Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65576 products of "Quinazoline and Quinoline Derivatives"
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2-Nitroso Riluzole
Controlled Product<p>Applications 2-Nitroso Riluzole is an impurity of Riluzole (R510000); is a neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant. Neuroprotective agent.<br>References Mizoule, J., et al.: Neuropharmacology, 24, 767 (1985), Wahl, F., et al.: Eur. J. Pharmacol., 230, 209 (1993) Bensimon, G., et al.: N. Engl. J. Med., 330, 585 (1994)<br></p>Formula:C8H3F3N2O2SColor and Shape:Dark GreenMolecular weight:248.182Everolimus Isomer C (>60%, contains everolimus)
CAS:Controlled Product<p>Stability Unstable in solution, revert back to Everolimus<br>Applications Everolimus Isomer C is an isomer of Everolimus (E945400), a derivative of Rapamycin (R124000). Everolimus inhibits cytokine-mediated lymphocyte proliferation.<br>References Dumont, F.J., et al.: Curr. Opin. Invest. Drugs, 2, 1220 (2001); Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001); Nashan, B., et al.: Ther. Drug Monit., 24, 53 (2002)<br></p>Formula:C53H83NO14Color and Shape:NeatMolecular weight:958.224-Chlorophenothiazine
CAS:Controlled Product<p>Applications Intermediate in the preparation of Prochlorperazine (P755800) and related compound.<br></p>Formula:C12H8ClNSColor and Shape:NeatMolecular weight:233.72N-Nitroso Amodiaquine
Controlled ProductFormula:C20H21ClN4O2Color and Shape:NeatMolecular weight:384.859Olanzapine Thiolactam Impurity
CAS:Formula:C17H20N4OSColor and Shape:Light YellowMolecular weight:328.43Hydroxy Saxagliptin
CAS:Controlled Product<p>Applications Hydroxy Saxagliptin is a metabolite of Saxagliptin (S143500).<br>References Patel, C. et al.: J. Clinic. Pharmacol., 50, 1211 (2010); Feng, J., et al.: J. Med. Chem., 50, 2297 (2007),:Rosenstock, J., et al.: Diabetes Obes. Metab., 10, 376 (2008);<br></p>Formula:C18H25N3O3Color and Shape:NeatMolecular weight:331.414'-(Bromomethyl)-[1,1'-biphenyl]-2-carboxamide
CAS:Controlled Product<p>Impurity Telmisartan Bromo Amide Impurity<br>Applications An impurity in the preparation of the angiotensin II receptor antagonist Telmisartan (T017000).<br>References Wienen, W., et al.: Brit. J. Pharmacol., 110, 245 (1993), Neutel, J.M., and Smith, D.H.G.: Adv. Ther., 15, 206 (1998)<br></p>Formula:C14H12BrNOColor and Shape:WhiteMolecular weight:290.16N-Methyl Topiramate
CAS:Controlled Product<p>Impurity Topiramate N-methyl impurity<br>Applications N-Methyl Topiramate, is an impurity of Topiramate (T540250); which is an anticonvulsant (antiepilepsy) drug, that has been approved for weight loss by FDA.<br>References Maryanoff, B.E., et al.: J. Med. Chem., 30, 880 (1987), Bialer, M.: Clin. Pharmacokinet., 24, 441 (193),<br></p>Formula:C13H23NO8SColor and Shape:NeatMolecular weight:353.39Quetiapine Dimer Impurity-d8
CAS:Controlled Product<p>Applications An impurity of labelled Quetiapine.<br>References Xu, H., et al.: J. Pharm. Biomed. Anal., 47, 658 (2008), Stolarczyk, E., et al.: Pharm. Develop. Technol., 14, 27 (2009),<br></p>Formula:C30H16D8N4S2Color and Shape:NeatMolecular weight:512.722-Thiopheneacetic Acid
CAS:Controlled ProductFormula:C6H6O2SColor and Shape:NeatMolecular weight:142.183-Ethynylaniline
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications Reagent in the preparation of a metabolite of Erlotinib (E625000).<br></p>Formula:C8H7NColor and Shape:Colourless To Dark RedMolecular weight:117.15Rilmazafone Hydrochloride
CAS:<p>Applications Rilmazafone Hydrochloride can be used in biological study of nitrazepam or rilmazafone hydrochloride combined with ethanol effects on human memory. It is also used as sleep aid medication.<br>References Suzuki, M., et al.: Neurosciences (Okayama, Japan), 20, 43 (1994)<br></p>Formula:C21H20Cl2N6O3·HClColor and Shape:NeatMolecular weight:475.33 + (36.46)Losartan Trityl Ether
CAS:<p>Impurity Losartan EP Impurity I<br>Applications Losartan Trityl Ether (Losartan EP Impurity I) is an impurity of Losartan.<br>References Duncia, J.V., et al.: J. Med. Chem., 33, 1312 (1990),<br></p>Formula:C41H37ClN6OColor and Shape:NeatMolecular weight:665.232-Nitrodeamino Fingolimod
