeatMolecular weight:248.16Homopiperazine
CAS:Controlled Product<p>Applications Homopiperazine acts as a corrosion inhibitor for iron. It has also been used in the preparation of potent H3 receptor antagonists for use as treatments for neurodegenerative conditions such as Alzheimer’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Granese, S. et al.: Corrosion., 44, 322 (1988); Pippel, D. et al.: Org. Proc. Res. Devel., 15, 638 (2011);<br></p>Formula:C5H12N2Color and Shape:NeatMolecular weight:100.16N,O-Diacetyl Pseudoephedrine
CAS:Controlled Product<p>Applications N,O-Diacetyl Pseudoephedrine is the diacetylated analogue of the non-selective adrenergic agonist Pseudoephedrine (P839350).<br></p>Formula:C14H19NO3Color and Shape:NeatMolecular weight:249.315-Ethenyl-2-pyrrolidinone
CAS:Controlled Product<p>Impurity Vigabatrin USP Related Compound A<br>Applications Vigabatrin (V253000) impurity. Vigabatrin USP Related Compound A.<br>References Durham, S. et al.: Drug Metab. Dispos. 21, 480 (1993).<br></p>Formula:C6H9NOColor and Shape:Colourless To BrownMolecular weight:111.14N-Nitrosopendimethalin-d4
Controlled ProductFormula:C13H14D4N4O5Color and Shape:NeatMolecular weight:337.367Isoproturon-d3
CAS:Controlled Product<p>Applications Labelled Isoproturon. Pre-and post-emergence herbicide for control of annual grasses and broad-leaved weeds. Herbicide.<br>References Fournier, J.-C., et al.: Chemosphere, 4, 207 (1975), Gonzales, P., et al.: Weed Res., 23, 39 (1983),<br></p>Formula:C122H3H15N2OColor and Shape:White To Off-WhiteMolecular weight:209.30N-nitroso Epinephrine dimer Impurity
Controlled ProductFormula:C16H17N3O5·HClColor and Shape:NeatMolecular weight:367.79Dasatinib Carboxylic Acid
CAS:Controlled Product<p>Applications An oxidative metabolite of Dasatinib (M6 metabolite); used in the treatment of cancers and immune diseases. It is a COVID19-related research product.<br>References Jaworski, T., et al.: Xenobiotica, 21, 1451 (1991), Shah, N., et al.: Science, 305, 399 (2004), O'Hare, T., et al.: Cancer Res., 65, 4500 (2005), Das, J., et al.: J. Med. Chem., 49, 6819 (2006), Christopher, L., et al.: Drug Metab. Dispos., 36, 1341 (2008),<br></p>Formula:C22H24ClN7O3SColor and Shape:Light YellowMolecular weight:501.99Valdecoxib Sulfonic Acid
CAS:Controlled Product<p>Applications Valdecoxib Sulfonic Acid is a metabolite of the potent and specific inhibitor of cyclooxygenase-2, Valdecoxib (V090000).<br>References Zhang, J.I. et al.: Drug Metab. Dispos., 31, 491 (2003); Yuan, J.J. et al.: Drug Metab. Dispos., 30, 1013 (2002);<br></p>Formula:C16H13NO4SColor and Shape:White To Off-WhiteMolecular weight:315.34(1S,2R)-2-(2-Benzylamino-1-hydroxyethyl)-6-fluorochromane
CAS:Controlled Product<p>Applications (-)-Nebivolol intermediate.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formula:C18H20FNO2Color and Shape:WhiteMolecular weight:301.36Efavirenz Penteneyne
Controlled Product<p>Applications Efavirenz penteneyne is an analog of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor and antiviral agent.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>Formula:C14H9ClF3NO2Color and Shape:NeatMolecular weight:315.672-Amino-5-cyanobenzotrifluoride
CAS:Controlled Product<p>Applications 2-Amino-5-cyanobenzotrifluoride is used in the design and synthesis of 4-phenylpyrrole derivatives as androgen receptor antagonists which show efficacy against prostate cancer cells.<br>References Yamamoto, S. et al.: Bioorg. Med. Chem. Lett., 20, 422 (2012), Chen, J. et al.: Synth. Met., 160, 1953 (2010);<br></p>Formula:C8H5F3N2Color and Shape:NeatMolecular weight:186.13394,6-Dichloro-2-(propylthio)pyrimidin-5-amine
CAS:Controlled Product<p>Applications Intermediate in the preparation of Ticagrelor (T437700) and reversible P2Y12 receptor antagonists.<br>References Zhang, H. et al.; Bioorg. Med. Chem. Lett. 22, 3598 (2012); Springthorpe, B. et al.; Bioorg. Med. Chem. Lett. 17, 6013 (2007)<br></p>Formula:C7H9Cl2N3SColor and Shape:NeatMolecular weight:238.14(R)-Desmethyl Citalopram Hydrochloride
CAS:Formula:C19H19FN2O·ClHColor and Shape:NeatMolecular weight:346.83N,N-Bis[2-(2-hydroxyethoxy)ethyl] Quetiapine Chloride
Controlled ProductFormula:C25H34ClN3O4SColor and Shape:NeatMolecular weight:508.074-[[3-[2-(3-Chlorophenyl)ethyl]-2-pyridinyl]carbonyl]-1-piperidinecarboxylic AcidEthyl Ester