CAS:Controlled Product<p>Applications An impurity of Fingolimod (F805000, HCl salt), a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs.<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),<br></p>Formula:C19H31NO4Color and Shape:NeatMolecular weight:337.451,4,8,11-Tetraazacyclotetradecane
CAS:Controlled Product<p>Applications 1,4,8,11-Tetraazacyclotetradecane is macrocyclic ligand that is used as an antioxidant in rubber and has been shown to suppress oxidation catalyzed by some metal ions.<br>References Goh, S.H.: Poly, Degrad, Stab., 8, 123 (1984);<br></p>Formula:C10H24N4Color and Shape:NeatMolecular weight:200.32Deschloro-4’-chloro Clomiphene Hydrochloride
CAS:Controlled Product<p>Applications An impurity of Clomiphene (C587025).<br></p>Formula:C26H29Cl2NOColor and Shape:NeatMolecular weight:442.422-(Trifluoroacetyl)-4-chloroaniline, Hydrochloride Hydrate
CAS:Controlled Product<p>Applications HIV reverse transcriptase inhibitor.<br></p>Formula:C8H5ClF3NO·ClHColor and Shape:NeatMolecular weight:260.04Methyl 3,4,5-Tris(benzyloxy)benzoate
CAS:Controlled Product<p>Applications Intermediate in the production of Gallic Acid derivatives.<br>References Dodo, K., et al.: Bioorg. Med. Chem., 16, 7975 (2008), Dodo, K., et al.: Chem. Pharm. Bull., 57, 190 (2009),<br></p>Formula:C29H26O5Color and Shape:NeatMolecular weight:454.514-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone
CAS:Controlled ProductFormula:C21H21N3O5Color and Shape:NeatMolecular weight:395.411-Nitroso-4-phenylpiperazine
CAS:Controlled Product<p>Applications Metabolite of N-Phenylpiperazine (P336040) found in wastewater treatment facilities.<br>References Jung, C. et al., Appl. Environ. Microb., 74, 6147 (2008)<br></p>Formula:C10H13N3OColor and Shape:NeatMolecular weight:191.23Hydroxymethyl Dasatinib
CAS:Controlled Product<p>Applications An oxidative metabolite of Dasatinib (M24 metabolite); used in the treatment of cancers and immune diseases. It is a COVID19-related research product.<br>References Jaworski, T., et al.: Xenobiotica, 21, 1451 (1991), Shah, N., et al.: Science, 305, 399 (2004), O'Hare, T., et al.: Cancer Res., 65, 4500 (2005), Das, J., et al.: J. Med. Chem., 49, 6819 (2006), Christopher, L., et al.: Drug Metab. Dispos., 36, 1341 (2008),<br></p>Formula:C22H26ClN7O3SColor and Shape:NeatMolecular weight:504.00Nitrofurantoin Monohydrate
CAS:Controlled Product<p>Applications 1-(((5-Nitrofuran-2-yl)methylene)amino)-imidazolidine-2,4-dione hydrate (CAS# 17140-81-7) is a useful research chemical compound.<br></p>Formula:C8H8N4O6Color and Shape:YellowMolecular weight:256.184-(2-Pyridinyl)benzaldehyde
CAS:Controlled Product<p>Impurity Atazanavir Impurity (Pyridinyl Benzaldehyde)<br>Applications Reactive metabolite of atazanavir. Atazanavir Impurity; Pyridinyl Benzaldehyde impurity<br>References F. Li et al., Drug Metabolism and Disposition 39, 294 (2011)<br></p>Formula:C12H9NOColor and Shape:NeatMolecular weight:183.211-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid Sodium Salt
CAS:<p>Applications 1-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid is an impurity of Rabeprazole. It is also a degradation product formed in stressed tablets of Rabeprazole sodium.<br>References Kommanaboyina, B., et al.: Drug Dev. Ind. Pharm., 25, 857 (1999); Carswel, C., et al.: Drugs, 61, 2327 (2001); Garcia, C., et al.: J. Pharm. Biomed. Anal., 46, 88 (2008)<br></p>Formula:C14H10N3NaO3Color and Shape:NeatMolecular weight:291.24Omeprazole Sodium Salt
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Omeprazole Sodium Salt is the salt analogue of Omeprazole (O635000), which binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative.<br>References Muller, P., et al.: Arzneimittel-Forsch., 33, 1685 (1983); Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984); Morii, M., et al.: J. Biol. chem., 268, 21553 (1993); Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)<br></p>Formula:C17H18N3O3S·Na·H2OColor and Shape:Off-WhiteMolecular weight:385.417-Demethyl Ivabradine Hydrochloride
CAS:Controlled Product<p>Applications Ivabradine (I940500) metabolite.<br>References Duffull, S., et al.: Eur. J. Pharm. Sci., 10, 285 (2000), Portoles, A., et al.: J. Clin. Pharmacol., 46, 1195 (2006),<br></p>Formula:C26H34N2O5·HClColor and Shape:NeatMolecular weight:491.02(R)-9-Hydroxy Risperidone
CAS:Controlled Product<p>Applications The R-enantiomer metabolite of Risperidone (R525000), a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tiberghien, F., et al.: Anticancer Drugs, 7, 568 (1996), Kansy, M., et al.: J. Med. Chem., 41, 1007 (1998), Kerns, E., et al.: J. Pharm. Sci., 90, 1838 (2001), Kerr, K., et al.: J. Biol. Chem., 276, 8657 (2001), Doran, A., et al.: Drug Metab. Dispos., 33, 165 (2005),<br></p>Formula:C23H27FN4O3Color and Shape:NeatMolecular weight:426.48N-Sulfamoylethyl Naratriptan Pyridinium Chloride
CAS:Controlled Product<p>Impurity Naratriptan Impurity F<br>Stability Hygroscopic<br>Applications 4-[1,5-Bis-(2-methylsulfamoylethyl)-1H-indol-3-yl]-1-methylpyridinium Chloride is an impurity of Naratriptan (N378730).<br></p>Formula:C20H27ClN4O4S2Color and Shape:NeatMolecular weight:487.04(±)-2'-Methylpropranolol Hydrochloride
CAS:Controlled Product<p>Applications (±)-2'-Methylpropranolol Hydrochloride, is an impurity of Nadolol (N201050), a β-Adrenergic blocker. Antihypertensive; antianginal.<br>References Dreyfuss, J., et al.: J. Clin. Pharmacol., 17, 300 (1977); Sibley, P.L., et al.: Toxicol. Appl. Pharmacol., 44, 379 (1978); Slusarek, L., et al.: Anal. Profiles Drug Subs., 9, 455 (1980)<br></p>Formula:C17H23NO2·ClHColor and Shape:NeatMolecular weight:309.833-(tert-Butyldimethylsilyl)morphinone
CAS:Controlled Product<p>Applications Protected Morphinone (M652350), a toxic metabolite of Morphine.<br>References James, R., et al.: J. Pharmacol. Exp. Ther., 221, 708 (1982), Yamano, S., et al.: J. Biol. Chem., 260, 5259(1985), Ishida, T., et al.: Drug Metab. Dispos., 17, 77 (1989), Yamano, S., et al.: Xenobiotica, 27, 645 (1997),<br></p>Formula:C23H31NO3SiColor and Shape:NeatMolecular weight:397.585’-Hydroxyphenyl Carvedilol
CAS:<p>Applications A metabolite of Carvedilol (C184625). It is used in the treatment of hypertension.<br>References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Fujimaki, M., ET AL.: Xenobiotica, 20, 1025 (1990), Ruffolo, R., et al.: Eur. J. Clin. Pharmacol., 38, S82 (1990), Schaefer, W.H., et al.: Drug Metab. Dispos., 26, 10, 958 (1998),<br></p>Formula:C24H26N2O5Color and Shape:NeatMolecular weight:422.47Valsartan Decarboxylic Acid
CAS:Controlled ProductFormula:C23H29N5OColor and Shape:NeatMolecular weight:391.5093N-Benzyl Epinephrine-d3
CAS:Controlled Product<p>Applications Labelled analogue of N-Benzyl Epinephrine, an impurity of Epinephrine (E588580).<br></p>Formula:C16H16D3NO3Color and Shape:NeatMolecular weight:276.35N,N’-Desethylene Levofloxacin Hydrochloride
CAS:<p>Impurity Levofloxacin USP Related Compound E<br>Applications Levofloxacin (L360000) impurity. A photodegradation product of Levofloxacin (L360000) in aqueous solution. Levofloxacin USP Related Compound E.<br>References Yoshida, Y., et al.: Arzneim.-Forsch., 43, 601 (1993),<br></p>Formula:C16H18FN3O4·ClHColor and Shape:Off White SolidMolecular weight:371.79(R)-Desmethyl Citalopram Hydrochloride
CAS:Formula:C19H19FN2O·ClHColor and Shape:NeatMolecular weight:346.83rac Methotrimeprazine Hydrochloride
CAS:Controlled Product<p>Applications Analgesic.<br>References Haddad, P., et al.: Drugs, 62, 1649 (2002), Chiu, P., et al.: J. Pharmacol. Sci., 95, 311 (2004), Dubin, A., et al.: J. Biomol. Screen, 10, 168 (2005),<br></p>Formula:C19H24N2OS·HClColor and Shape:NeatMolecular weight:364.93Dimenhydrinate
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications An antihistamine with antiemetic properties used to prevent nausea and motion sicknes composed of two drugs 8-Chlorotheophylline (C411440) and Diphenhydramine (D486900).<br>References Sibel, K. et al.: Arzneim.-Forsch. , 52, 529 (2002); Pytel, J. et al.: Clin. Therap., 29, 84 (2007); Scholtz, A.W. et al.: Clin. Therap., 26, 866 (2004);<br></p>Formula:C17H21NO·C7H7ClN4O2Color and Shape:NeatMolecular weight:469.96OPC 3930
CAS:Controlled Product<p>Applications A metabolite of Cilostazol (C441500), used as internal standard.<br>References Akiyama, H., et al.: Arzneim.-Forsch./Drug Res., 35, 1133 (1985), Akiyama, H., et al.: J. Chromatogr., 338, 456 (1985),<br></p>Formula:C19H23N5O2Color and Shape:NeatMolecular weight:353.423-Hydroxy-4-methoxybenzaldehyde
CAS:Controlled ProductFormula:C8H8O3Color and Shape:NeatMolecular weight:152.15Pazufloxacin Mesylate