CAS:Controlled Product<p>Applications Loratadine intermediate, as antiallergic agent.<br></p>Formula:C22H25ClN2O3Color and Shape:NeatMolecular weight:400.901,4-bis(7-Chloroquinolin-4-yl)piperazine
CAS:Controlled ProductFormula:C22H18Cl2N4Color and Shape:NeatMolecular weight:409.314-[[3-(4-Methylphenyl)-3-oxo-1-(trifluoromethyl)propylidene]amino]benzenesulfonamide
CAS:Controlled Product<p>Applications 4-[[3-(4-Methylphenyl)-3-oxo-1-(trifluoromethyl)propylidene]amino]benzenesulfonamide, is an impurity of Celecoxib (C251000), which is a selective cyclooxygenase-2 (COX-2) inhibitor, an anti-inflammatory agent. It is also used in treatment of familial adenomatous polyposis.<br>References Simon, L.S., et al.: Arthritis Rheum., 41, 1591 (1998), Silverstein, F.E., et al.: J. Am. Med. Assoc., 284, 1247 (2000), Steinbach, G., et al.: N. Engl. J. Med., 342, 1946 (2000),<br></p>Formula:C17H15F3N2O3SColor and Shape:YellowMolecular weight:384.37Flumequine Ethyl Ester
CAS:Controlled Product<p>Applications Flumequine Ethyl Ester is an impurity of Flumequine (F445000), a quinolone antibacterial.<br>References Stilwell, G., et al.: Antimicrob. Agents Chemother., 7, 483 (1975), Rohlfing, S.R., et al.: J. Antimicrob. Chemother., 3, 615 (1977),<br></p>Formula:C16H16FNO3Color and Shape:NeatMolecular weight:289.302-(2,4-Difluorophenyl)-1,2,3-propanetriol
CAS:<p>Applications 2-(2,4-Difluorophenyl)-1,2,3-propanetriol is used as a reagent in the synthesis of glycerol derivatives as intermediates for antifungal phenyltriazolylpropanediol derivatives. Also an impurity of the antifungal agent Fluconazole (F421000).<br>References Richard, K. et al.: Antimicrob. Ag. Chemother., 27, 832 (1985); Yasohara, Y., et al.: PCT Int. Appl. WO 9528374 A1 19951026. Oct 26, 1995<br></p>Formula:C9H10F2O3Color and Shape:NeatMolecular weight:204.174-O-Des(difluoromethyl) Roflumilast
CAS:Controlled ProductFormula:C16H14Cl2N2O3Color and Shape:NeatMolecular weight:353.20rac O-Desmethyl Naproxen-d3
CAS:Controlled ProductFormula:C13D3H9O3Color and Shape:Dark RedMolecular weight:219.253’-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]propyl Domperidine (Domperidine Impurity F)
CAS:Controlled Product<p>Impurity Domperidone EP Impurity F<br>Applications An impurity of the gastrokinetic and antinauseant drug Domperidone (D531100(P)), which is a novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent.<br>References Baudry, M., et al.: Arch. Pharmacol., 308, 231 (1979), Ennis, C., et al.: J. Pharm. Pharmacol., 31, 14 (1979), Brogden, R.N., Drugs, 24, 360 (1982),<br></p>Formula:C37H42Cl2N8O3Color and Shape:NeatMolecular weight:717.69Desmethyl-N-propyl Imiquimod
CAS:Controlled Product<p>Applications Desmethyl-N-propyl Imiquimod is a pharmacologically active compound related to Imiquimod (I475000), an immune response modifier. It stimulates the production of Interferon-a.<br>References Megyeri, K., et al.: Mol. Cell Biol., 15, 2207, (1995), Witt, P.L., et al.: Cancer Res., 53, 5176 (1993), Edwards, L., et al.: Arch. Dermatol., 134, 25 (1998); Gerster, J. et al.: J. Med. Chem., 48, 3481 (2005);<br></p>Formula:C13H14N4Color and Shape:NeatMolecular weight:226.28N-tert-Butyl-3-isopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-carboxamide
CAS:Controlled Product<p>Applications N-tert-Butyl-3-isopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-carboxamide is a metabolite of Amicarbazone (A605040); a triazolinone herbicide with a broad spectrum of weed control.<br>References Dayan, F., et al.: Weed Science, 57, 579 (2009); Elmore, M., et al.: Weed Technol., 27, 596 (2013); Dong, M., et al.: J. Sep. Sci., 38, 2245 (2015)<br></p>Formula:C10H18N4O2Color and Shape:White To Off-WhiteMolecular weight:226.283-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine Hydrochloride
CAS:<p>Applications Sitagliptin intermediate.<br>References Mohri, K., et al.: Chem. Pharm. Bull., 30, 3097 (1982), Sarges, R., et al.: J. Med. Chem., 33, 2240 (1990), Cameron, M., et al.: J. Pharm. Biomed. Anal., 28, 137 (2002),<br></p>Formula:C6H7F3N4·ClHColor and Shape:WhiteMolecular weight:228.60Quetiapine Dimer Impurity-d8
CAS:Controlled Product<p>Applications An impurity of labelled Quetiapine.<br>References Xu, H., et al.: J. Pharm. Biomed. Anal., 47, 658 (2008), Stolarczyk, E., et al.: Pharm. Develop. Technol., 14, 27 (2009),<br></p>Formula:C30H16D8N4S2Color and Shape:NeatMolecular weight:512.72
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