CAS:Controlled Product<p>Applications A fluorinated quinolone antibiotic. Antibacterial.<br>References Fukuoka,Y., et al.: Antimicrob. Ag. Chemother., 37, 384 (1993), Todo, Y., et al.: Chem. Pharm. Bull., 42, 2569 (1994)<br></p>Formula:C16H15FN2O4·CH4O3SColor and Shape:NeatMolecular weight:414.413,4-Dihydro-1-phenylisoquinoline Hydrochloride
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications 3,4-Dihydro-1-phenylisoquinoline has been shown to have anesthetic properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Moore, M.B., et. al.: J. Am. Chem. Soc., 76, 3656 (1954)<br></p>Formula:C15H13N·ClHColor and Shape:NeatMolecular weight:243.73MRX-2843
CAS:Controlled Product<p>Applications MRX-2843, is an orally available small-molecule inhibitor of both MERTK and FLT3.<br>References Minson, K. A. et al.: JCI Insight. 2016 Mar;1(3):e85630.;<br></p>Formula:C29H40N6OColor and Shape:NeatMolecular weight:488.67Desmethyl-N-propyl Imiquimod
CAS:Controlled Product<p>Applications Desmethyl-N-propyl Imiquimod is a pharmacologically active compound related to Imiquimod (I475000), an immune response modifier. It stimulates the production of Interferon-a.<br>References Megyeri, K., et al.: Mol. Cell Biol., 15, 2207, (1995), Witt, P.L., et al.: Cancer Res., 53, 5176 (1993), Edwards, L., et al.: Arch. Dermatol., 134, 25 (1998); Gerster, J. et al.: J. Med. Chem., 48, 3481 (2005);<br></p>Formula:C13H14N4Color and Shape:NeatMolecular weight:226.28Loratadine Impurity F
CAS:Controlled Product<p>Impurity Loratadine EP Impurity F; Loratadine USP Related Compound G Impurity<br>Applications Loratadine Impurity F (Loratadine EP Impurity F; Loratadine USP Related Compound G Impurity) is a fluorinated analog of Loratadine (L469575), which is a nonsedating-type histamine H1-receptor.<br>References Bruttmann, G., et al.: J. Allergy Clin. Immunol., 83, 411 (1989), Haria, M., et al.: Drugs, 48, 617 (1994)<br></p>Formula:C22H24ClFN2O2Color and Shape:White To Off-WhiteMolecular weight:402.89Efavirenz 3-Desoxy
CAS:<p>Applications Efavirenz 3-Desoxy is an analog of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>Formula:C15H11ClF3NOColor and Shape:Off White SolidMolecular weight:313.70(4S3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone
CAS:Controlled Product<p>Applications (4S3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone is used in the synthesis of Ezetimibe (E975000), an antihyperlipoproteinemic; a cholesterol absorption inhibitor.<br>References Bankowski, K., et. al.: Przemysl Chemiczny, 91, 289 (2012); van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997); van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>Formula:C39H46F2N2O5Si2Color and Shape:NeatMolecular weight:716.961Gabapentin Ethyl Ester Hydrochloride
CAS:Controlled Product<p>Applications Protected Gabapentin (G117250). Amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Used as an anticonvulsant.<br>References Vollmer, K.-O. et al.: Arzneimittel-Forshc., 36, 830 (1986), Saletu, B., et al.: Int. J. Clin. Pharmacol. Ther. Toxicol., 24, 362 (1986)<br></p>Formula:C11H21NO2·ClHColor and Shape:NeatMolecular weight:235.75Dimethylamine (40% aq.)
CAS:Controlled Product<p>Applications Dimethylamine (40% aq.) is a compound often used in industry as a precursor to Nitrosodimethylamine (N525625), a potent carcinogen that is produced during disinfection of wastewater effluent, and is also present in trace amounts in food and polluted air. Dimethylamine is also present in human urine and can be indicative of certain disorders.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gereke, A. & Sedlak, D.: Env. Sci. Tech., 37, 1331 (2003); Mitch, W., et al.: Env. Eng. Sci., 20, 389 (2003); Tsikas, D., et al.: J. Chromatogr. B, 851, 229 (2007)<br></p>Formula:C2H7NColor and Shape:NeatMolecular weight:45.084-(5-Chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-formylpiperidine
CAS:Controlled Product<p>Impurity Buspirone EP Impurity B<br>Applications An impurity of the gastrokinetic and antinauseant drug Domperidone (D531100).<br></p>Formula:C13H14ClN3O2Color and Shape:BeigeMolecular weight:279.72rac Ambrisentan-d3
CAS:Controlled Product<p>Applications Labeled rac-Ambrisentan (A575860) Nonpeptide endothelin ETA receptor antagonist. Antihypertensive.<br>References Riechers, H., et al.: J. Med. Chem., 39, 2123 (1996), Billman, G.E., et al.: Curr. Opin. Invest. Drugs, 3, 1483 (2002), Vatter, H., et al.: Clin. Neuropharmacol., 26, 73 (2003),<br></p>Formula:C222H3H19N2O4Color and Shape:Off White SolidMolecular weight:381.442’-Des(1-hydroxy-1-methylethyl)-2’-methycarboxy Montelukast Hydrochloride
CAS:Controlled Product<p>Applications 2’-Des(1-hydroxy-1-methylethyl)-2’-methycarboxy Montelukast Hydrochloride is an impurity of Montelukast (M568000), a selective leukotriene D4-receptor antagonist.<br>References Kumar, I.V. et al.: Asian J. Chem., 23, 4536 (2011)<br></p>Formula:C34H33Cl2NO4SColor and Shape:NeatMolecular weight:622.6Phenylbutazone(diphenyl-d10)
CAS:Controlled Product<p>Applications Phenylbutazone(diphenyl-d10) is the isotope labelled analog of Phenylbutazone (P319570); a non-steroidal anti-inflammatory compound and an inhibitor of cyclooxygenase that is also a substrate for peroxidation by cyclooxygenase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ali, S.L., Anal. Profiles Drug Subs., 11, 483 (1982); Hughes, M.F., et al.: Mol. Pharmacol., 34, 186 (1988)<br></p>Formula:C192H10H10N2O2Color and Shape:Off White CrystallineMolecular weight:318.445'-Hydroxyphenyl Carvedilol-d5
CAS:Controlled Product<p>Applications A Labelled metabolite of Carvedilol which is a multiple-action, neurohormonal antagonist that is used in the treatment of hypertension.<br>References Schaefer, W.H., et al.: Drug Metab. Dispos., 26, 958 (1998).<br></p>Formula:C24H21D5N2O5Color and Shape:NeatMolecular weight:427.52-Bromomethyl-6-nitrobenzoic Acid Methyl Ester
CAS:Controlled ProductFormula:C9H8BrNO4Color and Shape:Light YellowMolecular weight:274.07Aprepitant-13C2,d2 (Major)
CAS:Controlled Product<p>Applications This product is deuterated at the 1 position and on the ajacent methyl. The 1 position is the benylic position of the bis(trifluoromethyl) phenyl. This compound has a mixture of 1 to 4 deuterium atoms, there is no detectable unlabeled material.Aprepitant is a structurally novel substance P neurokinin 1 (NK1) receptor antagonist. In vitro studies using human liver microsomes indicate that aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1.<br>References Hale, J.J., et al.: J. Med. Chem., 41, 4607 (1998), Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001), Van Belle, S., et al.: Cancer, 94, 3032 (2002), Majumdar, A.K., et al.: J. Clin. Pharmacol., 46, 291 (2006),<br></p>Formula:C2113C2H19D2F7N4O3Color and Shape:Off White SolidMolecular weight:538.42Irbesartan N-β-D-Glucuronide
CAS:<p>Applications A metabolite of Irbesartan (M8).<br>References Cazaubon, C., et al.: J. Pharmacol. Exp. Ther., 265, 826 (1993), Eberhardt, R., et al.: J. Clin. Pharmacol., 33, 1023 (1993), Huskey, S., et al.: Drug Metab. Dispos., 21, 792 (1993), van Den Meiracker, A., et al.: Hypertension, 25, 22 (1995),<br></p>Formula:C31H36N6O7Color and Shape:NeatMolecular weight:604.65Tilidine-d6 Hydrochloride (100μg/ml in Methanol)
CAS:Controlled ProductFormula:C172H6H17NO2·ClHColor and Shape:ColourlessMolecular weight:315.87(R)-(+)-Tolvaptan
CAS:Controlled Product<p>Applications An enantiomer of Tolvaptan. It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).<br>References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000), Udelson, J., et al.: Circulation, 104, 2417 (2001), Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005), Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006),<br></p>Formula:C26H25ClN2O3Color and Shape:Off White SolidMolecular weight:448.94(D,L)-erythro-α-Phenyl-2-piperidineacetamide
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Intermediate in the preparation of D-threo-Methylphenidate (Ritalin)<br></p>Formula:C13H18N2OColor and Shape:NeatMolecular weight:218.29(S)-(-)-O-Desmethyl Carvedilol
CAS:Controlled Product<p>Applications An optically active metabolite of Carvedilol (C184625), a nonselective ß-adrenergic blocker with α1-blocking activity. [α]D= -18.7 (c= 0.1 methanol)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Fujimaki, M., et al.: Xenobiotica, 20, 1025 (1990), Ruffolo, R., et al.: Eur. J. Clin. Pharmacol., 38, S82 (1990), Clohs, L., et al.: J. Pharm. Biomed. Anal., 31, 407 (2003),<br></p>Formula:C23H24N2O4Color and Shape:NeatMolecular weight:392.45(4-Methyl-1H-imidazol-5-yl)methanol Hydrochloride
CAS:Controlled Product<p>Applications (4-Methyl-1H-imidazol-5-yl)methanol hydrochloride (cas# 38585-62-5) is a useful research chemical.<br></p>Formula:C5H8N2O·ClHColor and Shape:NeatMolecular weight:148.595-(4-methylphenyl)imidazolidine-2,4-dione
CAS:Controlled Product<p>Applications 5-(4-methylphenyl)imidazolidine-2,4-dione (cas# 69489-37-8) is a useful research chemical.<br></p>Formula:C10H10N2O2Color and Shape:NeatMolecular weight:190.20(S)-Hydroxy Timolol
CAS:Controlled Product<p>Applications (S)-(-)-Hydroxy Timolol is a metabolite of the non-selective beta-adrenergic receptor blocker, Timolol (T443710).<br>References Volotinen, M. et al.: Basic Clin. Pharmacol. Toxicol., 106, 302 (2010);<br></p>Formula:C13H24N4O4SColor and Shape:NeatMolecular weight:332.42(R)-5-Chloro-α-(cyclopropylethynyl)-2-amino-α-(trifluoromethyl) benzenemethanol
CAS:Controlled ProductFormula:C13H11ClF3NOColor and Shape:NeatMolecular weight:289.68Fimasartan
CAS:Controlled Product<p>Applications Fimasartan is a new angiotensin II receptor blocker antagonist and also functions as an antihypertensive agent.<br>References Lee, H., et al.: Drugs, 76, 1015 (2016)<br></p>Formula:C27H31N7OSColor and Shape:NeatMolecular weight:501.655-Amino-4-(4-nitro-1-oxoisoindolin-2-yl)-5-oxopentanoic Acid
CAS:Controlled ProductFormula:C13H13N3O6Color and Shape:Off-WhiteMolecular weight:307.2598-Hydroxy Efavirenz (~90%)
CAS:Controlled Product<p>Applications 8-Hydroxy Efavirenz is a metabolite of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor.<br>References Gorski, J., et al.: Biochem. Pharmacol., 47, 1643 (1994), Desta, Z., et al.: J. Pharmacol. Exp. Ther., 285, 428 (1998), Langmann, P., et al.: Eur. J. Med. Res., 7, 309(2002), Chang, T., et al.: Drug Metab. Dispos., 31, 7 (2003),<br></p>Formula:C14H9ClF3NO3Purity:~90%Color and Shape:NeatMolecular weight:331.672,3,3a,12b-Tetradehydro Asenapine
CAS:Controlled ProductFormula:C17H12ClNOColor and Shape:NeatMolecular weight:281.742-Methylthieno[2,3-d]isothiazol-3(2H)-one 1,1-Dioxide
CAS:Controlled ProductFormula:C6H5NO3S2Color and Shape:NeatMolecular weight:203.24Verapamil Ethyl Methanethiosulfonate, Bromide
CAS:Controlled Product<p>Applications An analog of Verapamil. P Glycoprotein drug binding domain verapamil methanethiosulfonate. Useful for mapping the pore region of L-type calcium channels and Kv1.3 potassium channels.<br>References Loo, T., et al.: J. Biol. Chem., 270, 843 (1995), Sharom, F., et al.: J. Membr. Biol., 160, 161 (1997), Kim, R., et al.: J. Clin. Invest., 101, 289 (1998), Lee, C., et al.: Biochemistry., 37, 3594 (1998),<br></p>Formula:C30H45N2O6S2·BrColor and Shape:NeatMolecular weight:673.722-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
CAS:Controlled Product<p>Applications 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one, is an impurity of Eltrombopag (E508000), which is agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia.<br>References Bussel, J., et al.: New Eng. J. Med., 357, 2237 (2007), Marsilje, T., et al.: Bioorg. Med. Chem. Lett., 18, 5259 (2008), Alper, P., et al.: Bioorg. Med. Chem. Lett., 18, 5255 (2008),<br></p>Formula:C12H14N2OColor and Shape:NeatMolecular weight:202.252,5-Bis(trifluoromethyl)aniline
CAS:Controlled Product<p>Applications 2,5-Bis(trifluoromethyl)aniline is a haloalkul substituted aniline used in the preparation of anti-benign prostatic hyperplasia drug, Dutasteride (D735000).<br>References Liang, Y. et al.: Jil. Dax. Xueb. Lixeub., 45, 1035 (2007);<br></p>Formula:C8H5F6NColor and Shape:ColourlessMolecular weight:229.122-(6-Methoxy-2-naphthyl)acetonitrile
CAS:Controlled Product<p>Applications 2-(6-Methoxy-2-naphthyl)acetonitrile (cas# 71056-96-7) is a compound useful in organic synthesis.<br></p>Formula:C13H11NOColor and Shape:NeatMolecular weight:197.23Diclazuril 6-Carboxylic Acid Butyl Ester
CAS:Controlled Product<p>Applications Diclazuril 6-carboxylic acid butyl ester is an impurity of Diclazuril (D436200), a nucleotide analog with broad-spectrum anticoccidial activity. Coccidiostat.<br>References Maes, L., et al.: J. Parasitol., 74, 931 (1988),<br></p>Formula:C22H17Cl3N4O4Color and Shape:NeatMolecular weight:507.75S-(s)-Verapamil-D6
CAS:Controlled Product<p>Applications Labelled S-Verapamil (V124991). Both isomers inhibit the p-glycoprotein efflux pump in multidrug resistant tumor cells.<br>References Peroutka, S., et al.: J. Ann. Neurol, 23, 500 (1988), Eliason, J.F., et al.: Int. J. Cancer, 46, 113 (1990),<br></p>Formula:C27H33D6ClN2O4Color and Shape:NeatMolecular weight:497.1Anagrelide-13C3
CAS:Controlled ProductFormula:C713C3H7Cl2N3OColor and Shape:NeatMolecular weight:259.07N-[[N-Methyl-N-[(2-isopropyl]-4-thiazolyl)methyl)amino]carbonyl-L-valine Carboxylic Acid
CAS:Controlled Product<p>Impurity Ritonavir EP Impurity A<br>Applications N-[[N-Methyl-N-[(2-isopropyl]-4-thiazolyl)methyl)amino]carbonyl-L-valine Carboxylic Acid (Ritonavir EP Impurity A) is an intermediate in the synthesis of Ritonavir.<br>References Hamada, Y., et al.: Bioorg. Med. Chem., 10, 4155 (2002),<br></p>Formula:C14H23N3O3SColor and Shape:NeatMolecular weight:313.42(S)-5-Chloro Naproxen
CAS:Controlled ProductFormula:C14H13ClO3Color and Shape:NeatMolecular weight:264.701-(2,4-Bis(benzyloxy)phenyl)ethanone
CAS:Controlled Product<p>Applications 1-(2,4-Bis(benzyloxy)phenyl)ethanone is a useful research chemical for organic synthesis and other chemical processes.<br>References Chen, D., et al.: Eur. J. Med. Chem., 87, 765 (2014); Malik, N., et al.: Tetrahedron Lett., 54, 4121 (2013)<br></p>Formula:C22H20O3Color and Shape:NeatMolecular weight:332.39Fingolimod Stearoate Amide
CAS:Controlled Product<p>Applications Fingolimod Stearoate Amide is an impurity of Fingolimod (F805000, HCl salt), a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),<br></p>Formula:C37H67NO3Color and Shape:NeatMolecular weight:573.93N-Aminocarbonyl Felbamate
CAS:Controlled Product<p>Applications N-Aminocarbonyl Felbamate is an impurity of Felbamate (F231000), an antiepileptic, structurally similar to meprobamate.<br></p>Formula:C12H15N3O5Color and Shape:NeatMolecular weight:281.264-[[3-[2-(3-Chlorophenyl)ethyl]-2-pyridinyl]carbonyl]-1-piperidinecarboxylic AcidEthyl Ester
CAS:Controlled Product<p>Applications Loratadine intermediate, as antiallergic agent.<br></p>Formula:C22H25ClN2O3Color and Shape:NeatMolecular weight:400.90Desmethyl Cariprazine
CAS:<p>Applications Desmethyl Cariprazine, is a derivative of Cariprazine (C183490) which is an orally active D2/D3 dopamine receptor antagonist (1,2,3). Cariprazine is an antipsychotic drug candidate for the potential treatment of schizophrenia, bipolar mania and depression.<br>References Gruender, G.: Curr. Opin. Invest. Drugs, 11, 823 (2010); Seneca, N. et al.: Psychopharmacology, 218, 579 (2011); Kiss, B. et al.: J. Pharmacol. Exp. Therap., 333, 328 (2010)<br></p>Formula:C20H30Cl2N4OColor and Shape:NeatMolecular weight:413.38ent-Rotigotine
CAS:<p>Applications It is a non-ergot dopamine agonist drug and is indicated for the treatment of Parkinson’s disease.<br>References Loschmann, P., et al.: Eur. J. Pharmacol., 166, 373 (1989), Edgar, D., et al.: J. Pharmacol. Exp. Ther., 283, 757 (1997), Ferreira, J., et al.: Lancet, 355, 1333 (2000), Arnulf, I., et al.: Neurology, 58, 1019 (2002), Wisor, J., et al.: Neuroscience, 132, 1027 (2005),<br></p>Formula:C19H25NOSColor and Shape:Brown OilyMolecular weight:315.474-Hydroxy Propranolol β-D-Glucuronide (Mixture of Diastereomers)
CAS:Controlled Product<p>Applications A metabolite of 4-Hydroxy propranolol. Antihypertensive; antianginal; antiarrhythmic (class II).<br>References Walle, T., et al.: Clin. Pharmacol. Ther., 46, 257 (1989), Christ, D.D., et al.: Drug Metab. Dispos., 18, 1 (1990),<br></p>Formula:C22H29NO9Color and Shape:NeatMolecular weight:451.47Ibudilast
CAS:Controlled Product<p>Applications A leukotriene D4 antagonist. Used as an antiallergic, antiasthmatic, and vasodilator (cerebral). PDE inhibitor (non-selective).<br>References Nishino, K., et al.: Japan J. Pharmacol., 33, 267 (1983), Ohashi, M., et al.: Arch. Int. Pharmacodyn., 280, 216 (1986), Armstead, W.M., et al.: J. Pharmacol., Exp. Ther., 244, 138 (1988),<br></p>Formula:C14H18N2OColor and Shape:NeatMolecular weight:230.31L-Valinol
CAS:Controlled Product<p>Applications L-Valinol is used as a reagent in the synthesis of simple 1,3-thiazolidine-2-thione derivatives which can exhibit fungicidal activity. L-Valinol is also used as a reagent in the synthesis of small-molecule inhibitors of MDM2-p53 protein-protein interaction (MDM2 inhibitors) in clinical trials for the treatment of cancer.<br>References Chen, N., et al.: Phosphorus Sulfur, 190, 112 (2015); Zhao, Y., et al.: J. Med. Chem., 58, 1038 (2015)<br></p>Formula:C5H13NOColor and Shape:WhiteMolecular weight:103.1639-Acridinecarboxylic acid
CAS:Controlled Product<p>Applications 9-Acridinecarboxylic acid is used in the synthesis of short DNA-binding peptides.<br></p>Formula:C14H9NO2Color and Shape:YellowMolecular weight:223.23Hydroxy Atrazine-d5
CAS:Controlled Product<p>Applications Labelled Hydroxy Atrazine (H828600). Hydroxy Atrazine is a major metabolite of Atrazine (A794600).<br>References Thurman, E., et al.: Environ. Sci. Technol., 26, 2440 (1992), Evgenidou, E., et al.: J. Agric. Food Chem., 50, 6423 (2002), Namiesnik, J., et al.: Anal. Bioanal. Chem., 381, 279 (2005), Hultgren, S., et al.: Anal. Bioanal. Chem., 393, 929 (2009),<br></p>Formula:C82H5H10N5OColor and Shape:NeatMolecular weight:202.273-[(1E)-2-[4-[[(2-Carboxyethyl)amino]carbonyl]phenyl]diazenyl] Balsalazide Sodium Salt (>90%)
CAS:Controlled Product<p>Applications An impurity of the anti-inflammatory drug Balsalazide (B116300).<br></p>Formula:C27H24N6O9xNaPurity:>90%Color and Shape:NeatMolecular weight:576.51(free acid)rac 6-Chloro-1,4-dihydro-4-(1-pentynyl)-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
CAS:Controlled Product<p>Applications An Efavirenz (E425000) impurity.<br></p>Formula:C14H11ClF3NO2Color and Shape:Off White SolidMolecular weight:317.69Moclobemide N-Oxide
CAS:<p>Applications Moclobemide N-Oxide is a metabolite of Moclobemide (M481000), a reversible monoamine oxidase inhibitor.<br>References Plenis, A., et. al.: Biomed. Chrom., 21, 958 (2007); Rakic, A., et. al.: J. Pharmaceut. Biomed. Anal., 43, 1416 (2007); Wiesel, F.A., et al.: Eur. J. Clin. Pharmacol., 28, 89 (1985), Burkard, W.P., et al.: J. Pharmacol. Exp. Ther., 248, 391 (1989)<br></p>Formula:C13H17ClN2O3Color and Shape:NeatMolecular weight:284.74Efavirenz Amino Alcohol Ethyl Carbamate
CAS:Controlled Product<p>Applications Efavirenz Amino Alcohol Ethyl Carbamate is used in the synthesis of Efavirenz (E425000), a potent non-nucleoside HIV-1 reverse transcriptase inhibitor. Antiviral<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>Formula:C16H15ClF3NO3Color and Shape:NeatMolecular weight:361.74Hydroxynorketamine Hydrochloride
CAS:Controlled Product<p>Applications Hydroxynorketamine is a metabolite of Ketamine (K165300, HCl salt) which is a medication used mainly for starting and maintaining anesthesia.<br>References Adams, J., et al.: Biomed. Mass Spec., 11, 527 (1981); Sass, W.C., et al.: Anal. Profiles Drug Subs., 6, 297 (1977); Reich, D.L., et al.: Can. J. Anaesth., 36, 186 (1989)<br></p>Formula:C12H15Cl2NO2Color and Shape:White To Off-WhiteMolecular weight:276.163-Amino-4-(2,4,5-trifluorophenyl)butanyl Sitagliptin
CAS:Controlled Product<p>Applications 3-Amino-4-(2,4,5-trifluorophenyl)butanyl Sitagliptin is an impurity of Sitagliptin (S490990). Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV inhibitor. It has recently been approved for the therapy of type II diabetes.<br>References Kim, D., et al.: J. Med. Chem., 48, 141 (2005), Ahren, B., et al.: Eur. J. Pharmacol., 521 164 (2005), Bergman, A., et al: Clin. Ther., 28, 55 (2006)<br></p>Formula:C26H23F9N6O2Color and Shape:NeatMolecular weight:622.4854Benzil
CAS:<p>Applications Benzil is used in organic synthesis as a building block and in polymer chemistry as a photoinitiator. It has also been found to be an inhibitor of mammalian carboxylesterases.<br>References Encinas, M., et al.: J. Polym. Sci. A1., 22, 2469 (1984); Wadkins, R., et al.: J. Med. Chem., 48, 2906 (2005); Hicks, L., et al.: Bioorgan. Med. Chem., 15, 3801 (2007);<br></p>Formula:C14H10O2Color and Shape:NeatMolecular weight:210.231-(3,4-Dimethylphenyl)ethanol
CAS:Controlled Product<p>Applications 1-(3,4-Dimethylphenyl)ethanol is an intermediate in the production of Medetomidine (M203250), α2-Adrenergic agonist. Sedative; analgesic.<br>References Kagechika, H., et al.: J. Med. Chem., 32, 1098 (1989), ; Scheinin, M., et al.: Br. J. Clin. Pharmacol., 24, 443 (1987),<br></p>Formula:C10H14OColor and Shape:NeatMolecular weight:150.22Tofogliflozin
CAS:Controlled Product<p>Applications A novel, potent, and highly selective SGLT2 inhibitor that has been shown to improve glycemic control in diabetic mice and rats.<br></p>Formula:C22H26O6Color and Shape:NeatMolecular weight:386.44
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